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Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
2092 - - 84.7
2
1878
3D
4jtdH03 - 96.2
3
1821 - - 92.6
4
1678 - - 76.3
5
1667 - - 99.8
6
1597 - - 75.3
7
1548 - - 97.1
8
1491 - - 81.8
9
1447 - - 84.7
10
1385 - - 91.0
11
1280 - - 75.6
12
1256 - - 88.2
13
1234 - - 53.6
14
1101 - - 83.9
15
1067 - - 80.2
16
999 - - 81.9
17
996 - - 85.3
18
988 - - 82.2
19
919
3D
4kfmA02 - 95.4
20
886 - - 83.6
21
856 - - 87.8
22
795
3D
5wc5B00 - 81.3
23
781 - - 76.1
24
778 - - 72.8
25
721 - - 71.9
26
710 - - 57.1
27
678 - - 82.6
28
671 - - 91.8
29
559 - - 43.9
30
546 - - 89.0
31
544 - - 73.5
32
539 - - 76.9
33
521 - - 90.3
34
487 - - 66.3
35
Eag-related
460 - - 78.8
48
454
3D
6nmpP01 - 91.3
36
451 - - 92.3
37
442 - - 97.0
39
436
3D
5kumA02 - 77.9
43
436
3D
6cq9B00 - 75.3
38
434 - - 71.3
40
421 - - 70.2
41
418 - - 71.3
42
417 - - 75.0
44
395 - - 74.9
45
378 - - 77.3
46
375 - - 79.8
47
365 - - 80.0
49
355 - - 86.3
50
326
3D
6jb1G02 - 72.8
51
314 - - 82.3
52
306 - - 63.9
53
300 - - 51.1
54
283 - - 73.7
55
273 - - 94.1
56
266 - - 64.8
57
260 - - 80.1
58
258 - - 88.2
59
255 - - 72.0
60
232 - - 89.5
61
221 - - 95.0
62
207 - - 87.2
63
202 - - 81.7
64
198 - - 86.6
66
196 - - 60.0
65
196 - - 88.4
67
190 - - 71.9
68
184 - - 75.4
69
182 - - 58.1
70
176 - - 82.7
71
170 - - 58.6
72
161 - - 84.4
73
154 - - 92.0
74
139 - - 80.6
76
133
3D
3ukmD01 - 72.7
75
132 - - 74.8
77
124 - - 77.4
78
124 - - 87.9
79
108 - - 57.8
82
106
3D
6hu9o01 - 98.5
80
104 - - 67.4
81
103 - - 55.7
83
101 - - 27.3
84
100 - - 66.9
85
94 - - 46.4
86
89 - - 97.8
92
89
3D
3vouA00 - 27.1
87
88 - - 28.2
88
87 - - 91.2
89
84 - - 97.9
90
82 - - 77.2
91
81 - - 77.6
93
76 - - 94.0
94
75 - - 91.2
106
74
3D
4wfhB00 - 72.2
97
73 - - 96.5
96
73 - - 59.2
95
73 - - 55.3
98
71 - - 73.4
99
71 - - 40.8
100
67 - - 88.5
101
65 - - 0.0
103
65 - - 59.3
102
65 - - 75.4
104
63 - - 56.3
105
61 - - 95.8
107
59 - - 82.3
108
58 - - 77.9
109
57 - - 5.0
110
56 - - 89.0
111
55 - - 44.3
112
55 - - 80.7
113
54 - - 51.0
114
53 - - 75.4
115
53 - - 87.8
116
51 - - 57.0
118
50 - - 94.5
117
50 - - 99.5
120
49 - - 67.0
122
49 - - 87.8
119
49 - - 77.2
121
49 - - 58.8
123
49 - - 95.9
125
48 - - 75.8
124
48 - - 76.4
126
46 - - 17.8
127
45 - - 81.0
128
45 - - 82.8
276
44
3D
5iwoD00 - 74.4
129
43 - - 88.5
130
42 - - 81.3
131
41 - - 2.6
132
40 - - 88.6
133
Potassium K ChaNNel, calcium activated
40 - - 22.3
134
40 - - 92.4
135
39 - - 24.6
136
38 - - 63.4
137
38 - - 49.8
138
37 - - 73.9
139
36 - - 79.8
140
36 - - 80.9
144
35 - - 83.9
143
35 - - 93.6
141
35 - - 71.1
142
35 - - 80.4
145
35 - - 61.7
146
34 - - 16.5
148
33 - - 36.3
150
33 - - 43.6
149
33 - - 74.8
147
33 - - 21.2
152
32 - - 12.2
151
32 - - 92.3
153
31 - - 77.6
154
30 - - 68.2
156
29 - - 86.0
155
29 - - 92.6
181
28
3D
3behD02 - 52.3
158
28 - - 23.6
157
28 - - 86.7
161
27 - - 32.0
160
27 - - 37.6
162
27 - - 98.8
159
eag-related
27 - - 12.5
