CATH Superfamily 2.30.30.40

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Enzyme?	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
19769	Purine-binding chemotaxis protein CheW	47591			-	-	100.0
19440	E3 ubiquitin-protein ligase SH3RF1	3479	EC	3D	2djqA00	-	92.4
19398	MAGUK p55 subfamily member 2	2406	EC		-	-	85.3
19352	CAP, isoform J	2107		3D	2lj0A00	-	80.5
19613	Guanine nucleotide exchange factor VAV3	1980		3D	2cubA00	-	92.9
19409	Growth factor receptor-bound protein 2	1755		3D	1azeA00	-	85.9
19364	Sorbin and SH3 domain-containing protein 2	1669		3D	2dl3A00	-	72.2
19467	Sorbin and SH3 domain-containing protein 2	1520		3D	2eczA00	-	89.5
19446	Src substrate cortactin, putative	1425		3D	3ulrB00	-	94.1
19700	Chemotaxis protein methyltransferase CheV	1408			-	-	94.8
19683	Abl interactor 1 isoform i	1334	EC	3D	3jv3A01	-	96.7
19716	Rho GTPase-activating protein 12	1297			-	-	84.2
19652	Intersectin 1 isoform ITSN-l Predicted	1210		3D	1ue9A00	-	92.5
19354	Proto-oncogene tyrosine-protein kinase Src	1091	EC	3D	1fmkA01	-	84.5
19351	Rho guanine nucleotide exchange factor 4	853		3D	2dx1A01	-	75.0
19350	Peripheral-type benzodiazepine receptor-associated protein 1	847		3D	1wieA01	-	91.5
19437	High osmolarity signaling protein SHO1	829	EC	3D	2vknA00	-	96.4
19657	Rho GTPase-activating protein 26	824		3D	2krmA00	-	95.9
19438	BAR adaptor protein RVS167	804		3D	2a08A00	-	86.1
19373	SH3-domain GRB2-like 3, isoform CRA_b	762		3D	2dbmA00	-	91.5
19433	Non-specific protein-tyrosine kinase	760	EC	3D	1awwA00	-	96.6
18983	Calcium channel voltage-dependent beta2 subunit	749		3D	1t0hA00	-	85.3
19646	Signal transduction histidine kinase	737	EC		-	-	82.7
19360	Peripheral-type benzodiazepine receptor-associated protein 1	735		3D	2csiA00	-	75.8
19357	Formin-binding protein 1 homolog	734		3D	2ct4A00	-	84.5
19333	cDNA FLJ51309, highly similar to Nebulin	716		3D	4f14A00	-	72.9
19254	Abl interactor 2	691		3D	2ed0A00	-	73.6
19287	Non-specific protein-tyrosine kinase	689	EC	3D	1aboA00	-	86.4
19423	Cytoplasmic protein NCK1, putative	661		3D	2js2A00	-	87.9
19610	Epidermal growth factor receptor kinase substrate 8	657	EC	3D	1aojA00	-	94.2
19387	Brain-specific angiogenesis inhibitor 1-associated protein 2	650		3D	3rnjA00	-	93.2
19780	Unconventional myosin-VIIa	639	EC	3D	3pvlA05	-	96.4
18998	Disks large homolog 1	604	EC		-	-	84.5
19617	Phosphoinositide phospholipase C	601	EC	3D	1hsqA00	-	96.4
19555	Spectrin alpha chain, brain	599	EC	3D	5fw9A00	-	93.5
19630	SH3-domain GRB2-like endophilin B1	589		3D	1x43A01	-	94.9
19596	Rho guanine nucleotide exchange factor 5	579			-	-	92.9
19404	Chromosome 2 SCAF14738, whole genome shotgun sequence	562			-	-	93.6
18995	SLIT-ROBO Rho GTPase-activating protein 2	508		3D	2dl8A00	-	62.2
19347	Adapter molecule crk	508		3D	2eyxA00	-	78.1
6723	Intersectin 1 isoform 8	488			-	-	91.5
19332	Adapter molecule crk	486		3D	2dvjA02	-	82.9
