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We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
960
3D
1qxpB02 - 97.3
6
619
3D
5qc4B00 - 90.4
2
612 - - 71.3
3
582
3D
5k16B00 - 74.7
4
503 - - 80.0
5
414 - - 84.8
7
367 - - 75.9
8
355 - - 72.2
9
354
3D
2vhfB00 - 86.0
10
351 - - 92.6
13
326
3D
6ml1B00 - 62.3
11
317 - - 72.4
12
315 - - 43.5
14
286 - - 69.6
15
273 - - 76.3
16
268 - - 81.9
17
252 - - 85.5
18
251 - - 72.9
31
251
3D
6ay2B00 - 94.1
21
231
3D
2cb5B01 - 91.9
19
231 - - 73.7
20
230 - - 47.1
24
222
3D
6dgfA00 - 77.0
23
219
3D
1s4vB00 - 90.9
22
218 - - 93.1
25
210
3D
3n3kA00 - 77.9
26
206 - - 89.0
27
204 - - 83.0
28
203 - - 73.9
29
198 - - 77.9
30
197 - - 71.2
32
196
3D
6iinB00 - 89.8
33
175
3D
3ihpB03 - 67.3
34
167 - - 50.6
36
160
3D
3ch3X00 - 75.7
35
159 - - 76.4
37
150 - - 79.6
38
146 - - 78.0
39
144 - - 95.4
40
142 - - 59.7
41
137 - - 84.2
43
131 - - 89.9
42
131 - - 74.9
44
130 - - 82.9
45
125 - - 76.9
47
115 - - 70.4
46
115 - - 86.8
48
113 - - 79.1
49
111 - - 87.8
50
110
3D
1m6dB00 - 72.5
51
101 - - 42.9
52
98 - - 54.6
58
97
3D
3mtnC00 - 76.4
53
96 - - 69.6
54
95 - - 93.4
55
94 - - 84.9
57
90 - - 89.7
56
90 - - 73.0
60
90
3D
1ef7B00 - 84.0
59
87 - - 70.9
138
87
3D
6exqB00 - 91.8
61
85 - - 44.4
62
84
3D
3pdfA02 - 72.6
63
81 - - 77.4
64
81 - - 87.0
65
80 - - 50.8
66
79 - - 79.3
67
77 - - 89.4
68
76 - - 76.0
69
76 - - 26.1
70
74 - - 80.3
71
71 - - 51.1
72
70 - - 75.7
74
67
3D
6czsA00 - 72.5
86
67
3D
2oulA00 - 37.6
73
66 - - 80.4
75
65 - - 67.9
76
64 - - 53.9
77
63 - - 60.4
78
62 - - 69.6
79
59 - - 82.9
80
58 - - 72.4
81
56 - - 90.3
82
55 - - 36.4
91
53
3D
3gcbA01 - 83.5
83
52 - - 83.7
84
52 - - 74.8
85
51 - - 69.2
88
50
3D
5chvB00 - 73.1
96
50
3D
4n4zA00 - 94.1
87
50 - - 85.6
204
48
3D
9papA00 - 86.2
89
45 - - 77.9
90
44 - - 94.6
92
43 - - 89.0
94
42 - - 35.3
93
42 - - 71.6
95
42 - - 71.6
97
40 - - 31.0
98
Pcalp
38 - - 27.0
99
38 - - 85.3
101
36 - - 71.1
100
36 - - 77.1
103
35 - - 93.6
102
35 - - 80.4
105
34 - - 72.5
106
34 - - 51.6
104
34 - - 94.7
109
33 - - 94.8
108
33 - - 83.2
107
33 - - 3.8
110
31 - - 61.5
168
30
3D
6r9qA01 - 65.1
111
30 - - 28.0
114
29 - - 97.5
112
29 - - 71.7
113
29 - - 75.2
190
28
