The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1946
3D
3g8mA01 - 94.3
2
1388
3D
1ejiD02 - 87.2
3
1087
3D
5usrG02 - 93.3
4
1010
3D
4adeB02 - 96.6
5
decarboxylating
941 - - 92.3
6
852
3D
1fc4B01 - 93.3
7
Decarboxylating
789 - - 85.3
9
775
3D
3elpD01 - 97.1
8
773
3D
3n75E02 - 94.9
10
750
3D
6czzD01 - 99.3
15
707
3D
3tatF02 - 91.9
11
707
3D
5vwoC02 - 89.7
14
680
3D
4grxD02 - 97.7
13
672
3D
1szuD02 - 94.7
12
644
3D
3tcmB03 - 86.2
16
561
3D
2jisB02 - 83.9
17
559
3D
3fz8F02 - 84.1
18
485
3D
2x5dD02 - 48.6
21
453
3D
5hdmB02 - 93.1
19
438
3D
4cvqB02 - 62.3
20
434
3D
4q6rB03 - 89.5
22
367
3D
3hbxF02 - 75.7
24
366
3D
4wljB02 - 94.9
25
352
3D
3k40B02 - 95.5
23
346 - - 98.1
26
344
3D
3pdbD02 - 86.5
27
331
3D
2bkwA02 - 93.4
33
282
3D
6f5vD02 - 96.5
28
Sec
280 - - 77.4
30
277
3D
3wlxB01 - 91.9
29
269 - - 89.9
41
259
3D
1s0aB02 - 83.2
31
225 - - 91.2
32
222
3D
1ijiA01 - 48.8
37
218
3D
4zahH01 - 58.8
34
decarboxylating
209 - - 77.9
35
206
3D
3ndnD01 - 94.2
36
197 - - 88.0
39
195
3D
4w4hB02 - 37.9
46
195
3D
5e4zA01 - 97.6
38
195
3D
1cs1D01 - 80.8
44
187
3D
6dndB02 - 82.0
40
178
3D
1mdzA01 - 77.0
42
165
3D
5db5B02 - 58.0
43
162
3D
1n8pD01 - 74.2
53
158
3D
1vp4B02 - 95.6
45
154 - - 62.5
51
144
3D
1iayA02 - 80.7
47
143 - - 77.8
48
142
3D
3pdxA02 - 94.2
49
137 - - 80.9
50
135 - - 78.6
52
120 - - 69.3
54
108 - - 95.3
55
107 - - 80.2
56
107 - - 80.8
57
106 - - 50.5
58
105 - - 69.5
62
99
3D
4itxB01 - 67.3
59
97 - - 72.7
60
96 - - 70.0
61
93 - - 41.7
64
93
3D
1yaaD02 - 85.0
63
86 - - 67.0
65
83 - - 56.6
66
82 - - 90.2
67
76 - - 64.6
68
70 - - 38.0
73
70
3D
2jjhA02 - 91.8
74
68
3D
4je5D00 - 93.5
81
68
3D
5ft8O02 - 34.1
70
Sec
68
3D
4zdoD00 - 64.9
71
66 - - 92.0
69
66 - - 41.7
72
62 - - 81.6
83
61
3D
3gzdD03 - 82.5
89
60
3D
3nyuD01 - 94.9
92
59
3D
2yhkB02 - 22.2
78
57
3D
3du4B02 - 90.0
76
54
3D
2o0rB02 - 75.0
79
54
3D
3bcxB01 - 73.0
75
54 - - 2.0
101
53
3D
4uqvL01 - 87.4
99
53
3D
3eibB02 - 89.5
90
52
3D
3dr7D01 - 96.5
77
51 - - 78.8
80
50 - - 93.9
88
50
3D
4a0rB03 - 68.3
84
49
3D
4isyD02 - 79.3
82
49 - - 84.7
87
45
3D
5vyeD02 - 62.0
93
45
3D
3bwoF02 - 66.3
85
44 - - 46.1
86
42 - - 85.7
91
38 - - 70.0
95
35
3D
2g6wA02 - 35.4
94
32 - - 84.6
96
30 - - 53.0
97
30 - - 50.0
98
29 - - 81.8
100
28 - - 81.6
102
inactive
27 - - 42.7
206
