CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family Alpha-(1,6)-fucosyltransferase

Enzyme Information

2.4.1.68
Glycoprotein 6-alpha-L-fucosyltransferase.
based on mapping to UniProt Q9BYC5
GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D- mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl- (1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N- acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D- glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D- glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N- acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta- D-glucosaminyl)asparagine.
-!- Catalyzes a reaction similar to that of EC 2.4.1.214, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha-1,6- linkage rather than an alpha-1,3-linkage.

UniProtKB Entries (1)

Q9BYC5
FUT8_HUMAN
Homo sapiens
Alpha-(1,6)-fucosyltransferase

PDB Structure

PDB 2DE0
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Crystal structure of mammalian {alpha}1,6-fucosyltransferase, FUT8
Ihara, H., Ikeda, Y., Toma, S., Wang, X., Suzuki, T., Gu, J., Miyoshi, E., Tsukihara, T., Honke, K., Matsumoto, A., Nakagawa, A., Taniguchi, N.
Glycobiology