3D
6aqrA02 - 17.4
115
28 - - 72.2
126
28
3D
6ffaA00 - 25.3
116
27 - - 86.3
117
27 - - 87.4
118
26 - - 64.6
119
26 - - 81.3
121
25 - - 72.5
122
25 - - 86.3
120
25 - - 28.1
127
24 - - 75.7
128
24 - - 79.7
125
24 - - 47.8
129
24 - - 88.6
130
24 - - 84.8
124
24 - - 65.0
123
24 - - 40.1
131
23 - - 79.4
132
22 - - 63.1
134
22 - - 73.7
133
22 - - 58.8
136
21 - - 72.3
137
21 - - 13.9
135
21 - - 69.0
139
20 - - 7.6
140
19 - - 66.2
142
18 - - 74.2
141
18 - - 17.7
148
18
3D
3zuaA01 - 42.2
146
17 - - 64.8
143
17 - - 86.9
144
17 - - 74.6
145
17 - - 84.0
149
17 - - 7.2
555
17
3D
6bkjD02 - 51.7
150
17 - - 93.8
147
17 - - 11.7
156
17
3D
1vjvA01 - 85.6
151
16 - - 12.2
155
16 - - 77.9
154
16 - - 6.8
152
16 - - 75.2
153
16 - - 26.6
157
15 - - 18.4
158
15 - - 81.8
159
15 - - 69.6
161
15 - - 76.0
160
15 - - 10.1
165
14 - - 76.6
167
14 - - 96.0
166
14 - - 62.8
164
14 - - 68.2
162
14 - - 64.5
163
14 - - 82.3
171
13 - - 85.5
169
13 - - 9.0
177
13 - - 84.3
175
13 - - 30.4
173
13 - - 21.8
174
13 - - 70.8
172
13 - - 93.2
170
13 - - 2.8
176
13 - - 70.4
180
12 - - 64.5
178
12 - - 78.4
179
12 - - 11.7
186
11 - - 12.4
183
11 - - 18.2
191
Human disease gene
11 - - 40.6
182
11 - - 17.0
184
11 - - 27.0
185
11 - - 33.8
189
11 - - 73.4
181
11 - - 13.5
187
11 - - 10.8
188
11 - - 14.8
205
10 - - 62.8
199
10 - - 71.8
195
10 - - 72.9
216
10
3D
4msxA02 - 2.1
208
10 - - 77.0
207
10 - - 74.2
201
10 - - 12.3
197
10 - - 33.9
198
10 - - 74.4
196
10 - - 88.0
206
10 - - 67.3
200
10 - - 17.0
202
10 - - 70.2
193
10 - - 31.7
192
10 - - 60.3
194
10 - - 59.0
203
10 - - 35.2
213
9 - - 22.6
209
9 - - 39.0
212
9 - - 69.9
408
9
3D
1o0eB00 - 58.6
214
9 - - 19.5
210
9 - - 15.6
211
9 - - 89.7
218
9 - - 80.5
217
9 - - 19.3
215
9 - - 1.1
219
9 - - 96.5
221
8 - - 79.6
227
8 - - 29.6
228
8 - - 13.7
232
8 - - 82.3
230
8 - - 34.9
225
8 - - 8.8
229
8 - - 8.9
223
8 - - 12.6
231
8 - - 77.9
222
8 - - 59.4
224
8 - - 34.1
226
8 - - 10.9
220
8 - - 53.0
251
7 - - 10.7
233
7 - - 17.6
246
7 - - 6.2
257
7 - - 67.7
240
7 - - 0.0
258
7 - - 45.3
234
7 - - 69.4
236
7 - - 4.0
242
7 - - 79.6
244
7 - - 7.4
243
7 - - 64.2
255
7 - - 0.0
253
7 - - 6.5
245
7 - - 10.0
249
7 - - 2.1
238
7 - - 13.7
237
7 - - 5.9
