The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
5' to 3' exonuclease, C-terminal subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
4620
3D
6gh5A03 - 92.6
2
910
3D
2kzzA04 - 94.4
3
710
3D
3zdeA02 - 99.3
4
614
3D
4kitB05 - 99.5
10
612
3D
5iioM02 - 99.0
5
582
3D
1kftA00 - 96.0
26
553
3D
9icyA02 - 89.0
6
518
3D
5tt5A05 - 98.8
7
504
3D
5tt5A04 - 100.0
14
DNA directed
465
3D
6mxoA03 - 96.6
8
464
3D
3ldaA01 - 95.9
9
434 - - 96.8
11
422
3D
5v0eZ02 - 98.6
12
395
3D
1hjpA02 - 58.8
13
393
3D
4kitB11 - 99.1
15
331
3D
2jzbB01 - 79.8
16
327 - - 69.7
19
309
3D
6ig1F03 - 96.5
17
271
3D
2mutA00 - 96.4
18
260
3D
1wclA00 - 83.1
20
242 - - 40.5
21
237 - - 72.3
22
230 - - 92.4
23
223 - - 76.0
24
217 - - 75.1
25
168
3D
3gqcD03 - 85.0
27
153 - - 78.3
28
152 - - 88.8
29
143
3D
1b22A00 - 60.6
30
140 - - 94.9
31
138 - - 85.6
32
128 - - 81.1
33
127 - - 0.0
34
126 - - 69.8
35
122 - - 70.9
36
DNA directed
117 - - 71.8
37
101 - - 84.2
40
82
3D
2mutB00 - 94.4
38
82 - - 89.0
52
81
3D
5ulxA03 - 35.4
39
DNA directed
77 - - 92.1
41
73 - - 89.1
42
68 - - 67.5
43
66 - - 53.2
44
66 - - 79.1
45
59 - - 48.9
46
51
3D
4m6wB02 - 71.5
53
51
3D
5hp4A02 - 17.1
47
47 - - 12.3
48
46
3D
4bxoA02 - 33.9
49
42 - - 21.2
65
42
3D
3e2eA05 - 18.5
51
41 - - 25.4
50
41 - - 81.7
54
35 - - 11.3
59
35
3D
4p4pA01 - 54.9
55
33 - - 70.5
57
33 - - 83.3
58
33 - - 81.6
56
33 - - 82.0
60
32 - - 80.3
62
26 - - 47.5
61
26 - - 55.2
87
26
3D
1a77A02 - 89.4
123
26
3D
5vtpA03 - 42.9
93
25
3D
2zteA02 - 21.1
64
25 - - 31.1
63
25 - - 79.6
66
25 - - 3.8
67
24 - - 2.2
68
24 - - 62.2
69
24 - - 8.3
70
23 - - 92.9
71
22 - - 74.8
72
20 - - 12.0
73
19 - - 50.7
74
19 - - 6.7
158
19
3D
4yxmB03 - 8.2
76
18 - - 8.9
77
18 - - 51.1
78
18 - - 10.2
75
18 - - 76.3
83
17 - - 2.5
81
Npl1
17 - - 61.3
82
17 - - 79.7
79
17 - - 13.7
80
17 - - 43.4
84
16 - - 3.0
86
16 - - 24.8
85
16 - - 6.5
89
15 - - 0.0
115
15
3D
5wmbA04 - 1.4
88
15 - - 12.2
90
14 - - 17.2
91
14 - - 73.9
92
14 - - 51.9
96
13 - - 83.4
94
13 - - 75.6
95
13 - - 10.6
102
12 - - 6.3
101
12 - - 6.3
98
12 - - 19.3
103
12 - - 81.7
97
12 - - 53.8
100
12 - - 7.6
99
12 - - 19.1
104
11 - - 6.8
107
11 - - 49.6
106
11 - - 0.0
105
11 - - 20.0
109
10 - - 13.6
110
10 - - 42.3
108
10 - - 11.6
111
10 - - 0.0
118
9 - - 24.6
114
9 - - 17.4
124
9 - - 75.7
119
9 - - 22.1
113
9 - - 91.6
116
9 - - 1.6
120
9 - - 48.9
122
9 - - 11.3
125
9 - - 43.1
112
9 - - 0.0
121
9 - - 10.5
126
9 - - 77.7
117
9 - - 10.2
127
8 - - 12.4
129
8 - - 0.0
131
8 - - 8.4
132
8 - - 81.1
128
8 - - 22.8
130
8 - - 1.3
139
7 - - 3.3
135
7 - - 9.0
140
7 - - 11.3
136
7 - - 0.0
161
7
3D
1x2iB00 - 20.1
157
7
3D
2w9mB02 - 80.2
138
7 - - 11.1
137
7 - - 14.0
142
7 - - 8.6
133
7 - - 10.5
141
7 - - 7.1
134
7 - - 76.4
153
6 - - 18.1
145
6 - - 1.7
152
6 - - 0.0
