CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family Mitogen-activated protein kinase kinase kinase 10

Enzyme Information

2.7.11.25
Mitogen-activated protein kinase kinase kinase.
based on mapping to UniProt Q02779
ATP + a protein = ADP + a phosphoprotein.
-!- This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation. -!- Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. -!- While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway. -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q02779
M3K10_HUMAN
Homo sapiens
Mitogen-activated protein kinase kinase kinase 10

PDB Structure

PDB 2RF0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of human Mixed lineage kinase MAP3K10 SH3 domain.
Ugochukwu, E., Eswaran, J., Elkins, J., Keates, T., Pike, A.C.W., Berridge, G., Savitsky, P., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., von Delft, F., Knapp, S.
To be Published