19396	Class E vacuolar protein-sorting machinery protein HSE1	473	EC		-	-	91.7
19338	Signal transducing adapter molecule 1	470		3D	2l0aA00	-	78.1
3564	Peripheral-type benzodiazepine receptor-associated protein 1	466		3D	2csqA01	-	67.3
19775	Lethal 2	463		3D	2dlpA00	-	84.8
19145	Rho guanine nucleotide exchange factor 7	460		3D	1zsgA00	-	76.7
19211	ADP-ribosylation factor GTPase-activating protein 2 isoform 1	442		3D	2x3wD00	-	66.2
19459	SH3 and cysteine-rich domain-containing protein	424		3D	2dl4A00	-	92.1
19493	Intersectin 1 isoform 5	418			-	-	80.4
19606	Sorting nexin lst-4	413	EC	3D	2enmA00	-	97.0
19466	C-Jun-amino-terminal kinase-interacting protein 1	398		3D	2fpdA00	-	85.9
19252	Intersectin 1 short form	387		3D	4iimA00	-	70.0
19448	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2	366		3D	2ed1A00	-	78.2
19152	Rho GTPase-activating protein 33	365			-	-	75.2
19497	Neutrophil cytosol factor 1	337		3D	1ov3A01	-	91.1
1096	SH3 domain-containing kinase-binding protein 1	331		3D	2krnA00	-	95.6
19337	Src kinase-associated phosphoprotein 1	330			-	-	93.1
19796	Ras GTPase-activating protein 1	299	EC	3D	2gqiA00	-	88.7
19627	Alpha- 1,6	295	EC	3D	2de0X03	-	89.0
19688	Actin cytoskeleton-regulatory complex protein SLA1	280			-	-	93.6
19662	SH3 domain-containing protein C23A1.17	264		3D	1tg0A00	-	82.1
19635	Neutrophil cytosol factor 2	247		3D	1k4uS00	-	90.7
1027	SH3 domain-containing kinase-binding protein 1	240		3D	2o2oA00	-	74.8
19582	Triple functional domain protein	236	EC		-	-	79.2
19227	Dedicator of cytokinesis 1	222		3D	2m0yA00	-	82.5
2941	Small G protein-signaling modulator 3	219		3D	2yuoA00	-	91.2
19010	Osteoclast-stimulating factor 1	217		3D	1x2kA00	-	77.8
3614	Bridging integrator 1, isoform CRA_j	211		3D	1muzA00	-	44.9
19799	Neutrophil cytosol factor 2	210		3D	2dmoA00	-	75.1
19043	Dynamin-binding protein	208		3D	1ug1A00	-	70.9
19108	SH3 and PX domains 2A	204			-	-	45.7
1464	Disks large homolog 5	198			-	-	69.8
19672	Related to budding protein BOI2	196		3D	2lx7A00	-	96.3
19084	E3 ubiquitin-protein ligase SH3RF1	193	EC		-	-	48.6
19366	SH3 domain-containing kinase-binding protein 1	192		3D	2k6dA00	-	82.1
19085	SH3 and PX domain-containing protein 2B	185			-	-	48.8
3998	SH3 domain-containing ring finger 1	184	EC		-	-	44.3
19148	SH3 domain-binding protein 4	173			-	-	65.1
19489	Guanine nucleotide exchange factor VAV2	170			-	-	89.6
19217	SH3 and PX domain-containing protein 2A	170		3D	2egcA00	-	53.0
19130	Intersectin 1 isoform ITSN-l Predicted	164			-	-	65.4
8877	Breast cancer anti-estrogen resistance 1	159		3D	1wyxA00	-	33.8
19676	YBL085Wp-like protein	158			-	-	82.9
19464	WGS project CCBQ000000000 data, contig 00015	156		3D	1yp5A00	-	89.5
19089	PACSIN2 protein	153			-	-	26.3
12625	Src-like-adapter	149		3D	2cudA00	-	76.3
19558	SH3 and PX domains 2B	148			-	-	81.0
13961	Chemotaxis protein cheW	144			-	-	0.0
10196	SH3 and PX domains 2B	144			-	-	58.4
