The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
960
3D
1qxpB02 - 97.3
6
619
3D
5qc4B00 - 90.4
2
612 - - 71.3
3
582
3D
5k16B00 - 74.7
4
503 - - 80.0
5
414 - - 84.8
7
367 - - 75.9
8
355 - - 72.2
9
354
3D
2vhfB00 - 86.0
10
351 - - 92.6
13
326
3D
6ml1B00 - 62.3
11
317 - - 72.4
12
315 - - 43.5
14
286 - - 69.6
15
273 - - 76.3
16
268 - - 81.9
17
252 - - 85.5
31
251
3D
6ay2B00 - 94.1
18
251 - - 72.9
21
231
3D
2cb5B01 - 91.9
19
231 - - 73.7
20
230 - - 47.1
24
222
3D
6dgfA00 - 77.0
23
219
3D
1s4vB00 - 90.9
22
218 - - 93.1
25
210
3D
3n3kA00 - 77.9
26
206 - - 89.0
27
204 - - 83.0
28
203 - - 73.9
29
198 - - 77.9
30
197 - - 71.2
32
196
3D
6iinB00 - 89.8
33
175
3D
3ihpB03 - 67.3
34
167 - - 50.6
36
160
3D
3ch3X00 - 75.7
35
159 - - 76.4
37
150 - - 79.6
38
146 - - 78.0
39
144 - - 95.4
40
142 - - 59.7
41
137 - - 84.2
42
131 - - 74.9
43
131 - - 89.9
44
130 - - 82.9
45
125 - - 76.9
47
115 - - 70.4
46
115 - - 86.8
48
113 - - 79.1
49
111 - - 87.8
50
110
3D
1m6dB00 - 72.5
51
101 - - 42.9
52
98 - - 54.6
58
97
3D
3mtnC00 - 76.4
53
96 - - 69.6
54
95 - - 93.4
55
94 - - 84.9
60
90
3D
1ef7B00 - 84.0
56
90 - - 73.0
57
90 - - 89.7
59
87 - - 70.9
138
87
3D
6exqB00 - 91.8
61
85 - - 44.4
62
84
3D
3pdfA02 - 72.6
63
81 - - 77.4
64
81 - - 87.0
65
80 - - 50.8
66
79 - - 79.3
67
77 - - 89.4
68
76 - - 76.0
69
76 - - 26.1
70
74 - - 80.3
71
71 - - 51.1
72
70 - - 75.7
74
67
3D
6czsA00 - 72.5
86
67
3D
2oulA00 - 37.6
73
66 - - 80.4
75
65 - - 67.9
76
64 - - 53.9
77
63 - - 60.4
78
62 - - 69.6
79
59 - - 82.9
80
58 - - 72.4
81
56 - - 90.3
82
55 - - 36.4
91
53
3D
3gcbA01 - 83.5
84
52 - - 74.8
83
52 - - 83.7
85
51 - - 69.2
88
50
3D
5chvB00 - 73.1
96
50
3D
4n4zA00 - 94.1
87
50 - - 85.6
204
48
3D
9papA00 - 86.2
89
45 - - 77.9
90
44 - - 94.6
92
43 - - 89.0
95
42 - - 71.6
94
42 - - 35.3
93
42 - - 71.6
97
40 - - 31.0
99
38 - - 85.3
98
Pcalp
38 - - 27.0
101
36 - - 71.1
100
36 - - 77.1
102
35 - - 80.4
103
35 - - 93.6
106
34 - - 51.6
104
34 - - 94.7
105
34 - - 72.5
107
33 - - 3.8
108
33 - - 83.2
109
33 - - 94.8
110
31 - - 61.5
111
30 - - 28.0
168
30
3D
6r9qA01 - 65.1
113
29 - - 75.2
114
29 - - 97.5
112
29 - - 71.7
190
28
3D
6aqrA02 - 17.4
126
28
3D
6ffaA00 - 25.3
115
28 - - 72.2
