The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
960
3D
1qxpB02 - 97.3
6
619
3D
5qc4B00 - 90.4
2
612 - - 71.3
3
582
3D
5k16B00 - 74.7
4
503 - - 80.0
5
414 - - 84.8
7
367 - - 75.9
8
355 - - 72.2
9
354
3D
2vhfB00 - 86.0
10
351 - - 92.6
13
326
3D
6ml1B00 - 62.3
11
317 - - 72.4
12
315 - - 43.5
14
286 - - 69.6
15
273 - - 76.3
16
268 - - 81.9
17
252 - - 85.5
31
251
3D
6ay2B00 - 94.1
18
251 - - 72.9
21
231
3D
2cb5B01 - 91.9
19
231 - - 73.7
20
230 - - 47.1
24
222
3D
6dgfA00 - 77.0
23
219
3D
1s4vB00 - 90.9
22
218 - - 93.1
25
210
3D
3n3kA00 - 77.9
26
206 - - 89.0
27
204 - - 83.0
28
203 - - 73.9
29
198 - - 77.9
30
197 - - 71.2
32
196
3D
6iinB00 - 89.8
33
175
3D
3ihpB03 - 67.3
34
167 - - 50.6
36
160
3D
3ch3X00 - 75.7
35
159 - - 76.4
37
150 - - 79.6
38
146 - - 78.0
39
144 - - 95.4
40
142 - - 59.7
41
137 - - 84.2
43
131 - - 89.9
42
131 - - 74.9
44
130 - - 82.9
45
125 - - 76.9
47
115 - - 70.4
46
115 - - 86.8
48
113 - - 79.1
49
111 - - 87.8
50
110
3D
1m6dB00 - 72.5
51
101 - - 42.9
52
98 - - 54.6
58
97
3D
3mtnC00 - 76.4
53
96 - - 69.6
54
95 - - 93.4
55
94 - - 84.9
60
90
3D
1ef7B00 - 84.0
57
90 - - 89.7
56
90 - - 73.0
138
87
3D
6exqB00 - 91.8
59
87 - - 70.9
61
85 - - 44.4
62
84
3D
3pdfA02 - 72.6
64
81 - - 87.0
63
81 - - 77.4
65
80 - - 50.8
66
79 - - 79.3
67
77 - - 89.4
69
76 - - 26.1
68
76 - - 76.0
70
74 - - 80.3
71
71 - - 51.1
72
70 - - 75.7
74
67
3D
6czsA00 - 72.5
86
67
3D
2oulA00 - 37.6
73
66 - - 80.4
75
65 - - 67.9
76
64 - - 53.9
77
63 - - 60.4
78
62 - - 69.6
79
59 - - 82.9
80
58 - - 72.4
81
56 - - 90.3
82
55 - - 36.4
91
53
3D
3gcbA01 - 83.5
84
52 - - 74.8
83
52 - - 83.7
85
51 - - 69.2
96
50
3D
4n4zA00 - 94.1
87
50 - - 85.6
88
50
3D
5chvB00 - 73.1
204
48
3D
9papA00 - 86.2
89
45 - - 77.9
90
44 - - 94.6
92
43 - - 89.0
94
42 - - 35.3
93
42 - - 71.6
95
42 - - 71.6
97
40 - - 31.0
98
Pcalp
38 - - 27.0
99
38 - - 85.3
101
36 - - 71.1
100
36 - - 77.1
102
35 - - 80.4
103
35 - - 93.6
104
34 - - 94.7
106
34 - - 51.6
105
34 - - 72.5
107
33 - - 3.8
109
33 - - 94.8
108
33 - - 83.2
110
31 - - 61.5
168
30
3D
6r9qA01 - 65.1
111
30 - - 28.0
113
29 - - 75.2
112
29 - - 71.7
114
29 - - 97.5
126
28
3D
6ffaA00 - 25.3
115
28 - - 72.2
190
28
3D
6aqrA02 - 17.4