144
6 - - 7.4
143
6 - - 3.2
151
6 - - 4.2
148
6 - - 9.8
147
6 - - 0.0
149
6 - - 1.8
150
6 - - 24.9
146
Prokaryotic heat shock protein
6 - - 46.5
163
5 - - 9.2
154
5 - - 40.6
159
5 - - 4.2
160
5 - - 0.0
162
5 - - 14.6
165
5 - - 1.7
167
5 - - 31.1
166
5 - - 46.1
156
5 - - 20.2
155
5 - - 13.7
164
5 - - 16.0
175
4 - - 13.0
168
4 - - 5.1
178
4 - - 8.4
181
4 - - 4.7
180
4 - - 76.6
174
4 - - 22.6
177
4 - - 6.4
183
4 - - 8.7
169
4 - - 5.1
171
4 - - 0.0
172
Dmc1 AFU_orthologue AFUA_7G02200
4 - - 72.3
176
4 - - 4.6
170
4 - - 10.0
179
4 - - 8.4
182
4 - - 11.1
173
4 - - 16.2
206
3 - - 1.6
194
3 - - 0.0
208
3 - - 74.1
199
3 - - 28.9
198
3 - - 11.9
202
3 - - 74.4
184
3 - - 35.2
195
3 - - 6.4
193
3 - - 2.4
201
3 - - 0.0
189
3 - - 0.0
188
3 - - 0.0
205
3 - - 66.4
200
3 - - 0.0
190
3 - - 20.4
197
3 - - 2.1
203
3 - - 2.2
204
3 - - 0.0
186
3 - - 0.0
191
3 - - 31.7
187
3 - - 7.0
207
3 - - 0.0
192
3 - - 6.4
185
3 - - 63.6
196
3 - - 7.3
233
2 - - 0.0
259
2 - - 5.0
220
2 - - 0.0
226
2 - - 6.8
211
2 - - 0.0
241
2 - - 0.0
236
2 - - 10.1
249
2 - - 0.0
218
2 - - 0.0
234
2 - - 0.0
244
2 - - 0.0
246
2 - - 7.0
240
2 - - 1.9
230
2 - - 9.6
214
2 - - 0.0
221
2 - - 32.6
229
2 - - 0.0
260
2 - - 0.0
237
2 - - 9.2
222
2 - - 2.1
254
2 - - 0.0
217
2 - - 3.2
239
2 - - 11.6
235
2 - - 36.6
213
2 - - 11.9
243
2 - - 3.6
231
2 - - 0.0
261
2 - - 4.1
247
2 - - 0.8
228
2 - - 14.7
224
2 - - 0.0
223
2 - - 0.0
262
2 - - 0.0
212
2 - - 4.1
238
2 - - 1.4
251
2 - - 0.0
253
2 - - 0.0
209
2 - - 1.5
256
2 - - 14.0
216
2 - - 0.0
227
2 - - 8.0
255
2 - - 5.9
232
2 - - 0.0
225
2 - - 8.0
263
2 - - 0.0
210
2 - - 30.2
258
2 - - 0.0
252
2 - - 2.0
250
2 - - 9.8
215
2 - - 0.0
245
2 - - 0.0
219
2 - - 0.0
257
2 - - 0.0
248
2 - - 2.7
242
2 - - 6.0
276
1 - - 0.0
331
1 - - 0.0
316
1 - - 0.0
292
1 - - 0.0
325
1 - - 0.0
291
1 - - 0.0
311
1 - - 0.0
327
1 - - 0.0
320
1 - - 0.0
280
1 - - 0.0
273
1 - - 0.0
285
1 - - 0.0
314
1 - - 0.0
307
1 - - 0.0
326
1 - - 0.0
270
1 - - 0.0
288
1 - - 0.0
324
1 - - 0.0
334
1 - - 0.0
299
1 - - 0.0
295
1 - - 0.0
266
1 - - 0.0
312
1 - - 0.0
302
1 - - 0.0
309
1 - - 0.0
315
1 - - 0.0
300
1 - - 0.0
286
1 - - 0.0
305
1 - - 0.0
308
1 - - 0.0
328
1 - - 0.0
281
1 - - 0.0
269
1 - - 0.0
301
1 - - 0.0
317
1 - - 0.0
296
1 - - 0.0
265
1 - - 0.0
329
1 - - 0.0
272
1 - - 0.0
298
1 - - 0.0
313
1 - - 0.0
287
1 - - 0.0
294
1 - - 0.0
275
1 - - 0.0
321
1 - - 0.0
284
1 - - 0.0
289
1 - - 0.0
333
1 - - 0.0
323
1 - - 0.0
268
1 - - 0.0
319
1 - - 0.0
282
1 - - 0.0
279
1 - - 0.0
264
DNA excision repair protein
1 - - 0.0
297
1 - - 0.0
277
1 - - 0.0
330
1 - - 0.0
290
1 - - 0.0
304
1 - - 0.0
293
1 - - 0.0
274
1 - - 0.0
306
1 - - 0.0
322
1 - - 0.0
310
1 - - 0.0
283
1 - - 0.0
303
1 - - 0.0
278
1 - - 0.0
271
1 - - 0.0
267
1 - - 0.0
318
1 - - 0.0
332
1 - - 0.0