The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1060
3D
6n4oA04 - 71.4
2
852
3D
1hjrD00 - 94.1
3
715
3D
2igiB00 - 97.1
4
586
3D
3iayA03 - 91.8
5
512
3D
4gmjF00 - 84.7
6
459 - - 88.2
17
452
3D
5hrsA00 - 76.4
8
440
3D
3aa5X00 - 84.5
9
407
3D
4kb1B00 - 75.3
25
397
3D
5j2qA05 - 78.5
7
376
3D
1wljA00 - 95.3
10
323 - - 90.6
12
291
3D
2xy8A00 - 94.7
11
288 - - 82.8
13
272 - - 78.7
14
237 - - 90.8
16
224
3D
3pufP01 - 94.0
15
218 - - 63.1
20
198
3D
4fzzB00 - 29.7
18
198
3D
4qclA03 - 86.8
19
194 - - 88.1
21
191 - - 82.1
22
190
3D
3sahB01 - 87.3
26
180
3D
2kzzA01 - 95.9
23
174 - - 46.5
24
171 - - 92.6
27
160 - - 82.0
28
149 - - 90.5
46
144
3D
5ywvB01 - 91.4
29
142
3D
2xriA01 - 47.4
30
141 - - 75.1
33
138
3D
4js5B01 - 90.0
31
134 - - 96.3
32
132 - - 96.7
34
124
3D
1zbuD01 - 90.9
35
A
122
3D
2a1sD01 - 65.1
36
117
3D
4fydB03 - 85.7
263
109
3D
5uoqB00 - 28.9
37
107 - - 74.4
38
107 - - 72.9
39
105 - - 85.4
40
102 - - 82.8
41
102 - - 92.8
49
100
3D
2qkkW00 - 77.7
42
A
100 - - 47.8
52
97
3D
3maqA03 - 77.3
45
96
3D
2p1jB01 - 98.2
43
96 - - 89.2
44
94 - - 7.7
47
93
3D
3vn5A02 - 91.4
48
90
3D
3g10A00 - 91.0
53
90
3D
2e6mA00 - 78.7
51
86 - - 77.6
50
86 - - 31.1
54
79 - - 96.5
55
78 - - 71.6
56
73 - - 73.5
57
69 - - 56.6
58
68 - - 87.6
59
66
3D
4nlcA01 - 88.5
60
64
3D
1yt3A01 - 82.1
61
61 - - 89.4
62
59 - - 72.7
63
55 - - 93.8
64
54 - - 71.8
65
54 - - 76.4
66
53 - - 74.9
67
51 - - 94.6
68
49 - - 63.2
72
47
3D
1nozB02 - 27.7
69
46 - - 70.6
70
45 - - 73.9
71
43 - - 47.7
73
43 - - 17.2
74
42 - - 87.7
75
41 - - 4.7
76
40 - - 95.0
77
39 - - 87.9
78
38 - - 82.2
79
38 - - 73.6
80
37 - - 80.6
82
36 - - 78.8
81
36 - - 83.5
83
35 - - 14.2
85
31 - - 21.9
84
31 - - 0.0
89
30
3D
3h08B00 - 88.2
86
29 - - 32.5
87
28 - - 83.3
88
28 - - 73.6
449
27
3D
2pzsD01 - 3.9
91
27 - - 85.8
92
27 - - 9.6
90
27 - - 86.7
161
26
3D
5v5fC00 - 88.0
107
A
26
3D
4b8cF00 - 77.5
93
26 - - 23.8
94
24 - - 29.6
95
24 - - 62.1
184
23
3D
4fw2B01 - 16.6
102
23
3D
5dmrA00 - 33.2
96
22 - - 63.6
97
22 - - 89.0
101
21 - - 77.8
139
21
3D
2dfhA01 - 92.7
99
21 - - 14.3
98
21 - - 49.3
100
Wrn
21 - - 84.2
157
20
3D
5dk5B01 - 90.0
105
19 - - 3.5