27
3D
2fm1D01 - 37.1
108
26
3D
4o6zD02 - 9.8
112
25
3D
4q76B02 - 46.7
103
25 - - 53.9
107
24
3D
1qz9A02 - 84.6
105
24 - - 7.1
104
24 - - 89.7
106
24 - - 2.4
110
22 - - 17.4
111
22 - - 79.5
109
22 - - 28.0
116
PLP
21 - - 30.9
115
21 - - 8.0
117
21 - - 72.8
113
decarboxylating
21 - - 57.1
114
21 - - 72.6
119
20 - - 84.5
214
20
3D
3kkiB02 - 0.0
118
20 - - 16.5
120
20 - - 85.3
121
20
3D
3k7yA02 - 8.6
122
19 - - 68.5
123
19 - - 66.0
138
18
3D
4raeB02 - 8.3
124
18 - - 11.8
127
17 - - 69.0
136
17
3D
3caiB02 - 16.0
128
17 - - 53.7
125
17 - - 72.5
129
17 - - 88.0
126
17 - - 21.4
264
16
3D
4wp0D02 - 33.1
130
16 - - 21.4
132
16 - - 1.9
135
16 - - 6.5
131
16 - - 26.4
133
16 - - 16.8
134
16 - - 5.9
137
15 - - 41.1
144
14 - - 26.4
191
AgxT
14
3D
3zrrB01 - 72.9
142
14 - - 53.4
140
14 - - 19.8
147
14 - - 40.1
139
14 - - 15.0
145
14 - - 12.8
143
14 - - 19.7
141
14 - - 65.4
146
14 - - 52.2
153
13 - - 12.1
151
13 - - 14.5
155
13 - - 15.2
154
13 - - 1.4
158
decarboxylating
13 - - 33.4
149
13 - - 39.8
156
13 - - 51.2
152
13 - - 15.3
150
13 - - 4.9
148
13 - - 8.5
157
13 - - 34.8
200
12
3D
3pj0D01 - 76.2
159
12 - - 55.8
160
11 - - 31.0
163
11 - - 7.9
165
11 - - 34.9
161
11 - - 7.2
162
11 - - 0.0
164
11 - - 13.7
170
10 - - 15.6
167
10 - - 29.3
259
10
3D
2fnuB01 - 7.8
319
10
3D
2z9xB02 - 8.4
168
10 - - 0.0
171
10 - - 10.6
169
10 - - 6.4
172
10 - - 92.5
166
10 - - 6.0
180
9 - - 12.6
177
9 - - 8.1
182
9 - - 69.3
175
9 - - 4.0
184
9 - - 86.9
181
9 - - 38.8
173
9 - - 8.4
178
9 - - 0.3
176
9 - - 61.5
174
9 - - 24.6
183
9 - - 40.0
179
9 - - 13.9
185
9 - - 85.0
193
8 - - 8.4
189
decarboxylating
8 - - 17.4
187
8 - - 9.3
198
8 - - 73.6
186
8 - - 1.4
196
8 - - 12.2
194
8 - - 50.9
197
decarboxylating
8 - - 13.6
192
8 - - 0.0
199
8 - - 54.4
195
8 - - 1.3
188
8 - - 3.6
190
8 - - 14.1
205
7 - - 10.4
207
7 - - 5.4
202
7 - - 0.0
209
7 - - 76.0
208
7 - - 0.0
201
7 - - 66.6
203
7 - - 8.7
204
7 - - 11.0
211
6 - - 18.3
236
6
3D
3ihjA03 - 41.6
218
6 - - 8.3
221
6 - - 66.4
212
6 - - 23.9
227
6 - - 90.6
225
6 - - 31.5
222
6 - - 83.4
217
6 - - 1.3
210
6 - - 19.0
219
6 - - 71.5
220
6 - - 14.1
226
6 - - 39.5
213
6 - - 69.7
224
decarboxylating
6 - - 76.3
215
6 - - 6.7
343
6
3D
5k8bD01 - 7.4
223
6 - - 0.0
216
6 - - 6.7
234
5 - - 0.4
232
5 - - 6.6
240
5 - - 8.9
