The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
43755
33671
EC
3D
3j7zT00 - 88.2
43271
7853
EC
3D
1cvjA02 - 82.0
43624
6616
EC
3D
1whxA00 - 80.5
43661
5746
EC
3D
1x5tA01 - 80.7
43574
4858
EC
3D
1b7fA02 - 83.2
43727
4826
EC
3D
1o0pA00 - 84.3
43242
3724
3D
2i2yA02 - 88.9
43241
3356
EC
3D
1u6fA00 - 87.4
42484
3331
EC
3D
3hi9A00 - 86.5
42834
3299
EC
- - 84.3
43231
3278
EC
3D
2dgoA01 - 81.8
43268
3157
EC
3D
2g4bA02 - 82.1
43620
2842
EC
3D
2mjnA02 - 84.5
43715
2661
3D
2ytcA01 - 88.6
42156
2659
EC
3D
2khcA00 - 84.2
43148
2631
EC
3D
1cvjA01 - 86.8
43688
2598
EC
3D
4pkdB01 - 94.5
43708
2597
EC
3D
2dguA00 - 77.6
42613
2493
EC
- - 82.1
43739
2446
EC
3D
1wg4A01 - 70.7
42518
2436
3D
1h2tZ00 - 80.0
43381
2403
EC
3D
2disA01 - 81.2
43362
2237
EC
3D
1hl6A00 - 81.8
42820
2120
3D
3b4dA00 - 88.7
43405
2117
3D
2hgmA01 - 81.7
42446
2089
3D
1ha1A01 - 90.8
42042
1969
3D
1ha1A02 - 88.7
43225
1940
EC
3D
2cqdA01 - 93.6
43138
1916
3D
2mssA00 - 89.9
43546
1904
EC
3D
1qm9A01 - 90.5
43051
1888
3D
4pkdB02 - 82.5
43210
1745
EC
3D
2cq0A00 - 83.7
43123
1687
EC
3D
1sjrA00 - 88.7
43587
1569
EC
3D
2ditA01 - 96.7
43402
1471
3D
2hgnA00 - 92.0
43560
1396
3D
2rt3A00 - 97.3
42416
1395
3D
2dnoA00 - 70.8
42329
1374
3D
2cjkA01 - 86.8
43371
1356 - - 83.4
42808
1342
3D
2cq3A00 - 85.3
43071
1308
3D
2kxnB01 - 87.4
43197
1258
EC
3D
1x5uA01 - 87.5
43550
1095
EC
- - 89.3
43396
1006
EC
3D
4p6qA02 - 89.3
42409
976 - - 89.1
43127
974
3D
2mkiA02 - 82.4
42175
962
3D
2dhsA01 - 80.6
41837
947
3D
2dhsA02 - 72.3
42925
933
3D
2kn4A02 - 77.7
42637
930
EC
3D
1qm9A02 - 98.9
43921
923
EC
- - 87.1
42000
921
3D
2cqiA00 - 67.8
42335
913
3D
2dnlA01 - 86.4
43555
894
3D
1wi8A01 - 84.9
43876
854
3D
3p5tL00 - 90.1
43777
843 - - 86.8
43483
836 - - 75.6
42087
832
3D
2jrsA01 - 92.7
43019
808
3D
2aymA00 - 99.7
42390
804 - - 71.6
43261
802
3D
2cpfA00 - 93.3
43084
765 - - 94.8
42427
763
EC
3D
5cyjA00 - 89.0
42356
753
3D
2m7sA01 - 66.4
42230
725
3D
1sjqA00 - 93.3
43117
720
EC
3D
2mzqA00 - 87.9
43653
720 - - 88.7
43504
678 - - 82.4
41603
U
677
EC
3D
2kxfA01 - 84.1
43344
675 - - 90.5
42372
666
3D
1x4eA00 - 74.8
42615
641
3D
1u2fA00 - 83.1
42990
623
3D
2rvjA01 - 91.9
42504
600
3D
2e44A01 - 82.9
82
598
3D
2mhnA01 - 78.0
42341
597
3D
2dgqA00 - 86.6
42020
596
3D
1wf2A00 - 96.3
