The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
19769
47591 - - 100.0
19440
3479
EC
3D
2djqA00 - 92.4
19398
2406
EC
- - 85.3
19352
2107
3D
2lj0A00 - 80.5
19613
1980
3D
2cubA00 - 92.9
19409
1755
3D
1azeA00 - 85.9
19364
1669
3D
2dl3A00 - 72.2
19467
1520
3D
2eczA00 - 89.5
19446
1425
3D
3ulrB00 - 94.1
19700
1408 - - 94.8
19683
1334
EC
3D
3jv3A01 - 96.7
19716
1297 - - 84.2
19652
Predicted
1210
3D
1ue9A00 - 92.5
19354
1091
EC
3D
1fmkA01 - 84.5
19351
853
3D
2dx1A01 - 75.0
19350
847
3D
1wieA01 - 91.5
19437
829
EC
3D
2vknA00 - 96.4
19657
824
3D
2krmA00 - 95.9
19438
804
3D
2a08A00 - 86.1
19373
762
3D
2dbmA00 - 91.5
19433
760
EC
3D
1awwA00 - 96.6
18983
749
3D
1t0hA00 - 85.3
19646
737
EC
- - 82.7
19360
735
3D
2csiA00 - 75.8
19357
734
3D
2ct4A00 - 84.5
19333
716
3D
4f14A00 - 72.9
19254
691
3D
2ed0A00 - 73.6
19287
689
EC
3D
1aboA00 - 86.4
19423
661
3D
2js2A00 - 87.9
19610
657
EC
3D
1aojA00 - 94.2
19387
650
3D
3rnjA00 - 93.2
19780
639
EC
3D
3pvlA05 - 96.4
18998
604
EC
- - 84.5
19617
601
EC
3D
1hsqA00 - 96.4
19555
599
EC
3D
5fw9A00 - 93.5
19630
589
3D
1x43A01 - 94.9
19596
579 - - 92.9
19404
562 - - 93.6
18995
508
3D
2dl8A00 - 62.2
19347
508
3D
2eyxA00 - 78.1
6723
488 - - 91.5
19332
486
3D
2dvjA02 - 82.9
19396
473
EC
- - 91.7
19338
470
3D
2l0aA00 - 78.1
3564
466
3D
2csqA01 - 67.3
19775
2
463
3D
2dlpA00 - 84.8
19145
460
3D
1zsgA00 - 76.7
19211
442
3D
2x3wD00 - 66.2
19459
424
3D
2dl4A00 - 92.1
19493
418 - - 80.4
19606
413
EC
3D
2enmA00 - 97.0
19466
398
3D
2fpdA00 - 85.9
19252
387
3D
4iimA00 - 70.0
19448
366
3D
2ed1A00 - 78.2
19152
365 - - 75.2
19497
337
3D
1ov3A01 - 91.1
1096
331
3D
2krnA00 - 95.6
19337
330 - - 93.1
19796
299
EC
3D
2gqiA00 - 88.7
19627
1,6
295
EC
3D
2de0X03 - 89.0
19688
280 - - 93.6
19662
264
3D
1tg0A00 - 82.1
19635
247
3D
1k4uS00 - 90.7
1027
240
3D
2o2oA00 - 74.8
19582
236
EC
- - 79.2
19227
222
3D
2m0yA00 - 82.5
2941
219
3D
2yuoA00 - 91.2
19010
217
3D
1x2kA00 - 77.8
3614
211
3D
1muzA00 - 44.9
19799
210
3D
2dmoA00 - 75.1
19043
208
3D
1ug1A00 - 70.9
19108
204 - - 45.7
1464
198 - - 69.8
19672
196
3D
2lx7A00 - 96.3
19084
193
EC
- - 48.6
19366
192
3D
2k6dA00 - 82.1
19085
185 - - 48.8
3998
184
EC
- - 44.3
19148
173 - - 65.1
19217
170
3D
2egcA00 - 53.0
19489
170 - - 89.6
19130
Predicted
164 - - 65.4