117
27 - - 87.4
116
27 - - 86.3
119
26 - - 81.3
118
26 - - 64.6
122
25 - - 86.3
121
25 - - 72.5
120
25 - - 28.1
127
24 - - 75.7
123
24 - - 40.1
125
24 - - 47.8
124
24 - - 65.0
128
24 - - 79.7
130
24 - - 84.8
129
24 - - 88.6
131
23 - - 79.4
132
22 - - 63.1
133
22 - - 58.8
134
22 - - 73.7
135
21 - - 69.0
137
21 - - 13.9
136
21 - - 72.3
139
20 - - 7.6
140
19 - - 66.2
142
18 - - 74.2
141
18 - - 17.7
148
18
3D
3zuaA01 - 42.2
144
17 - - 74.6
146
17 - - 64.8
143
17 - - 86.9
156
17
3D
1vjvA01 - 85.6
145
17 - - 84.0
147
17 - - 11.7
150
17 - - 93.8
149
17 - - 7.2
555
17
3D
6bkjD02 - 51.7
155
16 - - 77.9
153
16 - - 26.6
154
16 - - 6.8
152
16 - - 75.2
151
16 - - 12.2
157
15 - - 18.4
159
15 - - 69.6
160
15 - - 10.1
158
15 - - 81.8
161
15 - - 76.0
162
14 - - 64.5
164
14 - - 68.2
166
14 - - 62.8
163
14 - - 82.3
165
14 - - 76.6
167
14 - - 96.0
172
13 - - 93.2
176
13 - - 70.4
174
13 - - 70.8
177
13 - - 84.3
175
13 - - 30.4
173
13 - - 21.8
169
13 - - 9.0
171
13 - - 85.5
170
13 - - 2.8
180
12 - - 64.5
178
12 - - 78.4
179
12 - - 11.7
183
11 - - 18.2
185
11 - - 33.8
187
11 - - 10.8
191
Human disease gene
11 - - 40.6
184
11 - - 27.0
186
11 - - 12.4
182
11 - - 17.0
189
11 - - 73.4
181
11 - - 13.5
188
11 - - 14.8
201
10 - - 12.3
199
10 - - 71.8
200
10 - - 17.0
216
10
3D
4msxA02 - 2.1
208
10 - - 77.0
198
10 - - 74.4
195
10 - - 72.9
207
10 - - 74.2
193
10 - - 31.7
203
10 - - 35.2
205
10 - - 62.8
197
10 - - 33.9
194
10 - - 59.0
206
10 - - 67.3
196
10 - - 88.0
192
10 - - 60.3
202
10 - - 70.2
212
9 - - 69.9
209
9 - - 39.0
214
9 - - 19.5
217
9 - - 19.3
215
9 - - 1.1
213
9 - - 22.6
218
9 - - 80.5
408
9
3D
1o0eB00 - 58.6
211
9 - - 89.7
219
9 - - 96.5
210
9 - - 15.6
221
8 - - 79.6
230
8 - - 34.9
220
8 - - 53.0
229
8 - - 8.9
231
8 - - 77.9
228
8 - - 13.7
226
8 - - 10.9
224
8 - - 34.1
227
8 - - 29.6
223
8 - - 12.6
225
8 - - 8.8
232
8 - - 82.3
222
8 - - 59.4
258
7 - - 45.3
239
7 - - 5.9
248
7 - - 10.2
240
7 - - 0.0
249
7 - - 2.1
241
7 - - 72.3
238
7 - - 13.7
251
7 - - 10.7
250
7 - - 8.4
234
7 - - 69.4
236
7 - - 4.0
252
7 - - 9.0
235
7 - - 67.5
242
7 - - 79.6
233
7 - - 17.6
237
7 - - 5.9
256
7 - - 46.0
243
7 - - 64.2
245
7 - - 10.0
247
7 - - 8.0
254
7 - - 1.9
