CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Ubiquitin carboxyl-terminal hydrolase 46

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt O75317
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

O75317
UBP12_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 12

PDB Structure

PDB 5K16
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Li, H., Lim, K.S., Kim, H., Hinds, T.R., Jo, U., Mao, H., Weller, C.E., Sun, J., Chatterjee, C., D'Andrea, A.D., Zheng, N.
Mol.Cell