8877
159
3D
1wyxA00 - 33.8
19676
158 - - 82.9
19464
156
3D
1yp5A00 - 89.5
19089
153 - - 26.3
12625
149
3D
2cudA00 - 76.3
19558
148 - - 81.0
13961
144 - - 0.0
10196
144 - - 58.4
7658
143 - - 24.9
4214
FYB-120/130
142
3D
2gtjA01 - 52.8
8438
142
3D
2keaA00 - 29.4
19062
138 - - 73.9
19112
137 - - 70.5
19701
136 - - 73.8
18957
135 - - 58.8
19150
133
EC
3D
1w1fA00 - 77.1
8439
132
EC
3D
2e5kA01 - 38.7
12485
131 - - 14.9
307
129 - - 44.6
19247
129
EC
- - 31.1
19316
124 - - 69.3
19007
124
EC
- - 41.8
18996
124
EC
3D
1ad5A01 - 68.1
19104
124
EC
- - 59.0
19321
122
3D
2yupA01 - 67.8
1987
122 - - 2.1
10798
119
EC
- - 69.1
19637
119 - - 76.5
19095
114
3D
1w6xA00 - 75.5
19032
112
3D
1uhcA00 - 48.2
19009
111
EC
3D
1jegA00 - 61.1
1519
110
3D
1jxmA01 - 59.5
19097
108 - - 41.6
3249
108
3D
2bz8A00 - 51.8
19002
106 - - 77.0
19033
106 - - 72.3
2677
104 - - 52.1
19320
103 - - 85.2
18981
102
3D
4esrA00 - 39.2
8166
102 - - 36.3
19045
101
3D
1phtA00 - 58.8
4789
97
EC
- - 41.3
2754
96
EC
- - 54.4
19335
95
EC
- - 73.9
19113
95
3D
1h3hA00 - 50.2
19192
95
3D
1wxtA00 - 61.6
1740
95 - - 28.3
19143
95
3D
2creA00 - 60.2
19079
95
EC
- - 55.8
19686
92
3D
1jqqA00 - 83.8
18932
92
3D
1hjdA00 - 63.5
19541
91
3D
2a28A00 - 67.4
19790
89 - - 61.0
420
88 - - 18.5
19027
86
EC
- - 30.4
19195
86 - - 49.6
19599
85
3D
1z9zA00 - 87.2
3146
85 - - 49.5
8328
84 - - 35.7
1188
84 - - 42.2
19144
84
3D
2yunA00 - 52.2
13721
82 - - 14.6
18984
FYB-120/130
81
3D
1ri9A00 - 44.6
17796
79
EC
- - 53.5
19230
79 - - 36.7
8026
78 - - 21.6
19039
77
3D
1uhfA00 - 49.7
197
77
EC
- - 10.1
594
76 - - 26.7
4292
76 - - 39.9
19723
75 - - 46.4
5626
75 - - 13.6
19203
74 - - 67.1
18968
73
3D
2kt1A00 - 41.1
19214
73 - - 68.8
9951
70 - - 37.6
5160
70
3D
2ke9A00 - 28.8
3704
69 - - 72.1
3460
66 - - 25.9
7628
66 - - 6.8
3974
65 - - 14.7
19185
62
3D
2dilA00 - 53.7
4916
62
EC
3D
2rf0A00 - 17.2
6626
61 - - 1.5
18970
58 - - 54.0
18993
58 - - 67.7
19218
57
3D
1s1nA00 - 76.2
19110
57 - - 47.5
19153
56
3D
1ng2A02 - 70.7
18979
54 - - 32.3
9918
51
3D
2lcsA00 - 17.8
18987
51 - - 55.8
19131
50
EC
3D
2d8jA00 - 59.4
3213
47 - - 43.1
19016
47 - - 44.9
19531
46 - - 60.9
19291
45
EC
- - 53.4
19098
45 - - 49.6
5472
45
EC
- - 23.0
19056
43
EC
- - 58.4
19376
42
3D
2epdA00 - 48.6
19781
41 - - 52.0
4289