244
7 - - 7.4
257
7 - - 67.7
255
7 - - 0.0
246
7 - - 6.2
253
7 - - 6.5
260
6 - - 72.3
269
6 - - 3.7
271
6 - - 9.1
261
6 - - 83.2
279
6 - - 4.6
270
6 - - 8.0
280
6 - - 0.0
278
6 - - 18.4
281
6 - - 2.6
268
6 - - 3.8
259
6 - - 73.4
263
6 - - 0.0
265
6 - - 74.9
282
6 - - 8.3
277
6 - - 5.9
275
6 - - 0.4
267
6 - - 88.2
273
6 - - 2.5
276
6 - - 53.6
264
6 - - 38.0
274
6 - - 5.7
332
6
3D
1cs8A00 - 48.4
266
6 - - 70.5
284
6 - - 85.8
283
6 - - 5.7
262
6 - - 86.2
272
6 - - 3.1
315
5 - - 68.2
292
5 - - 72.3
313
5 - - 0.0
288
5 - - 76.7
308
5 - - 6.7
317
5 - - 41.8
314
5 - - 16.2
316
5 - - 39.2
320
5 - - 57.7
294
5 - - 3.4
321
5 - - 69.0
296
5 - - 4.3
300
5 - - 36.3
312
5 - - 8.9
309
5 - - 0.0
289
5 - - 75.4
295
5 - - 2.3
293
5 - - 6.1
301
5 - - 55.1
297
5 - - 9.3
319
5 - - 75.1
302
5 - - 2.9
310
5 - - 16.8
298
5 - - 6.4
311
5 - - 0.0
304
5 - - 4.0
286
5 - - 5.7
306
5 - - 34.1
303
5 - - 9.8
285
5 - - 2.4
305
5 - - 11.1
299
5 - - 47.0
290
5 - - 74.4
287
5 - - 19.2
307
5 - - 0.0
291
5 - - 73.4
318
5 - - 58.2
350
4 - - 38.0
351
4 - - 30.8
341
4 - - 9.8
338
4 - - 49.1
340
4 - - 0.0
349
4 - - 33.1
328
4 - - 58.4
329
4 - - 57.0
348
4 - - 1.2
331
4 - - 67.4
330
4 - - 58.7
339
4 - - 56.5
358
4 - - 74.2
355
4 - - 69.0
346
4 - - 12.6
353
4 - - 60.0
344
4 - - 72.7
357
4 - - 57.4
347
4 - - 7.9
354
4 - - 68.4
322
4 - - 8.1
356
4 - - 66.7
343
4 - - 0.0
345
4 - - 66.3
323
4 - - 8.2
325
4 - - 17.7
337
4 - - 62.6
327
4 - - 38.9
335
4 - - 64.9
342
4 - - 4.6
333
4 - - 49.2
336
4 - - 28.6
352
4 - - 41.5
324
4 - - 0.0
334
4 - - 59.7
326
4 - - 59.7
381
3 - - 46.4
368
3 - - 10.4
397
3 - - 9.1
359
3 - - 19.1
380
3 - - 22.9
389
3 - - 0.0
395
3 - - 3.0
393
3 - - 0.0
378
3 - - 12.9
411
3 - - 66.7
396
3 - - 5.2
419
3 - - 73.3
394
3 - - 9.2
402
3 - - 7.4
410
3 - - 56.7
418
AFU_orthologue AFUA_2G08440
3 - - 41.2
407
3 - - 26.7
405
3 - - 40.2
403
3 - - 13.1
361
3 - - 11.9
406
3 - - 43.8
388
3 - - 3.4
379
3 - - 12.4
370
3 - - 4.2
360
3 - - 42.8
369
3 - - 0.8
404
3 - - 8.2
392
3 - - 71.4
371
3 - - 3.9
372
3 - - 42.2
387
3 - - 8.9
391
3 - - 73.4
416
3 - - 38.0
383
3 - - 47.2
385
3 - - 0.5
362
3 - - 0.8
399
3 - - 0.0
390
3 - - 11.3
414
3 - - 71.7
417
3 - - 23.1
386
