CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Aspartic protease

Enzyme Information

3.4.23.21
Rhizopuspepsin.
based on mapping to UniProt P06026
Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.
-!- From the zygomycete fungi Rhizopus chinensis and R.niveus. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.17, EC 3.4.23.6, EC 3.4.23.9 and EC 3.4.99.25.

UniProtKB Entries (1)

P06026
CARP_RHICH
Rhizopus microsporus var. chinensis
Rhizopuspepsin

PDB Structure

PDB 1UH7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Effect of pH on the structure of rhizopuspepsin.
Prasad, B.V., Suguna, K.
Acta Crystallogr.,Sect.D