The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15920: Phospholipase C, epsilon 1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphoinositide phospholipase C. [EC:]
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
  • These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3).
  • They show activity toward phosphatidylinositol, i.e., the activity of EC in vitro at high calcium concentration.
43 A0A096P5P6 A0A096P5P8 A0A0D9R1M1 A0A1D5QRN1 B7ZM61 B7ZNH9 D2H3C5 F1MTE8 F1Q101 F1SC67
(33 more...)