The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
22959
9369
EC
3D
1a30A00 - 78.2
23154
7770
EC
- - 89.5
23181
7687
EC
3D
1t6eX02 - 93.4
23148
3874
EC
3D
2qzwA01 - 86.8
22912
Lysosomal aspartyl protease
3758
EC
3D
1bbsA01 - 92.4
23129
2105
EC
3D
1aptE02 - 92.3
11579
1650
EC
3D
2r5pA00 - 99.7
23027
1636
EC
3D
3lzsA00 - 99.7
23085
1599
3D
2i1aA00 - 89.2
23189
1451
EC
3D
1az5A00 - 97.3
22861
945
EC
3D
1dp5A02 - 88.2
22817
823
EC
3D
1fknA02 - 80.0
23002
A01 family
748
EC
3D
1lyaB00 - 87.2
22859
703
EC
3D
1fknA01 - 78.5
22885
575
EC
3D
1flhA02 - 88.9
22892
Pepsinogen A
459
EC
3D
1avfA01 - 81.2
22815
326
EC
3D
1leeA02 - 45.7
22819
316
EC
3D
1leeA01 - 26.6
22973
238
EC
3D
1avfA02 - 83.8
22976
191
EC
- - 90.1
202
170
EC
3D
2ewyA01 - 84.0
23050
142
EC
3D
2qzwA02 - 93.6
23169
107
EC
- - 83.4
2195
105
EC
- - 2.7
22834
93
EC
3D
1uh7A01 - 87.6
2022
88
EC
- - 1.9
22740
NCBI
87
EC
3D
4aa9A02 - 74.9
3047
79
EC
3D
1lyaA00 - 34.4
22837
78 - - 38.4
9253
77 - - 39.7
23091
63
EC
3D
2b7fA00 - 72.3
22945
53 - - 32.8
23009
52 - - 62.9
22963
45 - - 45.2
452
44 - - 9.6
7
43 - - 6.8
11104
41
3D
5c9dA00 - 19.5
1847
41 - - 0.0
1328
38
EC
- - 3.0
9427
36 - - 0.0
22946
35 - - 58.1
22969
35 - - 74.8
23184
28
EC
- - 98.0
1852
25 - - 2.6
899
20
EC
- - 4.6
6668
17 - - 9.3
8546
16
EC
3D
1mvpA00 - 3.7
3342
14 - - 25.9
23015
13
3D
1nsoA00 - 31.6
23019
12 - - 40.8
2291
12
EC
- - 9.1
22835
12
EC
3D
1b11A00 - 18.0
653
10 - - 0.6
1419
9
3D
3aupA02 - 0.0
591
9 - - 0.0
3530
9 - - 6.3
8740
9 - - 0.0
5868
8 - - 25.8
3060
8 - - 4.8
3595
7 - - 21.6
3113
7
EC
- - 0.7
23077
7
EC
3D
2jysA00 - 48.3
10112
6 - - 10.0
4268
6 - - 0.8
7283
5 - - 9.3
10692
5
EC
- - 7.6
20363
5
EC
- - 1.2
23047
4 - - 18.6
7342
4 - - 7.1
3802
4 - - 0.0
6884
4 - - 10.7
1964
4 - - 4.8
21297
4 - - 0.7
5224
4 - - 0.0
11692
3 - - 7.6
4496
3 - - 1.7
10871
3 - - 8.2
7489
3 - - 0.0
5338
3 - - 12.6
1214
2 - - 0.0
22766
2
EC
3D
1mppA01 - 0.7
22750
2
EC
- - 19.3
984
AP1
2 - - 0.0
3833
2 - - 0.8
5120
2 - - 0.7
1139
2
3D
1b5fA00 - 0.0
23163
2 - - 35.9
12036
2
EC
- - 0.0
3834
2 - - 4.7
23043
2
EC
- - 36.6
23092
1 - -
8422
1 - - 0.0
19955
1 - - 0.0
9231
1 - - 0.0
3325
1 - - 0.0
13392
1 - - 0.0
10872
1
EC
- - 0.0
8431
1
EC
- - 0.0
1487
1 - - 0.0
3694
1
EC
- - 0.0
21162
1 - - 0.0
8953
1
EC
- - 0.0
10234
1
EC
- - 0.0
3489
1 - - 0.0
10536
1 - - 0.0
22723
1 - - 0.0
23066
1 - - 0.0
5092
1
EC
- - 0.0