The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
849
3D
3qo6C02 - 91.2
8
828
3D
4wxvB01 - 87.9
2
796
3D
5brrE01 - 99.7
4
581
3D
5wi6D02 - 94.5
71
569
3D
8kme202 - 55.5
5
543
3D
1orfA02 - 92.6
85
537
3D
8kme201 - 72.7
3
505 - - 93.1
124
490
3D
6fidA02 - 53.9
11
481
3D
3f6uH01 - 67.2
13
461
3D
6mv4H02 - 98.2
14
418
3D
1t32A01 - 96.6
6
407 - - 94.6
9
399
3D
3lh3I01 - 84.1
7
396
3D
5lyoC02 - 98.1
17
381
3D
4h4fA01 - 86.7
29
363
3D
6bqkB02 - 77.0
16
352
3D
5f03B01 - 87.4
19
344
3D
6gfiB02 - 89.4
10
321
3D
5fahA01 - 96.3
33
312
3D
5c5oB01 - 81.7
45
294
3D
5c5oB02 - 81.0
12
292 - - 77.1
22
279
3D
2zu3A01 - 84.1
15
270 - - 96.5
30
252
3D
2zu3A02 - 91.1
18
225
3D
4mg3B01 - 96.5
70
221
3D
5zc5U02 - 83.2
20
215
3D
4mg3B02 - 92.0
65
206
3D
5hggB01 - 61.8
21
191 - - 86.2
23
161
3D
4o3uA01 - 82.2
25
156
3D
2hlcB02 - 93.4
24
153 - - 92.5
27
151
3D
4wjgW02 - 85.6
32
149
3D
3qumQ02 - 92.6
31
149
3D
4wjgW03 - 83.8
122
147
3D
9estA02 - 97.1
26
146
3D
4o3uA02 - 83.2
28
144
3D
2xxlB03 - 96.2
52
131
3D
6f5mB01 - 93.6
35
129
3D
2qy0D01 - 78.8
36
128
3D
1m9uC01 - 96.6
37
125
3D
2qy0D02 - 72.2
34
124 - - 96.8
38
119 - - 97.8
42
115
3D
1sgfZ01 - 84.4
41
114
3D
1npmB01 - 76.7
39
111 - - 88.6
176
110
3D
2jetC00 - 71.2
40
107 - - 55.6
46
105
3D
2i6sA02 - 77.7
43
104 - - 90.6
44
104 - - 84.7
248
104
3D
5tp0A01 - 56.6
47
101 - - 98.6
51
100
3D
2i6sA03 - 82.5
50
100
3D
4kkdB04 - 71.5
48
99 - - 59.7
49
98 - - 96.4
75
95
3D
2snwB02 - 55.3
54
94
3D
1gpzB02 - 90.1
55
93
3D
4qt8D01 - 77.6
73
93
3D
2vu8E02 - 98.5
58
92
3D
5brrE02 - 71.5
53
92 - - 86.3
56
90 - - 70.3
59
88
3D
5ubmA02 - 90.1
62
87
3D
4kkdB03 - 74.8
60
86
3D
1fizA02 - 94.6
57
86 - - 84.2
61
83 - - 74.6
64
83
3D
4qt8D02 - 70.4
287
83
3D
6r8xA02 - 38.8
63
82 - - 81.5
67
78
3D
5ubmA01 - 77.9
66
78
3D
2xrcD04 - 70.7
76
77
3D
1vcqB01 - 83.6
68
74 - - 96.7
69
71 - - 83.2
91
71
3D
4kgaB01 - 73.1
72
70 - - 86.8
88
69
3D
6qhcB02 - 64.0
74
68 - - 77.6
100
65
3D
4kgaB02 - 84.1
181
63
3D
2jetB00 - 73.4
77
62 - - 92.0
78
62 - - 96.3
79
60 - - 56.7
80
60 - - 79.3
86
57
3D
5ce1A02 - 36.8
87
Neuropsin/ovasin
56
3D
5ms4D02 - 75.2
82
55 - - 52.2
83
55
3D
2hrvB01 - 57.2
81
55 - - 72.0
89
54
3D
5jpmJ01 - 79.6
84
53
3D
2olgA02 - 88.6
93
49
3D
5jpmJ02 - 74.0
90
45 - - 32.5
97
44
3D
6b77B02 - 79.7
94
43
3D
2z6bD01 - 2.1
99
42