252
7 - - 9.0
254
7 - - 1.9
256
7 - - 46.0
248
7 - - 10.2
250
7 - - 8.4
247
7 - - 8.0
241
7 - - 72.3
235
7 - - 67.5
239
7 - - 5.9
278
6 - - 18.4
277
6 - - 5.9
271
6 - - 9.1
280
6 - - 0.0
265
6 - - 74.9
269
6 - - 3.7
261
6 - - 83.2
275
6 - - 0.4
284
6 - - 85.8
282
6 - - 8.3
279
6 - - 4.6
267
6 - - 88.2
283
6 - - 5.7
268
6 - - 3.8
259
6 - - 73.4
266
6 - - 70.5
260
6 - - 72.3
272
6 - - 3.1
332
6
3D
1cs8A00 - 48.4
274
6 - - 5.7
273
6 - - 2.5
263
6 - - 0.0
276
6 - - 53.6
270
6 - - 8.0
281
6 - - 2.6
262
6 - - 86.2
264
6 - - 38.0
299
5 - - 47.0
317
5 - - 41.8
318
5 - - 58.2
295
5 - - 2.3
306
5 - - 34.1
300
5 - - 36.3
311
5 - - 0.0
286
5 - - 5.7
315
5 - - 68.2
297
5 - - 9.3
303
5 - - 9.8
298
5 - - 6.4
319
5 - - 75.1
302
5 - - 2.9
304
5 - - 4.0
320
5 - - 57.7
291
5 - - 73.4
285
5 - - 2.4
289
5 - - 75.4
312
5 - - 8.9
314
5 - - 16.2
321
5 - - 69.0
313
5 - - 0.0
309
5 - - 0.0
290
5 - - 74.4
305
5 - - 11.1
296
5 - - 4.3
287
5 - - 19.2
294
5 - - 3.4
288
5 - - 76.7
292
5 - - 72.3
301
5 - - 55.1
316
5 - - 39.2
310
5 - - 16.8
307
5 - - 0.0
293
5 - - 6.1
308
5 - - 6.7
337
4 - - 62.6
338
4 - - 49.1
322
4 - - 8.1
352
4 - - 41.5
354
4 - - 68.4
324
4 - - 0.0
353
4 - - 60.0
323
4 - - 8.2
345
4 - - 66.3
331
4 - - 67.4
349
4 - - 33.1
335
4 - - 64.9
341
4 - - 9.8
339
4 - - 56.5
356
4 - - 66.7
326
4 - - 59.7
347
4 - - 7.9
350
4 - - 38.0
348
4 - - 1.2
346
4 - - 12.6
328
4 - - 58.4
358
4 - - 74.2
340
4 - - 0.0
327
4 - - 38.9
357
4 - - 57.4
334
4 - - 59.7
351
4 - - 30.8
333
4 - - 49.2
343
4 - - 0.0
355
4 - - 69.0
325
4 - - 17.7
329
4 - - 57.0
330
4 - - 58.7
336
4 - - 28.6
342
4 - - 4.6
344
4 - - 72.7
373
3 - - 63.4
390
3 - - 11.3
401
3 - - 56.1
396
3 - - 5.2
410
3 - - 56.7
366
3 - - 8.2
385
3 - - 0.5
360
3 - - 42.8
416
3 - - 38.0
407
3 - - 26.7
389
3 - - 0.0
372
3 - - 42.2
374
3 - - 12.5
376
3 - - 72.5
381
3 - - 46.4
370
3 - - 4.2
362
3 - - 0.8
414
3 - - 71.7
412
3 - - 61.1
393
3 - - 0.0
364
3 - - 1.1
388
3 - - 3.4
394
3 - - 9.2
363
3 - - 0.0
409
3 - - 44.7
387
3 - - 8.9
392
3 - - 71.4
413
3 - - 68.6
405
3 - - 40.2
380
3 - - 22.9
371
3 - - 3.9
415
3 - - 75.8
386
3 - - 7.4
365
3 - - 0.0
419
3 - - 73.3
369
3 - - 0.8
403
3 - - 13.1
420
3 - - 29.6
404
