The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Metal-dependent hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1219
3D
4cnuB02 - 86.7
2
760 - - 88.1
4
471
3D
2p53B02 - 96.1
3
456 - - 73.6
6
397
3D
2z2bA00 - 84.3
5
354
3D
1yixB00 - 95.0
7
348
3D
2g3fB02 - 93.9
8
291
3D
1pb0C00 - 67.2
9
261 - - 78.8
10
223
3D
2i5gB00 - 33.6
11
221 - - 31.1
15
191
3D
6hg1A00 - 75.4
12
184 - - 96.6
19
179
3D
3rn6A02 - 98.9
14
176
3D
2plmA02 - 97.4
13
168
3D
3e74D02 - 60.9
73
163
3D
4zsuB00 - 26.9
16
149 - - 91.5
17
140
3D
3lggB00 - 97.4
18
136
3D
4pe8A00 - 89.5
21
128
3D
4aqlA02 - 86.8
20
126 - - 80.9
38
123
3D
3t1gA00 - 78.8
29
121
3D
4ofcF00 - 91.0
22
117 - - 94.5
23
113 - - 86.0
25
111
3D
4yiwB02 - 13.6
28
108
3D
4gx9D00 - 73.5
24
108 - - 64.9
26
106 - - 40.5
27
102 - - 92.4
30
99
3D
1ituB00 - 86.3
32
93 - - 90.5
31
93 - - 90.7
33
92 - - 93.7
34
91
3D
2xioA00 - 76.4
36
90
3D
5nnlB00 - 98.5
35
89 - - 93.8
37
80 - - 83.4
39
72
3D
3pbmB00 - 90.2
42
69
3D
2aqvB02 - 70.9
40
57 - - 85.0
55
56
3D
4laoB00 - 77.6
41
56 - - 83.9
43
47 - - 72.9
44
47 - - 88.6
45
44 - - 58.9
46
42 - - 75.9
47
42
3D
2w9mB05 - 90.1
68
39
3D
4c65H02 - 14.7
48
35 - - 74.5
49
35
3D
5lewA01 - 34.3
50
33 - - 70.2
63
33
3D
4lefH00 - 4.3
51
32 - - 27.9
52
31 - - 73.3
76
30
3D
4b92B01 - 78.3
53
30 - - 75.4
174
30
3D
5yzbA02 - 12.0
54
30 - - 45.3
57
27 - - 88.4
56
27 - - 37.2
58
26 - - 30.5
61
24 - - 26.9
59
24 - - 77.2
60
24 - - 9.9
62
23 - - 32.8
144
22
3D
5ns5A00 - 17.7
64
22 - - 53.5
66
21
3D
6ii7A00 - 8.9
100
21
3D
4diaA00 - 79.7
67
20 - - 50.6
65
20 - - 83.1
85
19
3D
2vunD02 - 43.7
71
18 - - 74.7
69
18 - - 5.5
70
18 - - 77.6
78
17 - - 59.8
74
17 - - 76.0
77
17 - - 30.8
72
17 - - 65.8
75
17 - - 29.3
80
16 - - 7.2
79
16 - - 11.4
81
16 - - 39.4
249
15
3D
4rzbB02 - 4.1
84
15 - - 74.6
82
15 - - 80.3
83
15 - - 5.5
86
15 - - 35.8
87
14 - - 4.1
89
13 - - 76.3
91
13 - - 70.6
90
13 - - 34.1
88
13 - - 75.3
96
12 - - 0.0
98
12 - - 38.8
92
12 - - 9.2
94
12 - - 0.8
93
12 - - 12.3
97
12 - - 57.0
95
12 - - 0.0
101
11 - - 90.9
119
11
3D
3e2vB00 - 4.6
102
11 - - 0.4
105
11 - - 0.0
111
11
3D
3b40A01 - 13.0
99
11 - - 79.8
104
11 - - 21.0
103
11 - - 9.8
106
11 - - 24.7
107
10 - - 76.3
110
10 - - 14.5
112
10 - - 0.0
108
10 - - 84.6
184
PHP family
10
3D
2anuF00 - 60.1
222
10
3D
3ovgF00 - 18.9
113
10 - - 78.2
109
10 - - 7.8
114
10 - - 90.5
116
9 - - 13.4
115
9 - - 14.9
122
9 - - 77.9
117
9 - - 1.0
118
9 - - 8.9
120
9 - - 11.4
121
9 - - 13.1
127
8 - - 15.5
128
8 - - 0.9
130
8 - - 10.5
140
8
3D
3ipwA00 - 5.0
132
8 - - 9.6
125
8 - - 14.3
129
8 - - 4.8
135
8 - - 0.0
124
8 - - 5.1
126
8 - - 22.4
