CATH / Gene3D v4.3

151 million protein domains classified into 5,841 superfamilies

CATH annotations for the 21 model organisms predicted by AlphaFold (v2) are available to download (doi:10.1038/s42003-023-04488-9). Core classification files for the latest version of CATH-Plus (v4.3) are available to download. Daily updates of our very latest classifications are also available.

3D Structure

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Protein Evolution

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Protein Function

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Conserved Sites

Look at protein sites that are highly conserved and implicated in function

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What is CATH-Gene3D?

CATH is a classification of protein structures downloaded from the Protein Data Bank. We group protein domains into superfamilies when there is sufficient evidence they have diverged from a common ancestor.

Gene3D uses the information in CATH to predict the locations of structural domains on millions of protein sequences available in public databases. This allows us to include additional annotations to the CATH-Gene3D database such as functional information and active site residues.

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Latest Release Statistics Info

CATH-Plus 4.3.0 CATH (daily snapshot)
PDB Release 01-07-2019
Domains 500238 536613
Superfamilies 5481 6631
Annotated PDBs 150885 189379

Gene3D v21
Protein Sequences82,665,384
CATH Domain Predictions151,013,797


Citing this resource

If you find the information in this resource useful, please consider using the following citations:

CATH: increased structural coverage of functional space.
Sillitoe I, Bordin N, Dawson N, Waman VP, Ashford P, Scholes HM, Pang CSM, Woodridge L, Rauer C, Sen N, Abbasian M, Le Cornu S, Lam SD, Berka K, Varekova IH, Svobodova R, Lees J, Orengo CA.
Nucleic Acids Res. 2021 Jan
Gene3D: Extensive prediction of globular domains in proteins.
Lewis TE, Sillitoe I, Dawson N, Lam SD, Clarke T, Orengo CA, Lees JG.
Nucleic Acids Res. 2018 Jan

Funding

The CATH and Gene3D resources have enjoyed generous funding from a number of research councils.

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