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Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
849
3D
3qo6C02 - 91.2
8
828
3D
4wxvB01 - 87.9
2
796
3D
5brrE01 - 99.7
4
581
3D
5wi6D02 - 94.5
71
569
3D
8kme202 - 55.5
5
543
3D
1orfA02 - 92.6
85
537
3D
8kme201 - 72.7
3
505 - - 93.1
124
490
3D
6fidA02 - 53.9
11
481
3D
3f6uH01 - 67.2
13
461
3D
6mv4H02 - 98.2
14
418
3D
1t32A01 - 96.6
6
407 - - 94.6
9
399
3D
3lh3I01 - 84.1
7
396
3D
5lyoC02 - 98.1
17
381
3D
4h4fA01 - 86.7
29
363
3D
6bqkB02 - 77.0
16
352
3D
5f03B01 - 87.4
19
344
3D
6gfiB02 - 89.4
10
321
3D
5fahA01 - 96.3
33
312
3D
5c5oB01 - 81.7
45
294
3D
5c5oB02 - 81.0
12
292 - - 77.1
22
279
3D
2zu3A01 - 84.1
15
270 - - 96.5
30
252
3D
2zu3A02 - 91.1
18
225
3D
4mg3B01 - 96.5
70
221
3D
5zc5U02 - 83.2
20
215
3D
4mg3B02 - 92.0
65
206
3D
5hggB01 - 61.8
21
191 - - 86.2
23
161
3D
4o3uA01 - 82.2
25
156
3D
2hlcB02 - 93.4
24
153 - - 92.5
27
151
3D
4wjgW02 - 85.6
32
149
3D
3qumQ02 - 92.6
31
149
3D
4wjgW03 - 83.8
122
147
3D
9estA02 - 97.1
26
146
3D
4o3uA02 - 83.2
28
144
3D
2xxlB03 - 96.2
52
131
3D
6f5mB01 - 93.6
35
129
3D
2qy0D01 - 78.8
36
128
3D
1m9uC01 - 96.6
37
125
3D
2qy0D02 - 72.2
34
124 - - 96.8
38
119 - - 97.8
42
115
3D
1sgfZ01 - 84.4
41
114
3D
1npmB01 - 76.7
39
111 - - 88.6
176
110
3D
2jetC00 - 71.2
40
107 - - 55.6
46
105
3D
2i6sA02 - 77.7
43
104 - - 90.6
44
104 - - 84.7
248
104
3D
5tp0A01 - 56.6
47
101 - - 98.6
51
100
3D
2i6sA03 - 82.5
50
100
3D
4kkdB04 - 71.5
48
99 - - 59.7
49
98 - - 96.4
75
95
3D
2snwB02 - 55.3
54
94
3D
1gpzB02 - 90.1
55
93
3D
4qt8D01 - 77.6
73
93
3D
2vu8E02 - 98.5
53
92 - - 86.3
58
92
3D
5brrE02 - 71.5
56
90 - - 70.3
59
88
3D
5ubmA02 - 90.1
62
87
3D
4kkdB03 - 74.8
57
86 - - 84.2
60
86
3D
1fizA02 - 94.6
61
83 - - 74.6
287
83
3D
6r8xA02 - 38.8
64
83
3D
4qt8D02 - 70.4
63
82 - - 81.5
67
78
3D
5ubmA01 - 77.9
66
78
3D
2xrcD04 - 70.7
76
77
3D
1vcqB01 - 83.6
68
74 - - 96.7
91
71
3D
4kgaB01 - 73.1
69
71 - - 83.2
72
70 - - 86.8
88
69
3D
6qhcB02 - 64.0
74
68 - - 77.6
100
65
3D
4kgaB02 - 84.1
181
63
3D
2jetB00 - 73.4
78
62 - - 96.3
77
62 - - 92.0
79
60 - - 56.7
80
60 - - 79.3
86
57
3D
5ce1A02 - 36.8
87
Neuropsin/ovasin
56
3D
5ms4D02 - 75.2
83
55
3D
2hrvB01 - 57.2
82
55 - - 52.2
81
55 - - 72.0
89
54
3D
5jpmJ01 - 79.6
84
53
3D
2olgA02 - 88.6
93
49
3D
5jpmJ02 - 74.0
90
45 - - 32.5
97
44
3D
6b77B02 - 79.7