7658	C-Jun-amino-terminal kinase-interacting protein 2	143			-	-	24.9
4214	FYN binding protein FYB-120/130	142		3D	2gtjA01	-	52.8
8438	SAM domain-containing protein SAMSN-1	142		3D	2keaA00	-	29.4
19062	SH3 domain-containing protein 19	138			-	-	73.9
19112	RUN and SH3 domain-containing protein 1	137			-	-	70.5
19701	Dynamin-binding protein	136			-	-	73.8
18957	Melanoma inhibitory activity protein 2	135			-	-	58.8
19150	Non-specific protein-tyrosine kinase	133	EC	3D	1w1fA00	-	77.1
8439	Ubiquitin-associated and SH3 domain-containing protein B	132	EC	3D	2e5kA01	-	38.7
12485	Putative TWO-COMPONENT SYSTEM SENSOR HISTIDINE KINASE/RESPONSE REGULATOR	131			-	-	14.9
307	MAGUK p55 subfamily member 5	129			-	-	44.6
19247	E3 ubiquitin-protein ligase SH3RF1	129	EC		-	-	31.1
19007	Triple functional domain protein	124	EC		-	-	41.8
19104	Protein arginine N-methyltransferase 2	124	EC		-	-	59.0
18996	Non-specific protein-tyrosine kinase	124	EC	3D	1ad5A01	-	68.1
19316	RIMS-binding protein 2	124			-	-	69.3
19321	Vinexin isoform 1	122		3D	2yupA01	-	67.8
1987	K7_Bem1p	122			-	-	2.1
10798	Mitogen-activated protein kinase kinase kinase 11	119	EC		-	-	69.1
19637	SH3 and cysteine-rich domain-containing protein	119			-	-	76.5
19095	Neutrophil cytosol factor 4	114		3D	1w6xA00	-	75.5
19032	cDNA FLJ51432, highly similar to Dynamin-binding protein	112		3D	1uhcA00	-	48.2
19009	Non-specific protein-tyrosine kinase	111	EC	3D	1jegA00	-	61.1
1519	Disks large homolog 4	110		3D	1jxmA01	-	59.5
19097	SH3 and PX domain-containing protein 2A	108			-	-	41.6
3249	SH3 domain-containing kinase-binding protein 1	108		3D	2bz8A00	-	51.8
19002	Dynein heavy chain 11, axonemal	106			-	-	77.0
19033	Melanoma inhibitory activity protein 3	106			-	-	72.3
2677	Amphiphysin I variant NC1	104			-	-	52.1
19320	NADPH oxidase organizer 1	103			-	-	85.2
18981	Jouberin	102		3D	4esrA00	-	39.2
8166	Purine-binding chemotaxis protein CheW	102			-	-	36.3
19045	Phosphatidylinositol 3-kinase regulatory subunit alpha	101		3D	1phtA00	-	58.8
4789	Kalirin	97	EC		-	-	41.3
2754	Putative E3 ubiquitin-protein ligase SH3RF2	96	EC		-	-	54.4
19335	Putative E3 ubiquitin-protein ligase SH3RF2	95	EC		-	-	73.9
1740	Enhancer of filamentation 1	95			-	-	28.3
19079	Non-specific protein-tyrosine kinase	95	EC		-	-	55.8
19143	Cas scaffolding protein family member 4	95		3D	2creA00	-	60.2
19113	GRB2-related adapter protein 2	95		3D	1h3hA00	-	50.2
19192	cDNA FLJ78157	95		3D	1wxtA00	-	61.6
18932	Melanoma-derived growth regulatory protein	92		3D	1hjdA00	-	63.5
19686	Peroxisomal membrane protein PAS20	92		3D	1jqqA00	-	83.8
19541	Protein BZZ1	91		3D	2a28A00	-	67.4
19790	Chemotaxis protein CheW	89			-	-	61.0
420	Tight junction protein ZO-2	88			-	-	18.5
19027	Kalirin	86	EC		-	-	30.4
19195	GRB2-related adapter protein 2	86			-	-	49.6
19599	Actin cytoskeleton-regulatory complex protein SLA1	85		3D	1z9zA00	-	87.2
