CATH Domain 5dk5B01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family	Cell death-related nuclease 4

Enzyme Information

3.1.-.-

Acting on ester bonds.

based on mapping to UniProt Q10905

UniProtKB Entries (1)

CRN4_CAEEL

Caenorhabditis elegans

Cell death-related nuclease 4

PDB Structure

PDB	5DK5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES) Huang, K.-W., Hsu, K.-C., Chu, L.-Y., Yang, J.-M., Yuan, H.S., Hsiao, Y.-Y. J.Med.Chem.