94
43
3D
2z6bD01 - 2.1
99
42
3D
5lpfB01 - 68.3
92
42 - - 85.0
103
42
3D
3qo6C01 - 73.7
96
41 - - 90.1
98
41
3D
4xe4A01 - 69.8
108
41
3D
2wv5D01 - 31.7
95
41 - - 58.7
104
39
3D
6ieoA01 - 40.9
102
36 - - 74.9
101
36 - - 34.9
105
35 - - 90.7
106
35 - - 91.6
114
34
3D
3h5cB02 - 85.8
107
34 - - 82.2
109
33 - - 10.8
111
33 - - 94.8
110
33 - - 8.6
113
32 - - 73.1
112
32 - - 22.1
117
32
3D
3h5cB03 - 84.5
115
31 - - 28.0
118
30 - - 79.7
116
30 - - 93.1
153
28
3D
3s69A02 - 75.4
120
28 - - 96.3
119
28 - - 49.4
121
27 - - 13.2
123
26 - - 17.4
126
25 - - 23.0
125
25 - - 56.8
127
24 - - 65.0
128
24 - - 64.9
131
23 - - 53.2
158
23
3D
1op2A01 - 73.5
130
23 - - 85.2
129
23 - - 9.0
133
22 - - 74.1
132
22 - - 39.2
169
22
3D
2halA02 - 14.5
134
22 - - 87.4
202
22
3D
4gawL02 - 73.8
258
21
3D
2zpsA02 - 50.1
137
21 - - 82.5
136
21 - - 41.1
135
thrombin
21 - - 20.3
138
20 - - 47.4
139
20 - - 84.8
166
19
3D
5xwaA00 - 38.3
140
19 - - 48.0
184
19
3D
3gymB02 - 75.7
141
19 - - 81.5
144
18 - - 63.0
142
18 - - 20.2
143
18 - - 18.2
145
17 - - 83.4
146
17 - - 94.9
149
16 - - 7.0
172
16
3D
3qumQ01 - 26.6
151
16 - - 72.2
148
16 - - 70.5
150
16 - - 78.4
147
16 - - 49.6
154
15 - - 44.2
152
15 - - 59.8
157
15 - - 75.5
156
15 - - 94.4
155
15 - - 7.0
159
14 - - 86.8
160
13 - - 19.9
175
13
3D
2xxlB02 - 25.7
163
13 - - 57.1
161
13 - - 13.9
164
13 - - 77.5
162
13 - - 20.6
228
Serine proteinase MTB32B
12
3D
2z9iC01 - 18.9
165
12 - - 94.4
198
12
3D
5lpfB02 - 66.0
174
11 - - 0.0
178
11 - - 85.0
177
11 - - 92.5
171
11 - - 47.9
173
11 - - 11.7
170
11 - - 77.4
167
thrombin
11 - - 27.5
168
11 - - 7.0
206
10
3D
3k6zB02 - 7.8
180
10 - - 22.0
179
10 - - 6.9
182
10 - - 93.1
189
9 - - 85.2
185
9 - - 10.3
186
9 - - 2.1
187
9 - - 9.3
188
9 - - 78.9
183
9 - - 85.6
305
8
3D
2pkaX00 - 4.5
195
8 - - 69.6
196
8 - - 90.5
190
Thrombin
8 - - 21.5
197
8 - - 53.8
192
8 - - 23.4
194
8 - - 21.2
193
8 - - 0.5
191
8 - - 14.2
212
7 - - 77.9
200
7 - - 13.3
214
7 - - 81.2
199
7 - - 0.0
205
7 - - 0.0
211
7 - - 10.9
213
7 - - 83.2
209
7 - - 5.2
201
7 - - 79.2
203
7 - - 79.4
215
7 - - 75.0
208
7 - - 18.3
207
7 - - 0.0
216
7 - - 89.5
210
7 - - 18.4
204
7 - - 0.0
222
6 - - 15.9
372
6
3D
1fujD02 - 15.5
234
6 - - 74.8
224
6 - - 65.6
232
6 - - 67.7
475
6
3D
1fy3A01 - 39.2
227
6 - - 6.4
218
6 - - 22.4
217
6 - - 16.1
223
6 - - 29.7
221
6 - - 47.7
