×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 3.60.15.10

Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
10
DNA cross-link repair 1A
486
3D
 5ahrA01 - 81.6
1
Cleavage and polyadenylation specificity factor
387
3D
 6i1dA01 - 73.5
2
Ribonuclease Z
368
3D
 2cbnA00 - 90.6
7
Metallo-beta-lactamase NDM-1
333
3D
 6q30B00 - 7.6
3
Integrator complex subunit 11
269 - - 72.9
4
Probable L-ascorbate-6-phosphate lactonase UlaG
264
3D
 2wymD00 - 37.0
5
Cleavage and polyadenylation specificity factor subunit 3
255 - - 71.8
6
MBL fold metallo-hydrolase
248 - - 41.2
9
Anaerobic nitric oxide reductase flavorubredoxin
194
3D
 5lmcA01 - 32.1
8
Cleavage and polyadenylation specificity factor subunit 2
193 - - 85.5
11
integrator complex subunit 9
161 - - 44.2
13
Persulfide dioxygenase ETHE1, mitochondrial
156
3D
 4chlB01 - 88.5
20
Class B metallo-beta-lactamase
150
3D
 6ew3B00 - 17.7
12
Hydroxyacylglutathione hydrolase
149 - - 8.2
14
Zinc phosphodiesterase ELAC protein 2
141 - - 81.3
15
probable hydrolase PNKD isoform X1
116 - - 40.5
17
Lactamase beta 2
115
3D
 4ad9F01 - 88.7
16
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, putative
115 - - 82.7
19
Hydroxyacylglutathione hydrolase, mitochondrial
109
3D
 1qh5B00 - 85.7
18
DNA cross-link repair 1C
105 - - 88.0
21
Ribonuclease J
87
3D
 3zq4E01 - 78.7
22
DNA cross-link repair 1B
81
3D
 5ahoA01 - 69.1
23
Zinc phosphodiesterase ELAC protein 1
79
3D
 3zwfB00 - 64.7
24
Zinc phosphodiesterase ELAC protein 2
69 - - 73.0
25
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase
67 - - 35.8
26
metallo-beta-lactamase domain-containing protein 2
64 - - 24.4
27
DNA ligase 6
57 - - 87.0
30
Metallo-beta-lactamase family protein
52
3D
 3tp9B01 - 94.1
28
Integrator complex subunit 11 isoform X3
52 - - 83.6
29
Cyclic nucleotide-binding domain protein
47 - - 88.4
31
integrator complex subunit 11 isoform X2
42 - - 12.6
118
Metallo-beta-lactamase L1 type 3
41
3D
 5hh6A00 - 40.7
32
Metallo-hydrolase/oxidoreductase superfamily protein
38 - - 77.1
34
N-acyl homoserine lactonase family protein
38
3D
 4keqA00 - 19.3
35
Phosphonate metabolism protein PhnP
38
3D
 3p2uB00 - 12.6
50
Metallo-beta-lactamase type 2
37
3D
 6eweA00 - 28.2
33
MBL fold metallo-hydrolase
35 - - 88.4
36
DNA internalization-related competence protein ComEC/Rec2
34 - - 15.3
38
DNA cross-link repair protein pso2/snm1
33 - - 74.6
37
tRNAse Z4
33 - - 81.7
39
DNA repair metallo-beta-lactamase family protein
33 - - 85.9
40
Beta-lactamase
31 - - 0.0
41
Metallo-beta-lactamase domain protein
28 - - 80.8
42
Cleavage and polyadenylation specificity factor,putative
27 - - 49.6
60
N-acyl homoserine lactonase AiiA
27
3D
 5ehtA01 - 24.5
43
Cleavage and polyadenylation specificity factor subunit 3
26 - - 16.7
44
Hydroxyacylglutathione hydrolase
25 - - 35.7
45
Hydroxyacylglutathione hydrolase
23 - - 82.4
46
Cleavage and polyadenylation specificity factor subunit 3
22 - - 22.9
47
integrator complex subunit 11 isoform X2
21 - - 14.4
48
Zn-dependent hydrolase/oxidoreductase family protein, putative
21 - - 73.0
51
Ribonuclease Z, mitochondrial
20 - - 93.0
49
tRNase Z TRZ1
20 - - 43.2
53
protein artemis isoform X2
19 - - 33.0
52
tRNAse Z TRZ4, mitochondrial
19 - - 64.8
54
Metallo-beta-lactamase superfamily protein
19 - - 95.3
55
Cleavage and polyadenylation specificity factor protein
18 - - 7.5
58
DNA repair metallo-beta-lactamase-domain-containing protein
18 - - 71.7
56
integrator complex subunit 9
18 - - 15.5
57
Ribonuclease Z
18 - - 75.0
88
Quinolone signal response protein
17
3D
 5hisA00 - 0.8
61
