CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Serine hydroxymethyltransferase

Enzyme Information

2.1.2.1
Glycine hydroxymethyltransferase.
based on mapping to UniProt P0A825
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
-!- Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.

UniProtKB Entries (1)

P0A825
GLYA_ECOLI
Escherichia coli K-12
Serine hydroxymethyltransferase

PDB Structure

PDB 3G8M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Role of a conserved active site cation-pi interaction in Escherichia coli serine hydroxymethyltransferase.
Vivoli, M., Angelucci, F., Ilari, A., Morea, V., Angelaccio, S., di Salvo, M.L., Contestabile, R.
Biochemistry