163
26 - - 71.5
167
26 - - 76.1
164
26 - - 70.6
165
26 - - 67.7
166
26 - - 95.7
169
24 - - 80.5
168
24 - - 50.9
170
24 - - 86.9
171
23 - - 46.7
172
23 - - 93.6
174
Potassium K ChaNNel, calcium activated
22 - - 72.4
173
22 - - 58.1
175
22 - - 59.7
178
21 - - 45.0
179
21 - - 63.0
177
21 - - 39.0
176
21 - - 58.6
180
20 - - 89.0
182
20 - - 78.3
185
20 - - 75.1
183
Potassium K ChaNNel, calcium activated
20 - - 81.3
184
20 - - 36.7
186
19 - - 29.0
187
19 - - 73.4
498
18
3D
2x6bA01 - 8.2
190
18 - - 78.7
191
18 - - 68.1
189
18 - - 38.4
188
18 - - 35.9
192
17 - - 43.9
193
17 - - 92.6
194
17 - - 72.6
195
16 - - 73.8
196
16 - - 39.3
197
16 - - 35.8
199
16 - - 64.8
198
16 - - 83.9
206
15 - - 38.8
205
15 - - 11.4
202
15 - - 33.6
200
15 - - 70.7
204
15 - - 16.4
201
15 - - 72.0
207
15 - - 72.7
203
15 - - 22.9
216
14 - - 99.4
215
14 - - 93.7
212
14 - - 6.7
210
14 - - 90.2
208
14 - - 87.1
214
14 - - 14.8
213
14 - - 10.5
209
14 - - 70.5
211
14 - - 92.7
221
13 - - 53.4
218
13 - - 26.0
220
13 - - 16.6
222
VIC
13 - - 46.2
219
Potassium K ChaNNel, calcium activated
13 - - 28.2
217
13 - - 91.4
227
12 - - 37.9
229
12 - - 17.1
223
12 - - 51.4
228
12 - - 22.0
224
12 - - 9.7
230
Potassium
12 - - 44.4
226
12 - - 72.9
225
12 - - 71.9
231
11 - - 7.7
242
11 - - 90.0
239
11 - - 12.3
237
VIC
11 - - 9.9
233
11 - - 17.7
238
11 - - 24.9
240
11 - - 10.7
234
11 - - 36.6
244
11 - - 92.5
243
11 - - 89.3
232
AMPA
11 - - 43.6
241
11 - - 58.5
235
11 - - 83.9
236
11 - - 50.1
245
10 - - 76.9
246
10 - - 11.6
251
10 - - 36.2
248
10 - - 75.2
250
10 - - 35.1
249
10 - - 33.2
247
Potassium
10 - - 13.0
260
9 - - 2.4
254
9 - - 34.5
258
9 - - 6.4
266
9 - - 91.0
265
9 - - 89.6
262
9 - - 6.7
253
9 - - 15.6
259
9 - - 6.9
257
9 - - 24.4
252
9 - - 93.9
263
9 - - 63.0
255
9 - - 56.8
256
9 - - 68.4
261
9 - - 2.0
264
9 - - 61.2
749
9
3D
1lnqH01 - 0.0
281
8 - - 92.5
272
8 - - 13.6
275
8 - - 80.6
270
8 - - 90.1
278
8 - - 76.4
274
8 - - 78.7
269
8 - - 21.0
267
8 - - 16.1
280
8 - - 77.1
279
8 - - 8.1
277
Potassium K ChaNNel, calcium activated
8 - - 12.6
271
8 - - 13.3
282
8 - - 93.7
273
8 - - 36.7
268
8 - - 42.9
289
7 - - 24.6
287
7 - - 90.6
297
7 - - 96.4
299
7 - - 93.9
291
7 - - 11.8
293
7 - - 8.3
283
7 - - 82.1
298
7 - - 82.0
288
7 - - 21.0
294
7 - - 6.2
284
7 - - 44.7
290
7 - - 14.2
285
7 - - 46.3
296
7 - - 88.8
292
7 - - 66.4
295
7 - - 73.3
286
7 - - 94.7
310
6 - - 90.8
300
6 - - 85.9
315
6 - - 12.0
312
6 - - 8.9
316
6 - - 54.9
305
6 - - 12.5
302
6 - - 81.4
306
6 - - 5.9
301
6 - - 77.1
309
6 - - 75.6
307
6 - - 9.0
313
6 - - 17.5
311
6 - - 91.8
317
6 - - 72.3
319
6 - - 82.3
303
6 - - 16.0
308
6 - - 16.6
314
6 - - 81.0
318
6 - - 73.8
556
6
3D
3kg2D05 - 42.0
304
6 - - 8.4
338
5 - - 10.9
353
5 - - 74.4
340
5 - - 70.3
328
5 - - 0.0
334
5 - - 75.2
324
AMPA
5 - - 7.7
351
5 - - 76.8
354
5 - - 65.5
329
5 - - 26.1
327
VIC
5 - - 10.1
346
5 - - 9.2
321
5 - - 38.1
345
5 - - 10.2
331
5 - - 32.0
342
5 - - 21.8