Interstrand crosslink repair protein
17 - - 80.7
59
N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D
17 - - 73.3
63
tRNA processing endoribonuclease Trz1, putative
17 - - 80.5
62
DNA repair metallo-beta-lactamase protein
17 - - 3.6
65
Ribonuclease Z
15 - - 80.2
64
Probable 3',5'-cyclic-nucleotide phosphodiesterase
15 - - 82.1
66
Hydroxyacylglutathione hydrolase
14 - - 9.2
69
ElaC ribonuclease Z 1
13 - - 37.4
67
Metallo-beta-lactamase family protein
13 - - 78.1
72
Cleavage and polyadenylation specificity factor subunit 2
13
3D
 2i7xA01 - 16.9
70
Glyoxylase, beta-lactamase superfamily II
13 - - 59.3
68
Ribonuclease Z, mitochondrial
13 - - 82.3
71
Ribonuclease J
12 - - 13.0
75
Ribonuclease Z
12 - - 7.9
80
Ribonuclease Z, mitochondrial
12 - - 86.0
73
MBL fold metallo-hydrolase
12 - - 82.8
81
Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence
12 - - 38.7
74
Hydroxyacylglutathione hydrolase
12 - - 3.3
77
Ribonuclease J
12 - - 24.6
76
Cleavage and polyadenylation specificity factor,putative
12 - - 14.1
79
Metallo-hydrolase/oxidoreductase, putative
12 - - 6.2
78
Ribonuclease Z, putative
12 - - 79.8
82
DNA repair protein, putative
11 - - 31.3
83
Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence
11 - - 12.7
84
Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence
11 - - 15.6
85
Ribonuclease Z
11 - - 2.5
86
Ribonuclease Z
11 - - 76.4
90
DNA repair protein
10 - - 83.1
91
tRNA processing endoribonuclease Trz1, putative
10 - - 79.2
87
MBL fold metallo-hydrolase
10 - - 9.4
89
Possible hydrolase
10 - - 0.0
94
Probable metallo-hydrolase MT2357
9 - - 0.0
93
Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence
9 - - 13.8
92
Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence
9 - - 7.5
95
Metallo-hydrolase/oxidoreductase superfamily protein
9 - - 17.4
98
Ribonuclease Z
9 - - 6.1
96
Metallo-beta-lactamase type 2
9 - - 10.5
97
MBL fold metallo-hydrolase
9 - - 0.0
99
3',5'-cyclic-nucleotide phosphodiesterase
9 - - 3.5
103
ETHE1, persulfide dioxygenase
8 - - 4.1
105
Ribonuclease Z
8 - - 20.8
102
Cleavage and polyadenylation specificity factor subunit 2
8 - - 33.2
100
Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase + cyclase/dehydrase
8 - - 0.0
101
Putative metallo-beta-lactamase domain protein
8 - - 30.1
106
MoRTal germline
8 - - 68.2
104
Ribonuclease Z
8 - - 10.9
110
cAMP-specific phosphodiesterase
7 - - 70.5
147
Metallo-beta-lactamase type 2
7
3D
 3f9oA00 - 5.8
107
DNA cross-link repair 1C
7 - - 11.9
115
Cleavage and polyadenylation specificity factor 73 kDa subunit
7 - - 0.5
112
Metallo-beta-lactamase domain containing protein
7 - - 6.2
109
Bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase
7 - - 12.2
108
Cleavage and polyadenylation specificity factor subunit 2
7 - - 0.0
113
Hydroxyacylglutathione hydrolase
7 - - 0.0
117
DNA cross-link repair 1A protein, variant
7 - - 5.3
114
Protein CBG11581
7 - - 17.5
116
Cleavage and polyadenylation specificity factor, putative
7 - - 3.6
111
MBL fold metallo-hydrolase
7 - - 0.0
123
Metallo-beta-lactamase domain containing protein
6 - - 8.0
120
Beta lactamase like protein
6 - - 0.0
119
DNA internalization-related competence protein ComEC/Rec2
6 - - 15.1
125
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
6 - - 78.6
122
Metallo-beta-lactamase domain containing protein
6 - - 7.8
121
Cleavage and polyadenylation specificity factor, 73 kDa subunit
6 - - 6.4
124
DNA repair metallo-beta-lactamase, putative
6 - - 3.1
182
Acylhomoserine lactonase
6
3D
 4zo3B00 - 7.9
128
Unplaced genomic scaffold supercont2.2, whole genome shotgun sequence
