CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Coagulation factor XII |
Enzyme Information
| 3.4.21.38 |
Coagulation factor XIIa.
based on mapping to UniProt P00748
Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
-!- Also activates plasma prekallikrein and plasminogen. -!- Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (1)
| P00748 |
FA12_HUMAN
Homo sapiens
Coagulation factor XII
|
PDB Structure
| PDB | 6B77 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.
Blood Adv
|