CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.70 | Cathepsin D, subunit A; domain 1 |
|
2.40.70.10 | Acid Proteases |
Domain Context
CATH Clusters
| Superfamily | Acid Proteases |
| Functional Family | Pepsin B |
Enzyme Information
| 3.4.23.3 |
Gastricsin.
based on mapping to UniProt P20142
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.
-!- Formed from progastricsin, apparently in the gastric juice of most vertebrates. -!- In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. -!- Seminal plasma contains a zymogen that is immunologically identical with progastricsin. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.22.
|
UniProtKB Entries (1)
| P20142 |
PEPC_HUMAN
Homo sapiens
Gastricsin
|
PDB Structure
| PDB | 1AVF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin.
Nat.Struct.Biol.
|