41 - - 18.4
19370
40 - - 54.9
19000
40
3D
1uffA00 - 45.5
19226
38
3D
4m4zA01 - 62.4
714
38
EC
- - 65.5
1875
38
EC
- - 15.2
2222
37 - - 78.8
4377
37 - - 42.1
18985
36 - - 52.1
19785
36
EC
- - 90.1
6066
36 - - 39.0
11436
36 - - 0.0
4807
36 - - 14.6
13981
36 - - 0.0
12564
35 - - 8.9
18959
34
3D
2ekhA00 - 46.0
4499
Predicted
32 - - 26.3
5366
30
EC
- - 28.6
19128
30 - - 42.8
5079
29 - - 20.2
12907
29 - - 34.4
19090
27
EC
3D
1h92A00 - 55.3
2712
26 - - 10.7
19031
25
EC
- - 58.7
19005
25 - - 35.4
8266
24 - - 83.2
19222
24 - - 43.8
4756
23 - -
1098
22 - - 9.4
19379
22 - - 41.2
19066
21
EC
3D
2kgtA00 - 43.3
9436
21 - - 23.4
19674
20 - - 24.6
1336
19 - - 0.0
19633
19 - - 59.0
5367
18 - - 12.2
3485
18 - - 5.7
19117
18 - - 22.0
19675
17 - - 39.5
18933
17 - - 39.9
7782
17 - - 23.2
19804
17
EC
- - 89.2
11213
16 - - 0.0
11633
16 - - 21.0
19072
16
3D
1gcpA00 - 32.7
8874
15 - - 1.8
3041
14 - - 10.4
1923
14 - - 6.0
10383
1,6
13
EC
- - 21.9
8074
12 - - 2.8
2917
11 - - 29.4
2492
11 - - 29.4
3724
10 - - 9.2
7689
10 - - 9.5
4659
10 - - 14.0
2125
10 - - 27.0
19694
10 - - 40.2
6834
10 - - 15.5
19755
10 - - 70.5
1028
9
3D
3qwxX02 - 37.1
9396
9 - - 9.6
10480
8 - - 11.3
5899
8
EC
- - 27.9
13525
8 - - 14.0
19418
7
3D
1ycsB02 - 0.0
2331
7 - - 3.7
15015
7
EC
- - 19.9
19054
6 - - 10.9
2635
6 - - 15.0
1842
6 - - 4.0
12996
6
EC
- - 7.8
19127
6 - - 32.7
2111
6 - - 11.6
5730
5 - - 5.2
5307
5 - - 6.2
18936
5 - - 9.9
929
5 - - 13.1
1461
5 - - 19.7
9859
4 - - 0.0
3531
4 - - 3.5
10620
4
EC
- - 14.9
19216
4
EC
- - 24.2
19242
4 - - 27.2
444
3 - - 5.6
1911
3 - - 20.2
19215
3 - - 27.1
351
3 - - 3.0
14322
3 - - 19.1
7140
3 - - 6.9
4231
3
EC
- - 14.3
17117
2 - - 0.0
7125
2 - - 0.0
3089
2 - - 0.0
18976
2
EC
- - 16.3
10453
2
EC
- - 9.6
8114
2
EC
- - 18.8
1282
2 - - 0.0
19530
2 - - 0.0
1249
2 - - 0.0
15432
2 - - 9.9
6684
2 - - 15.6
3581
2 - - 1.5
3524
2 - -
582
2 - - 0.0
9377
1 - - 0.0
308
1 - - 0.0
16892
1 - - 0.0
15781
1 - - 0.0
8449
1 - - 0.0
1531
1 - - 0.0
13957
1 - - 0.0
2751
1 - - 0.0
3270
1 - - 0.0
1142
1 - - 0.0
8316
1 - - 0.0
16119
1 - - 0.0
2739
1 - - 0.0
2332
1 - - 0.0
2743
1 - -
19562
1 - - 0.0
759
1 - - 0.0
12470
1 - - 0.0
19276
1 - - 0.0
790
1 - - 0.0
9696
1 - - 0.0
11252
1 - -
11629
1 - - 0.0
19300
1 - - 0.0
13958
1
EC
- - 0.0
12735
1 - - 0.0