3D
5lpfB01 - 68.3
103
42
3D
3qo6C01 - 73.7
92
42 - - 85.0
96
41 - - 90.1
98
41
3D
4xe4A01 - 69.8
108
41
3D
2wv5D01 - 31.7
95
41 - - 58.7
104
39
3D
6ieoA01 - 40.9
101
36 - - 34.9
102
36 - - 74.9
106
35 - - 91.6
105
35 - - 90.7
107
34 - - 82.2
114
34
3D
3h5cB02 - 85.8
109
33 - - 10.8
110
33 - - 8.6
111
33 - - 94.8
113
32 - - 73.1
112
32 - - 22.1
117
32
3D
3h5cB03 - 84.5
115
31 - - 28.0
118
30 - - 79.7
116
30 - - 93.1
153
28
3D
3s69A02 - 75.4
119
28 - - 49.4
120
28 - - 96.3
121
27 - - 13.2
123
26 - - 17.4
126
25 - - 23.0
125
25 - - 56.8
127
24 - - 65.0
128
24 - - 64.9
129
23 - - 9.0
130
23 - - 85.2
131
23 - - 53.2
158
23
3D
1op2A01 - 73.5
202
22
3D
4gawL02 - 73.8
132
22 - - 39.2
169
22
3D
2halA02 - 14.5
133
22 - - 74.1
134
22 - - 87.4
135
thrombin
21 - - 20.3
136
21 - - 41.1
137
21 - - 82.5
258
21
3D
2zpsA02 - 50.1
139
20 - - 84.8
138
20 - - 47.4
184
19
3D
3gymB02 - 75.7
140
19 - - 48.0
166
19
3D
5xwaA00 - 38.3
141
19 - - 81.5
144
18 - - 63.0
142
18 - - 20.2
143
18 - - 18.2
145
17 - - 83.4
146
17 - - 94.9
151
16 - - 72.2
150
16 - - 78.4
148
16 - - 70.5
147
16 - - 49.6
172
16
3D
3qumQ01 - 26.6
149
16 - - 7.0
152
15 - - 59.8
155
15 - - 7.0
154
15 - - 44.2
157
15 - - 75.5
156
15 - - 94.4
159
14 - - 86.8
160
13 - - 19.9
161
13 - - 13.9
163
13 - - 57.1
175
13
3D
2xxlB02 - 25.7
162
13 - - 20.6
164
13 - - 77.5
198
12
3D
5lpfB02 - 66.0
165
12 - - 94.4
228
Serine proteinase MTB32B
12
3D
2z9iC01 - 18.9
168
11 - - 7.0
178
11 - - 85.0
177
11 - - 92.5
171
11 - - 47.9
170
11 - - 77.4
167
thrombin
11 - - 27.5
174
11 - - 0.0
173
11 - - 11.7
206
10
3D
3k6zB02 - 7.8
180
10 - - 22.0
182
10 - - 93.1
179
10 - - 6.9
189
9 - - 85.2
187
9 - - 9.3
188
9 - - 78.9
183
9 - - 85.6
186
9 - - 2.1
185
9 - - 10.3
194
8 - - 21.2
193
8 - - 0.5
197
8 - - 53.8
191
8 - - 14.2
192
8 - - 23.4
195
8 - - 69.6
305
8
3D
2pkaX00 - 4.5
190
Thrombin
8 - - 21.5
196
8 - - 90.5
211
7 - - 10.9
205
7 - - 0.0
213
7 - - 83.2
200
7 - - 13.3
212
7 - - 77.9
207
7 - - 0.0
215
7 - - 75.0
208
7 - - 18.3
199
7 - - 0.0
201
7 - - 79.2
214
7 - - 81.2
203
7 - - 79.4
204
7 - - 0.0
209
7 - - 5.2
216
7 - - 89.5
210
7 - - 18.4
220
6 - - 79.9
226
6 - - 15.8
218
6 - - 22.4
234
6 - - 74.8
221
6 - - 47.7
308
6
3D
4ic5C01 - 7.8
475
6
3D
1fy3A01 - 39.2
224
6 - - 65.6
256
6
3D
3f6uH02 - 47.3
372
6
3D
1fujD02 - 15.5
