CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.330
Functional Family Poly [ADP-ribose] polymerase 10

Enzyme Information

2.4.2.30
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt Q53GL7
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

Q53GL7
PAR10_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase 10

PDB Structure

PDB 2DHX
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution Structure of the RRM Domain in the Human Poly (ADP-ribose) Polymerase Family, Member 10 Variant
Zhao, C., Kigawa, T., Tochio, N., Koshiba, S., Inoue, M., Yokoyama, S.
To be Published