The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1520
3D
2lj1A00 - 85.0
2
1184
3D
2ed0A00 - 89.0
3
938
3D
4lnpA00 - 69.9
4
931
3D
4ln2A00 - 79.8
5
834
3D
2dl8A00 - 73.9
6
811
3D
1wieA01 - 93.2
7
772
3D
4f14A00 - 83.0
10
772
3D
1opkA01 - 88.9
8
764 - - 95.0
9
755
3D
1wyxB00 - 92.7
11
694 - - 74.5
12
662
3D
2rquA00 - 85.0
14
661
3D
2x3xE00 - 86.9
13
660
3D
2aklA02 - 79.7
15
637
3D
4deyA01 - 73.9
16
633
3D
2csiA00 - 89.2
17
629
3D
2ct4A00 - 78.0
18
629
3D
3rnjA00 - 83.4
19
622 - - 67.1
20
621 - - 77.1
21
609
3D
2ebpA00 - 66.5
23
581
3D
4z89J00 - 91.4
22
568
3D
2yt6A01 - 72.3
24
560
3D
6gbuH00 - 85.8
25
556
3D
6cpkA00 - 88.8
26
541
3D
3tszA02 - 35.6
27
500 - - 77.0
28
482
3D
1x43A01 - 57.0
29
450
3D
5i22A00 - 82.2
30
437 - - 70.3
36
436
3D
5fwcA00 - 71.3
32
430
3D
2fpfD00 - 85.7
31
429
3D
2egcA00 - 81.5
34
GEF
416
3D
2eswB00 - 71.5
33
412
3D
6gbuG00 - 91.9
35
401 - - 64.1
37
392
3D
2ysqA00 - 57.7
38
391
3D
1wfwA00 - 85.0
39
385
3D
2kbtA00 - 74.2
40
374
3D
1u3oA01 - 79.1
41
372
3D
3jv3A01 - 69.4
42
368
3D
2dnuA00 - 83.2
43
365 - - 80.8
44
364 - - 93.6
45
357 - - 63.6
46
356 - - 89.7
47
355 - - 77.8
48
353 - - 95.1
50
348
3D
4fssC00 - 62.6
49
345
3D
1vyuB01 - 82.2
51
340
3D
2hspA00 - 85.9
53
331
3D
2dbmA00 - 72.0
52
329
3D
2e5kA01 - 91.8
54
323 - - 75.8
55
315
3D
1ugvA00 - 85.6
57
314
3D
2rqrA00 - 64.5
56
311 - - 67.4
58
307 - - 65.2
59
303 - - 72.6
60
302
3D
2dl5A00 - 97.1
61
300
3D
2jw4A00 - 79.8
62
294
3D
2ke9A00 - 83.6
65
290
3D
2ggrA00 - 69.9
67
289
3D
2w0zA00 - 82.6
66
289
3D
4cc7M00 - 89.0
64
287
3D
3pe0B03 - 78.9
63
287 - - 77.9
72
277
3D
2xmfA00 - 97.3
68
271
3D
4zw2A01 - 61.8
71
267
3D
1i0cB00 - 87.9
75
266
3D
3i5sD00 - 88.1
69
265 - - 73.3
70
1,6
261
3D
2de0X03 - 94.2
76
260
3D
1griB01 - 67.4
73
257
3D
2dl4A00 - 75.3
83
257
3D
4k11A01 - 62.9
74
254 - - 85.0
95
253
3D
6nmwA00 - 83.6
77
250
3D
3nmzD00 - 60.0
79
247
3D
5k28B00 - 72.8
78
242 - - 82.0
80
236 - - 41.4
81
231 - - 29.2
87
230
3D
3ulrB00 - 79.1
82
230 - - 85.3
84
225
3D
1ug1A00 - 83.0
86
225
3D
2l0aA00 - 71.5
85
224
3D
3dkmA00 - 70.3
88
218 - - 97.8
89
216
3D
2ydlA00 - 74.4
90
211 - - 52.1
91
210 - - 66.8
92
208 - - 23.2
93
203
3D
2rqwA01 - 84.7
94
201
3D
2o2oA00 - 76.8
96
189
3D
2dmoA00 - 70.8
97
186 - - 89.4
98
185 - - 44.8
100
181
3D
2a08B00 - 93.0
99
181 - - 20.4
112
178
3D
2mcnA00 - 76.6
102
176
3D
3r6nB03 - 61.6
101
175 - - 83.1
103
173 - - 75.6
108
169
