CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Cathepsin D (A01 family)

Enzyme Information

3.4.23.5
Cathepsin D.
based on mapping to UniProt P07339
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
-!- Occurs intracellularly, in lysosomes. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.23.

UniProtKB Entries (1)

P07339
CATD_HUMAN
Homo sapiens
Cathepsin D

PDB Structure

PDB 1LYA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Baldwin, E.T., Bhat, T.N., Gulnik, S., Hosur, M.V., Sowder 2nd., R.C., Cachau, R.E., Collins, J., Silva, A.M., Erickson, J.W.
Proc.Natl.Acad.Sci.USA