The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15920: Phospholipase C, epsilon 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
2 Q99P84 (/IDA) Q9P212 (/IDA)
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
2 Q8K4S1 (/ISS) Q99P84 (/ISS)
Phospholipase C activity GO:0004629
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
2 Q8K4S1 (/ISS) Q99P84 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q8K4S1 (/IPI) Q9P212 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 Q8K4S1 (/ISS) Q99P84 (/ISS)
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
1 Q8K4S1 (/ISO)
Phosphatidylinositol phospholipase C activity GO:0004435
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
1 Q9P212 (/TAS)
Phospholipase C activity GO:0004629
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
1 Q9P212 (/IDA)
Phospholipase C activity GO:0004629
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
1 Q8K4S1 (/ISO)
Signal transducer activity, downstream of receptor GO:0005057
Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.
1 Q9P212 (/TAS)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q9P212 (/TAS)
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
1 Q99P84 (/IDA)
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
1 Q9P212 (/TAS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q9P212 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q8K4S1 (/ISO)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
2 Q8K4S1 (/ISS) Q99P84 (/ISS)
Phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
2 Q8K4S1 (/ISS) Q99P84 (/ISS)
Regulation of G-protein coupled receptor protein signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.
2 Q8K4S1 (/ISS) Q99P84 (/ISS)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
2 Q8K4S1 (/ISS) Q99P84 (/ISS)
Regulation of Ras protein signal transduction GO:0046578
Any process that modulates the frequency, rate or extent of Ras protein signal transduction.
2 Q8K4S1 (/ISS) Q99P84 (/ISS)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 Q9P212 (/IDA)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 Q8K4S1 (/ISO)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
1 Q9P212 (/TAS)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 Q9P212 (/IC)
Diacylglycerol biosynthetic process GO:0006651
The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
1 Q9P212 (/TAS)
Regulation of smooth muscle contraction GO:0006940
Any process that modulates the frequency, rate or extent of smooth muscle contraction.
1 Q9P212 (/TAS)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
1 Q9P212 (/NAS)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 Q9P212 (/NAS)
G-protein coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 Q99P84 (/IMP)
Phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
1 Q9P212 (/IDA)
Phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
1 Q8K4S1 (/ISO)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 Q9P212 (/TAS)
Protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
1 Q9P212 (/NAS)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 Q99P84 (/IDA)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 Q9P212 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q9P212 (/TAS)
Regulation of G-protein coupled receptor protein signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.
1 Q9P212 (/IDA)
Regulation of G-protein coupled receptor protein signaling pathway GO:0008277
Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.
1 Q8K4S1 (/ISO)
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q9P212 (/NAS)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 Q9P212 (/NAS)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 Q9P212 (/TAS)
Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
1 Q9P212 (/IMP)
Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
1 Q8K4S1 (/ISO)
Inositol phosphate metabolic process GO:0043647
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
1 Q9P212 (/TAS)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
1 Q9P212 (/IDA)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
1 Q8K4S1 (/ISO)
Regulation of Ras protein signal transduction GO:0046578
Any process that modulates the frequency, rate or extent of Ras protein signal transduction.
1 Q9P212 (/IDA)
Regulation of Ras protein signal transduction GO:0046578
Any process that modulates the frequency, rate or extent of Ras protein signal transduction.
1 Q8K4S1 (/ISO)
Inositol phosphate-mediated signaling GO:0048016
Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6).
1 Q9P212 (/TAS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8K4S1 (/ISS) Q99P84 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8K4S1 (/ISS) Q99P84 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q99P84 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9P212 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8K4S1 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9P212 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8K4S1 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9P212 (/TAS)