3146	Dedicator of cytokinesis 4	85			-	-	49.5
19144	Nostrin isoform 2	84		3D	2yunA00	-	52.2
1188	Unconventional myosin-Ie	84			-	-	42.2
8328	SAM and SH3 domain-containing protein 3	84			-	-	35.7
13721	Positive regulator of CheA protein activity CheW	82			-	-	14.6
18984	FYN binding protein FYB-120/130	81		3D	1ri9A00	-	44.6
19230	R3H domain-containing protein 2	79			-	-	36.7
17796	Proto-oncogene tyrosine-protein kinase LCK	79	EC		-	-	53.5
8026	FCH and double SH3 domains protein 2	78			-	-	21.6
19039	Putative uncharacterized protein ITSN2	77		3D	1uhfA00	-	49.7
197	Stardust protein MAGUK1 isoform	77	EC		-	-	10.1
4292	Putative adaptor protein pacsin	76			-	-	39.9
594	CASK interacting protein 1, isoform CRA_a	76			-	-	26.7
5626	Embryonal Fyn-associated substrate	75			-	-	13.6
19723	Actin-binding protein, putative	75			-	-	46.4
19203	Dynamin-binding protein	74			-	-	67.1
19214	SH3 domain-containing protein 19	73			-	-	68.8
18968	Phosphatidylinositol 3-kinase regulatory subunit beta	73		3D	2kt1A00	-	41.1
5160	CASK interacting protein 2	70		3D	2ke9A00	-	28.8
9951	Dynamin associated protein isoform Dap160-2	70			-	-	37.6
3704	SH3 domain-containing protein 19	69			-	-	72.1
7628	Cytokinesis protein 2	66			-	-	6.8
3460	Amphiphysin, isoform C	66			-	-	25.9
3974	Bzz1p	65			-	-	14.7
4916	Mitogen-activated protein kinase kinase kinase 10	62	EC	3D	2rf0A00	-	17.2
19185	Proline-serine-threonine phosphatase-interacting protein 1	62		3D	2dilA00	-	53.7
6626	Putative uncharacterized protein	61			-	-	1.5
18970	Ubiquitin-associated and SH3 domain-containing protein A	58			-	-	54.0
18993	Iporin	58			-	-	67.7
19218	cDNA FLJ58106, highly similar to Nephrocystin-1	57		3D	1s1nA00	-	76.2
19110	NCK-interacting protein with SH3 domain	57			-	-	47.5
19153	Neutrophil cytosol factor 1	56		3D	1ng2A02	-	70.7
18979	Peroxisomal biogenesis factor 13	54			-	-	32.3
18987	MAGUK p55 subfamily member 4	51			-	-	55.8
9918	Nbp2p	51		3D	2lcsA00	-	17.8
19131	Non-specific protein-tyrosine kinase	50	EC	3D	2d8jA00	-	59.4
3213	Cd GTPase activating protein-related, isoform C	47			-	-	43.1
19016	SH3 domain-containing protein 19	47			-	-	44.9
19531	Sorting nexin 18	46			-	-	60.9
19291	Guanine nucleotide exchange factor DBS	45	EC		-	-	53.4
19098	Rho guanine nucleotide exchange factor 37	45			-	-	49.6
5472	Non-specific protein-tyrosine kinase	45	EC		-	-	23.0
19056	Mitogen-activated protein kinase kinase kinase MLK4	43	EC		-	-	58.4
19376	Rho GTPase-activating protein 4	42		3D	2epdA00	-	48.6
19781	Purine-binding chemotaxis protein Chew, putative	41			-	-	52.0
4289	Dynamin-binding protein	41			-	-	18.4
19370	PIX-1, isoform a	40			-	-	54.9
19000	Putative endocytic adaptor protein intersectin	40		3D	1uffA00	-	45.5
19226	Src-like-adapter 2	38		3D	4m4zA01	-	62.4
714	Polychaetoid, isoform G	38	EC		-	-	65.5
1875	Mitogen-activated protein kinase kinase kinase 9	38	EC		-	-	15.2
4377	CG43729, isoform E	37			-	-	42.1
