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Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1060
3D
6n4oA04 - 71.4
2
852
3D
1hjrD00 - 94.1
3
715
3D
2igiB00 - 97.1
4
586
3D
3iayA03 - 91.8
5
512
3D
4gmjF00 - 84.7
6
459 - - 88.2
17
452
3D
5hrsA00 - 76.4
8
440
3D
3aa5X00 - 84.5
9
407
3D
4kb1B00 - 75.3
25
397
3D
5j2qA05 - 78.5
7
376
3D
1wljA00 - 95.3
10
323 - - 90.6
12
291
3D
2xy8A00 - 94.7
11
288 - - 82.8
13
272 - - 78.7
14
237 - - 90.8
16
224
3D
3pufP01 - 94.0
15
218 - - 63.1
20
198
3D
4fzzB00 - 29.7
18
198
3D
4qclA03 - 86.8
19
194 - - 88.1
21
191 - - 82.1
22
190
3D
3sahB01 - 87.3
26
180
3D
2kzzA01 - 95.9
23
174 - - 46.5
24
171 - - 92.6
27
160 - - 82.0
28
149 - - 90.5
46
144
3D
5ywvB01 - 91.4
29
142
3D
2xriA01 - 47.4
30
141 - - 75.1
33
138
3D
4js5B01 - 90.0
31
134 - - 96.3
32
132 - - 96.7
34
124
3D
1zbuD01 - 90.9
35
A
122
3D
2a1sD01 - 65.1
36
117
3D
4fydB03 - 85.7
263
109
3D
5uoqB00 - 28.9
38
107 - - 72.9
37
107 - - 74.4
39
105 - - 85.4
40
102 - - 82.8
41
102 - - 92.8
49
100
3D
2qkkW00 - 77.7
42
A
100 - - 47.8
52
97
3D
3maqA03 - 77.3
45
96
3D
2p1jB01 - 98.2
43
96 - - 89.2
44
94 - - 7.7
47
93
3D
3vn5A02 - 91.4
53
90
3D
2e6mA00 - 78.7
48
90
3D
3g10A00 - 91.0
51
86 - - 77.6
50
86 - - 31.1
54
79 - - 96.5
55
78 - - 71.6
56
73 - - 73.5
57
69 - - 56.6
58
68 - - 87.6
59
66
3D
4nlcA01 - 88.5
60
64
3D
1yt3A01 - 82.1
61
61 - - 89.4
62
59 - - 72.7
63
55 - - 93.8
65
54 - - 76.4
64
54 - - 71.8
66
53 - - 74.9
67
51 - - 94.6
68
49 - - 63.2
72
47
3D
1nozB02 - 27.7
69
46 - - 70.6
70
45 - - 73.9
71
43 - - 47.7
73
43 - - 17.2
74
42 - - 87.7
75
41 - - 4.7
76
40 - - 95.0
77
39 - - 87.9
79
38 - - 73.6
78
38 - - 82.2
80
37 - - 80.6
82
36 - - 78.8
81
36 - - 83.5
83
35 - - 14.2
85
31 - - 21.9
84
31 - - 0.0
89
30
3D
3h08B00 - 88.2
86
29 - - 32.5
87
28 - - 83.3
88
28 - - 73.6
92
27 - - 9.6
449
27
3D
2pzsD01 - 3.9
90
27 - - 86.7
91
27 - - 85.8
161
26
3D
5v5fC00 - 88.0
93
26 - - 23.8
107
A
26
3D
4b8cF00 - 77.5
95
24 - - 62.1
94
24 - - 29.6
102
23
3D
5dmrA00 - 33.2
184
23
3D
4fw2B01 - 16.6
97
22 - - 89.0
96
22 - - 63.6
139
21
3D
2dfhA01 - 92.7
100
Wrn
21 - - 84.2
99
21 - - 14.3
101
21 - - 77.8
98
21 - - 49.3
157
20
3D
5dk5B01 - 90.0
103
19 - - 69.4
104
19 - - 84.1
106
19 - - 7.2
105
19 - - 3.5
163
18
3D
5c0yB01 - 14.0
111
18 - - 22.4
110
18 - - 4.8
142
18
3D
4hhtA00 - 77.7
108
18 - - 1.2
112
18 - - 9.4
109
18 - - 69.6
115
17 - - 89.6
119
17 - - 34.1
120
A
17 - - 83.2
117
17 - - 0.7
118
A
17 - - 3.8
116
3'-5' exonuclease
17 - - 4.5
114
17 - - 75.1
113
17 - - 81.7
122
16 - - 5.8
124
16 - - 4.8
123
A
16 - - 8.9
134
16
3D
1wnsA02 - 25.6
121
16 - - 17.7
126
15 - - 13.7
131
15 - - 78.1
125
15 - - 0.0
129
15 - - 7.9
130
15 - - 61.6
128
A
15 - - 48.2
