CATH Domain 4xe4A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Coagulation factor XII

Enzyme Information

3.4.21.38

Coagulation factor XIIa.

based on mapping to UniProt P00748

Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.

-!- Also activates plasma prekallikrein and plasminogen. -!- Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00748

FA12_HUMAN

Homo sapiens

Coagulation factor XII

PDB Structure

PDB	4XE4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Coagulation factor XII protease domain crystal structure. Pathak, M., Wilmann, P., Awford, J., Li, C., Hamad, B.K., Fischer, P.M., Dreveny, I., Dekker, L.V., Emsley, J. J.Thromb.Haemost.