CATH Superfamily 3.10.20.90

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Enzyme?	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
16199	Polyubiquitin containing 7 ubiquitin monomers	14269	EC	3D	3q3fA02	-	87.2
16135	Autophagy-related protein 8	5069		3D	4co7A00	-	79.6
16490	Small ubiquitin-related modifier 3	4252	EC	3D	3pgeA01	-	89.7
16531	Ubiquitin-like protein 5	3526	EC	3D	1m94A00	-	76.4
16333	Ubiquitin-like protein Nedd8	2509	EC	3D	1nddA00	-	75.6
16211	Band 4.1-like protein 1	2093		3D	1gg3A02	-	88.8
3699	Ubiquitin-like protein 3	1882		3D	1wghA01	-	80.2
16502	Protein kinase C, zeta	1735	EC	3D	1vd2A00	-	90.4
16491	NSFL1 cofactor p47 homolog	1570		3D	1i42A00	-	90.2
16446	Ubiquitin-like domain-containing CTD phosphatase	1466	EC	3D	2kx3A00	-	97.4
16440	UV excision repair protein Rad23	1394		3D	1oqyA01	-	86.0
16558	Growth factor receptor-bound protein 14	1343		3D	1wgrA01	-	74.6
16295	Putative radixin moesin	1335	EC	3D	1ni2A01	-	90.0
16362	Serine/threonine-protein kinase WNK3-like protein	1295	EC		-	-	90.2
16431	Ubiquitin-like protein ATG12	1268		3D	3w1sC00	-	90.3
16105	Microtubule-associated proteins 1A/1B light chain 3B	1203		3D	5dprA00	-	90.7
16438	Probable serine/threonine-protein kinase WNK1	1000	EC		-	-	93.1
16015	Ubiquitin-fold modifier 1, putative	952		3D	1wxsA00	-	91.3
16452	Ral guanine nucleotide dissociation stimulator	859		3D	1raxA00	-	88.3
16323	Partitioning defective 6 gamma	830		3D	1wmhB00	-	89.8
16627	Splicing factor 3A subunit 1	789	EC	3D	1zkhA00	-	84.6
16481	Talin-1 isoform 2	712	EC	3D	2kc2A00	-	84.6
16451	Unconventional myosin heavy chain 6	688	EC	3D	3pvlA02	-	97.3
16437	Ubiquitin carboxyl-terminal hydrolase 14	630	EC	3D	1wggA01	-	96.4
16568	Transmembrane and ubiquitin-like domain-containing protein 1	623			-	-	96.1
15968	Plexin A4 isoform 1	621		3D	3ig3A02	-	72.1
16521	RAF proto-oncogene serine/threonine-protein kinase	621	EC	3D	1c1yB00	-	82.9
16271	Guanine nucleotide exchange factor	600			-	-	94.6
16143	Membrane-anchored ubiquitin-fold protein 2	554		3D	4x57B00	-	96.7
16261	Unconventional myosin heavy chain 6	530	EC		-	-	80.2
16309	cDNA FLJ60127, highly similar to Ubiquilin-2	513		3D	2klcA00	-	99.8
16455	Protein kinase regulator Ste50	462			-	-	81.3
16710	Ubiquitin carboxyl-terminal hydrolase 15	458	EC	3D	3ppaA02	-	91.6
16640	B-lymphocyte antigen CD19	441		3D	3goeA00	-	88.8
16409	Large proline-rich protein BAG6	434		3D	1wx9A00	-	98.6
16573	E3 ubiquitin-protein ligase UHRF1	398	EC	3D	2fazA00	-	97.0
16130	Band 4.1-like protein 5	366			-	-	90.0
16442	FERM, RhoGEF and pleckstrin domain-containing protein 1	359			-	-	93.8
16183	Ras association domain-containing protein 7	340		3D	2cs4A00	-	73.0
16106	FERM domain-containing protein 4A	339			-	-	82.7
16287	Talin-1 isoform 2	336		3D	2kc1A00	-	87.0
