CATH Classification

Domain Context

CATH Clusters

Superfamily Metal-dependent hydrolases
Functional Family 2-pyrone-4,6-dicarboxylate hydrolase

Enzyme Information

3.1.1.57
2-pyrone-4,6-dicarboxylate lactonase.
based on mapping to UniProt O87170
2-oxo-2H-pyran-4,6-dicarboxylate + H(2)O = (1E)-4-oxobut-1-ene-1,2,4- tricarboxylate.
-!- The product is most likely the keto-form of 4-oxalmesaconate (shown). -!- It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4- trioate, either spontaneously or by EC 5.3.2.8.

UniProtKB Entries (1)

O87170
LIGI_SPHSK
Sphingobium sp. SYK-6
2-pyrone-4,6-dicarboxylate hydrolase

PDB Structure

PDB 4DIA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation.
Hobbs, M.E., Malashkevich, V., Williams, H.J., Xu, C., Sauder, J.M., Burley, S.K., Almo, S.C., Raushel, F.M.
Biochemistry