131
8 - - 5.2
270
8
3D
2czvB00 - 31.7
133
8 - - 8.3
123
8 - - 44.3
134
8 - - 1.2
136
7 - - 19.9
138
7 - - 72.1
137
7 - - 21.4
142
7 - - 0.0
147
7 - - 12.1
149
7 - - 13.8
139
7 - - 77.6
145
7 - - 14.2
150
7 - - 3.1
143
7 - - 6.5
148
7 - - 2.6
141
7 - - 12.4
146
7 - - 2.4
153
6 - - 44.8
160
6 - - 4.6
151
6 - - 37.4
155
6 - - 14.5
163
6 - - 0.0
154
6 - - 2.6
217
6
3D
1kcxB02 - 20.0
158
6 - - 2.4
165
6 - - 29.3
156
6 - - 0.0
206
6
3D
3ls9B02 - 1.1
152
6 - - 33.7
161
6 - - 8.8
159
6 - - 14.4
162
6 - - 0.0
157
6 - - 0.0
164
6 - - 41.8
211
5
3D
5nksA02 - 41.0
180
5 - - 5.7
177
5 - - 10.9
170
5 - - 4.4
167
5 - - 37.0
250
5
3D
2yb4A01 - 15.9
175
5 - - 7.1
181
5 - - 59.4
173
5 - - 39.7
168
5 - - 16.4
178
5 - - 5.5
171
5 - - 22.5
176
5 - - 48.7
169
5 - - 1.2
172
5 - - 2.0
179
5 - - 9.2
166
5 - - 13.0
193
4 - - 0.0
189
4 - - 2.9
205
4 - - 6.3
191
4 - - 5.1
187
4 - - 71.2
212
4 - - 22.2
182
4 - - 5.8
207
4 - - 10.0
198
4 - - 6.3
202
4 - - 7.0
214
AFU_orthologue AFUA_8G02860
4 - - 64.6
186
4 - - 38.8
209
4 - - 39.1
210
4 - - 10.1
196
4 - - 13.7
194
4 - - 4.2
237
4
3D
2imrA02 - 73.5
213
4 - - 64.8
200
4 - - 7.0
197
4 - - 7.8
192
4 - - 8.6
215
4 - - 36.1
208
4 - - 0.7
199
4 - - 27.8
195
4 - - 12.5
201
4 - - 10.9
188
4 - - 65.8
183
4 - - 9.7
190
4 - - 3.8
203
4 - - 12.8
204
4 - - 11.6
216
4 - - 85.0
185
4 - - 71.9
236
3 - - 6.9
218
3 - - 0.0
234
3 - - 0.0
246
3 - - 3.8
221
3 - - 27.2
227
3 - - 0.8
255
3 - - 30.4
232
3 - - 14.3
225
3 - - 1.2
240
3 - - 0.8
230
3 - - 0.0
229
3 - - 12.1
239
3 - - 0.0
247
3 - - 2.1
252
3 - - 11.1
219
3 - - 9.7
242
3 - - 11.9
220
3 - - 42.2
226
3 - - 5.6
244
3 - - 0.0
254
3 - - 44.6
235
3 - - 0.0
224
3 - - 8.0
251
3 - - 1.8
256
3 - - 35.3
245
3 - - 6.5
233
3 - - 9.6
241
3 - - 3.8
243
3 - - 0.0
231
3 - - 28.4
228
3 - - 12.7
223
3 - - 8.1
238
3 - - 3.7
253
3 - - 53.0
248
3 - - 9.2
325
2 - - 5.5
311
2 - - 11.9
285
2 - - 0.0
288
2 - - 3.2
260
2 - - 0.0
308
2 - - 0.0
301
2 - - 0.0
272
2 - - 37.7
287
2 - - 0.0
294
2 - - 0.0
323
2 - - 0.0
262
2 - - 0.0
264
2 - - 35.7
330
2 - - 36.4
274
2 - - 2.1
303
2 - - 2.7
278
2 - - 0.0
257
2 - - 0.0
276
2 - - 0.0
259
2 - - 0.0
320
2 - - 0.0
307
2 - - 0.0
326
2 - - 0.0
299
2 - - 0.0
315
2 - - 2.6
305
2 - - 8.0
328
2 - - 26.5
281
2 - - 0.0
269
2 - - 25.3
317
2 - - 5.7
313
2 - - 7.3
284
2 - - 4.2
289
2 - - 1.4
319
2 - - 2.3
297
2 - - 0.0
290
2 - - 1.5
283
2 - - 0.0
271
2 - - 13.6
331
2 - - 40.9
324
2 - - 0.0
295
2 - - 4.2
312
2 - - 0.8
309
2 - - 10.2
300
2 - - 15.4
286
2 - - 0.8
296
2 - - 0.0
265
2 - - 0.0
329
2 - - 0.0
275
2 - - 0.0
279
2 - - 2.0
263
2 - - 32.3
293
2 - - 4.8
322