3D
1k1zA00 - 75.8
104
169 - - 14.1
105
168 - - 57.6
106
166 - - 43.1
107
164 - - 86.6
110
163
3D
2fryA00 - 86.0
109
161
3D
1wxuA01 - 92.1
111
GEF
157 - - 73.9
113
156
3D
3pvlA05 - 70.9
114
154 - - 58.0
115
149
3D
2yuoA00 - 59.1
116
145 - - 77.2
117
145 - - 62.0
121
144
3D
1wlpB02 - 82.2
118
142 - - 65.7
119
142
3D
2eqiA00 - 92.3
120
140 - - 57.5
122
138
3D
6h5tB00 - 82.2
123
134 - - 36.2
124
133
3D
1v1cA00 - 48.1
126
132
3D
2js0A00 - 77.3
128
Pex13
131
3D
2v1rB00 - 90.4
127
130
3D
1wlpB01 - 82.4
125
130 - - 51.5
129
122 - - 45.4
130
121 - - 66.0
132
119
3D
4esrB00 - 90.8
131
117 - - 40.6
133
117
3D
2gtoA01 - 76.2
182
116
3D
4znxD00 - 72.0
134
114
3D
2cudA00 - 86.8
135
111 - - 58.2
136
110 - - 96.4
137
110 - - 20.0
157
107
3D
5l23A00 - 63.7
152
106
3D
4d8kA01 - 84.0
138
106 - - 83.9
139
105 - - 75.2
146
105
3D
1jegA00 - 57.5
140
104 - - 33.5
149
104
3D
2dybB02 - 81.3
141
103 - - 87.7
145
102
3D
1x6gA00 - 89.5
144
102
3D
3uatA01 - 36.2
142
102 - - 78.1
143
101 - - 79.5
147
100
3D
2creA00 - 70.7
150
98
3D
2dilA00 - 96.3
148
98 - - 62.6
153
95
3D
1x6bA01 - 67.1
151
95 - - 71.6
154
93 - - 66.5
155
92 - - 75.8
158
92
3D
3ehrB01 - 27.1
156
92
3D
1ri9A00 - 78.5
160
88
3D
4glmD00 - 80.9
159
85 - - 42.5
163
84
3D
2lqwA02 - 42.4
161
83 - - 87.5
162
82 - - 75.5
165
82 - - 84.1
166
82 - - 52.1
164
82 - - 85.2
167
81 - - 66.4
168
Cyk3
80 - - 77.4
176
80
3D
2rnaA00 - 77.2
175
79
3D
5ixbB00 - 72.5
169
79 - - 79.0
171
78
3D
1s1nA00 - 93.0
170
78 - - 95.6
181
75
3D
2w10B00 - 46.7
172
75 - - 82.3
173
75
3D
2djqA00 - 77.0
174
74 - - 86.1
177
GEF
72 - - 97.7
178
71 - - 81.5
179
71 - - 46.6
180
70
3D
1wxbA00 - 76.3
183
66 - - 80.2
184
65 - - 66.5
185
65 - - 68.8
187
64
3D
1k4uS00 - 52.2
186
64
3D
2yunA00 - 78.3
189
63 - - 75.4
188
63 - - 69.2
190
61 - - 67.6
191
59 - - 75.6
192
59 - - 17.5
194
58
3D
2ekhA00 - 59.2
193
58 - - 76.2
195
57
3D
1wxtA00 - 82.1
199
56
3D
2enmA00 - 36.6
196
56 - - 71.0
197
55 - - 51.2
198
55 - - 51.1
202
55
3D
3kfvA01 - 58.0
200
54 - - 27.6
201
54 - - 74.4
213
53
3D
2vknA00 - 88.5
203
53 - - 87.5
204
52 - - 10.6
206
51 - - 25.7
205
51 - - 36.2
207
51 - - 75.7
208
51 - - 82.3
211
50 - - 90.8
212
50 - - 78.5
217
50
3D
2d8jA00 - 71.8
209
50 - - 22.2
216
50
3D
2lx7A00 - 86.4
210
50 - - 47.9
215
49 - - 39.5
214
49 - - 38.2
218
46 - - 52.3
219
45 - - 89.2
220
44 - - 77.7
221
44 - - 85.7
224
43
3D
4m4zA01 - 94.2
222
43 - - 59.7
223