3 - - 7.4
413
3 - - 68.6
384
3 - - 29.9
415
3 - - 75.8
374
3 - - 12.5
366
3 - - 8.2
401
3 - - 56.1
376
3 - - 72.5
364
3 - - 1.1
400
3 - - 0.0
412
3 - - 61.1
409
3 - - 44.7
375
3 - - 72.0
367
3 - - 6.4
398
3 - - 2.2
373
3 - - 63.4
363
3 - - 0.0
365
3 - - 0.0
382
3 - - 43.9
420
3 - - 29.6
377
3 - - 73.1
531
2 - - 0.0
445
2 - - 0.0
484
2 - - 5.8
520
AFU_orthologue AFUA_2G08440
2 - - 0.0
456
2 - - 20.4
432
2 - - 39.6
529
2 - - 6.2
443
2 - - 8.9
548
2 - - 32.3
530
2 - - 8.9
486
2 - - 2.0
422
2 - - 0.0
539
2 - - 0.0
454
2 - - 0.0
521
2 - - 0.0
447
2 - - 10.6
499
2 - - 7.3
490
2 - - 1.8
457
2 - - 32.1
444
2 - - 0.0
485
2 - - 0.5
462
2 - - 38.5
512
2 - - 39.3
561
2 - - 42.3
500
2 - - 0.0
509
2 - - 36.6
483
2 - - 1.8
558
2 - - 37.2
491
2 - - 0.0
446
2 - - 0.0
453
2 - - 0.0
455
2 - - 1.9
501
2 - - 0.0
487
2 - - 10.0
560
2 - - 39.0
472
2 - - 12.2
477
2 - - 8.8
550
2 - - 35.6
513
2 - - 40.8
465
2 - - 42.2
426
2 - - 21.8
559
2 - - 41.2
482
2 - - 4.8
434
2 - - 36.5
463
2 - - 37.0
515
2 - - 28.8
473
2 - - 37.5
424
2 - - 0.0
551
2 - - 34.6
517
2 - - 9.6
498
2 - - 8.7
436
2 - - 3.0
467
2 - - 38.6
452
2 - - 0.0
508
2 - - 0.0
475
2 - - 17.0
538
2 - - 28.0
464
2 - - 40.8
433
2 - - 42.4
442
2 - - 0.0
541
2 - - 0.7
427
2 - - 31.9
435
2 - - 0.6
514
2 - - 49.2
476
2 - - 10.2
466
2 - - 39.6
425
2 - - 0.0
437
2 - - 0.5
540
2 - - 0.0
516
2 - - 31.3
423
2 - - 22.5
549
2 - - 39.7
528
2 - - 0.0
474
2 - - 17.6
537
2 - - 38.1
525
2 - - 6.9
566
2 - - 39.3
504
2 - - 0.0
428
2 - - 31.9
494
2 - - 4.6
440
2 - - 0.0
523
2 - - 0.0
449
2 - - 6.2
564
2 - - 43.5
506
2 - - 4.0
533
2 - - 1.9
542
2 - - 0.0
438
2 - - 3.1
496
2 - - 0.0
535
2 - - 18.4
527
2 - - 13.3
441
2 - - 0.0
524
2 - - 11.7
451
2 - - 0.0
505
AFU_orthologue AFUA_5G13620
2 - - 0.0
478
2 - - 26.5
493
2 - - 1.5
495
AFU_orthologue AFUA_1G07555
2 - - 0.0
536
2 - - 20.9
480
2 - - 27.9
552
2 - - 35.7
489
2 - - 0.8
503
2 - - 7.6
526
2 - - 1.4
565
2 - - 44.8
450
2 - - 0.0
459
2 - - 34.3
497
2 - - 2.2
518
2 - - 10.9
468
2 - - 34.8
481
2 - - 0.0
507
2 - - 2.2
534
2 - - 13.1
563
2 - - 34.4
519
2 - - 9.3
546
2 - - 31.0
553
2 - - 34.9
510
2 - - 34.9
502
2 - - 5.5
458
2 - - 12.9
471
2 - - 36.7
492
2 - - 11.6
460
2 - - 36.1
