CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family sphingosine-1-phosphate lyase 1

Enzyme Information

4.1.2.27
Sphinganine-1-phosphate aldolase.
based on mapping to UniProt O95470
Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.

UniProtKB Entries (1)

O95470
SGPL1_HUMAN
Homo sapiens
Sphingosine-1-phosphate lyase 1

PDB Structure

PDB 4Q6R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis.
Weiler, S., Braendlin, N., Beerli, C., Bergsdorf, C., Schubart, A., Srinivas, H., Oberhauser, B., Billich, A.
J.Med.Chem.