43 - - 89.6
226
42 - - 25.1
225
42 - - 34.9
227
41 - - 15.1
229
41
3D
2kgtA00 - 94.8
228
40 - - 34.4
232
38
3D
2egeA00 - 85.0
230
37 - - 8.9
231
37 - - 29.6
233
36 - - 84.2
236
35
3D
5o1qA00 - 17.0
234
35 - - 84.5
235
35
3D
5f3yA05 - 38.7
237
33 - - 47.4
238
32 - - 71.2
256
30
3D
2v1qB00 - 82.8
239
30 - - 12.2
241
29 - - 32.6
240
29 - - 36.9
243
29 - - 84.4
242
29 - - 83.6
244
28 - - 19.8
245
28 - - 6.8
246
27 - - 87.3
250
27 - - 14.4
249
27 - - 92.4
266
27
3D
4rugB00 - 56.1
247
27 - - 13.6
248
27 - - 16.9
251
26 - - 68.1
253
26 - - 73.9
252
26 - - 47.2
254
25 - - 85.8
255
25 - - 65.1
283
25
3D
2lcsA00 - 76.6
271
25
3D
2a28D00 - 68.8
260
24 - - 51.4
262
24 - - 33.1
257
24 - - 15.6
259
24 - - 80.3
261
24 - - 0.0
258
24 - - 10.1
265
23 - - 22.2
264
23 - - 93.3
263
23 - - 36.8
267
23 - - 43.5
268
23 - - 66.3
277
23
3D
2rpnA00 - 61.4
274
22
3D
1zx6A00 - 62.2
270
22 - - 50.5
269
22 - - 14.6
272
21 - - 6.5
273
21 - - 72.4
275
20 - - 44.7
279
20 - - 75.1
278
20 - - 38.6
276
20 - - 0.0
280
19 - - 26.2
281
19 - - 17.6
282
19
3D
1uffA00 - 30.6
285
18 - - 0.0
286
18 - - 16.2
287
18 - - 79.0
316
18
3D
1zukB00 - 74.6
284
18 - - 0.0
288
16 - - 60.1
291
16 - - 11.7
289
GEF
16 - - 18.9
290
16 - - 35.3
295
15 - - 33.7
296
15 - - 93.1
294
15 - - 0.0
293
15 - - 56.4
292
15 - - 18.1
300
14 - - 76.4
322
14
3D
1zuyB00 - 8.5
299
14 - - 25.6
298
14 - - 55.0
297
14 - - 16.4
301
13 - - 3.9
303
Zonula Occludens tight junctional protein
13 - - 19.7
302
13 - - 68.0
305
13 - - 6.5
304
13 - - 10.3
306
13 - - 15.3
311
Boi2
12 - - 38.2
312
12 - - 78.3
309
12 - - 0.0
308
12 - - 9.3
310
12 - - 46.5
314
12 - - 67.6
307
12 - - 97.1
313
12 - - 85.3
325
11 - - 19.1
324
11 - - 77.8
323
11 - - 5.5
327
11 - - 18.1
320
11 - - 25.2
326
11 - - 14.8
315
11 - - 84.9
328
11 - - 80.8
317
11 - - 12.3
321
Scaffold protein
11 - - 0.0
319
11 - - 12.6
318
11 - - 12.2
356
11
3D
3qwyB02 - 64.1
331
10 - - 70.9
337
10 - - 48.9
329
10 - - 17.1
333
10 - - 81.9
330
10 - - 0.0
332
10 - - 47.0
335
10 - - 7.8
334
10 - - 11.9
336
10 - - 19.7
350
9 - - 15.7
340
9 - - 1.9
348
9 - - 7.3
351
9 - - 25.7
342
9 - - 1.8
341
9 - - 1.5
349
9 - - 11.9
346
9 - - 28.6
352
9 - - 40.6
353
9 - - 72.6
354
9 - - 16.0
347
9 - - 28.7
338
9 - - 52.4
343
9 - - 11.9
339
9 - - 15.2
345
9 - - 11.0
344
9 - - 0.0
358
8 - - 42.2
364
8 - - 18.6
367
8 - - 75.2
366
8 - - 59.8
359
8 - - 34.9
360
8 - - 5.6
368
8 - - 88.5
361