116
27 - - 86.3
117
27 - - 87.4
118
26 - - 64.6
119
26 - - 81.3
120
25 - - 28.1
122
25 - - 86.3
121
25 - - 72.5
127
24 - - 75.7
129
24 - - 88.6
124
24 - - 65.0
128
24 - - 79.7
130
24 - - 84.8
125
24 - - 47.8
123
24 - - 40.1
131
23 - - 79.4
132
22 - - 63.1
133
22 - - 58.8
134
22 - - 73.7
135
21 - - 69.0
136
21 - - 72.3
137
21 - - 13.9
139
20 - - 7.6
140
19 - - 66.2
142
18 - - 74.2
148
18
3D
3zuaA01 - 42.2
141
18 - - 17.7
145
17 - - 84.0
144
17 - - 74.6
150
17 - - 93.8
555
17
3D
6bkjD02 - 51.7
143
17 - - 86.9
147
17 - - 11.7
149
17 - - 7.2
156
17
3D
1vjvA01 - 85.6
146
17 - - 64.8
153
16 - - 26.6
152
16 - - 75.2
151
16 - - 12.2
155
16 - - 77.9
154
16 - - 6.8
160
15 - - 10.1
161
15 - - 76.0
159
15 - - 69.6
158
15 - - 81.8
157
15 - - 18.4
167
14 - - 96.0
163
14 - - 82.3
162
14 - - 64.5
165
14 - - 76.6
166
14 - - 62.8
164
14 - - 68.2
177
13 - - 84.3
171
13 - - 85.5
176
13 - - 70.4
170
13 - - 2.8
175
13 - - 30.4
174
13 - - 70.8
169
13 - - 9.0
172
13 - - 93.2
173
13 - - 21.8
178
12 - - 78.4
180
12 - - 64.5
179
12 - - 11.7
189
11 - - 73.4
191
Human disease gene
11 - - 40.6
187
11 - - 10.8
182
11 - - 17.0
184
11 - - 27.0
181
11 - - 13.5
188
11 - - 14.8
183
11 - - 18.2
186
11 - - 12.4
185
11 - - 33.8
206
10 - - 67.3
194
10 - - 59.0
193
10 - - 31.7
205
10 - - 62.8
200
10 - - 17.0
197
10 - - 33.9
207
10 - - 74.2
192
10 - - 60.3
208
10 - - 77.0
199
10 - - 71.8
198
10 - - 74.4
202
10 - - 70.2
195
10 - - 72.9
201
10 - - 12.3
203
10 - - 35.2
216
10
3D
4msxA02 - 2.1
196
10 - - 88.0
211
9 - - 89.7
218
9 - - 80.5
213
9 - - 22.6
212
9 - - 69.9
215
9 - - 1.1
214
9 - - 19.5
217
9 - - 19.3
209
9 - - 39.0
210
9 - - 15.6
219
9 - - 96.5
408
9
3D
1o0eB00 - 58.6
220
8 - - 53.0
226
8 - - 10.9
221
8 - - 79.6
224
8 - - 34.1
227
8 - - 29.6
232
8 - - 82.3
225
8 - - 8.8
230
8 - - 34.9
229
8 - - 8.9
222
8 - - 59.4
231
8 - - 77.9
228
8 - - 13.7
223
8 - - 12.6
236
7 - - 4.0
234
7 - - 69.4
244
7 - - 7.4
246
7 - - 6.2
237
7 - - 5.9
254
7 - - 1.9
235
7 - - 67.5
251
7 - - 10.7
256
7 - - 46.0
255
7 - - 0.0
250
7 - - 8.4
245
7 - - 10.0
257
7 - - 67.7
233
7 - - 17.6
241
7 - - 72.3
249
7 - - 2.1
240
7 - - 0.0
239
7 - - 5.9
243
7 - - 64.2
247
7 - - 8.0
238