227
6 - - 6.4
232
6 - - 67.7
225
6 - - 11.3
233
6 - - 84.3
230
6 - - 15.4
229
6 - - 67.6
222
6 - - 15.9
217
6 - - 16.1
231
6 - - 45.3
223
6 - - 29.7
219
6 - - 74.1
236
5 - - 0.0
244
5 - - 12.0
246
5 - - 9.6
237
5 - - 0.0
235
5 - - 71.9
251
5 - - 77.1
250
5 - - 44.9
245
5 - - 87.5
241
5 - - 73.3
249
5 - - 81.3
240
5 - - 78.7
239
5 - - 56.9
243
5 - - 40.9
247
5 - - 9.6
238
5 - - 35.9
253
5 - - 73.0
252
5 - - 76.6
242
5 - - 61.9
285
4 - - 84.1
288
4 - - 78.3
260
4 - - 14.0
286
4 - - 42.9
254
4 - - 39.4
265
4 - - 13.7
272
4 - - 13.3
275
4 - - 64.0
262
4 - - 0.0
279
4 - - 6.9
255
4 - - 63.7
264
4 - - 15.9
263
4 - - 0.0
274
4 - - 61.5
278
4 - - 62.6
267
4 - - 3.9
257
4 - - 81.5
276
4 - - 13.0
259
4 - - 31.0
291
4 - - 45.6
280
4 - - 51.0
273
4 - - 0.0
270
4 - - 9.0
266
4 - - 6.8
269
4 - - 7.1
281
4 - - 53.1
261
4 - - 2.5
284
4 - - 73.9
289
4 - - 84.5
268
4 - - 87.3
282
4 - - 76.9
277
4 - - 38.9
290
4 - - 79.5
283
4 - - 74.0
271
4 - - 7.3
331
3 - - 0.0
325
3 - - 6.9
337
3 - - 72.7
311
3 - - 1.2
324
3 - - 5.5
295
3 - - 9.8
312
3 - - 55.8
309
3 - - 3.3
300
3 - - 48.0
301
3 - - 80.0
296
3 - - 0.0
329
3 - - 2.9
294
3 - - 7.0
333
3 - - 47.4
323
3 - - 7.7
330
3 - - 1.5
293
3 - - 34.5
322
3 - - 0.7
310
3 - - 11.2
303
3 - - 8.3
332
3 - - 5.4
316
3 - - 3.1
292
3 - - 24.7
327
3 - - 42.6
320
3 - - 2.4
314
3 - - 11.7
307
3 - - 2.2
326
3 - - 4.0
335
3 - - 74.7
334
3 - - 73.2
299
3 - - 73.0
302
3 - - 30.5
315
3 - - 5.9
328
3 - - 13.7
317
3 - - 13.4
298
3 - - 8.4
313
3 - - 71.9
321
3 - - 8.8
319
3 - - 0.0
336
3 - - 74.2
297
3 - - 4.8
304
3 - - 11.0
306
3 - - 7.1
318
3 - - 8.2
443
2 - - 15.6
358
2 - - 5.6
437
2 - - 38.0
463
2 - - 37.9
458
2 - - 34.5
451
2 - - 12.5
454
2 - - 0.0
378
2 - - 30.4
350
2 - - 2.6
431
2 - - 6.0
382
2 - - 9.8
340
2 - - 48.3
389
2 - - 5.3
418
2 - - 2.1
348
2 - - 0.0
388
2 - - 1.9
364
2 - - 36.8
367
2 - - 44.4
391
2 - - 6.3
460
2 - - 37.8
453
2 - - 0.0
351
2 - - 13.6
410
2 - - 38.4
430
2 - - 3.8
447
2 - - 1.8
379
2 - - 33.3
415
2 - - 38.3
452
2 - - 7.7
342
2 - - 4.8
480
2 - - 43.0
341
2 - - 3.1
438
2 - - 44.2
444
2 - - 31.7
417
2 - - 40.0
405
2 - - 2.4
370
2 - - 47.9
416
2 - - 41.1
380
2 - - 0.0
381
2 - - 0.0
392
2 - - 0.0
373
2 - - 47.1
399
2 - - 11.9
436
2 - - 4.2
456
2 - - 17.0
386
2 - - 0.0
445
2 - - 44.5
366
2 - - 38.4
400
2 - - 0.0
468