337
5 - - 14.9
339
5 - - 8.0
333
5 - - 63.3
323
BK
5 - - 7.1
343
5 - - 43.8
350
5 - - 85.4
322
5 - - 8.0
336
5 - - 16.3
325
5 - - 17.6
347
5 - - 18.3
349
5 - - 47.8
332
5 - - 66.9
341
5 - - 39.8
335
5 - - 4.6
326
5 - - 8.7
344
Potassium K ChaNNel, calcium activated
5 - - 10.2
352
5 - - 76.1
355
5 - - 57.3
330
5 - - 70.2
348
5 - - 22.3
320
5 - - 38.1
365
4 - - 9.4
362
4 - - 6.8
388
4 - - 70.2
366
4 - - 47.4
384
4 - - 62.1
357
4 - - 6.0
359
4 - - 24.1
370
4 - - 64.8
391
4 - - 63.3
387
4 - - 57.7
389
4 - - 1.7
381
4 - - 19.9
360
4 - - 87.7
383
4 - - 74.8
372
4 - - 8.9
375
4 - - 11.9
358
4 - - 80.3
393
4 - - 76.8
376
4 - - 8.7
377
4 - - 24.7
379
4 - - 10.2
371
4 - - 9.7
364
4 - - 10.0
392
4 - - 73.4
386
4 - - 45.3
385
4 - - 47.8
373
4 - - 15.2
382
4 - - 24.2
368
4 - - 28.9
356
4 - - 72.2
363
4 - - 17.8
378
Potassium K ChaNNel, calcium activated
4 - - 10.5
367
4 - - 41.9
369
4 - - 35.2
361
4 - - 5.1
380
4 - - 8.0
374
4 - - 12.1
390
4 - - 74.3
428
3 - - 24.9
410
3 - - 81.2
440
3 - - 35.8
438
3 - - 31.7
398
3 - - 66.3
400
3 - - 61.0
424
3 - - 5.0
394
3 - - 46.3
434
3 - - 23.0
439
3 - - 60.8
437
3 - - 33.1
399
3 - - 11.1
397
3 - - 58.0
442
3 - - 35.4
431
3 - - 7.8
445
3 - - 24.7
416
3 - - 15.2
412
CAKC
3 - - 5.3
421
3 - - 0.0
415
3 - - 18.4
446
3 - - 44.6
427
3 - - 7.5
429
3 - - 33.8
423
3 - - 0.0
406
3 - - 34.7
433
3 - - 11.3
402
3 - - 64.8
405
3 - - 32.9
413
3 - - 9.7
407
3 - - 54.7
409
3 - - 47.0
443
3 - - 33.4
401
3 - - 10.1
426
3 - - 8.6
435
3 - - 0.0
403
3 - - 28.5
441
3 - - 42.7
432
3 - - 0.0
395
3 - - 2.4
447
3 - - 39.8
419
3 - - 0.0
417
3 - - 33.8
425
3 - - 0.0
436
3 - - 30.5
411
3 - - 12.5
396
3 - - 34.2
422
3 - - 0.0
414
3 - - 11.0
408
3 - - 60.9
444
3 - - 55.9
404
3 - - 20.1
420
3 - - 74.8
418
Isl
3 - - 36.6
448
3 - - 70.7
430
3 - - 3.1
551
2 - - 2.3
466
2 - - 17.2
500
2 - - 25.0
557
2 - - 28.9
559
2 - - 35.6
524
2 - - 0.0
534
2 - - 23.5
488
2 - - 4.3
462
2 - - 7.6
453
2 - - 6.8
465
2 - - 41.9
451
2 - - 2.6
528
2 - - 10.0
566
2 - - 0.0
470
2 - - 11.3
459
2 - - 7.3
457
2 - - 37.9
510
2 - - 36.6
494
2 - - 4.5
540
2 - - 0.0
484
2 - - 2.9
538
2 - - 0.0
553
2 - - 4.2
562
2 - - 36.6
565
2 - - 44.0
460
2 - - 5.2
481
2 - - 9.1
523
2 - - 10.3
489
2 - - 7.7
506
2 - - 30.1
487
2 - - 0.7
502
2 - - 0.0
558
2 - - 34.8
533
2 - - 3.9
491
2 - - 8.1
505
2 - - 29.9
497
Potassium
2 - - 2.7
499
2 - - 11.0
454
2 - - 0.0
537
2 - - 7.6
476
2 - - 40.4
539
2 - - 10.0
560
2 - - 32.7
493
2 - - 1.1
531
2 - - 7.8
542
2 - - 10.1
516
2 - - 3.7
545
2 - - 0.0
521
2 - - 2.0
512
2 - - 42.6
458
2 - - 33.3
546
2 - - 0.0
515
2 - - 0.9
529
2 - - 8.9
527
2 - - 32.0
475
2 - - 40.3
472
2 - - 31.0
554
2 - - 26.9
483
2 - - 4.0
535
2 - - 0.0
526
2 - - 32.5
532
2 - - 0.0
541
2 - - 3.1
503
2 - - 27.1
464
2 - - 8.8
547
2 - - 10.8
549
2 - - 0.0
471
2 - - 34.8
450
2 - - 0.0
517
2 - - 3.4
519
2 - - 4.7
536
2 - - 11.0
479
2 - - 38.3
525
2 - - 0.0
477
2 - - 41.5
522
2 - - 0.0
511
2 - - 40.0