8 - - 0.0
355
8 - - 10.5
363
8 - - 15.3
362
8 - - 7.2
357
8 - - 2.0
365
8 - - 8.9
378
7 - - 7.7
379
Intersectin
7 - - 13.8
370
7 - - 17.4
380
7 - - 6.1
381
Non-Catalytic region of tyrosine Kinase
7 - - 22.6
373
7 - - 0.0
369
7 - - 35.8
372
7 - - 4.2
375
7 - - 2.3
374
7 - - 0.0
377
7 - - 1.8
376
7 - - 8.1
371
7 - - 68.0
382
6 - - 14.4
389
GTPase activating protein
6 - - 17.5
388
6 - - 7.9
391
Intersectin
6 - - 0.0
392
6 - - 0.0
399
6 - - 75.0
386
6 - - 2.1
400
6 - - 52.4
394
6 - - 43.9
393
6 - - 5.5
387
Intersectin
6 - - 0.0
395
6 - - 0.0
385
6 - - 74.1
398
6 - - 75.9
384
1,6
6 - - 67.8
397
6 - - 90.4
404
6
3D
2epdA00 - 56.2
383
6 - - 12.2
396
6 - - 8.8
390
Intersectin
6 - - 0.0
405
5 - - 13.7
402
5 - - 24.6
407
5 - - 76.1
401
5 - - 18.6
406
5 - - 6.0
403
5 - - 53.9
418
4 - - 85.0
410
4 - - 0.0
415
4 - - 34.8
417
4 - - 9.1
416
4 - - 11.5
413
4 - - 63.1
414
4 - - 74.7
409
4 - - 6.7
412
4 - - 75.8
411
4 - - 20.1
420
4 - - 79.6
419
4 - - 8.9
421
4 - - 78.3
408
4 - - 6.9
443
3 - - 1.6
437
3 - - 13.8
451
3 - - 34.0
454
3 - - 33.6
431
3 - - 9.2
509
3
3D
1gl5A00 - 23.8
453
3 - - 58.0
430
3 - - 0.0
447
3 - - 1.9
452
3 - - 4.9
438
3 - - 13.6
444
3 - - 3.3
436
3 - - 8.9
445
3 - - 1.7
441
3 - - 1.1
432
3 - - 45.2
427
3 - - 13.2
446
3 - - 13.6
426
3 - - 5.3
428
3 - - 1.8
449
3 - - 1.6
425
3 - - 1.7
424
3 - - 15.4
434
3 - - 27.4
442
3 - - 13.4
429
CheW
3 - - 0.0
433
3 - - 76.1
440
3 - - 3.3
423
3 - - 58.6
422
3 - - 1.9
439
3 - - 7.5
435
3 - - 37.8
448
3 - - 0.0
450
3 - - 11.6
512
1,6
2 - - 0.0
463
2 - - 10.8
517
ZZ-type
2 - - 0.0
458
2 - - 42.1
540
2 - - 9.9
527
2 - - 11.7
495
2 - - 23.7
486
2 - - 0.0
485
2 - - 0.0
523
2 - - 1.7
460
2 - - 0.0
488
2 - - 0.0
536
2 - - 0.0
480
CheW
2 - - 7.7
535
2 - - 0.0
508
2 - - 0.0
541
2 - - 2.5
507
2 - - 0.0
506
2 - - 0.0
496
2 - - 14.2
456
2 - - 3.1
493
2 - - 39.5
525
2 - - 0.0
534
2 - - 0.0
468
2 - - 1.7
475
2 - - 3.1
515
2 - - 2.9
519
2 - - 8.5
545
2 - - 51.6
542
2 - - 48.8
498
2 - - 0.0
483
2 - - 0.0
526
2 - - 0.0
500
2 - - 0.0
533
2 - - 0.0
462
2 - - 0.0
477
2 - - 0.0
514
2 - - 7.5
513
2 - - 0.0
476
2 - - 2.1
510
2 - - 7.2
469
2 - - 30.1
501
2 - - 0.0
490
2 - - 0.0
543
2 - - 47.6
461
2 - - 0.0
539
2 - - 0.0
520
2 - - 8.9
532
2 - - 33.3
492
2 - - 41.3
511
2 - - 0.0
489
2 - - 41.1
471
2 - - 3.5
465
2 - - 9.3
502
2 - - 7.9
479
2 - - 0.0
538
2 - - 0.0
524
2 - - 3.1
521
2 - - 0.0
467
2 - - 0.0
481
2 - - 0.0