2 - - 39.7
441
2 - - 43.7
413
2 - - 36.7
349
2 - - 0.0
432
2 - - 5.2
346
2 - - 0.0
427
2 - - 5.2
446
2 - - 3.1
352
2 - - 4.5
426
2 - - 0.5
369
2 - - 42.4
428
2 - - 9.1
359
2 - - 0.0
462
2 - - 37.5
414
2 - - 28.4
477
2 - - 41.0
394
2 - - 0.0
360
2 - - 0.0
476
2 - - 38.5
393
2 - - 0.0
449
2 - - 0.0
469
2 - - 43.0
353
2 - - 0.0
375
2 - - 47.1
387
2 - - 0.0
354
2 - - 0.5
461
2 - - 38.9
425
2 - - 6.1
368
2 - - 42.3
424
2 - - 0.0
395
2 - - 0.0
347
2 - - 4.7
434
2 - - 5.3
374
2 - - 42.7
442
2 - - 0.0
429
2 - - 3.2
409
2 - - 30.3
471
2 - - 42.6
361
2 - - 0.0
465
2 - - 42.4
412
2 - - 35.6
385
2 - - 0.0
355
2 - - 0.0
479
2 - - 44.8
433
2 - - 0.0
440
2 - - 43.7
377
2 - - 28.9
423
2 - - 0.0
467
2 - - 38.5
474
2 - - 44.5
481
2 - - 46.2
422
2 - - 5.8
402
2 - - 0.0
338
2 - - 11.6
464
2 - - 37.3
363
2 - - 10.1
472
2 - - 43.4
362
2 - - 8.3
439
2 - - 42.1
411
2 - - 36.6
478
2 - - 46.5
384
2 - - 0.0
398
2 - - 4.1
407
2 - - 22.7
376
2 - - 6.1
343
2 - - 2.2
397
2 - - 0.0
459
2 - - 39.4
371
2 - - 38.3
435
2 - - 2.1
401
2 - - 0.0
339
2 - - 12.7
345
2 - - 0.0
404
2 - - 9.4
420
2 - - 1.5
344
2 - - 0.0
448
2 - - 3.7
357
2 - - 5.9
455
2 - - 27.6
457
2 - - 0.0
383
2 - - 0.0
419
2 - - 0.0
406
2 - - 10.3
396
2 - - 4.6
365
2 - - 0.0
470
2 - - 36.0
403
2 - - 0.0
466
2 - - 38.6
421
2 - - 0.0
450
2 - - 41.7
473
2 - - 41.6
390
2 - - 0.0
356
2 - - 0.0
408
2 - - 36.1
559
1 - - 0.0
560
1 - - 0.0
580
1 - - 0.0
512
1 - - 0.0
517
1 - - 0.0
634
1 - - 0.0
578
1 - - 0.0
695
1 - - 0.0
572
1 - - 0.0
675
1 - - 0.0
540
1 - - 0.0
684
1 - - 0.0
527
1 - - 0.0
571
1 - - 0.0
495
1 - - 0.0
548
1 - - 0.0
662
1 - - 0.0
706
1 - - 0.0
627
1 - - 0.0
594
1 - - 0.0
653
1 - - 0.0
486
1 - - 0.0
509
1 - - 0.0
569
1 - - 0.0
686
1 - - 0.0
485
1 - - 0.0
685
1 - - 0.0
523
1 - - 0.0
586
1 - - 0.0
637
1 - - 0.0
595
1 - - 0.0
488
1 - - 0.0
690
1 - - 0.0
536
1 - - 0.0
579
1 - - 0.0
535
1 - - 0.0
683
1 - - 0.0
541
1 - - 0.0
508
1 - - 0.0
558
1 - - 0.0
507
1 - - 0.0
573
1 - - 0.0
638
1 - - 0.0
567
1 - - 0.0
506
1 - - 0.0
661
1 - - 0.0
581
1 - - 0.0
496
1 - - 0.0
678
1 - - 0.0
605
1 - - 0.0
607
1 - - 0.0
644
1 - - 0.0
694
1 - - 0.0
568
1 - - 0.0
652
1 - - 0.0
493
1 - - 0.0
525
1 - - 0.0
582
1 - - 0.0
534
1 - - 0.0
633
1 - - 0.0
557
1 - - 0.0
700
1 - - 0.0
672
1 - - 0.0
515
1 - - 0.0
606
1 - - 0.0
666
1 - - 0.0