231
6 - - 45.3
233
6 - - 84.3
229
6 - - 67.6
308
6
3D
4ic5C01 - 7.8
219
6 - - 74.1
225
6 - - 11.3
230
6 - - 15.4
256
6
3D
3f6uH02 - 47.3
226
6 - - 15.8
220
6 - - 79.9
252
5 - - 76.6
246
5 - - 9.6
238
5 - - 35.9
237
5 - - 0.0
240
5 - - 78.7
249
5 - - 81.3
253
5 - - 73.0
251
5 - - 77.1
245
5 - - 87.5
239
5 - - 56.9
241
5 - - 73.3
243
5 - - 40.9
235
5 - - 71.9
242
5 - - 61.9
244
5 - - 12.0
236
5 - - 0.0
250
5 - - 44.9
247
5 - - 9.6
290
4 - - 79.5
254
4 - - 39.4
269
4 - - 7.1
271
4 - - 7.3
280
4 - - 51.0
273
4 - - 0.0
257
4 - - 81.5
265
4 - - 13.7
286
4 - - 42.9
289
4 - - 84.5
272
4 - - 13.3
274
4 - - 61.5
285
4 - - 84.1
266
4 - - 6.8
278
4 - - 62.6
277
4 - - 38.9
260
4 - - 14.0
262
4 - - 0.0
259
4 - - 31.0
264
4 - - 15.9
291
4 - - 45.6
276
4 - - 13.0
270
4 - - 9.0
283
4 - - 74.0
255
4 - - 63.7
267
4 - - 3.9
268
4 - - 87.3
281
4 - - 53.1
284
4 - - 73.9
279
4 - - 6.9
282
4 - - 76.9
263
4 - - 0.0
261
4 - - 2.5
288
4 - - 78.3
275
4 - - 64.0
296
3 - - 0.0
321
3 - - 8.8
313
3 - - 71.9
323
3 - - 7.7
311
3 - - 1.2
309
3 - - 3.3
333
3 - - 47.4
331
3 - - 0.0
334
3 - - 73.2
295
3 - - 9.8
322
3 - - 0.7
312
3 - - 55.8
306
3 - - 7.1
314
3 - - 11.7
300
3 - - 48.0
332
3 - - 5.4
324
3 - - 5.5
299
3 - - 73.0
337
3 - - 72.7
317
3 - - 13.4
328
3 - - 13.7
318
3 - - 8.2
327
3 - - 42.6
307
3 - - 2.2
293
3 - - 34.5
326
3 - - 4.0
302
3 - - 30.5
330
3 - - 1.5
316
3 - - 3.1
304
3 - - 11.0
320
3 - - 2.4
310
3 - - 11.2
336
3 - - 74.2
297
3 - - 4.8
303
3 - - 8.3
298
3 - - 8.4
301
3 - - 80.0
319
3 - - 0.0
329
3 - - 2.9
294
3 - - 7.0
335
3 - - 74.7
315
3 - - 5.9
292
3 - - 24.7
325
3 - - 6.9
408
2 - - 36.1
479
2 - - 44.8
395
2 - - 0.0
444
2 - - 31.7
407
2 - - 22.7
389
2 - - 5.3
349
2 - - 0.0
374
2 - - 42.7
442
2 - - 0.0
351
2 - - 13.6
436
2 - - 4.2
448
2 - - 3.7
410
2 - - 38.4
366
2 - - 38.4
385
2 - - 0.0
353
2 - - 0.0
420
2 - - 1.5
450
2 - - 41.7
399
2 - - 11.9
404
2 - - 9.4
447
2 - - 1.8
360
2 - - 0.0
416
2 - - 41.1
463
2 - - 37.9
430
2 - - 3.8
345
2 - - 0.0
377
2 - - 28.9
402
2 - - 0.0
461
2 - - 38.9
456
2 - - 17.0
378
2 - - 30.4
426
2 - - 0.5
429
2 - - 3.2
459
2 - - 39.4
390
2 - - 0.0
464
2 - - 37.3
352
2 - - 4.5
419
2 - - 0.0
401
2 - - 0.0
396
2 - - 4.6
403
2 - - 0.0
369
2 - - 42.4
462
2 - - 37.5
439
2 - - 42.1
354
2 - - 0.5
373
2 - - 47.1
470
2 - - 36.0
455
2 - - 27.6
425
2 - - 6.1
380