106
19 - - 7.2
104
19 - - 84.1
103
19 - - 69.4
112
18 - - 9.4
108
18 - - 1.2
142
18
3D
4hhtA00 - 77.7
111
18 - - 22.4
109
18 - - 69.6
110
18 - - 4.8
163
18
3D
5c0yB01 - 14.0
116
3'-5' exonuclease
17 - - 4.5
117
17 - - 0.7
113
17 - - 81.7
120
A
17 - - 83.2
119
17 - - 34.1
115
17 - - 89.6
118
A
17 - - 3.8
114
17 - - 75.1
124
16 - - 4.8
121
16 - - 17.7
122
16 - - 5.8
123
A
16 - - 8.9
134
16
3D
1wnsA02 - 25.6
127
15 - - 11.7
128
A
15 - - 48.2
129
15 - - 7.9
131
15 - - 78.1
130
15 - - 61.6
125
15 - - 0.0
126
15 - - 13.7
136
A
14 - - 18.3
137
14 - - 0.0
132
14 - - 17.0
135
14 - - 17.0
160
14
3D
1kcfB00 - 87.4
138
14 - - 78.0
140
14 - - 95.3
133
14 - - 49.7
147
13 - - 14.0
149
13 - - 83.8
145
13 - - 78.1
183
13
3D
4fcyB03 - 26.8
148
13 - - 3.6
141
13 - - 21.3
146
13 - - 62.8
164
13
3D
2ajqF01 - 13.9
144
13 - - 13.8
151
13 - - 79.5
150
13 - - 80.3
143
13 - - 6.6
153
12 - - 0.0
155
12 - - 2.8
154
12 - - 92.1
158
12 - - 47.8
152
12 - - 1.9
156
12 - - 84.6
159
12 - - 83.6
165
11 - - 42.1
167
11 - - 82.8
162
11 - - 28.4
166
11 - - 82.7
170
10 - - 1.4
175
10 - - 86.8
168
10 - - 32.2
178
10 - - 8.2
174
10 - - 31.3
179
10 - - 65.3
177
10 - - 42.2
173
10 - - 62.2
171
10 - - 0.0
176
10 - - 17.7
169
10 - - 76.9
172
10 - - 41.0
180
9 - - 38.9
187
9 - - 66.2
181
9 - - 84.5
182
9 - - 2.6
186
9 - - 85.4
185
9 - - 9.6
191
8 - - 11.8
192
8 - - 7.4
195
8 - - 69.1
188
8 - - 0.7
193
8 - - 37.6
189
8 - - 43.4
196
A
8 - - 41.1
194
8 - - 36.9
208
8
3D
1s5jA02 - 74.1
190
8 - - 18.1
212
7 - - 15.4
207
7 - - 3.3
198
7 - - 32.6
202
7 - - 69.1
217
7 - - 62.6
209
7 - - 2.9
210
7 - - 5.5
213
7 - - 0.0
200
7 - - 62.5
199
7 - - 15.5
203
7 - - 13.5
204
7 - - 21.1
211
7 - - 1.1
218
7 - - 41.3
221
7 - - 95.3
205
7 - - 1.3
214
7 - - 15.5
219
7 - - 67.0
206
7 - - 8.3
220
7 - - 80.8
197
7 - - 32.2
215
7 - - 91.7
201
7 - - 38.8
216
7 - - 3.3
232
6 - - 72.2
225
6 - - 5.9
229
6 - - 13.9
222
6 - - 47.2
224
6 - - 12.2
233
6 - - 5.3
228
6 - - 12.6
238
6 - - 55.7
236
6 - - 5.4
234
6 - - 8.9
227
6 - - 4.5
240
6 - - 92.3
230
6 - - 0.6
239
6 - - 23.5
226
6 - - 0.0
237
6 - - 0.5
235
6 - - 4.3
231
6 - - 4.0
223
6 - - 69.3
246