469
2 - - 40.6
557
2 - - 20.2
544
2 - - 23.2
562
2 - - 41.0
511
2 - - 40.6
479
2 - - 27.3
470
2 - - 41.1
488
2 - - 11.3
461
2 - - 34.2
430
2 - - 36.4
439
2 - - 2.5
522
2 - - 2.3
554
2 - - 40.1
547
2 - - 32.3
421
2 - - 14.8
545
2 - - 32.6
431
2 - - 36.4
448
2 - - 0.0
556
2 - - 35.0
429
2 - - 29.1
532
2 - - 37.4
543
2 - - 38.7
893
1 - - 0.0
750
1 - - 0.0
713
1 - - 0.0
759
1 - - 0.0
642
1 - - 0.0
851
1 - - 0.0
633
1 - - 0.0
817
1 - - 0.0
606
1 - - 0.0
664
1 - - 0.0
797
1 - - 0.0
878
1 - - 0.0
880
1 - - 0.0
768
1 - - 0.0
627
1 - - 0.0
889
1 - - 0.0
635
1 - - 0.0
781
1 - - 0.0
676
1 - - 0.0
808
1 - - 0.0
715
1 - - 0.0
895
1 - - 0.0
751
1 - - 0.0
717
1 - - 0.0
897
1 - - 0.0
778
1 - - 0.0
793
1 - - 0.0
813
1 - - 0.0
850
1 - - 0.0
604
1 - - 0.0
625
1 - - 0.0
666
1 - - 0.0
637
1 - - 0.0
859
1 - - 0.0
881
1 - - 0.0
908
1 - - 0.0
708
1 - - 0.0
623
1 - - 0.0
815
1 - - 0.0
795
1 - - 0.0
674
1 - - 0.0
868
1 - - 0.0
780
1 - - 0.0
789
1 - - 0.0
618
1 - - 0.0
579
1 - - 0.0
677
1 - - 0.0
570
1 - - 0.0
682
1 - - 0.0
738
1 - - 0.0
626
1 - - 0.0
665
1 - - 0.0
840
1 - - 0.0
663
1 - - 0.0
796
1 - - 0.0
849
1 - - 0.0
634
1 - - 0.0
816
1 - - 0.0
607
1 - - 0.0
828
1 - - 0.0
588
1 - - 0.0
741
1 - - 0.0
894
1 - - 0.0
714
1 - - 0.0
838
1 - - 0.0
673
1 - - 0.0
571
1 - - 0.0
698
1 - - 0.0
605
1 - - 0.0
624
1 - - 0.0
603
1 - - 0.0
728
1 - - 0.0
841
1 - - 0.0
652
1 - - 0.0
794
1 - - 0.0
636
1 - - 0.0
569
1 - - 0.0
814
1 - - 0.0
667
1 - - 0.0
740
1 - - 0.0
592
1 - - 0.0
675
1 - - 0.0
896
1 - - 0.0
749
1 - - 0.0
716
1 - - 0.0
690
1 - - 0.0
731
1 - - 0.0
597
1 - - 0.0
699
1 - - 0.0
662
1 - - 0.0
611
1 - - 0.0
830
1 - - 0.0
685
1 - - 0.0
644
1 - - 0.0
839
1 - - 0.0
657
1 - - 0.0
821
1 - - 0.0
581
1 - - 0.0
748
1 - - 0.0
683
1 - - 0.0
568
1 - - 0.0
720
1 - - 0.0
729
1 - - 0.0
730
1 - - 0.0
593
1 - - 0.0
691
1 - - 0.0
739
1 - - 0.0
602
1 - - 0.0
831
1 - - 0.0
610
1 - - 0.0
653
1 - - 0.0
646
1 - - 0.0
578
1 - - 0.0
619
1 - - 0.0
580
1 - - 0.0
820
1 - - 0.0
687
1 - - 0.0
655
1 - - 0.0
589
1 - - 0.0
829
1 - - 0.0
721
1 - - 0.0
848
1 - - 0.0
595
1 - - 0.0
672
1 - - 0.0
858
1 - - 0.0
871
1 - - 0.0
779
1 - - 0.0
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