2 - - 0.0
467
2 - - 38.5
338
2 - - 11.6
371
2 - - 38.3
415
2 - - 38.3
468
2 - - 39.7
481
2 - - 46.2
346
2 - - 0.0
441
2 - - 43.7
386
2 - - 0.0
476
2 - - 38.5
358
2 - - 5.6
443
2 - - 15.6
340
2 - - 48.3
435
2 - - 2.1
365
2 - - 0.0
357
2 - - 5.9
398
2 - - 4.1
342
2 - - 4.8
405
2 - - 2.4
474
2 - - 44.5
384
2 - - 0.0
449
2 - - 0.0
397
2 - - 0.0
344
2 - - 0.0
472
2 - - 43.4
382
2 - - 9.8
379
2 - - 33.3
356
2 - - 0.0
478
2 - - 46.5
431
2 - - 6.0
388
2 - - 1.9
361
2 - - 0.0
445
2 - - 44.5
477
2 - - 41.0
433
2 - - 0.0
409
2 - - 30.3
387
2 - - 0.0
460
2 - - 37.8
363
2 - - 10.1
394
2 - - 0.0
375
2 - - 47.1
347
2 - - 4.7
411
2 - - 36.6
392
2 - - 0.0
453
2 - - 0.0
350
2 - - 2.6
423
2 - - 0.0
466
2 - - 38.6
413
2 - - 36.7
348
2 - - 0.0
451
2 - - 12.5
421
2 - - 0.0
454
2 - - 0.0
362
2 - - 8.3
339
2 - - 12.7
424
2 - - 0.0
432
2 - - 5.2
469
2 - - 43.0
400
2 - - 0.0
414
2 - - 28.4
406
2 - - 10.3
391
2 - - 6.3
412
2 - - 35.6
422
2 - - 5.8
452
2 - - 7.7
364
2 - - 36.8
393
2 - - 0.0
359
2 - - 0.0
434
2 - - 5.3
427
2 - - 5.2
457
2 - - 0.0
465
2 - - 42.4
418
2 - - 2.1
343
2 - - 2.2
440
2 - - 43.7
376
2 - - 6.1
428
2 - - 9.1
458
2 - - 34.5
341
2 - - 3.1
417
2 - - 40.0
446
2 - - 3.1
381
2 - - 0.0
368
2 - - 42.3
471
2 - - 42.6
438
2 - - 44.2
367
2 - - 44.4
355
2 - - 0.0
383
2 - - 0.0
480
2 - - 43.0
473
2 - - 41.6
437
2 - - 38.0
370
2 - - 47.9
662
1 - - 0.0
639
1 - - 0.0
706
1 - - 0.0
603
1 - - 0.0
543
1 - - 0.0
535
1 - - 0.0
576
1 - - 0.0
482
1 - - 0.0
601
1 - - 0.0
541
1 - - 0.0
497
1 - - 0.0
619
1 - - 0.0
484
1 - - 0.0
568
1 - - 0.0
581
1 - - 0.0
691
1 - - 0.0
700
1 - - 0.0
515
1 - - 0.0
567
1 - - 0.0
583
1 - - 0.0
555
1 - - 0.0
498
1 - - 0.0
693
1 - - 0.0
664
1 - - 0.0
525
1 - - 0.0
570
1 - - 0.0
629
1 - - 0.0
659
1 - - 0.0
539
1 - - 0.0
562
1 - - 0.0
643
1 - - 0.0
635
1 - - 0.0
503
1 - - 0.0
492
1 - - 0.0
676
1 - - 0.0
641
1 - - 0.0
501
1 - - 0.0
668
1 - - 0.0
681
1 - - 0.0
494
1 - - 0.0
591
1 - - 0.0
519
1 - - 0.0
487
1 - - 0.0
615
1 - - 0.0
683
1 - - 0.0
655
1 - - 0.0
625
1 - - 0.0
593
1 - - 0.0
488
1 - - 0.0
564
1 - - 0.0
667
1 - - 0.0
529
1 - - 0.0
559
1 - - 0.0
670
1 - - 0.0
556
1 - - 0.0
526
1 - - 0.0
698
1 - - 0.0
493
1 - - 0.0
561
1 - - 0.0
588
1 - - 0.0
502
1 - - 0.0
530
1 - - 0.0
642
1 - - 0.0
697
1 - - 0.0
587
1 - - 0.0
684
1 - - 0.0
594
1 - - 0.0
491
1 - - 0.0
563