5 - - 66.7
272
5 - - 53.5
262
5 - - 2.5
257
5 - - 9.2
247
5 - - 80.4
252
5 - - 1.8
271
5 - - 85.3
242
5 - - 72.4
254
5 - - 0.0
267
5 - - 12.0
273
5 - - 76.5
243
5 - - 29.5
268
5 - - 7.6
253
5 - - 5.5
258
5 - - 13.0
248
5 - - 3.5
260
5 - - 6.3
264
5 - - 0.0
255
5 - - 11.9
274
5 - - 77.5
250
5 - - 9.2
276
5 - - 76.0
259
DNA directed
5 - - 33.4
249
5 - - 2.1
269
5 - - 78.7
244
5 - - 68.4
265
5 - - 8.5
275
5 - - 66.8
251
5 - - 2.5
256
5 - - 4.7
245
5 - - 12.3
241
5 - - 50.5
270
5 - - 0.0
266
5 - - 79.3
261
5 - - 6.5
285
4 - - 9.5
308
4 - - 70.0
301
4 - - 5.3
294
4 - - 36.3
278
4 - - 59.9
307
4 - - 46.2
335
4
3D
2lsnA00 - 14.4
299
Plant
4 - - 12.8
305
4 - - 12.5
281
4 - - 21.4
284
4 - - 0.0
289
4 - - 9.0
290
4 - - 0.7
309
4 - - 70.0
279
4 - - 80.8
293
4 - - 19.6
310
4 - - 63.1
280
4 - - 28.1
302
A
4 - - 19.4
298
4 - - 74.8
288
4 - - 2.5
287
4 - - 12.9
303
4 - - 10.3
297
4 - - 68.7
283
4 - - 7.7
295
4 - - 1.9
300
A
4 - - 44.5
286
4 - - 5.8
296
4 - - 3.0
292
4 - - 5.7
291
4 - - 7.5
282
4 - - 72.7
277
4 - - 25.7
304
4 - - 87.8
306
4 - - 65.8
350
3 - - 51.6
340
3 - - 1.3
311
3 - - 2.1
349
3 - - 6.9
323
3 - - 56.9
330
3 - - 2.1
353
3 - - 38.4
326
3 - - 0.4
315
3 - - 33.4
317
3 - - 1.2
319
3 - - 4.0
344
3 - - 0.0
336
3 - - 9.8
351
3 - - 37.5
342
3 - - 53.5
341
3 - - 4.7
329
3 - - 9.4
346
3 - - 9.4
322
3 - - 17.8
354
3 - - 81.4
316
3 - - 58.3
314
3 - - 31.4
334
3 - - 10.4
339
3 - - 14.0
345
3 - - 11.5
318
DNA directed
3 - - 2.4
325
3 - - 0.0
337
3 - - 9.0
333
3 - - 0.0
347
3 - - 8.3
320
3 - - 13.5
338
DNA directed
3 - - 5.3
328
3 - - 12.2
313
3 - - 25.6
331
3 - - 16.8
348
3 - - 0.0
324
3 - - 0.0
312
3 - - 9.6
352
3 - - 65.4
332
3 - - 5.0
327
3 - - 0.5
343
A
3 - - 11.8
321
3 - - 35.3
463
2 - - 6.3
458
2 - - 0.0
486
2 - - 39.9
391
2 - - 1.1
444
2 - - 0.0
456
2 - - 0.4
366
2 - - 47.2
468
2 - - 36.7
413
2 - - 0.0
432
2 - - 33.0
359
2 - - 1.2
477
2 - - 0.0
360
2 - - 39.1
375
2 - - 10.1
490
2 - - 11.5
387
2 - - 45.8
461
2 - - 6.9
425
2 - - 0.0
395
2 - - 2.1
361
2 - - 0.0
412
2 - - 0.7
440
2 - - 9.0
467
2 - - 0.0
481
2 - - 21.1
474
2 - - 0.0
472
2 - - 0.0
457
2 - - 0.0
383
2 - - 30.7
419
