CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Serine hydroxymethyltransferase

Enzyme Information

2.1.2.1
Glycine hydroxymethyltransferase.
based on mapping to UniProt P50431
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
-!- Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.

UniProtKB Entries (1)

P50431
GLYC_MOUSE
Mus musculus
Serine hydroxymethyltransferase, cytosolic

PDB Structure

PDB 1EJI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers.
Szebenyi, D.M., Liu, X., Kriksunov, I.A., Stover, P.J., Thiel, D.J.
Biochemistry