42309
588
3D
1hd0A00 - 88.7
43097
587
3D
4wiiA02 - 74.2
43559
574
3D
1ywxA01 - 98.5
41962
570 - - 75.1
42092
558 - - 89.5
42610
557 - - 87.8
43118
556 - - 97.6
42466
553 - - 84.4
43342
522
3D
2hglA01 - 92.4
43604
AFU_orthologue; AFUA_5G08330
521 - - 90.1
41627
U
512
3D
2kxfA02 - 72.9
43069
510
3D
3ulhA00 - 92.2
43589
508 - - 84.3
42762
500
3D
2do0A01 - 91.2
42908
AFU_orthologue AFUA_6G12300
498 - - 68.1
43690
490
3D
1by9A00 - 92.0
42796
487 - - 84.4
43647
472 - - 83.4
41967
U
466
3D
3dxbA02 - 39.3
42839
464 - - 92.7
43304
454 - - 94.7
43186
452 - - 91.6
43020
445 - - 89.0
43029
430
3D
2mb0B01 - 98.8
43413
415
3D
2divA01 - 92.0
42225
400
3D
2e5iA01 - 87.1
43576
395 - - 87.8
43833
392
3D
3r27A01 - 91.9
42451
391
3D
1x5sA01 - 88.3
41928
389 - - 69.6
43636
382
EC
- - 99.0
42342
378
3D
4wiiA01 - 77.7
42895
370 - - 87.7
43527
RRM
368 - - 85.9
42852
366
3D
2cqhA00 - 93.8
42866
364
EC
- - 82.8
43704
364 - - 87.2
42353
356
3D
1uw4A00 - 85.7
42636
346
3D
2mpuA00 - 84.4
42756
344 - - 86.4
41624
342
EC
- - 78.2
20448
338
3D
2dh8A01 - 48.9
42611
337
3D
1kohA01 - 97.0
42382
333 - - 84.5
43082
329
3D
2dnqA01 - 92.6
41794
324 - - 92.2
43612
Nop4
312 - - 83.8
42221
311 - - 88.0
43063
307 - - 80.3
41759
299 - - 76.3
43164
294 - - 89.8
41775
289
3D
1wf0A01 - 87.9
43176
288 - - 73.7
43380
287
3D
2cqgA01 - 69.1
41918
287 - - 79.9
41799
285
3D
2la6A01 - 79.4
43529
282 - - 94.1
41625
278 - - 67.0
16920
277 - - 35.4
43388
274 - - 93.6
42876
253
3D
2ek1A00 - 84.6
42824
253
3D
2mkhA02 - 66.4
42039
253 - - 84.7
27251
253 - - 36.6
42255
252 - - 83.3
33524
249 - - 44.4
43630
246 - - 95.1
2410
237 - - 51.8
43315
236 - - 79.0
32275
235
3D
2dgvA01 - 61.7
41906
234
3D
2dgtA01 - 60.7
42587
223
3D
2xs2A00 - 80.2
43121
222 - - 87.6
41825
219
3D
3sdeB01 - 77.7
42906
219 - - 84.4
14126
215
3D
4p6qA03 - 70.8
43421
208 - - 94.6
43851
207
3D
3h2uB03 - 80.4
43111
207 - - 75.1
153
203 - - 50.2
42016
203 - - 45.9
43855
uracil-5-
201
EC
- - 86.0
42473
198
3D
2cphA01 - 83.0
43383
196 - - 88.6
42070
194
EC
- - 81.3
18274
192 - - 68.7
42886
189
3D
1b7fA01 - 86.6
43061
188 - - 64.1
3940
186 - - 81.8
13920
185 - - 46.3
42488
183 - - 90.9
44001
182 - - 83.5
42294
182
3D
3j7yU00 - 93.9
41832
A
182
EC
3D
1whvA00 - 58.7
43565
179 - - 90.0
43090
172 - - 88.9