16354	Ras association domain-containing protein 2	332			-	-	81.7
16297	RanBP-type and C3HC4-type zinc finger-containing protein 1	331	EC	3D	2lgyA00	-	91.6
16401	Protein TFG, putative	328	EC		-	-	87.9
16632	Phosphatidylinositol 3-kinase gamma isoform	316	EC	3D	1e8yA01	-	95.8
16270	STE20/SPS1-related proline-alanine-rich protein kinase	296	EC	3D	2v3sA00	-	84.5
1161	Transcription elongation factor B polypeptide 2	278		3D	1lm8B00	-	84.9
16033	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	247	EC	3D	2rd0A01	-	60.6
1977	Afadin	229			-	-	58.9
15929	Phosphoinositide phospholipase C	223	EC	3D	2byfA01	-	76.8
16041	FAS-associated factor 2	221			-	-	48.1
16516	E3 ubiquitin-protein ligase parkin	219	EC	3D	1mg8A00	-	97.1
7242	AN1-type zinc finger protein 4	200			-	-	84.6
16192	Regulator of G-protein-signaling 12	194			-	-	38.6
16274	Ubiquitin-like 4, isoform CRA_b	191		3D	2dziA00	-	92.8
15946	Focal adhesion kinase 1	188	EC	3D	4ny0A01	-	67.5
16559	MAP kinase kinase kinase Ste11	188	EC	3D	1k8rB00	-	94.4
16668	Kinesin-like calmodulin-binding protein ZWICHEL	185			-	-	90.0
16539	Putative RNA methyltransferase bin3	181			-	-	92.7
10384	FERM domain-containing protein 5	179			-	-	75.0
3096	Tether-containing UBX domain for GLUT4	177			-	-	69.1
16292	Octicosapeptide/Phox/Bem1p domain-containing family protein	176			-	-	88.5
16463	2'-5'-oligoadenylate synthase-like protein 1	176	EC	3D	1wh3A01	-	95.3
16537	BAG family molecular chaperone regulator 1	173	EC	3D	2lwpA00	-	95.5
15989	Tyrosine-protein phosphatase non-receptor type 21	171	EC		-	-	55.3
15902	Pleckstrin-likey domain-containing family H member 2	169			-	-	73.0
10380	Protein cordon-bleu	167			-	-	52.8
16624	DNA damage-inducible protein 1	165			-	-	93.7
7637	Mitogen-activated protein kinase kinase kinase 2	163	EC	3D	2cu1A01	-	59.1
3088	Unconventional myosin-IXa	162			-	-	42.7
16236	Regulator of G-protein-signaling 12	156			-	-	74.1
5805	Putative uncharacterized protein DKFZp459O016	151			-	-	31.9
7934	Mitogen-activated protein kinase kinase kinase 3	151	EC	3D	2c60A01	-	64.4
1921	Afadin	147		3D	1wxaA00	-	44.2
15065	RB1-inducible coiled-coil protein 1	144			-	-	62.2
16218	Ras-associating and dilute domain-containing protein	144		3D	5khoA00	-	72.5
16159	Ubiquitin carboxyl-terminal hydrolase 48	143	EC		-	-	55.3
14602	Tether-containing UBX domain for GLUT4	139		3D	2al3A00	-	90.5
16168	Fas associated factor 1	137	EC	3D	1h8cA00	-	58.9
15995	FERM domain-containing protein 3	136			-	-	69.3
15924	Serine/threonine-protein kinase WNK1	134	EC		-	-	44.0
13597	Sorting nexin-27	131			-	-	24.6
5804	Dual specificity mitogen-activated protein kinase kinase 5	129	EC	3D	2nptA01	-	54.4
2199	Virus-encoded semaphorin protein receptor	129		3D	3kuzA00	-	70.0
5506	Tyrosine-protein phosphatase non-receptor type 13	125	EC		-	-	42.9
9313	K7_Bem1p	123			-	-	0.0