1 - - 0.0
516
1 - - 0.0
575
1 - - 0.0
504
1 - - 0.0
547
1 - - 0.0
644
1 - - 0.0
607
1 - - 0.0
679
1 - - 0.0
592
1 - - 0.0
520
1 - - 0.0
550
1 - - 0.0
682
1 - - 0.0
510
1 - - 0.0
608
1 - - 0.0
548
1 - - 0.0
536
1 - - 0.0
705
1 - - 0.0
656
1 - - 0.0
626
1 - - 0.0
483
1 - - 0.0
598
1 - - 0.0
661
1 - - 0.0
688
1 - - 0.0
630
1 - - 0.0
542
1 - - 0.0
602
1 - - 0.0
584
1 - - 0.0
616
1 - - 0.0
694
1 - - 0.0
663
1 - - 0.0
597
1 - - 0.0
687
1 - - 0.0
544
1 - - 0.0
507
1 - - 0.0
675
1 - - 0.0
604
1 - - 0.0
647
1 - - 0.0
692
1 - - 0.0
620
1 - - 0.0
582
1 - - 0.0
650
1 - - 0.0
579
1 - - 0.0
648
1 - - 0.0
709
1 - - 0.0
610
1 - - 0.0
508
1 - - 0.0
636
1 - - 0.0
634
1 - - 0.0
573
1 - - 0.0
537
1 - - 0.0
622
1 - - 0.0
690
1 - - 0.0
701
1 - - 0.0
652
1 - - 0.0
580
1 - - 0.0
538
1 - - 0.0
612
1 - - 0.0
571
1 - - 0.0
606
1 - - 0.0
703
1 - - 0.0
546
1 - - 0.0
517
1 - - 0.0
489
1 - - 0.0
586
1 - - 0.0
614
1 - - 0.0
696
1 - - 0.0
528
1 - - 0.0
495
1 - - 0.0
558
1 - - 0.0
632
1 - - 0.0
669
1 - - 0.0
540
1 - - 0.0
518
1 - - 0.0
600
1 - - 0.0
654
1 - - 0.0
624
1 - - 0.0
565
1 - - 0.0
527
1 - - 0.0
557
1 - - 0.0
673
1 - - 0.0
637
1 - - 0.0
534
1 - - 0.0
522
1 - - 0.0
590
1 - - 0.0
680
1 - - 0.0
552
1 - - 0.0
671
1 - - 0.0
512
1 - - 0.0
638
1 - - 0.0
646
1 - - 0.0
506
1 - - 0.0
686
1 - - 0.0
596
1 - - 0.0
514
1 - - 0.0
499
1 - - 0.0
617
1 - - 0.0
628
1 - - 0.0
485
1 - - 0.0
658
1 - - 0.0
618
1 - - 0.0
500
1 - - 0.0
569
1 - - 0.0
532
1 - - 0.0
640
1 - - 0.0
627
1 - - 0.0
657
1 - - 0.0
554
1 - - 0.0
665
1 - - 0.0
524
1 - - 0.0
551
1 - - 0.0
521
1 - - 0.0
513
1 - - 0.0
566
1 - - 0.0
553
1 - - 0.0
585
1 - - 0.0
523
1 - - 0.0
695
1 - - 0.0
599
1 - - 0.0
689
1 - - 0.0
511
1 - - 0.0
672
1 - - 0.0
496
1 - - 0.0
560
1 - - 0.0
708
1 - - 0.0
649
1 - - 0.0
509
1 - - 0.0
545
1 - - 0.0
577
1 - - 0.0
533
1 - - 0.0
605
1 - - 0.0
674
1 - - 0.0
490
1 - - 0.0
707
1 - - 0.0
531
1 - - 0.0
578
1 - - 0.0
651
1 - - 0.0
702
1 - - 0.0
621
1 - - 0.0
666
1 - - 0.0
613
1 - - 0.0
653
1 - - 0.0
685
1 - - 0.0
595
1 - - 0.0
623
1 - - 0.0
486
1 - - 0.0
572
1 - - 0.0
611
1 - - 0.0
699
1 - - 0.0
589
1 - - 0.0
609
1 - - 0.0
710
1 - - 0.0
660
1 - - 0.0
549
1 - - 0.0
505
1 - - 0.0
574
1 - - 0.0
645
1 - - 0.0
677
1 - - 0.0
633
1 - - 0.0
704
1 - - 0.0
678
1 - - 0.0
631
1 - - 0.0
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