691
1 - - 0.0
519
1 - - 0.0
677
1 - - 0.0
708
1 - - 0.0
650
1 - - 0.0
710
1 - - 0.0
590
1 - - 0.0
545
1 - - 0.0
664
1 - - 0.0
588
1 - - 0.0
646
1 - - 0.0
617
1 - - 0.0
542
1 - - 0.0
651
1 - - 0.0
498
1 - - 0.0
483
1 - - 0.0
629
1 - - 0.0
574
1 - - 0.0
660
1 - - 0.0
526
1 - - 0.0
566
1 - - 0.0
500
1 - - 0.0
533
1 - - 0.0
604
1 - - 0.0
556
1 - - 0.0
671
1 - - 0.0
632
1 - - 0.0
514
1 - - 0.0
610
1 - - 0.0
692
1 - - 0.0
663
1 - - 0.0
513
1 - - 0.0
615
1 - - 0.0
510
1 - - 0.0
658
1 - - 0.0
549
1 - - 0.0
659
1 - - 0.0
645
1 - - 0.0
682
1 - - 0.0
635
1 - - 0.0
575
1 - - 0.0
709
1 - - 0.0
589
1 - - 0.0
614
1 - - 0.0
501
1 - - 0.0
699
1 - - 0.0
687
1 - - 0.0
490
1 - - 0.0
543
1 - - 0.0
626
1 - - 0.0
583
1 - - 0.0
591
1 - - 0.0
539
1 - - 0.0
603
1 - - 0.0
565
1 - - 0.0
620
1 - - 0.0
520
1 - - 0.0
532
1 - - 0.0
611
1 - - 0.0
584
1 - - 0.0
492
1 - - 0.0
511
1 - - 0.0
665
1 - - 0.0
649
1 - - 0.0
689
1 - - 0.0
648
1 - - 0.0
642
1 - - 0.0
489
1 - - 0.0
585
1 - - 0.0
674
1 - - 0.0
622
1 - - 0.0
502
1 - - 0.0
553
1 - - 0.0
704
1 - - 0.0
555
1 - - 0.0
681
1 - - 0.0
619
1 - - 0.0
698
1 - - 0.0
538
1 - - 0.0
621
1 - - 0.0
524
1 - - 0.0
554
1 - - 0.0
679
1 - - 0.0
680
1 - - 0.0
552
1 - - 0.0
521
1 - - 0.0
598
1 - - 0.0
647
1 - - 0.0
602
1 - - 0.0
612
1 - - 0.0
701
1 - - 0.0
564
1 - - 0.0
563
1 - - 0.0
668
1 - - 0.0
688
1 - - 0.0
657
1 - - 0.0
693
1 - - 0.0
503
1 - - 0.0
673
1 - - 0.0
593
1 - - 0.0
641
1 - - 0.0
576
1 - - 0.0
616
1 - - 0.0
640
1 - - 0.0
484
1 - - 0.0
544
1 - - 0.0
623
1 - - 0.0
628
1 - - 0.0
562
1 - - 0.0
630
1 - - 0.0
518
1 - - 0.0
497
1 - - 0.0
608
1 - - 0.0
705
1 - - 0.0
546
1 - - 0.0
537
1 - - 0.0
522
1 - - 0.0
599
1 - - 0.0
587
1 - - 0.0
609
1 - - 0.0
667
1 - - 0.0
601
1 - - 0.0
551
1 - - 0.0
529
1 - - 0.0
504
1 - - 0.0
697
1 - - 0.0
707
1 - - 0.0
624
1 - - 0.0
656
1 - - 0.0
531
1 - - 0.0
596
1 - - 0.0
516
1 - - 0.0
613
1 - - 0.0
669
1 - - 0.0
702
1 - - 0.0
639
1 - - 0.0
494
1 - - 0.0
487
1 - - 0.0
636
1 - - 0.0
577
1 - - 0.0
561
1 - - 0.0
643
1 - - 0.0
600
1 - - 0.0
696
1 - - 0.0
676
1 - - 0.0
550
1 - - 0.0
505
1 - - 0.0
670
1 - - 0.0
592
1 - - 0.0
625
1 - - 0.0
547
1 - - 0.0
631
1 - - 0.0
482
1 - - 0.0
530
1 - - 0.0
499
1 - - 0.0
570
1 - - 0.0
654
1 - - 0.0
618
1 - - 0.0
655
1 - - 0.0
703
1 - - 0.0
491
1 - - 0.0
597
1 - - 0.0
528
1 - - 0.0