CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family Non-specific protein-tyrosine kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P07948
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07948
LYN_HUMAN
Homo sapiens
Tyrosine-protein kinase Lyn

PDB Structure

PDB 1W1F
External Links
Method SOLUTION NMR
Organism
Primary Citation
Structural Characterization of Lyn-SH3 Domain in Complex with a Herpesviral Protein Reveals an Extended Recognition Motif that Enhances Binding Affinity.
Bauer, F., Schweimer, K., Meiselbach, H., Hoffmann, S., Roesch, P., Sticht, H.
Protein Sci.