31382
171 - - 2.5
27135
170 - - 0.0
34902
170 - - 14.8
41500
166
EC
3D
2f3jA02 - 71.9
43935
165
EC
- - 90.7
1653
165 - - 72.8
4194
Drosophila
164 - - 33.2
42702
163
3D
2krrA02 - 90.8
43533
162 - - 94.9
42721
159
3D
1s79A00 - 90.2
6252
157 - - 91.4
20643
156
3D
2mkcA00 - 36.4
43277
156 - - 93.1
43540
A
155 - - 89.0
43881
154
3D
2wbrA00 - 90.7
42157
154 - - 85.3
42467
152
3D
2fc9A00 - 85.6
43336
150 - - 88.5
43840
149
EC
- - 77.2
15327
147 - - 61.7
42950
146 - - 90.8
19844
145 - - 76.7
41424
145 - - 57.6
43629
142 - - 91.9
42487
142
3D
1owxA00 - 94.3
43609
142 - - 89.5
41782
142 - - 51.5
43746
RRM/RBD/RNP motifs
141 - - 88.0
41557
140 - - 34.3
21672
A
140 - - 26.8
31549
140 - - 26.0
41453
134 - - 60.3
42348
132
3D
2fc8A00 - 64.2
16411
129
EC
- - 57.4
7674
125 - - 69.6
2599
125 - - 65.6
42579
124 - - 87.2
6256
122 - - 1.2
41535
122 - - 66.9
5180
122 - - 71.7
34267
121 - - 59.1
22576
121 - - 30.6
43511
121 - - 68.1
35334
119 - - 15.5
33717
118 - - 30.5
42729
118
3D
2d9oA00 - 75.9
41446
118 - - 67.8
43969
116 - - 86.1
42055
116
3D
2lkzA01 - 35.6
42105
115
EC
- - 60.1
42938
113 - - 61.6
39649
113 - - 40.9
42803
112
EC
3D
2cq2A01 - 75.3
12406
112
3D
1welA00 - 34.1
42179
112 - - 66.0
35340
112
3D
2dnnA01 - 22.0
42887
111 - - 88.7
41923
110
EC
3D
2dnrA00 - 58.5
20387
109
EC
- - 21.5
43440
108 - - 77.2
311
107 - - 22.4
43637
107
3D
2mzsA00 - 84.0
43348
107 - - 89.2
43844
107
3D
2m88A01 - 55.6
19496
107 - - 76.0
43119
105 - - 87.6
43456
103
3D
2ghpA02 - 67.5
42223
101 - - 45.1
36806
101
3D
4qu7A00 - 71.0
18343
101 - - 1.1
42126
100 - - 77.8
42440
98 - - 73.8
152
97 - - 7.8
29139
96
3D
2dnpA01 - 32.2
42109
94 - - 83.6
15631
91 - - 50.2
36050
91 - - 0.0
28580
90
EC
3D
3s8sA00 - 16.0
4219
90 - - 57.9
41539
90 - - 61.9
6105
90
3D
1x4fA00 - 32.9
43443
89 - - 65.3
43219
88 - - 83.1
41657
88 - - 53.7
17643
88 - - 9.7
505
88
3D
2lxiA00 - 63.0
1429
87
3D
2m2bA00 - 31.6
42228
87 - - 83.3
22765
87
3D
3h2uB01 - 33.4
12770
85 - - 21.3
43087
A
83
EC
3D
2e5gA01 - 69.6
43818
83 - - 76.0
15649
82 - - 1.1
1485
82 - - 2.3
18158
82
EC
- - 36.2
42668
82 - - 86.1
43911
RRM/RBD/RNP motifs
81 - - 87.5
37454
81
3D
2lmiA01 - 61.6
43874
81 - - 92.8
43095
80 - - 80.6
42779
79
3D
3tp2A02 - 77.4
42743
Zebrafish
78 - - 69.4
41721
78 - - 67.0
