The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Acid Proteases
".
FunFam 22912: Cathepsin D (Lysosomal aspartyl protease)
There are 10 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
Cathepsin D.
[EC: 3.4.23.5]
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
|
52 |
A0A074T3W0
A0A084G9U0
A0A086K9K0
A0A086KM05
A0A086LAA3
A0A086LZI4
A0A086Q2X1
A0A086QG87
A0A0D2MF35
A0A139XZ46 (42 more...) |
Phytepsin.
[EC: 3.4.23.40]
Prefers hydrophobic residues Phe, Val, Ile, Leu, and Ala at P1 and P1', but also cleaves -Phe-|-Asp- and -Asp-|-Asp- bonds in 2S albumin from plant seeds.
|
34 |
A0A084G9U0
A0A0B2P2L1
A0A0B2P5X3
A0A0B2PY44
A0A0B2QD39
A0A0B2QDD4
A0A0B2QX92
A0A0B2RKZ4
A0A0B2RVB1
A0A0B2S2B8 (24 more...) |
Saccharopepsin.
[EC: 3.4.23.25]
Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not act on esters of Tyr or Arg.
|
30 |
A0A084G9U0
A0A0B7FUH8
A0A0J5PY94
A0A0J6IM61
A0A0J6YGT1
A0A0J8R1L0
A0A0J8UCV1
A0A0L8VFV1
A6ZW99
B0XXK9 (20 more...) |
Renin.
[EC: 3.4.23.15]
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
|
11 |
P00796
P00797
P06281
P08424
P52115
P60016
Q6DLS0
Q6DLW5
Q6DYE7
Q7M3D2 (1 more...) |
Gastricsin.
[EC: 3.4.23.3]
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.
|
9 | A0A084G9U0 P81498 Q64411 Q689Z7 Q6HA02 Q9DDV5 Q9DE45 Q9GMY3 Q9GMY4 |
Pepsin A.
[EC: 3.4.23.1]
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.
|
8 | A0A0F4YSP8 G3Y3K2 Q00070 Q6HA03 Q6HA04 Q6HA05 Q9PUR8 Q9PUR9 |
Pepsin B.
[EC: 3.4.23.2]
Degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than that of pepsin A; does not cleave 1-Phe-|-Val-2, 4-Gln-|-His-5 or 23-Gly-|-Phe-24.
|
1 | Q8SQ41 |
Sterol 3-beta-glucosyltransferase.
[EC: 2.4.1.173]
UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside.
|
1 | A0A139IVU9 |
Candidapepsin.
[EC: 3.4.23.24]
Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.
|
1 | A3LYI5 |
Chymosin.
[EC: 3.4.23.4]
Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single 104-Ser-Phe-|-Met-Ala-107 bond in kappa-chain of casein.
|
1 | U6A6W7 |