CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family 4-aminobutyrate aminotransferase

Enzyme Information

2.6.1.48
5-aminovalerate transaminase.
based on mapping to UniProt P22256
5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate.
2.6.1.19
4-aminobutyrate--2-oxoglutarate transaminase.
based on mapping to UniProt P22256
4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
-!- Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate.

UniProtKB Entries (1)

P22256
GABT_ECOLI
Escherichia coli K-12
4-aminobutyrate aminotransferase GabT

PDB Structure

PDB 1SZU
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coligamma-Aminobutyrate Aminotransferase.
Liu, W., Peterson, P.E., Langston, J.A., Jin, X., Zhou, X., Fisher, A.J., Toney, M.D.
Biochemistry