CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA polymerase eta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q04049
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q04049
POLH_YEAST
Saccharomyces cerevisiae S288C
DNA polymerase eta

PDB Structure

PDB 5VTP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The C-terminal region of translesion synthesis DNA polymerase eta is partially unstructured and has high conformational flexibility.
Powers, K.T., Elcock, A.H., Washington, M.T.
Nucleic Acids Res.