16124	Phosphatidylinositol 3-kinase delta catalytic subunit	122	EC		-	-	74.3
7591	Apoptosis-stimulating of p53 protein 1	120			-	-	28.8
13807	FERM domain containing 6	120			-	-	65.2
16707	Protein-tyrosine kinase 2-beta isoform 1	118	EC	3D	4ekuA01	-	88.6
16152	Rap guanine nucleotide exchange factor 5	117			-	-	81.8
10971	Polycomb group RING finger protein 6	116			-	-	54.6
15935	Ubiquitin domain-containing protein 2	115		3D	1ttnA01	-	30.8
8401	Very-long-chain enoyl-CoA reductase	114	EC	3D	2dzjA00	-	50.2
15952	Band 4.1-like protein 4A	113			-	-	77.1
1584	Splicing factor 3A subunit 1	111			-	-	29.7
16223	Transmembrane and ubiquitin-like domain-containing protein 2	110		3D	1wiaA01	-	75.2
11537	Tyrosine-protein phosphatase non-receptor type 14	109	EC		-	-	32.0
15896	Ras and Rab interactor 2	108			-	-	58.0
16123	IKBKB protein	107	EC	3D	4e3cA02	-	77.7
7537	Neighbor of BRCA1 gene 1	105		3D	1wj6A01	-	50.1
4555	Unconventional myosin-X	103		3D	3au4A02	-	29.1
5002	Ras association domain-containing protein 9	103			-	-	53.7
16620	Rho guanine nucleotide exchange factor scd1	102		3D	1pqsA00	-	93.9
300	UBX domain-containing protein 4	101		3D	2kxjA00	-	41.8
16254	Deubiquitination-protection protein dph1	99		3D	2bweS00	-	52.0
16288	Homocysteine-induced endoplasmic reticulum protein, isoform A	94		3D	1wgdA00	-	80.3
16492	Related to Adenylate cyclase	93	EC		-	-	98.4
8917	Serine/threonine-protein kinase WNK4	93	EC		-	-	27.9
9738	Unconventional myosin-XV	92			-	-	44.6
16012	Ubiquitin carboxyl-terminal hydrolase 24	92	EC		-	-	39.2
16032	Putative sorting nexin-17	92		3D	4gxbA01	-	42.1
16706	2'-5'-oligoadenylate synthase-like protein 2	92	EC		-	-	92.9
16056	Ras association domain-containing protein 6	92			-	-	65.5
2572	Rad23p	91		3D	2nbuA00	-	10.4
533	Ras association domain-containing protein 3	90			-	-	72.8
15897	Protein Arap1	89			-	-	41.6
16006	Tyrosine-protein phosphatase non-receptor type	87	EC		-	-	53.8
2828	cDNA FLJ52474, highly similar to Sequestosome-1	87	EC	3D	4mjsB00	-	76.2
3075	Ubiquitin-like protein MDY2	85			-	-	0.0
16239	E3 ubiquitin-protein ligase MYLIP	81	EC		-	-	55.9
14029	Uncharacterized protein	81			-	-	0.0
3765	Small nuclear ribonucleoprotein 25kDa U11/U12	81			-	-	25.8
2847	Protein Arap3	80			-	-	29.8
6582	FERM and PDZ domain-containing protein 4	80			-	-	34.0
834	Canoe, isoform I	79			-	-	19.9
15984	Tether-containing UBX domain for GLUT4	79			-	-	59.9
15969	Ubiquitin-associated domain-containing protein 1	79			-	-	77.7
16651	Putative enoyl reductase C646.07c	77	EC		-	-	86.8
15906	Rho GTPase-activating protein 20	77			-	-	74.6
8558	Uncharacterized protein	73			-	-	76.3
15932	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta	73	EC		-	-	45.8
15892	Unconventional myosin-IXb	72			-	-	39.8
4997	Sorting nexin-31	72			-	-	74.8
