CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Cysteine desulfurase IscS

Enzyme Information

2.8.1.7
Cysteine desulfurase.
based on mapping to UniProt Q9Y697
L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.
-!- The sulfur from free L-cysteine is first transferred to a cysteine residue in the active site, and then passed on to various other acceptors. -!- The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin). -!- In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation.

UniProtKB Entries (2)

P0A6A8
ACP_ECOLI
Escherichia coli K-12
Acyl carrier protein
Q9Y697
NFS1_HUMAN
Homo sapiens
Cysteine desulfurase, mitochondrial

PDB Structure

PDB 5USR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.
Cory, S.A., Van Vranken, J.G., Brignole, E.J., Patra, S., Winge, D.R., Drennan, C.L., Rutter, J., Barondeau, D.P.
Proc. Natl. Acad. Sci. U.S.A.