474
2 - - 0.0
503
2 - - 0.0
484
2 - - 0.0
544
2 - - 49.5
464
2 - - 2.1
518
2 - - 0.0
497
2 - - 32.8
472
2 - - 0.0
478
2 - - 0.0
537
2 - - 0.0
522
2 - - 0.0
529
2 - - 0.0
504
2 - - 0.0
459
2 - - 0.0
531
2 - - 5.8
516
ZZ-type
2 - - 0.0
494
2 - - 50.3
487
2 - - 46.0
455
2 - - 35.6
457
2 - - 35.2
505
2 - - 0.0
482
2 - - 7.8
499
2 - - 4.1
530
2 - - 1.9
470
2 - - 0.0
466
2 - - 0.0
491
2 - - 47.5
473
2 - - 0.0
528
2 - - 13.8
559
1 - - 0.0
560
1 - - 0.0
580
1 - - 0.0
634
1 - - 0.0
578
1 - - 0.0
572
1 - - 0.0
675
1 - - 0.0
571
1 - - 0.0
548
1 - - 0.0
662
1 - - 0.0
627
1 - - 0.0
594
1 - - 0.0
653
1 - - 0.0
569
1 - - 0.0
586
1 - - 0.0
637
1 - - 0.0
595
1 - - 0.0
579
1 - - 0.0
683
1 - - 0.0
558
1 - - 0.0
573
1 - - 0.0
638
1 - - 0.0
567
1 - - 0.0
661
1 - - 0.0
581
1 - - 0.0
678
1 - - 0.0
605
1 - - 0.0
607
1 - - 0.0
644
1 - - 0.0
568
1 - - 0.0
652
1 - - 0.0
582
1 - - 0.0
633
1 - - 0.0
557
1 - - 0.0
672
1 - - 0.0
606
1 - - 0.0
666
1 - - 0.0
677
1 - - 0.0
650
1 - - 0.0
590
1 - - 0.0
664
1 - - 0.0
588
1 - - 0.0
646
1 - - 0.0
617
1 - - 0.0
651
1 - - 0.0
629
1 - - 0.0
574
1 - - 0.0
660
1 - - 0.0
566
1 - - 0.0
604
1 - - 0.0
556
1 - - 0.0
671
1 - - 0.0
632
1 - - 0.0
610
1 - - 0.0
663
1 - - 0.0
615
1 - - 0.0
658
1 - - 0.0
549
1 - - 0.0
659
1 - - 0.0
645
1 - - 0.0
682
1 - - 0.0
635
1 - - 0.0
575
1 - - 0.0
589
1 - - 0.0
614
1 - - 0.0
626
1 - - 0.0
583
1 - - 0.0
591
1 - - 0.0
603
1 - - 0.0
565
1 - - 0.0
620
1 - - 0.0
611
1 - - 0.0
584
1 - - 0.0
665
1 - - 0.0
649
1 - - 0.0
648
1 - - 0.0
642
1 - - 0.0
585
1 - - 0.0
674
1 - - 0.0
622
1 - - 0.0
553
1 - - 0.0
555
1 - - 0.0
681
1 - - 0.0
619
1 - - 0.0
621
1 - - 0.0
554
1 - - 0.0
680
1 - - 0.0
679
1 - - 0.0
552
1 - - 0.0
598
1 - - 0.0
647
1 - - 0.0
602
1 - - 0.0
612
1 - - 0.0
564
1 - - 0.0
563
1 - - 0.0
668
1 - - 0.0
657
1 - - 0.0
673
1 - - 0.0
593
1 - - 0.0
641
1 - - 0.0
576
GEF
1 - - 0.0
616
1 - - 0.0
640
1 - - 0.0
623
1 - - 0.0
628
1 - - 0.0
562
1 - - 0.0
630
1 - - 0.0
608
1 - - 0.0
546
1 - - 0.0
599
1 - - 0.0
609
1 - - 0.0
587
1 - - 0.0
667
1 - - 0.0
601
1 - - 0.0
551
1 - - 0.0
624
1 - - 0.0
656
1 - - 0.0
596
1 - - 0.0
613
1 - - 0.0
669
1 - - 0.0
639
1 - - 0.0
636
1 - - 0.0
577
1 - - 0.0
561
1 - - 0.0
643
1 - - 0.0
600
1 - - 0.0
676
1 - - 0.0
550
1 - - 0.0
670
1 - - 0.0
592
1 - - 0.0
625
1 - - 0.0
547
1 - - 0.0
631
1 - - 0.0
570
1 - - 0.0
654
1 - - 0.0
618
Drosophila
1 - - 0.0
655
1 - - 0.0
597
1 - - 0.0