CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Ubiquitin carboxyl-terminal hydrolase 2

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt O75604
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

O75604
UBP2_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 2

PDB Structure

PDB 6DGF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.
Pascoe, N., Seetharaman, A., Teyra, J., Manczyk, N., Satori, M.A., Tjandra, D., Makhnevych, T., Schwerdtfeger, C., Brasher, B.B., Moffat, J., Costanzo, M., Boone, C., Sicheri, F., Sidhu, S.S.
J. Mol. Biol.