127
15 - - 11.7
135
14 - - 17.0
137
14 - - 0.0
138
14 - - 78.0
160
14
3D
1kcfB00 - 87.4
136
A
14 - - 18.3
140
14 - - 95.3
132
14 - - 17.0
133
14 - - 49.7
141
13 - - 21.3
164
13
3D
2ajqF01 - 13.9
147
13 - - 14.0
150
13 - - 80.3
148
13 - - 3.6
145
13 - - 78.1
149
13 - - 83.8
143
13 - - 6.6
183
13
3D
4fcyB03 - 26.8
144
13 - - 13.8
146
13 - - 62.8
151
13 - - 79.5
156
12 - - 84.6
152
12 - - 1.9
154
12 - - 92.1
153
12 - - 0.0
155
12 - - 2.8
159
12 - - 83.6
158
12 - - 47.8
162
11 - - 28.4
166
11 - - 82.7
167
11 - - 82.8
165
11 - - 42.1
176
10 - - 17.7
170
10 - - 1.4
173
10 - - 62.2
172
10 - - 41.0
174
10 - - 31.3
168
10 - - 32.2
175
10 - - 86.8
179
10 - - 65.3
171
10 - - 0.0
169
10 - - 76.9
177
10 - - 42.2
178
10 - - 8.2
181
9 - - 84.5
187
9 - - 66.2
185
9 - - 9.6
182
9 - - 2.6
180
9 - - 38.9
186
9 - - 85.4
193
8 - - 37.6
188
8 - - 0.7
194
8 - - 36.9
192
8 - - 7.4
190
8 - - 18.1
196
A
8 - - 41.1
189
8 - - 43.4
208
8
3D
1s5jA02 - 74.1
191
8 - - 11.8
195
8 - - 69.1
204
7 - - 21.1
220
7 - - 80.8
202
7 - - 69.1
215
7 - - 91.7
219
7 - - 67.0
203
7 - - 13.5
211
7 - - 1.1
217
7 - - 62.6
218
7 - - 41.3
200
7 - - 62.5
206
7 - - 8.3
210
7 - - 5.5
216
7 - - 3.3
207
7 - - 3.3
198
7 - - 32.6
197
7 - - 32.2
201
7 - - 38.8
209
7 - - 2.9
221
7 - - 95.3
213
7 - - 0.0
205
7 - - 1.3
199
7 - - 15.5
214
7 - - 15.5
212
7 - - 15.4
226
6 - - 0.0
235
6 - - 4.3
239
6 - - 23.5
231
6 - - 4.0
223
6 - - 69.3
237
6 - - 0.5
238
6 - - 55.7
224
6 - - 12.2
222
6 - - 47.2
236
6 - - 5.4
230
6 - - 0.6
225
6 - - 5.9
229
6 - - 13.9
233
6 - - 5.3
228
6 - - 12.6
240
6 - - 92.3
227
6 - - 4.5
232
6 - - 72.2
234
6 - - 8.9
247
5 - - 80.4
250
5 - - 9.2
248
5 - - 3.5
256
5 - - 4.7
270
5 - - 0.0
276
5 - - 76.0
241
5 - - 50.5
264
5 - - 0.0
262
5 - - 2.5
260
5 - - 6.3
245
5 - - 12.3
266
5 - - 79.3
253
5 - - 5.5
249
5 - - 2.1
274
5 - - 77.5
272
5 - - 53.5
273
5 - - 76.5
254
5 - - 0.0
252
5 - - 1.8
275
5 - - 66.8
261
5 - - 6.5
244
5 - - 68.4
242
5 - - 72.4
268
5 - - 7.6
267
5 - - 12.0
255
5 - - 11.9
243
5 - - 29.5
259
DNA directed
5 - - 33.4
251
5 - - 2.5
258
5 - - 13.0
265
5 - - 8.5
257
5 - - 9.2
271
5 - - 85.3
246
5 - - 66.7
269
5 - - 78.7
292
4 - - 5.7
288
4 - - 2.5
287
4 - - 12.9
294
4 - - 36.3
301
4 - - 5.3
281
4 - - 21.4
310
4 - - 63.1
308
4 - - 70.0
293
4 - - 19.6
307
4 - - 46.2
285
4 - - 9.5
289
4 - - 9.0
309
4 - - 70.0
296
4 - - 3.0
305
4 - - 12.5
290
4 - - 0.7
335
4
3D
2lsnA00 - 14.4
282
4 - - 72.7
279
4 - - 80.8
298
4 - - 74.8
303
4 - - 10.3
284
4 - - 0.0
297
4 - - 68.7
283
4 - - 7.7
304
4 - - 87.8
302
A
4 - - 19.4
291
4 - - 7.5
277
4 - - 25.7
278
4 - - 59.9
299
Plant
4 - - 12.8
300
A
4 - - 44.5
306
4 - - 65.8
295
4 - - 1.9
286
4 - - 5.8
280
4 - - 28.1
325
3 - - 0.0
