CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family Phosphoinositide phospholipase C

Enzyme Information

3.1.4.11
Phosphoinositide phospholipase C.
based on mapping to UniProt P19174
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (1)

P19174
PLCG1_HUMAN
Homo sapiens
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

PDB Structure

PDB 1HSQ
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the SH3 domain of phospholipase C-gamma.
Kohda, D., Hatanaka, H., Odaka, M., Mandiyan, V., Ullrich, A., Schlessinger, J., Inagaki, F.
Cell(Cambridge,Mass.)