7 - - 13.7
253
7 - - 6.5
258
7 - - 45.3
252
7 - - 9.0
248
7 - - 10.2
242
7 - - 79.6
260
6 - - 72.3
265
6 - - 74.9
272
6 - - 3.1
275
6 - - 0.4
262
6 - - 86.2
279
6 - - 4.6
264
6 - - 38.0
263
6 - - 0.0
274
6 - - 5.7
278
6 - - 18.4
267
6 - - 88.2
332
6
3D
1cs8A00 - 48.4
276
6 - - 53.6
259
6 - - 73.4
280
6 - - 0.0
273
6 - - 2.5
270
6 - - 8.0
266
6 - - 70.5
269
6 - - 3.7
281
6 - - 2.6
261
6 - - 83.2
284
6 - - 85.8
268
6 - - 3.8
282
6 - - 8.3
277
6 - - 5.9
283
6 - - 5.7
271
6 - - 9.1
311
5 - - 0.0
285
5 - - 2.4
288
5 - - 76.7
295
5 - - 2.3
312
5 - - 8.9
309
5 - - 0.0
300
5 - - 36.3
286
5 - - 5.7
308
5 - - 6.7
301
5 - - 55.1
296
5 - - 4.3
287
5 - - 19.2
294
5 - - 3.4
293
5 - - 6.1
310
5 - - 16.8
303
5 - - 9.8
316
5 - - 39.2
292
5 - - 72.3
291
5 - - 73.4
320
5 - - 57.7
307
5 - - 0.0
314
5 - - 16.2
299
5 - - 47.0
302
5 - - 2.9
315
5 - - 68.2
305
5 - - 11.1
317
5 - - 41.8
298
5 - - 6.4
313
5 - - 0.0
321
5 - - 69.0
289
5 - - 75.4
319
5 - - 75.1
297
5 - - 9.3
290
5 - - 74.4
304
5 - - 4.0
306
5 - - 34.1
318
5 - - 58.2
331
4 - - 67.4
358
4 - - 74.2
325
4 - - 17.7
350
4 - - 38.0
337
4 - - 62.6
340
4 - - 0.0
348
4 - - 1.2
324
4 - - 0.0
351
4 - - 30.8
342
4 - - 4.6
341
4 - - 9.8
329
4 - - 57.0
349
4 - - 33.1
346
4 - - 12.6
333
4 - - 49.2
323
4 - - 8.2
352
4 - - 41.5
330
4 - - 58.7
322
4 - - 8.1
353
4 - - 60.0
354
4 - - 68.4
347
4 - - 7.9
327
4 - - 38.9
355
4 - - 69.0
326
4 - - 59.7
335
4 - - 64.9
334
4 - - 59.7
338
4 - - 49.1
328
4 - - 58.4
343
4 - - 0.0
339
4 - - 56.5
345
4 - - 66.3
344
4 - - 72.7
357
4 - - 57.4
336
4 - - 28.6
356
4 - - 66.7
378
3 - - 12.9
382
3 - - 43.9
389
3 - - 0.0
418
AFU_orthologue AFUA_2G08440
3 - - 41.2
364
3 - - 1.1
388
3 - - 3.4
367
3 - - 6.4
391
3 - - 73.4
410
3 - - 56.7
379
3 - - 12.4
415
3 - - 75.8
417
3 - - 23.1
405
3 - - 40.2
370
3 - - 4.2
416
3 - - 38.0
380
3 - - 22.9
381
3 - - 46.4
392
3 - - 71.4
373
3 - - 63.4
399
3 - - 0.0
386
3 - - 7.4
366
3 - - 8.2
400
3 - - 0.0
413
3 - - 68.6
369
3 - - 0.8
372
3 - - 42.2
359
3 - - 19.1
414
3 - - 71.7
394
3 - - 9.2
360
3 - - 42.8
393
3 - - 0.0
375
3 - - 72.0
387
3 - - 8.9
368
3 - - 10.4
395
3 - - 3.0
374
3 - - 12.5
409
3 - - 44.7
361
3 - - 11.9
412
3 - - 61.1
385
3 - - 0.5