496
2 - - 0.0
513
2 - - 37.5
468
2 - - 30.0
482
2 - - 4.1
564
2 - - 33.4
473
2 - - 38.2
449
2 - - 0.0
485
CAKC
2 - - 0.0
509
2 - - 39.6
486
2 - - 0.7
550
2 - - 42.0
507
2 - - 28.7
495
2 - - 1.6
501
2 - - 12.9
543
2 - - 0.0
492
2 - - 8.9
504
2 - - 26.9
478
2 - - 41.0
520
2 - - 9.9
455
2 - - 0.0
518
2 - - 0.0
452
2 - - 0.0
463
2 - - 3.1
456
2 - - 10.1
548
2 - - 1.0
561
2 - - 39.7
567
2 - - 48.8
530
2 - - 30.6
514
2 - - 12.7
490
2 - - 10.6
555
2 - - 31.7
474
2 - - 37.5
563
2 - - 36.4
552
2 - - 0.0
508
2 - - 38.6
480
2 - - 42.9
461
2 - - 0.0
544
2 - - 8.9
469
2 - - 29.4
467
2 - - 19.4
754
1 - - 0.0
683
1 - - 0.0
806
1 - - 0.0
672
1 - - 0.0
675
1 - - 0.0
797
1 - - 0.0
727
1 - - 0.0
799
1 - - 0.0
729
1 - - 0.0
570
1 - - 0.0
746
1 - - 0.0
605
1 - - 0.0
715
1 - - 0.0
602
1 - - 0.0
712
1 - - 0.0
594
1 - - 0.0
658
1 - - 0.0
633
1 - - 0.0
791
1 - - 0.0
721
1 - - 0.0
789
1 - - 0.0
787
1 - - 0.0
606
1 - - 0.0
716
1 - - 0.0
745
1 - - 0.0
731
1 - - 0.0
742
1 - - 0.0
623
1 - - 0.0
693
1 - - 0.0
781
1 - - 0.0
805
1 - - 0.0
584
1 - - 0.0
802
1 - - 0.0
760
1 - - 0.0
739
1 - - 0.0
676
1 - - 0.0
737
1 - - 0.0
772
1 - - 0.0
598
1 - - 0.0
783
1 - - 0.0
654
1 - - 0.0
699
1 - - 0.0
629
1 - - 0.0
697
1 - - 0.0
627
1 - - 0.0
775
1 - - 0.0
646
1 - - 0.0
705
1 - - 0.0
615
1 - - 0.0
691
1 - - 0.0
621
1 - - 0.0
702
1 - - 0.0
612
1 - - 0.0
733
1 - - 0.0
758
1 - - 0.0
706
1 - - 0.0
687
1 - - 0.0
616
1 - - 0.0
645
1 - - 0.0
689
1 - - 0.0
723
1 - - 0.0
793
1 - - 0.0
588
1 - - 0.0
642
1 - - 0.0
631
1 - - 0.0
681
1 - - 0.0
637
1 - - 0.0
660
1 - - 0.0
639
1 - - 0.0
776
1 - - 0.0
576
1 - - 0.0
765
1 - - 0.0
800
1 - - 0.0
762
1 - - 0.0
738
1 - - 0.0
684
1 - - 0.0
753
1 - - 0.0
788
1 - - 0.0
634
1 - - 0.0
593
1 - - 0.0
740
1 - - 0.0
694
1 - - 0.0
624
1 - - 0.0
710
1 - - 0.0
600
1 - - 0.0
657
1 - - 0.0
659
KCNK5
1 - - 0.0
575
1 - - 0.0
766
1 - - 0.0
670
1 - - 0.0
583
1 - - 0.0
798
1 - - 0.0
728
1 - - 0.0
651
1 - - 0.0
572
1 - - 0.0
665
1 - - 0.0
653
1 - - 0.0
784
1 - - 0.0
638
1 - - 0.0
662
1 - - 0.0
581
1 - - 0.0
734
1 - - 0.0
688
1 - - 0.0
587
1 - - 0.0
640
1 - - 0.0
589
1 - - 0.0
591
1 - - 0.0
794
1 - - 0.0
724
1 - - 0.0
759
1 - - 0.0
610
1 - - 0.0
700
1 - - 0.0
757
1 - - 0.0
666
1 - - 0.0
770
1 - - 0.0
599
eag-related
1 - - 0.0
597
1 - - 0.0
751
1 - - 0.0
698
1 - - 0.0
628
1 - - 0.0
667
1 - - 0.0
630
1 - - 0.0
669
1 - - 0.0
596
1 - - 0.0
744
1 - - 0.0
568
1 - - 0.0
573
1 - - 0.0
648
1 - - 0.0
661
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582
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585
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804
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756
1 - - 0.0
680
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752
1 - - 0.0
618
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708
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674
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763
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586
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755
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690
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620
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595
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714
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604
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592
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778
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730
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769
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767
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644
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761
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748
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656
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780
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774
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663
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718
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571
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608
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655
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577
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579
1 - - 0.0
790
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720
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678
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614
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704
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701
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611
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743
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636
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590
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625
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617
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686
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619
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803
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647
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668
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632
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671
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732
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741
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703
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613
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768
1 - - 0.0
726
1 - - 0.0
796
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735
1 - - 0.0
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