CATH Domain 3pufP01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family	Ribonuclease

Enzyme Information

3.1.26.4

Ribonuclease H.

based on mapping to UniProt O75792

Endonucleolytic cleavage to 5'-phosphomonoester.

-!- Acts on RNA-DNA hybrids.

UniProtKB Entries (1)

RNH2C_HUMAN

Homo sapiens

Ribonuclease H2 subunit C

PDB Structure

PDB	3PUF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects. Figiel, M., Chon, H., Cerritelli, S.M., Cybulska, M., Crouch, R.J., Nowotny, M. J.Biol.Chem.