377
3 - - 73.1
402
3 - - 7.4
363
3 - - 0.0
362
3 - - 0.8
411
3 - - 66.7
384
3 - - 29.9
398
3 - - 2.2
407
3 - - 26.7
376
3 - - 72.5
397
3 - - 9.1
371
3 - - 3.9
401
3 - - 56.1
404
3 - - 8.2
420
3 - - 29.6
383
3 - - 47.2
419
3 - - 73.3
406
3 - - 43.8
396
3 - - 5.2
365
3 - - 0.0
403
3 - - 13.1
390
3 - - 11.3
559
2 - - 41.2
443
2 - - 8.9
560
2 - - 39.0
512
2 - - 39.3
437
2 - - 0.5
463
2 - - 37.0
517
2 - - 9.6
458
2 - - 12.9
451
2 - - 0.0
454
2 - - 0.0
540
2 - - 0.0
527
2 - - 13.3
431
2 - - 36.4
548
2 - - 32.3
495
AFU_orthologue AFUA_1G07555
2 - - 0.0
486
2 - - 2.0
509
2 - - 36.6
485
2 - - 0.5
523
2 - - 0.0
460
2 - - 36.1
453
2 - - 0.0
488
2 - - 11.3
430
2 - - 36.4
447
2 - - 10.6
536
2 - - 20.9
452
2 - - 0.0
480
2 - - 27.9
438
2 - - 3.1
535
2 - - 18.4
444
2 - - 0.0
541
2 - - 0.7
508
2 - - 0.0
558
2 - - 37.2
507
2 - - 2.2
506
2 - - 4.0
496
2 - - 0.0
436
2 - - 3.0
456
2 - - 20.4
493
2 - - 1.5
445
2 - - 0.0
525
2 - - 6.9
534
2 - - 13.1
557
2 - - 20.2
468
2 - - 34.8
475
2 - - 17.0
441
2 - - 0.0
515
2 - - 28.8
432
2 - - 39.6
519
2 - - 9.3
427
2 - - 31.9
545
2 - - 32.6
446
2 - - 0.0
426
2 - - 21.8
542
2 - - 0.0
498
2 - - 8.7
483
2 - - 1.8
428
2 - - 31.9
566
2 - - 39.3
526
2 - - 1.4
500
2 - - 0.0
533
2 - - 1.9
556
2 - - 35.0
462
2 - - 38.5
477
2 - - 8.8
514
2 - - 49.2
513
2 - - 40.8
476
2 - - 10.2
510
2 - - 34.9
449
2 - - 6.2
549
2 - - 39.7
469
2 - - 40.6
501
2 - - 0.0
490
2 - - 1.8
543
2 - - 38.7
461
2 - - 34.2
425
2 - - 0.0
539
2 - - 0.0
565
2 - - 44.8
520
AFU_orthologue AFUA_2G08440
2 - - 0.0
532
2 - - 37.4
424
2 - - 0.0
492
2 - - 11.6
511
2 - - 40.6
434
2 - - 36.5
442
2 - - 0.0
429
2 - - 29.1
489
2 - - 0.8
471
2 - - 36.7
465
2 - - 42.2
502
2 - - 5.5
553
2 - - 34.9
479
2 - - 27.3
538
2 - - 28.0
524
2 - - 11.7
554
2 - - 40.1
552
2 - - 35.7
521
2 - - 0.0
433
2 - - 42.4
440
2 - - 0.0
423
2 - - 22.5
467
2 - - 38.6
474
2 - - 17.6
481
2 - - 0.0
422
2 - - 0.0
564
2 - - 43.5
563
2 - - 34.4
503
2 - - 7.6
484
2 - - 5.8
544
2 - - 23.2
464
2 - - 40.8
562
2 - - 41.0
518
2 - - 10.9
497
2 - - 2.2
472
2 - - 12.2
439
2 - - 2.5
478
2 - - 26.5
546
2 - - 31.0
537
2 - - 38.1
522
2 - - 2.3
551
2 - - 34.6
529
2 - - 6.2
504
2 - - 0.0
459
2 - - 34.3
435