3 - - 8.2
399
3 - - 0.0
402
3 - - 7.4
377
3 - - 73.1
378
3 - - 12.9
395
3 - - 3.0
418
AFU_orthologue AFUA_2G08440
3 - - 41.2
417
3 - - 23.1
368
3 - - 10.4
383
3 - - 47.2
367
3 - - 6.4
400
3 - - 0.0
406
3 - - 43.8
391
3 - - 73.4
359
3 - - 19.1
361
3 - - 11.9
375
3 - - 72.0
411
3 - - 66.7
398
3 - - 2.2
397
3 - - 9.1
384
3 - - 29.9
379
3 - - 12.4
382
3 - - 43.9
467
2 - - 38.6
455
2 - - 1.9
483
2 - - 1.8
425
2 - - 0.0
468
2 - - 34.8
443
2 - - 8.9
429
2 - - 29.1
459
2 - - 34.3
556
2 - - 35.0
526
2 - - 1.4
502
2 - - 5.5
491
2 - - 0.0
563
2 - - 34.4
504
2 - - 0.0
547
2 - - 32.3
520
AFU_orthologue AFUA_2G08440
2 - - 0.0
550
2 - - 35.6
548
2 - - 32.3
436
2 - - 3.0
562
2 - - 41.0
539
2 - - 0.0
503
2 - - 7.6
475
2 - - 17.0
519
2 - - 9.3
430
2 - - 36.4
564
2 - - 43.5
461
2 - - 34.2
535
2 - - 18.4
482
2 - - 4.8
479
2 - - 27.3
541
2 - - 0.7
444
2 - - 0.0
484
2 - - 5.8
497
2 - - 2.2
442
2 - - 0.0
515
2 - - 28.8
498
2 - - 8.7
465
2 - - 42.2
427
2 - - 31.9
457
2 - - 32.1
440
2 - - 0.0
428
2 - - 31.9
458
2 - - 12.9
486
2 - - 2.0
549
2 - - 39.7
446
2 - - 0.0
471
2 - - 36.7
480
2 - - 27.9
566
2 - - 39.3
432
2 - - 39.6
469
2 - - 40.6
553
2 - - 34.9
523
2 - - 0.0
511
2 - - 40.6
560
2 - - 39.0
545
2 - - 32.6
434
2 - - 36.5
531
2 - - 0.0
478
2 - - 26.5
522
2 - - 2.3
552
2 - - 35.7
433
2 - - 42.4
477
2 - - 8.8
506
2 - - 4.0
499
2 - - 7.3
500
2 - - 0.0
451
2 - - 0.0
554
2 - - 40.1
421
2 - - 14.8
524
2 - - 11.7
537
2 - - 38.1
538
2 - - 28.0
517
2 - - 9.6
495
AFU_orthologue AFUA_1G07555
2 - - 0.0
518
2 - - 10.9
470
2 - - 41.1
542
2 - - 0.0
481
2 - - 0.0
441
2 - - 0.0
544
2 - - 23.2
507
2 - - 2.2
476
2 - - 10.2
508
2 - - 0.0
435
2 - - 0.6
464
2 - - 40.8
561
2 - - 42.3
493
2 - - 1.5
530
2 - - 8.9
516
2 - - 31.3
510
2 - - 34.9
462
2 - - 38.5
439
2 - - 2.5
536
2 - - 20.9
448
2 - - 0.0
492
2 - - 11.6
450
2 - - 0.0
501
2 - - 0.0
447
2 - - 10.6
487
2 - - 10.0
463
2 - - 37.0
494
2 - - 4.6
488
2 - - 11.3
456
2 - - 20.4
426
2 - - 21.8
529
2 - - 6.2
559
2 - - 41.2
543
2 - - 38.7
525
2 - - 6.9
438
2 - - 3.1
505
AFU_orthologue AFUA_5G13620
2 - - 0.0
437
2 - - 0.5
473
2 - - 37.5
551
2 - - 34.6
454
2 - - 0.0
521
2 - - 0.0
424
2 - - 0.0
513
2 - - 40.8
496
2 - - 0.0