2222	Myosin i myo5	37			-	-	78.8
6066	Dedicator of cytokinesis protein 3	36			-	-	39.0
11436	Purine-binding chemotaxis protein Chew, putative	36			-	-	0.0
19785	Tyrosine-protein kinase Srms	36	EC		-	-	90.1
13981	Purine-binding chemotaxis protein Chew, putative	36			-	-	0.0
18985	SH3 domain-containing YSC84-like protein 1	36			-	-	52.1
4807	Rho guanine nucleotide exchange factor 3	36			-	-	14.6
12564	Chemotaxis protein CheV	35			-	-	8.9
18959	SH3 and PX domain-containing protein 2A	34		3D	2ekhA00	-	46.0
4499	Myosin IF Predicted	32			-	-	26.3
19128	Rho guanine nucleotide exchange factor 37	30			-	-	42.8
5366	Activated Cdc42 kinase-like, isoform C	30	EC		-	-	28.6
5079	Ephexin, isoform D	29			-	-	20.2
12907	Rho GTPase-activating protein 27	29			-	-	34.4
19090	Proto-oncogene tyrosine-protein kinase LCK	27	EC	3D	1h92A00	-	55.3
2712	Nap1 Binding Protein homologue, putative	26			-	-	10.7
19031	B lymphoid tyrosine kinase	25	EC		-	-	58.7
19005	Dedicator of cytokinesis protein 2	25			-	-	35.4
8266	Putative uncharacterized protein	24			-	-	83.2
19222	NADPH oxidase activator 1	24			-	-	43.8
4756	Myosin-5	23			-	-
1098	Nervous wreck, isoform D	22			-	-	9.4
19379	NCK-1, isoform a	22			-	-	41.2
19066	Protein-tyrosine kinase 6	21	EC	3D	2kgtA00	-	43.3
9436	E3 ubiquitin-protein ligase SH3RF1	21			-	-	23.4
19674	Peroxisomal biogenesis protein peroxin	20			-	-	24.6
1336	Bud emergence protein 1	19			-	-	0.0
19633	Myosin-1	19			-	-	59.0
5367	Guanine nucleotide exchange factor SDC25	18			-	-	12.2
3485	Cyk3p	18			-	-	5.7
19117	Rho guanine nucleotide exchange factor 16	18			-	-	22.0
19675	Myosin-1	17			-	-	39.5
7782	Vav ortholog, isoform C	17			-	-	23.2
18933	Tight junction protein ZO-3	17			-	-	39.9
19804	Tyrosine-protein kinase sid-3	17	EC		-	-	89.2
11633	Dynamin-binding protein	16			-	-	21.0
11213	Response regulator receiver:CheW-like protein	16			-	-	0.0
19072	Proto-oncogene vav	16		3D	1gcpA00	-	32.7
8874	Sallimus, isoform P	15			-	-	1.8
3041	Amphiphysin	14			-	-	10.4
1923	Shal K[+] channel interacting protein, isoform E	14			-	-	6.0
10383	Alpha- 1,6	13	EC		-	-	21.9
8074	CIN85 and CD2AP orthologue, isoform C	12			-	-	2.8
2492	ITSN-1, isoform c	11			-	-	29.4
2917	HUM-4, isoform b	11			-	-	29.4
2125	RRC-1, isoform c	10			-	-	27.0
19755	Actin cytoskeleton-regulatory complex protein sla1	10			-	-	70.5
4659	Crk, isoform E	10			-	-	14.0
7689	Crk-associated substrate	10			-	-	9.5
19694	AbpA	10			-	-	40.2
6834	Myoblast city, isoform B	10			-	-	15.5
3724	Muscle M-line assembly protein unc-89	10			-	-	9.2
9396	Sponge, isoform D	9			-	-	9.6
1028	Cell death abnormality protein 2	9		3D	3qwxX02	-	37.1
5899	Non-specific protein-tyrosine kinase	8	EC		-	-	27.9
13525	Non-receptor tyrosine-protein kinase TNK1 isoform 2	8			-	-	14.0
10480	NADPH oxidase organizer 1	8			-	-	11.3
2331	Putative myosin-5 protein	7			-	-	3.7
15015	Non-specific protein-tyrosine kinase	7	EC		-	-	19.9