2 - - 0.6
531
2 - - 0.0
516
2 - - 31.3
487
2 - - 10.0
494
2 - - 4.6
561
2 - - 42.3
448
2 - - 0.0
455
2 - - 1.9
457
2 - - 32.1
550
2 - - 35.6
505
AFU_orthologue AFUA_5G13620
2 - - 0.0
547
2 - - 32.3
482
2 - - 4.8
530
2 - - 8.9
499
2 - - 7.3
470
2 - - 41.1
466
2 - - 39.6
421
2 - - 14.8
450
2 - - 0.0
491
2 - - 0.0
473
2 - - 37.5
528
2 - - 0.0
882
1 - - 0.0
737
1 - - 0.0
580
1 - - 0.0
767
1 - - 0.0
798
1 - - 0.0
898
1 - - 0.0
805
1 - - 0.0
722
1 - - 0.0
846
1 - - 0.0
634
1 - - 0.0
578
1 - - 0.0
695
1 - - 0.0
728
1 - - 0.0
742
1 - - 0.0
889
1 - - 0.0
572
1 - - 0.0
675
1 - - 0.0
684
1 - - 0.0
861
1 - - 0.0
833
1 - - 0.0
571
1 - - 0.0
825
1 - - 0.0
859
1 - - 0.0
739
1 - - 0.0
876
1 - - 0.0
662
1 - - 0.0
783
1 - - 0.0
758
1 - - 0.0
706
1 - - 0.0
789
1 - - 0.0
834
1 - - 0.0
772
1 - - 0.0
627
1 - - 0.0
594
1 - - 0.0
715
1 - - 0.0
653
1 - - 0.0
569
1 - - 0.0
716
1 - - 0.0
686
1 - - 0.0
685
1 - - 0.0
743
1 - - 0.0
778
1 - - 0.0
720
1 - - 0.0
586
1 - - 0.0
723
1 - - 0.0
637
1 - - 0.0
595
1 - - 0.0
690
1 - - 0.0
752
1 - - 0.0
835
1 - - 0.0
901
1 - - 0.0
862
1 - - 0.0
579
1 - - 0.0
683
1 - - 0.0
765
1 - - 0.0
881
1 - - 0.0
784
1 - - 0.0
897
1 - - 0.0
573
1 - - 0.0
762
1 - - 0.0
638
1 - - 0.0
734
1 - - 0.0
875
1 - - 0.0
567
1 - - 0.0
824
1 - - 0.0
661
1 - - 0.0
800
1 - - 0.0
581
1 - - 0.0
906
1 - - 0.0
678
1 - - 0.0
605
1 - - 0.0
607
1 - - 0.0
773
1 - - 0.0
813
1 - - 0.0
644
1 - - 0.0
759
1 - - 0.0
851
1 - - 0.0
694
1 - - 0.0
816
1 - - 0.0
568
1 - - 0.0
652
1 - - 0.0
874
1 - - 0.0
791
1 - - 0.0
796
1 - - 0.0
844
1 - - 0.0
787
1 - - 0.0
582
1 - - 0.0
775
1 - - 0.0
746
1 - - 0.0
744
1 - - 0.0
888
1 - - 0.0
633
1 - - 0.0
718
1 - - 0.0
700
1 - - 0.0
868
1 - - 0.0
672
1 - - 0.0
764
1 - - 0.0
769
1 - - 0.0
803
1 - - 0.0
853
1 - - 0.0
751
1 - - 0.0
606
1 - - 0.0
724
1 - - 0.0
691
1 - - 0.0
666
1 - - 0.0
860
1 - - 0.0
677
1 - - 0.0
907
1 - - 0.0
708
1 - - 0.0
650
1 - - 0.0
710
1 - - 0.0
590
1 - - 0.0
895
1 - - 0.0
856
1 - - 0.0
664
1 - - 0.0
588
1 - - 0.0
646
1 - - 0.0
756
1 - - 0.0
617
1 - - 0.0
651
1 - - 0.0
629
1 - - 0.0
810
1 - - 0.0
574
1 - - 0.0
660
1 - - 0.0
887
1 - - 0.0
806
1 - - 0.0
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