13116	Regulator of G-protein signaling 14	70			-	-	43.3
16150	Tubulin-specific chaperone E	69		3D	1wjnA00	-	56.3
15920	Phospholipase C, epsilon 1	68	EC	3D	2byeA01	-	44.2
15936	Serine/threonine-protein kinase WNK2	67	EC		-	-	28.5
16265	ISG15 ubiquitin-like modifier	66		3D	1z2mA02	-	71.9
8043	Apoptosis-stimulating of p53 protein 2	64		3D	2uwqA00	-	27.8
13622	Rap guanine nucleotide exchange factor-like 1	63		3D	2dhzA01	-	23.3
6162	Ral guanine nucleotide exchange factor	61			-	-	73.7
15945	Tubulin folding cofactor B	60		3D	1v6eA01	-	41.2
9871	CG34347, isoform B	55			-	-	49.6
10977	FERM domain-containing protein 7	54			-	-	59.1
15959	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	53			-	-	38.6
16212	T-lymphoma invasion and metastasis-inducing protein 2	53			-	-	54.3
16023	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform	51	EC	3D	4bfrA01	-	44.4
6138	SH3 and multiple ankyrin repeat domains 3	51			-	-	21.6
16097	Neutrophil cytosol factor 2	51		3D	1oeyA00	-	55.9
5426	Growth factor receptor-bound protein	51			-	-	65.3
15966	Trans-2,3-enoyl-CoA reductase-like	51			-	-	52.2
16424	Ubiquitin D	50		3D	2mbeA00	-	74.8
4155	Putative uncharacterized protein	50			-	-	0.0
5495	Serine/threonine-protein kinase WNK3	50	EC		-	-	29.6
501	Ste50p	49			-	-	2.9
15998	Protein cordon-bleu	49			-	-	48.2
16139	Coffea canephora DH200=94 genomic scaffold, scaffold_25	48			-	-	74.0
15904	UBX domain-containing protein 1	48			-	-	14.1
1922	cDNA FLJ58111, highly similar to Plexin-D1	47			-	-	20.3
16091	E3 ubiquitin-protein ligase parkin	45	EC	3D	1iyfA00	-	30.2
9996	Myosin 10A, isoform E	45	EC		-	-	16.1
13389	Locomotion defects, isoform B	44			-	-	26.3
16013	Tyrosine-protein phosphatase non-receptor type	38	EC		-	-	33.8
16178	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma	38	EC		-	-	60.6
14820	Tether-containing UBX domain for GLUT4	37			-	-	85.2
2958	Uncharacterized protein	36	EC		-	-	0.0
15893	Neutrophil cytosol factor 4	36		3D	2dybA03	-	45.7
2523	Diacylglycerol kinase	36	EC		-	-	17.5
16688	Cytochrome b5 domain-containing protein 1	36			-	-	79.0
16203	Regulator of G-protein signaling 14	35		3D	1wfyA01	-	47.5
2093	Canoe, isoform C	35			-	-	4.4
16296	Ubiquitin-like protein ISG15	35		3D	1z2mA01	-	66.4
15909	UBX domain-containing protein 6	34			-	-	45.5
7539	FERM and PDZ domain-containing protein 1	34			-	-	32.7
16626	Transcription initiation factor TFIID subunit 1	34			-	-	63.7
16367	Clustered mitochondria protein homolog	31			-	-	69.4
10426	Yurt, isoform D	31			-	-	3.1
15454	U11/U12 small nuclear ribonucleoprotein 25 kDa protein	30		3D	1v2yA00	-	79.9
16468	Diacylglycerol kinase theta	29	EC		-	-	38.0
13809	Locomotion defects, isoform F	26			-	-	19.1
4269	Diacylglycerol kinase	25	EC		-	-	29.1
13825	GH23060	25			-	-	5.9
16415	GM23182	23			-	-	13.0
6485	Rhea, isoform B	21			-	-	15.8