2 - - 5.2
406
2 - - 0.0
365
2 - - 10.0
421
2 - - 0.0
491
2 - - 45.1
408
2 - - 3.8
443
2 - - 0.0
431
2 - - 12.1
382
2 - - 37.8
367
2 - - 14.5
453
2 - - 4.8
488
2 - - 39.1
405
2 - - 0.0
392
2 - - 7.5
399
2 - - 1.6
436
2 - - 45.8
386
2 - - 43.2
427
2 - - 20.0
426
2 - - 0.0
483
2 - - 34.0
372
2 - - 20.6
462
2 - - 0.5
414
2 - - 5.4
476
2 - - 0.0
469
2 - - 5.1
471
2 - - 1.9
355
2 - - 0.0
423
2 - - 0.0
422
2 - - 7.5
402
2 - - 0.0
464
2 - - 0.0
439
2 - - 12.2
362
2 - - 5.0
407
2 - - 0.0
376
2 - - 22.3
371
2 - - 7.6
435
2 - - 36.9
494
2 - - 34.8
487
2 - - 24.7
448
2 - - 8.9
396
2 - - 0.0
482
2 - - 31.2
450
2 - - 0.0
473
2 - - 0.0
356
2 - - 0.0
451
2 - - 0.0
454
2 - - 0.0
378
2 - - 30.9
389
2 - - 11.2
410
2 - - 0.7
430
2 - - 24.1
447
2 - - 2.6
415
2 - - 11.3
480
2 - - 0.0
438
2 - - 44.2
417
2 - - 2.7
381
2 - - 32.8
373
2 - - 24.6
493
2 - - 43.6
400
2 - - 0.0
475
2 - - 0.0
446
2 - - 0.6
393
2 - - 0.0
424
2 - - 0.0
434
2 - - 39.0
442
2 - - 0.0
465
2 - - 5.1
385
2 - - 38.8
479
2 - - 50.8
377
2 - - 25.3
484
2 - - 35.4
363
2 - - 0.7
397
2 - - 0.0
459
2 - - 0.0
401
2 - - 0.0
404
2 - - 0.0
357
2 - - 0.0
455
2 - - 2.8
470
2 - - 0.0
390
2 - - 0.0
358
2 - - 0.0
437
2 - - 38.4
418
2 - - 0.0
388
2 - - 0.0
364
2 - - 4.4
485
2 - - 37.4
460
2 - - 0.0
379
2 - - 28.5
452
2 - - 0.0
370
2 - - 18.0
416
2 - - 0.0
380
2 - - 33.1
445
2 - - 0.6
441
2 - - 0.0
369
2 - - 17.8
428
2 - - 10.1
394
2 - - 0.0
368
2 - - 10.0
492
2 - - 41.8
374
2 - - 22.1
429
2 - - 16.6
409
2 - - 0.0
489
2 - - 43.9
433
2 - - 29.8
411
2 - - 0.0
478
2 - - 9.3
398
2 - - 1.0
384
2 - - 40.5
420
2 - - 0.0
403
2 - - 4.3
466
2 - - 0.0
512
1 - - 0.0
517
1 - - 0.0
722
1 - - 0.0
728
1 - - 0.0
742
1 - - 0.0
495
1 - - 0.0
569
1 - - 0.0
686
1 - - 0.0
690
1 - - 0.0
536
1 - - 0.0
508
1 - - 0.0
558
1 - - 0.0
573
1 - - 0.0
638
1 - - 0.0
506
1 - - 0.0
661
1 - - 0.0
581
1 - - 0.0
678
1 - - 0.0
652
1 - - 0.0
700
1 - - 0.0
606
1 - - 0.0
666
1 - - 0.0
708
1 - - 0.0
710
1 - - 0.0
545
1 - - 0.0
588
1 - - 0.0
756
1 - - 0.0
542
1 - - 0.0
574
1 - - 0.0
660
1 - - 0.0
526
1 - - 0.0
566
1 - - 0.0
604
1 - - 0.0
659
1 - - 0.0
682
1 - - 0.0
501
1 - - 0.0
626
1 - - 0.0
736
