The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22912: Cathepsin D (Lysosomal aspartyl protease)

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
6 O65390 (/IDA) O96009 (/IDA) P00796 (/IDA) P06281 (/IDA) P08424 (/IDA) Q59U59 (/IDA)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
4 O93428 (/IDA) P00797 (/IDA) P07267 (/IDA) Q9DD89 (/IDA)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
3 O96009 (/IDA) P00797 (/IDA) P07267 (/IDA)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 P00797 (/IPI) P08424 (/IPI)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2 O09043 (/ISO) P06281 (/ISO)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 O09043 (/IMP)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 O09043 (/ISO)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
1 P00797 (/EXP)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
1 P06281 (/ISO)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
1 Q21966 (/ISS)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
1 O96009 (/NAS)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P06281 (/ISO)
Insulin-like growth factor receptor binding GO:0005159
Interacting selectively and non-covalently with the insulin-like growth factor receptor.
1 P08424 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O09043 (/IPI)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 O96009 (/TAS)
Oligosaccharide binding GO:0070492
Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
1 P07267 (/IDA)
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
1 P07267 (/IPI)
Aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902944
Any aspartic-type endopeptidase activity that is involved in amyloid precursor protein catabolic process.
1 Q9VLK3 (/IDA)

There are 61 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Surfactant homeostasis GO:0043129
Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Retinal pigment epithelium development GO:0003406
The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.
4 A0A0R4IBQ0 (/IMP) Q8AWD9 (/IMP) Q8JH28 (/IMP) Q9DD89 (/IMP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
4 A0A0R4IBQ0 (/IDA) Q8AWD9 (/IDA) Q8JH28 (/IDA) Q9DD89 (/IDA)
Muscle structure development GO:0061061
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
4 A0A0R4IBQ0 (/IMP) Q8AWD9 (/IMP) Q8JH28 (/IMP) Q9DD89 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
3 O65390 (/IDA) O93428 (/IDA) P00797 (/IDA)
Establishment of imaginal disc-derived wing hair orientation GO:0001737
Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
2 O76921 (/IMP) Q9W5G3 (/IMP)
Angiotensin maturation GO:0002003
The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood.
2 P00797 (/IDA) P08424 (/IDA)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
2 P00797 (/TAS) P08424 (/TAS)
Programmed cell death GO:0012501
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
2 O76856 (/IDA) Q05744 (/IDA)
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
2 O76921 (/IMP) Q9W5G3 (/IMP)
Salivary gland cell autophagic cell death GO:0035071
The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis.
2 Q7K485 (/IEP) Q9VEK5 (/IEP)
Autophagic cell death GO:0048102
A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.
2 Q7K485 (/IEP) Q9VEK5 (/IEP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 P00797 (/IMP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 P06281 (/ISO)
Mesonephros development GO:0001823
The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.
1 P06281 (/IEP)
Angiotensin maturation GO:0002003
The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood.
1 P06281 (/IMP)
Angiotensin maturation GO:0002003
The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood.
1 P06281 (/ISO)
Angiotensin maturation GO:0002003
The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood.
1 P00797 (/TAS)
Regulation of blood volume by renin-angiotensin GO:0002016
The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.
1 P06281 (/IMP)
Renin-angiotensin regulation of aldosterone production GO:0002018
The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.
1 P06281 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 Q21966 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 P06281 (/ISO)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 O96009 (/NAS)
Autophagy GO:0006914
The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
1 P07267 (/IMP)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q7K485 (/IMP)
Eggshell chorion assembly GO:0007306
Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell.
1 Q9VQ13 (/IEP)
Eggshell chorion assembly GO:0007306
Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell.
1 Q9VQ13 (/IGC)
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
1 P08424 (/IMP)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
1 Q05744 (/IEP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
1 P06281 (/IEP)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 P07267 (/IMP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 O65390 (/IEP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
1 O65390 (/IDA)
Hormone-mediated signaling pathway GO:0009755
A series of molecular signals mediated by the detection of a hormone.
1 P06281 (/IDA)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P06281 (/IDA)
Lysosomal microautophagy GO:0016237
The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment.
1 P07267 (/IMP)
CVT pathway GO:0032258
A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast.
1 P07267 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P08424 (/IEP)
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
1 O96009 (/IDA)
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
1 O09043 (/IMP)
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
1 O09043 (/ISO)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P08424 (/IEP)
Response to immobilization stress GO:0035902
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.
1 P08424 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P08424 (/IDA)
Drinking behavior GO:0042756
The specific behavior of an organism relating to the intake of liquids, especially water.
1 P06281 (/IMP)
Surfactant homeostasis GO:0043129
Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.
1 O96009 (/IDA)
Surfactant homeostasis GO:0043129
Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.
1 O09043 (/ISO)
Regulation of MAPK cascade GO:0043408
Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
1 P00797 (/IDA)
Regulation of MAPK cascade GO:0043408
Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
1 P06281 (/ISO)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
1 O96009 (/TAS)
Nurse cell apoptotic process GO:0045476
Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process.
1 Q7K485 (/IMP)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
1 P00796 (/IDA)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q9XEC4 (/IEP)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
1 P06281 (/IMP)
Beta-amyloid metabolic process GO:0050435
The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP).
1 P08424 (/IEP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 Q7K485 (/IMP)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 P08424 (/IDA)
Proteolysis involved in cellular protein catabolic process GO:0051603
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
1 P07267 (/IMP)
Necrotic cell death GO:0070265
A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
1 Q21966 (/IGI)
Response to cGMP GO:0070305
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus.
1 P08424 (/IDA)

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Alveolar lamellar body GO:0097208
A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 O96009 (/IDA) P00795 (/IDA) P00796 (/IDA) P00797 (/IDA) P06281 (/IDA) P08424 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
6 O09043 (/IDA) O76856 (/IDA) O96009 (/IDA) Q05744 (/IDA) Q21966 (/IDA) Q7K485 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
3 A2QDI4 (/IDA) O42630 (/IDA) P06281 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 G5EEI4 (/IDA) P08424 (/IDA) Q21966 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 O76856 (/IDA) Q7K485 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 O09043 (/ISO) P06281 (/ISO)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
2 O65390 (/IDA) Q8VYL3 (/IDA)
Alveolar lamellar body GO:0097208
A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
2 O09043 (/IDA) O96009 (/IDA)
Fungal-type vacuole GO:0000324
A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
1 P07267 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P00797 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 O76856 (/RCA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 O09043 (/ISO)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 O76856 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 B9RXH6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O65390 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P00797 (/TAS)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 O65390 (/IDA)
Chorion GO:0042600
A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish.
1 Q9VQ13 (/IGC)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
1 P07267 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 P00797 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O96009 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O09043 (/ISO)
Alveolar lamellar body GO:0097208
A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
1 O09043 (/ISO)
Multivesicular body lumen GO:0097486
The volume enclosed by the outermost membrane of a multivesicular body.
1 O96009 (/TAS)
External side of apical plasma membrane GO:0098591
The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 G5EEI4 (/IDA)