230
5 - - 8.8
229
5 - - 2.0
239
5 - - 10.2
242
5 - - 0.3
244
5 - - 8.3
237
5 - - 12.8
235
5 - - 6.8
245
5 - - 71.3
233
5 - - 2.6
241
5 - - 38.4
243
5 - - 1.6
231
5 - - 8.7
228
5 - - 70.2
238
5 - - 27.5
246
4 - - 3.7
260
4 - - 4.4
262
4 - - 58.7
255
4 - - 6.8
250
4 - - 16.6
257
4 - - 11.9
249
4 - - 6.2
247
4 - - 67.5
252
4 - - 31.0
254
4 - - 58.0
265
4 - - 30.8
251
4 - - 5.9
256
4 - - 0.0
263
4 - - 12.1
261
4 - - 10.2
253
4 - - 62.8
277
4
3D
2aeuA02 - 12.6
258
4 - - 3.1
248
4 - - 11.0
285
3 - - 0.0
288
3 - - 43.1
272
Eurofung
3 - - 0.0
287
3 - - 12.8
294
3 - - 43.9
274
3 - - 15.2
278
3 - - 15.1
276
3 - - 24.5
281
3 - - 19.6
269
3 - - 43.2
284
3 - - 2.7
289
3 - - 56.2
290
3 - - 0.2
283
3 - - 5.6
271
3 - - 0.0
295
3 - - 60.1
286
3 - - 3.7
296
3 - - 63.8
275
3 - - 45.7
279
3 - - 56.8
293
3 - - 28.6
267
Sec
3 - - 0.0
292
3 - - 0.0
291
3 - - 8.0
280
3 - - 46.0
273
3 - - 1.9
270
3 - - 0.0
266
decarboxylating
3 - - 0.0
268
3 - - 37.8
282
3 - - 69.1
325
2 - - 29.4
378
2 - - 34.2
350
2 - - 1.5
337
2 - - 42.6
340
2 - - 0.0
311
2 - - 6.7
308
2 - - 0.0
373
2 - - 31.9
301
2 - - 36.5
366
2 - - 36.0
349
2 - - 12.5
333
Eurofung
2 - - 0.0
323
2 - - 1.2
359
2 - - 23.1
330
Eurofung
2 - - 0.0
360
2 - - 1.8
353
2 - - 7.5
375
2 - - 41.0
303
2 - - 45.0
347
2 - - 0.0
320
2 - - 0.0
361
2 - - 0.8
307
2 - - 6.0
326
2 - - 21.0
335
2 - - 31.4
299
Sec
2 - - 0.0
377
2 - - 40.6
315
2 - - 0.8
338
2 - - 45.4
305
S
2 - - 9.0
328
2 - - 0.0
363
2 - - 0.0
317
2 - - 0.0
313
2 - - 3.0
344
2 - - 0.0
357
PLP
2 - - 39.7
336
2 - - 35.2
297
decarboxylating
2 - - 2.2
365
2 - - 6.8
358
2 - - 12.7
331
2 - - 0.0
348
2 - - 0.0
364
2 - - 4.0
367
2 - - 40.2
324
2 - - 0.0
351
2 - - 0.0
379
2 - - 37.6
342
2 - - 8.0
341
2 - - 7.2
312
2 - - 0.0
370
2 - - 15.1
309
2 - - 0.0
300
2 - - 0.0
329
2 - - 12.6
346
2 - - 7.3
352
2 - - 3.5
369
2 - - 0.0
372
2 - - 24.6
322
2 - - 0.0
310
2 - - 3.5
354
2 - - 1.8
332
2 - - 2.2
368
2 - - 0.0
316
2 - - 2.4
374
2 - - 31.7
327
2 - - 39.5
314
2 - - 0.0
355
Cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase
2 - - 0.0
334
2 - - 29.7
302
2 - - 38.4
362
2 - - 14.2
376
2 - - 40.0
298
2 - - 0.0
321
2 - - 1.0
371
2 - - 0.0
339
2 - - 0.0
345
2 - - 0.0
304
2 - - 12.0
306
2 - - 1.0
318
2 - - 0.0
356
2 - - 6.2
512
1 - - 0.0
463
1 - - 0.0
