CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Pyridoxal phosphate-dependent aminotransferase

Enzyme Information

2.6.1.2
Alanine transaminase.
based on mapping to UniProt P0A959
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.
-!- 2-aminobutanoate acts slowly instead of alanine.

UniProtKB Entries (1)

P0A959
ALAA_ECOLI
Escherichia coli K-12
Glutamate-pyruvate aminotransferase AlaA

PDB Structure

PDB 4CVQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
Pena-Soler, E., Fernandez, F.J., Lopez-Estepa, M., Garces, F., Richardson, A.J., Quintana, J.F., Rudd, K.E., Coll, M., Vega, M.C.
PLoS ONE