1 - - 0.0
539
1 - - 0.0
520
1 - - 0.0
532
1 - - 0.0
584
1 - - 0.0
665
1 - - 0.0
649
1 - - 0.0
648
1 - - 0.0
642
1 - - 0.0
704
1 - - 0.0
681
1 - - 0.0
554
1 - - 0.0
552
1 - - 0.0
563
1 - - 0.0
673
1 - - 0.0
748
1 - - 0.0
711
1 - - 0.0
546
1 - - 0.0
537
1 - - 0.0
741
1 - - 0.0
529
1 - - 0.0
729
1 - - 0.0
735
1 - - 0.0
636
1 - - 0.0
600
1 - - 0.0
696
1 - - 0.0
505
1 - - 0.0
670
1 - - 0.0
625
1 - - 0.0
712
1 - - 0.0
570
1 - - 0.0
655
1 - - 0.0
597
1 - - 0.0
559
1 - - 0.0
580
1 - - 0.0
675
1 - - 0.0
739
1 - - 0.0
662
1 - - 0.0
653
1 - - 0.0
509
1 - - 0.0
716
1 - - 0.0
685
1 - - 0.0
743
1 - - 0.0
523
1 - - 0.0
723
1 - - 0.0
595
1 - - 0.0
507
1 - - 0.0
644
1 - - 0.0
568
1 - - 0.0
525
1 - - 0.0
691
1 - - 0.0
650
1 - - 0.0
498
1 - - 0.0
629
1 - - 0.0
533
1 - - 0.0
615
1 - - 0.0
635
1 - - 0.0
575
1 - - 0.0
709
1 - - 0.0
699
1 - - 0.0
543
1 - - 0.0
757
1 - - 0.0
603
1 - - 0.0
565
1 - - 0.0
511
1 - - 0.0
674
1 - - 0.0
502
1 - - 0.0
553
1 - - 0.0
555
1 - - 0.0
680
1 - - 0.0
679
1 - - 0.0
647
1 - - 0.0
593
1 - - 0.0
641
1 - - 0.0
616
1 - - 0.0
640
1 - - 0.0
562
1 - - 0.0
705
1 - - 0.0
599
1 - - 0.0
609
1 - - 0.0
587
1 - - 0.0
753
1 - - 0.0
726
1 - - 0.0
624
1 - - 0.0
656
1 - - 0.0
749
1 - - 0.0
596
1 - - 0.0
613
1 - - 0.0
713
1 - - 0.0
547
1 - - 0.0
631
1 - - 0.0
499
1 - - 0.0
528
1 - - 0.0
560
1 - - 0.0
634
1 - - 0.0
578
1 - - 0.0
695
1 - - 0.0
540
1 - - 0.0
684
1 - - 0.0
571
1 - - 0.0
758
1 - - 0.0
706
1 - - 0.0
594
1 - - 0.0
586
1 - - 0.0
734
1 - - 0.0
534
1 - - 0.0
746
1 - - 0.0
744
1 - - 0.0
633
1 - - 0.0
515
1 - - 0.0
724
1 - - 0.0
519
1 - - 0.0
646
1 - - 0.0
556
1 - - 0.0
717
1 - - 0.0
671
1 - - 0.0
692
1 - - 0.0
663
1 - - 0.0
510
1 - - 0.0
658
1 - - 0.0
549
1 - - 0.0
614
1 - - 0.0
583
1 - - 0.0
591
1 - - 0.0
689
1 - - 0.0
727
1 - - 0.0
754
1 - - 0.0
619
1 - - 0.0
698
1 - - 0.0
621
1 - - 0.0
524
1 - - 0.0
598
1 - - 0.0
602
1 - - 0.0
612
1 - - 0.0
701
1 - - 0.0
564
1 - - 0.0
731
1 - - 0.0
657
1 - - 0.0
503
1 - - 0.0
576
1 - - 0.0
738
1 - - 0.0
544
1 - - 0.0
623
1 - - 0.0
628
1 - - 0.0
733
1 - - 0.0
630
1 - - 0.0
608
1 - - 0.0
522
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