458
1 - - 0.0
517
1 - - 0.0
451
1 - - 0.0
454
1 - - 0.0
389
1 - - 0.0
495
1 - - 0.0
486
1 - - 0.0
391
1 - - 0.0
410
1 - - 0.0
430
1 - - 0.0
447
1 - - 0.0
536
1 - - 0.0
415
1 - - 0.0
480
1 - - 0.0
438
1 - - 0.0
444
1 - - 0.0
508
1 - - 0.0
417
1 - - 0.0
506
1 - - 0.0
381
Decarboxylating
1 - - 0.0
456
1 - - 0.0
493
1 - - 0.0
400
1 - - 0.0
534
1 - - 0.0
468
1 - - 0.0
475
1 - - 0.0
413
1 - - 0.0
515
1 - - 0.0
432
1 - - 0.0
519
1 - - 0.0
446
1 - - 0.0
526
1 - - 0.0
477
1 - - 0.0
510
1 - - 0.0
393
1 - - 0.0
449
1 - - 0.0
501
1 - - 0.0
490
1 - - 0.0
387
1 - - 0.0
461
1 - - 0.0
425
1 - - 0.0
520
1 - - 0.0
532
1 - - 0.0
424
1 - - 0.0
395
1 - - 0.0
434
1 - - 0.0
442
1 - - 0.0
465
1 - - 0.0
412
1 - - 0.0
385
Class 5
1 - - 0.0
479
1 - - 0.0
524
1 - - 0.0
440
1 - - 0.0
467
1 - - 0.0
481
1 - - 0.0
474
1 - - 0.0
503
1 - - 0.0
484
1 - - 0.0
472
1 - - 0.0
537
1 - - 0.0
522
1 - - 0.0
529
1 - - 0.0
397
1 - - 0.0
459
1 - - 0.0
401
1 - - 0.0
404
1 - - 0.0
516
1 - - 0.0
455
1 - - 0.0
457
1 - - 0.0
383
1 - - 0.0
505
1 - - 0.0
419
1 - - 0.0
406
1 - - 0.0
530
1 - - 0.0
470
1 - - 0.0
421
1 - - 0.0
491
1 - - 0.0
390
1 - - 0.0
408
1 - - 0.0
443
1 - - 0.0
437
1 - - 0.0
431
1 - - 0.0
527
1 - - 0.0
382
1 - - 0.0
418
1 - - 0.0
388
1 - - 0.0
509
1 - - 0.0
485
1 - - 0.0
523
1 - - 0.0
460
1 - - 0.0
453
1 - - 0.0
488
1 - - 0.0
452
1 - - 0.0
535
1 - - 0.0
405
1 - - 0.0
507
1 - - 0.0
416
1 - - 0.0
380
decarboxylating
1 - - 0.0
392
1 - - 0.0
496
1 - - 0.0
399
1 - - 0.0
436
DegT/DnrJ/Eryc1 family
1 - - 0.0
386
1 - - 0.0
445
1 - - 0.0
525
1 - - 0.0
441
1 - - 0.0
427
1 - - 0.0
426
1 - - 0.0
498
1 - - 0.0
483
1 - - 0.0
428
1 - - 0.0
500
1 - - 0.0
533
1 - - 0.0
414
1 - - 0.0
462
1 - - 0.0
394
1 - - 0.0
514
1 - - 0.0
513
1 - - 0.0
476
1 - - 0.0
469
1 - - 0.0
492
1 - - 0.0
511
1 - - 0.0
429
1 - - 0.0
409
1 - - 0.0
489
1 - - 0.0
471
1 - - 0.0
502
1 - - 0.0
521
1 - - 0.0
433
1 - - 0.0
423
1 - - 0.0
422
1 - - 0.0
402
1 - - 0.0
464
1 - - 0.0
497
1 - - 0.0
518
1 - - 0.0
439
1 - - 0.0
411
1 - - 0.0
478
1 - - 0.0
398
1 - - 0.0
384
1 - - 0.0
407
1 - - 0.0
504
1 - - 0.0
435
1 - - 0.0
531
1 - - 0.0
420
1 - - 0.0
494
1 - - 0.0
487
1 - - 0.0
448
1 - - 0.0
396
1 - - 0.0
482
1 - - 0.0
499
1 - - 0.0
403
1 - - 0.0
466
1 - - 0.0
450
1 - - 0.0
473
1 - - 0.0
528
1 - - 0.0