5 - - 12.8
129
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
5 - - 40.9
133
Cleavage and polyadenylation specificity factor, 73 kDa subunit
5 - - 4.3
127
Beta-lactamase superfamily domain/DNA repair metallo-beta-lactamase, putative
5 - - 32.7
130
Metallo-beta-lactamase superfamily protein
5 - - 72.3
135
Ribonuclease Z
5 - - 81.6
132
MBL fold metallo-hydrolase
5 - - 12.7
126
Glyoxylase, beta-lactamase superfamily II
5 - - 14.3
136
N-Acyl Phosphatidyl Ethanolamine specific phospholipase D
NAPE-PLD
5 - - 44.7
131
Zn-dependent hydrolases, including glyoxylases
5 - - 0.0
134
Metallo-beta-lactamase superfamily protein
5 - - 82.6
138
Hypothetical_protein_-_conserved
4 - - 10.2
139
Ribonuclease Z
4 - - 10.2
137
Putative metallo-beta-lactamase
4 - - 0.0
142
Chromosome 10, whole genome shotgun sequence
4 - - 84.6
140
Ribonuclease J
4 - - 6.3
141
Ribonuclease Z 1
4 - - 75.0
152
Subunit of mRNA cleavage and polyadenylation specificity factor
3 - - 7.4
143
MBL fold metallo-hydrolase
3 - - 6.2
155
Metallo-hydrolase/oxidoreductase
3 - - 1.9
150
Glyoxalase II
3 - - 0.0
149
Cleavage and polyadenylation specific factor 3
3 - - 5.3
148
Beta-lactamase
3 - - 0.0
145
Predicted protein
3 - - 46.7
157
Ribonuclease Z 2, mitochondrial
3 - - 71.7
153
Cleavage and polyadenylation specificity factor subunit 2
3 - - 0.0
146
MBL fold metallo-hydrolase
3 - - 10.7
154
Cleavage and polyadenylation specificity factor subunit 2
3 - - 11.7
151
Unplaced genomic scaffold supercont2.13, whole genome shotgun sequence
3 - - 7.0
144
Predicted protein
3 - - 38.8
156
Ribonuclease Z, putative
3 - - 5.7
186
Uncharacterized protein
2 - - 16.4
201
CPSF3L protein
2 - - 22.6
181
Metal-dependent hydrolase, beta-lactamase superfamily III
2 - - 0.8
194
Rubredoxin:oxygen/nitric oxide oxidoreductase
2 - - 0.0
164
Uncharacterized protein
2 - - 4.5
174
MBL fold metallo-hydrolase
2 - - 0.0
161
Predicted protein
2 - - 32.9
171
Beta-lactamase superfamily domain/DNA repair metallo-beta-lactamase, putative
2 - - 0.0
184
Uncharacterized protein
2 - - 41.4
191
Prostate cancer susceptibility protein-like protein
2 - - 0.7
159
Rhodanese domain protein / beta-lactamase domain protein
2 - - 0.0
158
MBL fold metallo-hydrolase
2 - - 0.0
196
Protein artemis
2 - - 0.0
166
Uncharacterized protein
2 - - 0.0
176
Beta-lactamase domain protein
2 - - 6.5
189
Beta-lactamase-like protein
2 - - 1.1
188
Prostate cancer susceptibility protein-like protein
2 - - 2.6
162
DNA repair protein, putative
AFU_orthologue AFUA_1G04570
2 - - 0.0
172
Integrator complex subunit 11 isoform X3
2 - - 0.0
195
Flavo-diiron protein FprA2
2 - - 0.0
165
Uncharacterized protein
2 - - 0.0
175
Slr2005 protein
2 - - 0.0
192
Uncharacterized protein
2 - - 0.0
190
Putative metallo-beta-lactamase-like protein
2 - - 13.2
187
Uncharacterized protein
2 - - 33.9
183
Uncharacterized protein
2 - - 32.2
160
Rhodanese domain protein / beta-lactamase domain protein
2 - - 0.0
170
Metallo-beta-lactamase family protein
2 - - 4.5
177
MBL fold metallo-hydrolase
2 - - 0.0
167
Uncharacterized protein
2 - - 0.0
193
Flavo-diiron protein FprA1
2 - - 0.0
197
Uncharacterized protein
2 - - 0.7
180
Ribonuclease Z
2 - - 8.4
163
Uncharacterized protein
2 - - 0.0
173
ElaC ribonuclease Z 2
2 - - 40.1
202
Uncharacterized protein
2 - - 6.4
168
MBL fold metallo-hydrolase
2 - - 0.0
169
Uncharacterized protein
2 - - 1.8
178
Hydroxyacylglutathione hydrolase 3, mitochondrial
2 - - 8.1
200
Ribonuclease Z 2, mitochondrial
2 - - 41.0
179
Uncharacterized protein
2 - - 2.1
185
Uncharacterized protein
2 - - 37.5
199
Metallo-beta-lactamase superfamily protein