2 - - 0.0
310
2 - - 0.0
267
2 - - 9.5
332
2 - - 35.6
316
NagA
2 - - 0.0
292
2 - - 10.2
291
2 - - 0.0
327
2 - - 0.0
280
2 - - 9.2
273
2 - - 39.7
314
2 - - 7.5
266
2 - - 10.3
302
2 - - 0.0
298
2 - - 0.0
261
2 - - 0.9
321
2 - - 0.0
268
2 - - 20.6
282
2 - - 9.4
277
2 - - 0.0
304
2 - - 0.0
258
2 - - 3.2
306
2 - - 1.1
318
2 - - 6.3
463
1 - - 0.0
458
1 - - 0.0
451
1 - - 0.0
454
1 - - 0.0
378
1 - - 0.0
350
1 - - 0.0
337
1 - - 0.0
340
1 - - 0.0
389
1 - - 0.0
486
1 - - 0.0
391
1 - - 0.0
410
1 - - 0.0
430
1 - - 0.0
447
1 - - 0.0
415
1 - - 0.0
480
1 - - 0.0
438
1 - - 0.0
444
1 - - 0.0
417
1 - - 0.0
381
1 - - 0.0
373
1 - - 0.0
456
1 - - 0.0
366
1 - - 0.0
400
1 - - 0.0
468
1 - - 0.0
475
1 - - 0.0
413
1 - - 0.0
349
1 - - 0.0
432
1 - - 0.0
333
1 - - 0.0
446
1 - - 0.0
359
1 - - 0.0
477
1 - - 0.0
360
Fragment
1 - - 0.0
393
1 - - 0.0
449
1 - - 0.0
353
1 - - 0.0
375
1 - - 0.0
490
1 - - 0.0
387
1 - - 0.0
461
1 - - 0.0
425
1 - - 0.0
424
1 - - 0.0
395
1 - - 0.0
347
1 - - 0.0
434
1 - - 0.0
442
1 - - 0.0
361
1 - - 0.0
465
1 - - 0.0
412
1 - - 0.0
385
1 - - 0.0
479
1 - - 0.0
335
1 - - 0.0
440
1 - - 0.0
377
1 - - 0.0
467
1 - - 0.0
481
1 - - 0.0
474
1 - - 0.0
338
1 - - 0.0
484
1 - - 0.0
363
1 - - 0.0
472
1 - - 0.0
397
1 - - 0.0
459
1 - - 0.0
401
1 - - 0.0
404
1 - - 0.0
344
1 - - 0.0
357
1 - - 0.0
455
1 - - 0.0
336
1 - - 0.0
457
1 - - 0.0
383
1 - - 0.0
419
1 - - 0.0
406
1 - - 0.0
365
1 - - 0.0
470
1 - - 0.0
421
1 - - 0.0
491
1 - - 0.0
390
1 - - 0.0
408
1 - - 0.0
443
1 - - 0.0
358
1 - - 0.0
437
1 - - 0.0
431
1 - - 0.0
382
1 - - 0.0
418
1 - - 0.0
348
1 - - 0.0
388
1 - - 0.0
364
1 - - 0.0
367
1 - - 0.0
485
1 - - 0.0
460
1 - - 0.0
453
1 - - 0.0
351
1 - - 0.0
488
1 - - 0.0
379
1 - - 0.0
342
1 - - 0.0
452
1 - - 0.0
341
1 - - 0.0
405
1 - - 0.0
370
1 - - 0.0
416
1 - - 0.0
380
1 - - 0.0
392
1 - - 0.0
399
1 - - 0.0
436
1 - - 0.0
386
1 - - 0.0
445
1 - - 0.0
441
1 - - 0.0
346
1 - - 0.0
427
1 - - 0.0
352
1 - - 0.0
426
1 - - 0.0
369
1 - - 0.0
483
1 - - 0.0
372
1 - - 0.0
428
1 - - 0.0
414
1 - - 0.0
462
1 - - 0.0
394
1 - - 0.0
476
1 - - 0.0
469
1 - - 0.0
354
1 - - 0.0
368
1 - - 0.0
492
1 - - 0.0
374
1 - - 0.0
429
1 - - 0.0
409
1 - - 0.0
489
1 - - 0.0
471
1 - - 0.0
355
1 - - 0.0
433
1 - - 0.0
334
1 - - 0.0
423
1 - - 0.0
422
1 - - 0.0
402
1 - - 0.0
464
1 - - 0.0
362
1 - - 0.0
439
1 - - 0.0
411
1 - - 0.0
478
1 - - 0.0
384
1 - - 0.0
398
1 - - 0.0
407
1 - - 0.0
376
1 - - 0.0
343
1 - - 0.0
371
1 - - 0.0
435
1 - - 0.0
339
1 - - 0.0
345
1 - - 0.0
420
1 - - 0.0
487
1 - - 0.0
448
1 - - 0.0
396
1 - - 0.0
482
1 - - 0.0
403
1 - - 0.0
466
1 - - 0.0
450
1 - - 0.0
473
1 - - 0.0
356
1 - - 0.0