19418	Apoptosis-stimulating of p53 protein	7		3D	1ycsB02	-	0.0
19127	Cell death abnormality protein 2	6			-	-	32.7
19054	Signal transducing adapter molecule 2	6			-	-	10.9
2111	Probable peroxisomal membrane protein PEX13	6			-	-	11.6
2635	Guanine nucleotide exchange factor UNC-73A	6			-	-	15.0
1842	Lasp, isoform C	6			-	-	4.0
12996	ARK-1, isoform b	6	EC		-	-	7.8
929	Uncharacterized protein	5			-	-	13.1
5730	Peroxin-13	5			-	-	5.2
5307	Plenty of SH3s	5			-	-	6.2
18936	E3 ubiquitin-protein ligase SH3RF1	5			-	-	9.9
1461	Peroxin 13	5			-	-	19.7
9859	L-alanyl-D-glutamate peptidase	4			-	-	0.0
3531	Activated CDC42 kinase 1	4			-	-	3.5
19216	Protein arginine N-methyltransferase 2	4	EC		-	-	24.2
19242	Class I myosin	4			-	-	27.2
10620	Histidine kinase	4	EC		-	-	14.9
351	SD08724p	3			-	-	3.0
14322	Sorbin and SH3 domain-containing protein 2	3			-	-	19.1
4231	Tyrosine-protein kinase isoform SRK1	3	EC		-	-	14.3
444	CIN85 and CD2AP orthologue, isoform F	3			-	-	5.6
7140	RIMS-binding protein 3	3			-	-	6.9
1911	Im:7162391	3			-	-	20.2
19215	Myosin, putative	3			-	-	27.1
6684	Myosin ID heavy chain	2			-	-	15.6
19530	Peripheral-type benzodiazepine receptor-associated protein 1	2			-	-	0.0
15432	Chemotaxis sensor histidine kinase CheA	2			-	-	9.9
582	CD2-associated protein	2			-	-	0.0
17117	Putative uncharacterized protein F12M12_80	2			-	-	0.0
7125	Protein vav-1	2			-	-	0.0
3089	Protein vav-1	2			-	-	0.0
18976	Putative palmitoyltransferase ZDHHC6	2	EC		-	-	16.3
8114	Probable serine/threonine-protein kinase mkcF	2	EC		-	-	18.8
1282	Uncharacterized protein	2			-	-	0.0
1249	Uncharacterized protein	2			-	-	0.0
3581	Bridging integrator 1	2			-	-	1.5
10453	Mitogen-activated protein kinase kinase kinase 10	2	EC		-	-	9.6
3524	MLK-1, isoform a	2			-	-
3270	Rho GTPase-activating protein gacJJ	1			-	-	0.0
16119	Chemotaxis protein CheV	1			-	-	0.0
2739	Myosin I	1			-	-	0.0
790	Class E vacuolar protein-sorting machinery protein HSE1	1			-	-	0.0
11252	Histidine kinase	1			-	-
11629	Myosin-G heavy chain	1			-	-	0.0
19300	Myosin-1	1			-	-	0.0
15781	Intersectin 1 isoform 12	1			-	-	0.0
1531	Disks large homolog 4	1			-	-	0.0
13957	Dipeptidyl-peptidase 6	1			-	-	0.0
8316	Uncharacterized protein	1			-	-	0.0
2743	Nuclear fusion protein FUS1	1			-	-
759	CBN-SDPN-1 protein	1			-	-	0.0
9377	Nephrocystin-1-like protein	1			-	-	0.0
308	Uncharacterized protein	1			-	-	0.0
8449	Protein BZZ1	1			-	-	0.0
2751	Uncharacterized protein	1			-	-	0.0
1142	CDC25-like protein	1			-	-	0.0
2332	Signal transducing adapter molecule 1	1			-	-	0.0
19276	Uncharacterized protein	1			-	-	0.0
16892	E3 ubiquitin-protein ligase SH3RF1	1			-	-	0.0
19562	Protein scd2/ral3	1			-	-	0.0
12470	NADPH oxidase organizer 1	1			-	-	0.0
9696	Protein arginine methyltransferase 2	1			-	-	0.0
13958	Tyrosine-protein kinase transforming protein Src	1	EC		-	-	0.0
12735	Histidine kinase	1			-	-	0.0