CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA repair endonuclease XPF isoform X2

Enzyme Information

3.1.-.-
Acting on ester bonds.
based on mapping to UniProt Q92889

UniProtKB Entries (1)

P07992
ERCC1_HUMAN
Homo sapiens
DNA excision repair protein ERCC-1

PDB Structure

PDB 2MUT
External Links
Method SOLUTION NMR
Organism
Primary Citation
The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex.
Faridounnia, M., Wienk, H., Kovacic, L., Folkers, G.E., Jaspers, N.G., Kaptein, R., Hoeijmakers, J.H., Boelens, R.
J.Biol.Chem.