10973	Protein sprint	20			-	-	14.8
15962	cDNA FLJ57524, highly similar to Plexin-B1	20		3D	2jphA00	-	33.3
13822	Tyrosine-protein phosphatase	19	EC		-	-	10.8
5795	CBS domain-containing protein CBSCBSPB1	18			-	-	22.4
6910	Octicosapeptide/Phox/Bem1p domain-containing protein kinase	18	EC		-	-	21.5
15882	Phosphatidylinositol 3-kinase catalytic delta polypeptide	18		3D	4ajwA01	-	52.7
9314	Ubiquitin-like protein ATG12	17			-	-	34.1
13808	Polehole	16	EC		-	-	11.0
7258	Ubiquitin thioesterase OTU1	16	EC		-	-	30.4
1516	UBX domain-containing protein 4	16			-	-	5.8
2710	U11/U12 small nuclear ribonucleoprotein 25 kDa protein	15			-	-	30.8
307	Plant UBX domain-containing protein 10	15			-	-	14.6
7195	Putative Ser/Thr protein kinase	15			-	-	20.6
10980	BAG family molecular chaperone regulator 1	15		3D	4hwiB01	-	20.2
6197	Atypical protein kinase C	13	EC		-	-	19.4
15871	cDNA FLJ50412, highly similar to Plexin-B3	13			-	-	41.4
8588	Defense repressor 1, isoform A	12			-	-	4.2
10477	Pez, isoform A	12	EC		-	-	11.4
11765	Os09g0484300 protein	12			-	-	4.0
7042	SHN-1, isoform b	12			-	-	29.9
15922	ARAP2 protein	12			-	-	0.0
4444	WNK homolog, isoform F	12			-	-	12.4
10098	UBX domain-containing protein 4	12			-	-	4.4
3786	Putative uncharacterized protein An01g14100	11			-	-	7.0
12685	cDNA clone:J023135J22, full insert sequence	11	EC		-	-	7.9
7645	Protein kinase family protein	11			-	-	16.5
16063	Ubiquitin thioesterase OTU1	11	EC		-	-	23.0
16601	Ubiquitin D	11			-	-	45.0
8997	BAG family molecular chaperone regulator 3	10			-	-	20.2
939	Bud emergence protein 1	10			-	-	0.0
9312	Auxin-responsive protein IAA28	9			-	-	11.8
2727	Diacylglycerol kinase	9	EC		-	-	15.6
16008	NPL4-like protein 2	9			-	-	30.3
8399	NADPH oxidase activator 1	9			-	-	17.5
12245	Protein 4.1 homolog	9			-	-	0.0
4939	Carboxylate clamp-tetratricopeptide repeat protein	9			-	-	35.6
15457	Sacsin	8			-	-	26.2
1718	HUM-7, isoform b	8			-	-	8.3
6144	Very-long-chain enoyl-CoA reductase	8	EC		-	-	5.7
12554	Auxin response factor 1	8			-	-	0.0
15211	Putative autophagy-related protein 8E	8			-	-	26.7
6467	CBS domain-containing protein CBSCBSPB3	7			-	-	12.0
15853	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	7		3D	2rd0A02	-	17.9
7587	GE20681	6			-	-	15.3
4836	Myosin 28B1, isoform A	6	EC		-	-	9.3
9990	GM18214	6			-	-	4.1
6226	Diacylglycerol kinase	6	EC		-	-	14.8
10271	Predicted protein	6			-	-	12.7
10901	Gamma-aminobutyric acid receptor-associated protein	6			-	-	18.1
15982	Ubiquitin domain-containing protein DSK2a	6			-	-	34.3
6140	CBS domain-containing protein CBSCBSPB4	5			-	-	0.0
10555	FRM-1, isoform a	5			-	-	9.0
6465	UBX domain-containing protein 1-A	5			-	-	6.1
2608	Ras association domain-containing protein 10	5			-	-	12.0
5811	Ubtd2 protein	5			-	-	0.0
158	Uncharacterized protein	5			-	-	14.1