2 - - 38.2
198
Predicted protein
2 - - 38.1
214
CPSF3L protein
1 - - 0.0
262
Uncharacterized protein
1 - - 0.0
236
Protein CBR-NAPE-2
1 - - 0.0
226
Artemis-related DNA-crosslink repair exonuclease
1 - - 0.0
272
Uncharacterized protein
1 - - 0.0
265
Chromosome 7, whole genome shotgun sequence
1 - - 0.0
241
Uncharacterized protein
1 - - 0.0
275
Putative DNA interstrand cross-link repair protein
1 - - 0.0
246
ElaC ribonuclease Z 1
1 - - 0.0
206
DNA cross-link repair 1C
1 - - 0.0
254
Uncharacterized protein
1 - - 0.0
283
Uncharacterized protein
1 - - 0.0
260
Chromosome 7, whole genome shotgun sequence
1 - - 0.0
231
Zinc metallohydrolase, glyoxalase II family
1 - - 0.0
270
RNase Z-like protein
1 - - 0.0
221
Uncharacterized protein
1 - - 0.0
277
Uncharacterized protein
1 - - 0.0
216
Uncharacterized protein
1 - - 0.0
251
Ribonuclease Z
1 - - 0.0
234
Uncharacterized protein
1 - - 0.0
267
Uncharacterized protein
1 - - 0.0
224
Uncharacterized protein
1 - - 0.0
280
Uncharacterized protein
1 - - 0.0
263
ElaC ribonuclease Z 2
1 - - 0.0
273
Uncharacterized protein
1 - - 0.0
268
Uncharacterized protein
1 - - 0.0
269
Uncharacterized protein
1 - - 0.0
282
Uncharacterized protein
1 - - 0.0
244
Predicted protein
1 - - 0.0
278
AGAP000597-PA
1 - - 0.0
204
Chromosome 9, whole genome shotgun sequence
1 - - 0.0
279
Uncharacterized protein
1 - - 0.0
211
Chromosome 1, whole genome shotgun sequence
1 - - 0.0
256
RNA-metabolising metallo-beta-lactamase family protein
1 - - 0.0
252
Uncharacterized protein
1 - - 0.0
210
Predicted protein
1 - - 0.0
243
Uncharacterized protein
1 - - 0.0
203
Predicted protein
1 - - 0.0
207
Uncharacterized protein
1 - - 0.0
255
Predicted protein
1 - - 0.0
247
Uncharacterized protein
1 - - 0.0
238
Uncharacterized protein
1 - - 0.0
239
Uncharacterized protein
1 - - 0.0
228
Uncharacterized protein
1 - - 0.0
229
Ribonuclease Z
1 - - 0.0
215
Uncharacterized protein
1 - - 0.0
281
Uncharacterized protein
1 - - 0.0
233
YALI0E32527p
1 - - 0.0
223
Chromosome 10, whole genome shotgun sequence
1 - - 0.0
264
Uncharacterized protein
1 - - 0.0
250
Predicted protein
1 - - 0.0
227
Cleavage and polyadenylation specificity factor 73-like Protein
1 - - 0.0
212
Uncharacterized protein
1 - - 0.0
237
Uncharacterized protein
1 - - 0.0
249
7,8-dihydropterin-6-methyl-4-
beta-D-ribofuranosyl
1 - - 0.0
248
Putative hydrolase C777.06c
1 - - 0.0
274
DNA repair metallo-beta-lactamase family protein
1 - - 0.0
209
Artemis-related DNA-crosslink repair exonuclease
1 - - 0.0
208
Uncharacterized protein
1 - - 0.0
261
Ribonuclease Z, putative
1 - - 0.0
245
Coenzyme PQQ synthesis protein B
1 - - 0.0
220
Uncharacterized protein
1 - - 0.0
257
Uncharacterized protein
1 - - 0.0
271
Uncharacterized protein
1 - - 0.0
205
Predicted protein
1 - - 0.0
230
Metallo-beta-lactamase fold-containing protein ST1585
1 - - 0.0
219
Uncharacterized protein
1 - - 0.0
218
Chromosome 1, whole genome shotgun sequence
1 - - 0.0
253
RNA-metabolising metallo-beta-lactamase family protein
1 - - 0.0
242
Uncharacterized protein
1 - - 0.0
213
DNA repair metallo-beta-lactamase family protein
1 - - 0.0
259
Uncharacterized protein
1 - - 0.0
258
Cleavage and polyadenylation specific factor 3
1 - - 0.0
235
Uncharacterized protein
1 - - 0.0
240
Uncharacterized protein
1 - - 0.0
225
Uncharacterized protein
1 - - 0.0
266
Uncharacterized protein
1 - - 0.0
232
Arylsulfatase
1 - - 0.0
222
Os09g0439000 protein
1 - - 0.0
217
DNA repair protein, putative
1 - - 0.0
276
Predicted protein
1 - - 0.0
CATH-Gene3D is a Global Biodata Core Resource Learn more...