43606
78 - - 54.9
41413
76 - - 42.2
8798
75 - - 17.4
43068
74 - - 88.3
17566
74 - - 68.3
43463
74
3D
2go9A01 - 6.2
42123
72 - - 65.7
24044
72 - - 1.4
43597
71 - - 93.9
43998
71 - - 91.2
42821
70 - - 75.6
8165
70 - - 25.8
108
69 - - 17.6
41458
69 - - 36.0
42750
68 - - 86.3
14069
68 - - 28.7
33865
68 - - 33.3
36131
68
3D
2cpyA01 - 20.6
42325
66 - - 82.9
43832
Prp24
66 - - 92.1
14878
65 - - 10.6
16570
65 - - 20.4
37276
65 - - 11.1
6073
63 - - 39.4
41762
63 - - 33.6
42919
63
3D
3ns5A00 - 50.3
12747
63 - - 24.6
26702
63 - - 67.0
32046
61 - - 43.5
4532
61 - - 48.7
43733
61 - - 74.0
26119
59 - - 8.8
21422
59 - - 23.6
13694
58
EC
- - 19.3
42521
58 - - 86.6
43819
58 - - 38.5
42361
58 - - 71.6
41496
57 - - 58.7
43957
56
EC
3D
2j8aA01 - 11.2
10316
56 - - 18.0
5010
56 - - 53.8
28045
55 - - 2.5
20641
55 - - 42.7
43185
54
3D
2e5jA01 - 78.2
42425
54 - - 27.6
14046
54
3D
2rs2A00 - 59.2
6259
A
53 - - 10.5
43558
52 - - 90.8
13970
52 - - 24.4
28026
52 - - 24.7
796
51 - - 3.9
27109
51 - - 39.3
2738
51 - - 77.6
42438
50 - - 74.0
26004
50 - - 17.1
25601
49 - - 0.0
41580
48 - - 42.4
41426
47 - - 57.1
41717
47 - - 36.3
15973
47 - - 18.4
8454
45 - - 9.6
42396
45 - - 54.4
43501
45 - - 89.0
15896
45 - - 19.8
20002
45 - - 51.3
42324
44 - - 42.8
43641
43 - - 83.3
43883
42 - - 93.9
3338
42 - - 13.3
1392
42 - - 54.0
12359
41 - - 1.3
4232
40 - - 22.5
43531
40 - - 78.7
4358
39 - - 55.8
13469
39 - - 4.8
17888
39 - - 30.3
42077
39 - - 72.7
11470
38 - - 33.0
5271
38 - - 16.2
14869
38 - - 1.3
16212
37 - - 66.3
31527
37 - - 11.9
24035
36 - - 22.4
42049
35 - - 41.8
43577
34 - - 80.8
42059
34 - - 70.2
38774
34 - - 58.4
29681
33 - - 1.3
16176
33 - - 0.0
43108
31 - - 46.7
43314
31 - - 74.3
42988
31 - - 62.9
25825
29 - - 8.3
18199
29 - - 12.2
25205
29 - - 0.0
36859
29
EC
3D
2dhxA01 - 11.0
2675
29 - - 33.3
43857
28 - - 82.3
43635
28 - - 15.9
7499
28 - - 20.2
43549
28 - - 5.6
7716
28 - - 12.2
41430
28 - - 22.4
29662
27 - - 22.8
29697
27 - - 0.0
2745
27 - - 30.4
9813
27 - - 30.7
10223
26 - - 2.3
364
25 - - 56.5
16470
25 - - 0.0
24085
25 - - 25.6
43532
22 - - 83.9
10760
22 - - 51.2
9096
22 - - 27.8
22973
21 - - 25.5
36240
21 - - 24.6
6636
21 - - 49.6
27639
21 - - 26.0
42125
21 - - 22.8
20913
20 - - 47.0
28020
20 - - 3.4
43866
20 - - 73.4
9878
