CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family L-tryptophan--pyruvate aminotransferase 1

Enzyme Information

2.6.1.99
L-tryptophan--pyruvate aminotransferase.
based on mapping to UniProt Q9S7N2
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine.
-!- This plant enzyme, along with EC 1.14.13.168, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.
2.6.1.27
Tryptophan transaminase.
based on mapping to UniProt Q9S7N2
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate.
-!- Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids.

UniProtKB Entries (1)

Q9S7N2
TAA1_ARATH
Arabidopsis thaliana
L-tryptophan--pyruvate aminotransferase 1

PDB Structure

PDB 3BWO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for the shade avoidance response of plants
Tao, Y., Ferrer, J.-L., Pojer, F., Hong, F., Ljung, K., Long, J.A., Li, L., Moreno, J.E., Bowman, M.E., Ivans, L.J., Lim, J., Ballare, C.L., Sandberg, G., Noel, J.P., Chory, J.
To be Published