343
A
3 - - 11.8
329
3 - - 9.4
336
3 - - 9.8
316
3 - - 58.3
330
3 - - 2.1
344
3 - - 0.0
342
3 - - 53.5
327
3 - - 0.5
340
3 - - 1.3
328
3 - - 12.2
346
3 - - 9.4
332
3 - - 5.0
314
3 - - 31.4
312
3 - - 9.6
334
3 - - 10.4
333
3 - - 0.0
313
3 - - 25.6
351
3 - - 37.5
321
3 - - 35.3
315
3 - - 33.4
341
3 - - 4.7
319
3 - - 4.0
339
3 - - 14.0
348
3 - - 0.0
320
3 - - 13.5
350
3 - - 51.6
347
3 - - 8.3
326
3 - - 0.4
318
DNA directed
3 - - 2.4
317
3 - - 1.2
338
DNA directed
3 - - 5.3
337
3 - - 9.0
354
3 - - 81.4
324
3 - - 0.0
322
3 - - 17.8
352
3 - - 65.4
331
3 - - 16.8
345
3 - - 11.5
311
3 - - 2.1
353
3 - - 38.4
323
3 - - 56.9
349
3 - - 6.9
437
2 - - 38.4
473
2 - - 0.0
383
2 - - 30.7
355
2 - - 0.0
367
2 - - 14.5
438
2 - - 44.2
368
2 - - 10.0
417
2 - - 2.7
418
2 - - 0.0
359
2 - - 1.2
490
2 - - 11.5
422
2 - - 7.5
452
2 - - 0.0
406
2 - - 0.0
391
2 - - 1.1
400
2 - - 0.0
454
2 - - 0.0
424
2 - - 0.0
466
2 - - 0.0
485
2 - - 37.4
453
2 - - 4.8
423
2 - - 0.0
375
2 - - 10.1
411
2 - - 0.0
460
2 - - 0.0
445
2 - - 0.6
361
2 - - 0.0
431
2 - - 12.1
379
2 - - 28.5
382
2 - - 37.8
472
2 - - 0.0
489
2 - - 43.9
397
2 - - 0.0
384
2 - - 40.5
474
2 - - 0.0
398
2 - - 1.0
357
2 - - 0.0
365
2 - - 10.0
435
2 - - 36.9
476
2 - - 0.0
358
2 - - 0.0
386
2 - - 43.2
441
2 - - 0.0
481
2 - - 21.1
371
2 - - 7.6
415
2 - - 11.3
380
2 - - 33.1
470
2 - - 0.0
439
2 - - 12.2
462
2 - - 0.5
369
2 - - 17.8
403
2 - - 4.3
419
2 - - 5.2
464
2 - - 0.0
493
2 - - 43.6
456
2 - - 0.4
426
2 - - 0.0
378
2 - - 30.9
488
2 - - 39.1
402
2 - - 0.0
377
2 - - 25.3
487
2 - - 24.7
463
2 - - 6.3
494
2 - - 34.8
404
2 - - 0.0
447
2 - - 2.6
399
2 - - 1.6
420
2 - - 0.0
492
2 - - 41.8
450
2 - - 0.0
448
2 - - 8.9
395
2 - - 2.1
370
2 - - 18.0
480
2 - - 0.0
471
2 - - 1.9
381
2 - - 32.8
446
2 - - 0.6
486
2 - - 39.9
428
2 - - 10.1
376
2 - - 22.3
458
2 - - 0.0
440
2 - - 9.0
465
2 - - 5.1
427
2 - - 20.0
457
2 - - 0.0
434
2 - - 39.0
393
2 - - 0.0
364
2 - - 4.4
412
2 - - 0.7
414
2 - - 5.4
469
2 - - 5.1
432
2 - - 33.0
362
2 - - 5.0
451
2 - - 0.0
421
2 - - 0.0
413
2 - - 0.0
392
2 - - 7.5
394
2 - - 0.0
363
2 - - 0.7
409
2 - - 0.0
387
2 - - 45.8
433
2 - - 29.8
477
2 - - 0.0
388
2 - - 0.0
356
2 - - 0.0
478
2 - - 9.3
405
2 - - 0.0
443
2 - - 0.0
468
2 - - 36.7
467
2 - - 0.0
455
2 - - 2.8
483
2 - - 34.0
425
2 - - 0.0
373
2 - - 24.6
401
2 - - 0.0
396
2 - - 0.0
491
2 - - 45.1
390
2 - - 0.0
429
2 - - 16.6
459
2 - - 0.0
461
2 - - 6.9
430
2 - - 24.1
360
2 - - 39.1
416
2 - - 0.0
475
2 - - 0.0
385
2 - - 38.8
410
2 - - 0.7
366
2 - - 47.2
436
2 - - 45.8
442
2 - - 0.0
374
2 - - 22.1
484
2 - - 35.4
444
2 - - 0.0
407
2 - - 0.0
389
2 - - 11.2
372
2 - - 20.6
482
2 - - 31.2
479
2 - - 50.8
408
2 - - 3.8
631
1 - - 0.0
720
1 - - 0.0