20 - - 13.2
43320
20 - - 79.8
43712
19 - - 69.3
43757
19 - - 26.8
6426
19 - - 12.4
12889
19 - - 8.0
13054
19 - - 3.1
334
19 - - 1.3
41629
18 - - 18.8
9890
18 - - 18.0
43850
18 - - 61.8
26065
18 - - 12.2
37768
18 - - 29.7
41957
18 - - 50.5
43528
17 - - 64.7
22433
17
EC
- - 22.2
41963
17 - - 27.7
42909
16 - - 49.5
43125
16 - - 48.0
18332
U
16 - - 12.9
26371
15 - - 18.6
35865
15 - - 24.7
43817
15 - - 65.8
15303
15 - - 65.8
10394
15 - - 26.3
15082
14 - - 51.6
7204
14 - - 36.4
8084
14 - - 61.1
11744
14 - - 13.5
33762
14 - - 10.7
38965
13 - - 26.0
42959
13 - - 39.3
11224
13 - - 8.6
41475
13 - - 54.4
29101
12 - - 7.7
453
12 - - 13.6
19557
12 - - 8.5
16148
12 - - 8.1
28767
12 - - 9.1
14579
11 - - 22.3
42840
11 - - 58.3
16009
10 - - 40.0
43203
10 - - 15.1
31152
10
3D
5ca5A02 - 7.4
28042
10 - - 12.7
43072
10 - - 4.3
29658
10 - - 49.4
16759
10 - - 21.1
21018
10 - - 36.3
15597
9 - - 19.5
25810
9 - - 0.0
23936
9 - - 29.8
15088
9 - - 0.0
12929
9 - - 9.6
22336
9 - - 11.8
42735
AFU_orthologue AFUA_6G12300
9 - - 67.0
42737
9 - - 12.9
27564
9 - - 23.9
34275
9 - - 0.0
32163
8 - - 30.8
43143
8 - - 10.9
39680
8 - - 20.5
43543
8 - - 40.5
9688
8 - - 25.5
12204
8 - - 21.2
4947
8 - - 5.9
17491
8 - - 15.3
8294
8 - - 29.3
13789
7 - - 28.8
13756
7 - - 34.4
17085
7 - - 6.5
32658
7 - - 17.1
34878
7 - - 7.7
15871
7 - - 29.6
25424
7 - - 9.3
32889
6 - - 17.7
37183
6 - - 8.9
42915
6 - - 44.6
447
6 - - 18.5
4448
6 - - 63.4
585
6 - - 0.0
43982
6
EC
- - 71.7
9716
6 - - 0.0
1211
6 - - 17.6
28014
6 - - 22.2
1720
6 - - 12.3
12010
6 - - 19.1
29839
6 - - 9.6
41572
6 - - 1.7
43353
6 - - 41.1
43626
6 - - 68.0
43495
5 - - 76.9
10734
5 - - 0.0
42222
5 - - 41.5
20607
5 - - 14.6
28956
5 - - 17.6
15003
5 - - 26.6
906
5 - - 21.2
28976
5 - - 1.6
42428
5 - - 20.6
31201
5 - - 5.9
25181
5 - - 11.3
11385
5 - - 9.2
15653
5 - - 16.3
7014
5 - - 1.8
25818
5 - - 0.0
12887
5 - - 14.9
14059
5 - - 3.3
4876
5 - - 20.0
5786
5 - - 16.8
17535
5 - - 26.3
29688
5 - - 0.0
11433
5 - - 16.5
21936
5
EC
- - 9.2
37722
5 - - 12.7
43451
5 - - 70.6
38206
5 - - 12.9
3140
5 - - 0.0
31288
5 - - 25.2
3388
5 - - 19.0
4473
4 - - 13.1
32098
4 - - 7.1
32648
4 - - 17.3
23
4 - - 0.0
9180
RRM
4 - - 3.8
30586
4 - - 15.2
8170
4 - - 0.0
35527
4 - - 20.7
20283
4 - - 21.5
17241
4 - - 0.0
38527
