CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.10 | Ribonuclease H-like superfamily/Ribonuclease H |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease H-like superfamily/Ribonuclease H |
| Functional Family | Interferon-stimulated exonuclease gene 20 |
Enzyme Information
| 3.1.13.1 |
Exoribonuclease II.
based on mapping to UniProt Q96AZ6
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for single-stranded RNA. -!- The enzyme processes 3'-terminal extra-nucleotides of monomeric tRNA precursors, following the action of EC 3.1.26.5. -!- Similar enzymes: RNase Q, RNase BN, RNase PIII, RNase Y. -!- Formerly EC 3.1.4.20.
|
UniProtKB Entries (1)
| Q96AZ6 |
ISG20_HUMAN
Homo sapiens
Interferon-stimulated gene 20 kDa protein
|
PDB Structure
| PDB | 1WLJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease
Febs Lett.
|