8413	Putative uncharacterized protein At1g64630	5	EC		-	-	7.8
8179	Ubiquitin thioesterase OTU1	5	EC		-	-	12.1
5126	Ubiquitin-like family protein	5			-	-	9.6
16548	Probable serine/threonine-protein kinase pats1	4	EC		-	-	59.3
8861	Sorting nexin-31	4			-	-	7.3
7579	Genomic DNA, chromosome 3, TAC clone:K7P8	4			-	-	6.0
16423	Class VII unconventional myosin	4			-	-	67.6
12561	Small ubiquitin-related modifier 5	4			-	-	0.0
10550	Phosphatidylinositol 4-kinase gamma 4	3	EC		-	-	11.3
7207	PB1 domain-containing protein tyrosine kinase	3			-	-	2.9
16019	NADPH oxidase activator 1	3			-	-	18.5
4000	Ubiquitin family protein	3			-	-	4.6
16654	Putative bifunctional E2/E3 enzyme	3	EC		-	-	55.5
11619	Phosphatidylinositol 4-kinase gamma 2	3	EC		-	-	9.6
12250	Ubiquitin carboxyl-terminal hydrolase 26	3	EC		-	-	3.7
16403	DNA damage-inducible protein 1	3			-	-	45.2
14049	Probable very-long-chain enoyl-CoA reductase art-1	3	EC		-	-	4.5
10285	Phosphatidylinositol 4-kinase gamma 3	2	EC		-	-	7.7
8410	CBS domain-containing protein CBSCBSPB2	2			-	-	8.9
13629	Mitogen-activated protein kinase kinase kinase A	2	EC		-	-	0.0
5807	Sorting nexin-31	2			-	-	0.0
6078	Ubiquitin-associated /TS-N domain-containing protein	2			-	-	6.8
7530	Tyrosine-protein phosphatase 1	2	EC		-	-	7.0
14849	Fas associated factor 1	2			-	-	0.0
16414	Protein kinase activator Bem1, putative AFU_orthologue; AFUA_4G04120	2			-	-	46.1
4220	Putative ubiquitin-like protein	2			-	-	3.5
15993	Plexin B2b long isoform	2			-	-	9.4
6506	DNA-damage inducible protein DDI1-like	2			-	-	1.4
10984	Probable serine/threonine-protein kinase WNK4	2	EC		-	-	4.6
4558	DNA damage-inducible protein 1	2			-	-	0.0
7975	Carboxylate clamp-tetratricopeptide repeat protein	2			-	-	5.2
7936	Actin binding protein	2			-	-	9.2
7531	BAG family molecular chaperone regulator 4	2			-	-	5.2
9045	Fimbrin	2			-	-	6.8
9623	Predicted protein	2	EC		-	-	7.1
14782	Sacs protein	2			-	-	0.0
5814	Serine/threonine-protein kinase phg2	2	EC		-	-	12.4
7117	Octicosapeptide/Phox/Bem1p domain-containing protein kinase	2			-	-	9.7
8403	Talin-A	1			-	-	0.0
6145	Myosin-I heavy chain	1			-	-	0.0
14180	Uncharacterized protein C17C9.11c	1			-	-	0.0
15040	Diacylglycerol kinase theta	1	EC		-	-	0.0
6471	Ras guanine nucleotide exchange factor V	1			-	-	0.0
2209	Ribosomal protein S30, isoform A	1			-	-	0.0
14562	AVO1-like protein	1			-	-	0.0
13162	Uncharacterized protein	1			-	-	0.0
8591	RanBP-type and C3HC4-type zinc finger-containing protein 1	1			-	-	0.0
16182	Uncharacterized protein	1			-	-	0.0
5566	Phosphoinositide phospholipase C	1	EC		-	-	0.0
5812	Ras guanine nucleotide exchange factor K	1			-	-	0.0
3933	Ubiquitin family protein	1			-	-	0.0
14456	Serine/threonine-protein kinase pkpA	1	EC		-	-	0.0
4158	Ubiquitin and WLM domain-containing metalloprotease SPCC1442.07c	1			-	-	0.0