509
2 - - 36.6
533
2 - - 1.9
490
2 - - 1.8
422
2 - - 0.0
452
2 - - 0.0
534
2 - - 13.1
431
2 - - 36.4
445
2 - - 0.0
512
2 - - 39.3
460
2 - - 36.1
514
2 - - 49.2
485
2 - - 0.5
453
2 - - 0.0
423
2 - - 22.5
532
2 - - 37.4
466
2 - - 39.6
474
2 - - 17.6
546
2 - - 31.0
449
2 - - 6.2
472
2 - - 12.2
489
2 - - 0.8
528
2 - - 0.0
558
2 - - 37.2
540
2 - - 0.0
527
2 - - 13.3
557
2 - - 20.2
565
2 - - 44.8
843
1 - - 0.0
799
1 - - 0.0
661
1 - - 0.0
751
1 - - 0.0
721
1 - - 0.0
630
1 - - 0.0
713
1 - - 0.0
616
1 - - 0.0
675
1 - - 0.0
909
1 - - 0.0
868
1 - - 0.0
778
1 - - 0.0
610
1 - - 0.0
709
1 - - 0.0
883
1 - - 0.0
855
1 - - 0.0
825
1 - - 0.0
733
1 - - 0.0
777
1 - - 0.0
636
1 - - 0.0
867
1 - - 0.0
795
1 - - 0.0
698
1 - - 0.0
588
1 - - 0.0
801
1 - - 0.0
642
1 - - 0.0
684
1 - - 0.0
594
1 - - 0.0
697
1 - - 0.0
587
1 - - 0.0
644
1 - - 0.0
607
1 - - 0.0
905
1 - - 0.0
592
1 - - 0.0
682
1 - - 0.0
891
1 - - 0.0
679
1 - - 0.0
829
1 - - 0.0
859
1 - - 0.0
608
1 - - 0.0
705
1 - - 0.0
861
1 - - 0.0
771
1 - - 0.0
746
1 - - 0.0
643
1 - - 0.0
816
1 - - 0.0
830
1 - - 0.0
780
1 - - 0.0
740
1 - - 0.0
668
1 - - 0.0
765
1 - - 0.0
727
1 - - 0.0
875
1 - - 0.0
757
1 - - 0.0
667
1 - - 0.0
655
1 - - 0.0
786
1 - - 0.0
683
1 - - 0.0
625
1 - - 0.0
836
1 - - 0.0
593
1 - - 0.0
728
1 - - 0.0
758
1 - - 0.0
810
1 - - 0.0
712
1 - - 0.0
898
1 - - 0.0
576
1 - - 0.0
897
1 - - 0.0
884
1 - - 0.0
734
1 - - 0.0
601
1 - - 0.0
842
1 - - 0.0
581
1 - - 0.0
691
1 - - 0.0
879
1 - - 0.0
769
1 - - 0.0
732
1 - - 0.0
882
1 - - 0.0
844
1 - - 0.0
807
1 - - 0.0
714
1 - - 0.0
629
1 - - 0.0
808
1 - - 0.0
659
1 - - 0.0
570
1 - - 0.0
651
1 - - 0.0
621
1 - - 0.0
730
1 - - 0.0
880
1 - - 0.0
613
1 - - 0.0
716
1 - - 0.0
846
1 - - 0.0
699
1 - - 0.0
871
1 - - 0.0
589
1 - - 0.0
572
1 - - 0.0
761
1 - - 0.0
710
1 - - 0.0
828
1 - - 0.0
609
1 - - 0.0
858
1 - - 0.0
886
1 - - 0.0
633
1 - - 0.0
677
1 - - 0.0
736
1 - - 0.0
574
1 - - 0.0
775
1 - - 0.0
910
1 - - 0.0
827
1 - - 0.0
857
1 - - 0.0
865
1 - - 0.0
678
1 - - 0.0
840
1 - - 0.0
742
1 - - 0.0
784
1 - - 0.0
834
1 - - 0.0
797
1 - - 0.0
585
1 - - 0.0
695
1 - - 0.0
798
1 - - 0.0
812
1 - - 0.0
907
1 - - 0.0
708
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