4 - - 26.7
806
4 - - 9.4
13651
4 - - 0.0
11854
4 - - 26.7
19508
4 - - 0.0
17556
4 - - 0.0
42972
4 - - 0.0
42980
4 - - 49.1
222
4 - - 14.0
2325
4 - - 10.3
43994
4 - - 67.0
12838
4 - - 16.6
6917
RRM/RBD/RNP motifs
4 - - 0.0
9530
4 - - 7.9
28889
4 - - 13.4
36160
3 - - 9.4
7353
3 - - 0.0
31466
RRM/RBD/RNP motifs
3 - - 8.1
8796
3 - - 7.6
10740
3 - - 12.9
43859
3 - - 39.6
28902
3 - - 11.5
43691
3 - - 45.0
29919
3 - - 8.4
16598
3 - - 6.6
16472
3 - - 0.0
9299
3 - - 18.2
32901
3 - - 17.3
14190
3 - - 7.1
43722
3 - - 35.4
13011
3 - - 11.2
6036
3 - -
6887
3 - - 8.4
5722
3 - - 9.1
9288
3 - - 20.8
25301
3 - - 11.8
28878
3 - - 4.4
33206
3 - - 8.8
39192
3 - - 3.2
7890
3 - - 2.3
25180
3 - - 0.0
20051
3 - - 22.8
20984
2 - - 4.3
43487
2 - - 42.1
43974
2 - - 45.2
25712
2 - - 0.0
42288
2 - - 38.4
43494
2 - - 38.0
43410
2 - - 42.5
32880
2 - - 0.0
18518
2 - - 2.4
41584
2 - - 0.0
30629
2 - - 8.0
25515
2
EC
- - 1.2
31465
2 - - 4.3
10423
2 - - 5.9
31413
2 - - 2.5
29019
2 - - 3.0
43841
2 - - 45.0
3958
2 - - 15.5
35790
2 - - 0.0
43349
2 - - 0.0
15358
2 - - 0.0
37783
2 - - 10.3
27129
A
2
EC
- - 0.0
34260
2 - - 0.0
1857
2 - - 12.3
39016
2 - - 0.0
7604
2 - - 14.5
7891
2 - - 18.8
42856
2 - - 0.0
1486
2 - - 0.0
18636
2 - - 10.5
43479
2 - - 43.0
10313
2 - - 0.0
27073
2 - - 11.7
43547
2 - - 6.3
36857
2 - - 0.0
6767
2 - - 5.3
18733
2 - - 2.7
21898
2 - - 0.0
28449
2 - - 4.4
5306
2 - - 9.8
2193
2 - - 0.0
37583
2 - - 11.9
7997
2 - - 4.5
33620
1 - - 0.0
13652
1 - - 0.0
40979
1 - - 0.0
42897
1 - - 0.0
43318
1 - - 0.0
11450
1 - - 0.0
34271
1 - - 0.0
42926
1 - - 0.0
21774
1 - - 0.0
9491
1 - - 0.0
14036
1 - - 0.0
29424
1 - - 0.0
41410
1 - - 0.0
8471
1 - - 0.0
3860
1 - - 0.0
15645
1 - - 0.0
38783
1 - -
7313
1 - - 0.0
41333
1 - - 0.0
23121
1 - - 0.0
36162
1 - - 0.0
41425
1 - -
12447
Mxc
1 - - 0.0
27278
1 - - 0.0
2304
1 - - 0.0
17177
1 - - 0.0
18359
1 - - 0.0
2233
1 - - 0.0
41324
1 - - 0.0
9171
1 - - 0.0
8400
1 - - 0.0
41105
1 - - 0.0
22513
1 - - 0.0
817
1 - -
1967
1 - - 0.0
22965
1 - - 0.0
25192
1 - - 0.0
37218
1 - - 0.0
2347
1 - - 0.0
24613
1 - - 0.0
8570
1 - - 0.0
43431
1 - - 0.0
942
1 - -
20649
1 - - 0.0
36743
1 - - 0.0
10307
1 - - 0.0
4084
1
EC
- - 0.0
3181
1 - - 0.0
40815
1 - - 0.0
38963
1 - - 0.0
35059
1 - - 0.0
40711
1 - - 0.0
5158
1 - - 0.0