750
1 - - 0.0
704
1 - - 0.0
747
1 - - 0.0
645
1 - - 0.0
505
1 - - 0.0
660
1 - - 0.0
748
1 - - 0.0
611
1 - - 0.0
685
1 - - 0.0
756
1 - - 0.0
653
1 - - 0.0
595
1 - - 0.0
726
1 - - 0.0
623
1 - - 0.0
666
1 - - 0.0
702
1 - - 0.0
578
1 - - 0.0
674
1 - - 0.0
533
1 - - 0.0
577
1 - - 0.0
509
1 - - 0.0
649
1 - - 0.0
496
1 - - 0.0
672
1 - - 0.0
599
1 - - 0.0
689
1 - - 0.0
513
1 - - 0.0
551
1 - - 0.0
521
1 - - 0.0
715
1 - - 0.0
569
1 - - 0.0
532
1 - - 0.0
618
1 - - 0.0
617
1 - - 0.0
514
1 - - 0.0
735
1 - - 0.0
638
1 - - 0.0
512
1 - - 0.0
741
1 - - 0.0
534
1 - - 0.0
637
1 - - 0.0
673
1 - - 0.0
527
1 - - 0.0
557
1 - - 0.0
654
1 - - 0.0
624
1 - - 0.0
565
1 - - 0.0
600
1 - - 0.0
719
1 - - 0.0
540
1 - - 0.0
528
1 - - 0.0
558
1 - - 0.0
586
1 - - 0.0
696
1 - - 0.0
546
1 - - 0.0
703
1 - - 0.0
606
1 - - 0.0
571
1 - - 0.0
739
1 - - 0.0
690
1 - - 0.0
622
1 - - 0.0
652
1 - - 0.0
580
1 - - 0.0
745
1 - - 0.0
508
1 - - 0.0
648
1 - - 0.0
579
1 - - 0.0
731
1 - - 0.0
620
1 - - 0.0
692
1 - - 0.0
582
1 - - 0.0
650
1 - - 0.0
604
1 - - 0.0
647
1 - - 0.0
544
1 - - 0.0
507
1 - - 0.0
597
1 - - 0.0
687
1 - - 0.0
584
1 - - 0.0
663
1 - - 0.0
694
1 - - 0.0
602
1 - - 0.0
542
1 - - 0.0
598
1 - - 0.0
711
1 - - 0.0
688
1 - - 0.0
656
1 - - 0.0
753
1 - - 0.0
626
1 - - 0.0
723
1 - - 0.0
536
1 - - 0.0
510
1 - - 0.0
749
1 - - 0.0
575
1 - - 0.0
516
1 - - 0.0
530
1 - - 0.0
561
1 - - 0.0
670
1 - - 0.0
529
1 - - 0.0
559
1 - - 0.0
717
1 - - 0.0
615
1 - - 0.0
681
1 - - 0.0
718
1 - - 0.0
591
1 - - 0.0
501
1 - - 0.0
641
1 - - 0.0
737
1 - - 0.0
676
1 - - 0.0
635
1 - - 0.0
738
1 - - 0.0
555
1 - - 0.0
583
1 - - 0.0
664
1 - - 0.0
693
1 - - 0.0
525
1 - - 0.0
567
1 - - 0.0
754
1 - - 0.0
724
1 - - 0.0
568
1 - - 0.0
700
1 - - 0.0
619
1 - - 0.0
722
1 - - 0.0
752
1 - - 0.0
543
1 - - 0.0
603
1 - - 0.0
706
1 - - 0.0
662
1 - - 0.0
639
1 - - 0.0
678
1 - - 0.0
633
1 - - 0.0
736
1 - - 0.0
677
1 - - 0.0
574
1 - - 0.0
710
1 - - 0.0
549
1 - - 0.0
609
1 - - 0.0
699
1 - - 0.0
589
1 - - 0.0
572
1 - - 0.0
613
1 - - 0.0
716
1 - - 0.0
651
1 - - 0.0
621
1 - - 0.0
730
1 - - 0.0
531
1 - - 0.0
744
1 - - 0.0
707
1 - - 0.0
605
1 - - 0.0
545
1 - - 0.0
560
1 - - 0.0
708
1 - - 0.0
511
1 - - 0.0
585
1 - - 0.0
553
1 - - 0.0
523
1 - - 0.0
695
1 - - 0.0
566
1 - - 0.0
742
1 - - 0.0
554
1 - - 0.0
665
1 - - 0.0
524
1 - - 0.0
627
1 - - 0.0
657
1 - - 0.0
640
1 - - 0.0
500
1 - - 0.0
628
1 - - 0.0
658
1 - - 0.0
499
1 - - 0.0
686
1 - - 0.0
755
1 - - 0.0
596
1 - - 0.0
725
1 - - 0.0
506
1 - - 0.0
646
1 - - 0.0
743
1 - - 0.0
671
1 - - 0.0
590
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522
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680
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552
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518
1 - - 0.0
669
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632
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729
1 - - 0.0
495
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614
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517
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612
1 - - 0.0
538
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701
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537
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573
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634
1 - - 0.0
733
1 - - 0.0
636
1 - - 0.0
610
1 - - 0.0
709
1 - - 0.0
675
1 - - 0.0
713
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616
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751
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721
1 - - 0.0
630
1 - - 0.0
661
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705
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548
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608
1 - - 0.0
520
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592
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550
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682
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644
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607
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684
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563
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587
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642
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556
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667
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625
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564
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727
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757
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519
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740
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668
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503
1 - - 0.0
746
1 - - 0.0
643
1 - - 0.0
539
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562
1 - - 0.0
629
1 - - 0.0
659
1 - - 0.0
570
1 - - 0.0
498
1 - - 0.0
714
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515
1 - - 0.0
581
1 - - 0.0
691
1 - - 0.0
732
1 - - 0.0
497
1 - - 0.0
541
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601
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576
1 - - 0.0
734
1 - - 0.0
535
1 - - 0.0
712
1 - - 0.0
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