CATH Superfamily 2.30.42.10

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Enzyme?	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
24028	Periplasmic serine protease Do	43742	EC	3D	1ky9A03	-	99.7
24085	Periplasmic serine protease Do	40890	EC	3D	1ky9B04	-	97.9
4972	Serine endoprotease	24440	EC	3D	1sotA03	-	41.2
23577	Zinc metallopeptidase RseP	13189		3D	2zplA00	-	51.1
23881	Tail-specific protease C-terminal-processing peptidase	7030	EC		-	-	93.2
24083	Partitioning defective 3 homolog	5676	EC	3D	3b76A00	-	87.7
24100	MAGUK p55 subfamily member 2	4773	EC	3D	1kwaA00	-	88.1
24029	Zinc metallopeptidase RseP	4769		3D	2zpmA00	-	98.0
23891	Disks large homolog 1	3408	EC	3D	4oajA00	-	92.6
24039	Syntrophin-like 1, isoform C	2581	EC	3D	2dc2A00	-	92.8
24097	Golgi reassembly-stacking protein 2	2276		3D	4reyA01	-	85.5
23925	Na + +	1927		3D	1gq5A00	-	89.4
24207	PDZ domain-containing protein GIPC1	1766	EC	3D	1ujvA00	-	83.9
23528	Disks large homolog 1	1382		3D	5jxbA00	-	85.4
23894	Multiple PDZ domain protein	1322	EC	3D	1d5gA00	-	94.9
2028	2-alkenal reductase	1249	EC		-	-	7.9
23883	Membrane-associated guanylate kinase	1160	EC	3D	1ueqA00	-	93.6
23601	Regulating synaptic membrane exocytosis 2	1135		3D	2cssA00	-	78.0
23997	Membrane-associated guanylate kinase, WW and PDZ domain-containing	1082		3D	1uewA00	-	89.8
24158	Pro-apoptotic serine protease nma111	1061	EC	3D	3qo6A03	-	91.0
23742	Tight junction protein ZO-1	1034	EC	3D	4yyxA00	-	82.8
23761	Partitioning defective 6 gamma	1023		3D	1ry4A00	-	92.8
23851	Amyloid beta A4 protein related	1022		3D	1u39A00	-	82.8
23570	Spinophilin, isoform I	935		3D	4xhvA00	-	92.7
23683	Multiple PDZ domain protein	894		3D	2dm8A00	-	81.9
23435	Tax1-binding protein 3	888		3D	3diwA00	-	69.4
23774	Multiple PDZ domain protein	886		3D	2d92A00	-	88.5
15032	RIP metalloprotease RseP	872			-	-	1.4
23931	Segment polarity protein dishevelled	865		3D	1mc7A00	-	78.2
23662	Microtubule-associated serine/threonine-protein kinase 4	861	EC	3D	2kqfA00	-	88.9
23811	Magi1 protein	848		3D	1wfvA01	-	85.3
23694	PDZ and LIM domain 1	848		3D	2pktA00	-	93.2
23696	Oncorhynchus mykiss genomic scaffold, scaffold_5542	802		3D	1uepA00	-	85.7
24131	Proteasome 26S non-ATPase subunit 9	794	EC		-	-	89.6
23960	Multiple PDZ domain protein	772			-	-	77.5
23750	Multiple PDZ domain protein	762		3D	2dluA00	-	85.4
23708	Tight junction protein ZO-1	758		3D	3shuA00	-	89.2
23695	Serine protease htrA-like	732			-	-	81.6
23740	Multiple PDZ domain protein	698		3D	2fcfA00	-	97.0
23492	Partitioning defective 3 homolog	693		3D	2kohA00	-	88.1
23869	Partitioning defective 3 homolog	680			-	-	88.7
23522	Cortactin-binding protein 1	670		3D	3o5nA00	-	66.1
23766	Multiple PDZ domain protein	664		3D	2qg1A00	-	85.2
23958	Guanine nucleotide exchange factor	626			-	-	96.1
23691	Signal-induced proliferation-associated 1-like protein 1	612			-	-	86.8
23962	Magi1 protein	547			-	-	90.1
23703	Tyrosine-protein phosphatase non-receptor type	538	EC	3D	2cs5A01	-	88.7
23590	CNK3/IPCEF1 fusion protein long isoform	523			-	-	77.0
23723	Rho guanine nucleotide exchange factor 11	498		3D	2dlsA00	-	93.7
23664	PDZ domain-containing protein 11	484		3D	1wi2A00	-	69.5
23956	Probable periplasmic serine endoprotease DegP-like	469	EC		-	-	97.8
24093	Stage IV sporulation serine peptidase	467	EC	3D	3wklA02	-	98.7
23938	Probable periplasmic serine endoprotease DegP-like	456	EC		-	-	86.1
24153	Putative zinc metalloprotease SP_0263	446			-	-	95.3
23671	Glutamate receptor-interacting protein 1	445		3D	1v5qA00	-	75.8
23857	Protein Shroom3	442		3D	2edpA01	-	86.2
23557	Glutamate receptor-interacting protein 1	438		3D	1n7eA00	-	40.8
23882	Dyschronic, isoform J	418			-	-	84.6
24147	General secretion pathway protein C	403		3D	2i6vA00	-	83.9
23672	Glutamate receptor-interacting protein 1	402		3D	2qt5A01	-	69.0
23593	Protein scribble homolog	394		3D	1ujuA00	-	55.7
23627	Protein scribble homolog	381		3D	4wytA01	-	55.8
23548	Protein scribble homolog	378		3D	1x5qA01	-	64.7
6906	Neuroblast differentiation-associated protein AHNAK	377			-	-	76.3
23950	Pro-apoptotic serine protease nma111	370			-	-	97.1
16959	Probable CtpA-like serine protease	369			-	-	0.0
24197	Membrane-associated zinc metalloprotease	366			-	-	96.2
23445	Multiple PDZ domain protein	365		3D	2dazA01	-	71.7
23682	E3 ubiquitin-protein ligase PDZRN3	363	EC	3D	1wh1A01	-	69.3
23503	Glutamate receptor-interacting protein 1	358		3D	1p1dA02	-	63.0
23667	GA15635, isoform F	358			-	-	80.2
19859	Membrane-associated zinc metalloprotease, putative	353			-	-	12.4
23678	Glutamate receptor-interacting protein 1	342		3D	2jilA00	-	83.0
23755	Syntenin-1 isoform 1	331		3D	1n99A02	-	91.2
23733	E3 ubiquitin-protein ligase LNX	326	EC	3D	3vqfA00	-	83.6
23845	PICK1 ortholog, isoform A	318		3D	2gzvA01	-	85.4
23870	Regulator of G-protein signaling 12	314		3D	2kv8A00	-	83.8
23947	LIM domain kinase 2	300	EC	3D	2yubA01	-	89.5
87	Rho GTPase-activating protein 23	298			-	-	81.8
23730	E3 ubiquitin-protein ligase LNX	294	EC		-	-	75.1
23571	Multiple PDZ domain protein	292			-	-	84.8
23877	Rho GTPase-activating protein 100F	270			-	-	82.8
23531	Serine protease HTRA1	266		3D	2joaA01	-	70.0
2129	Scribbled, isoform Q	256			-	-	18.6
14350	LIM domain-binding protein 3	255		3D	1wjlA00	-	38.7
17523	Deafness, autosomal recessive 31, isoform CRA_b	249		3D	1ufxA00	-	77.0
23579	Multiple PDZ domain protein	242			-	-	72.9
3853	Afadin	242		3D	3axaA00	-	67.2
23555	PDZD7 splice variant 7	238		3D	2eehA00	-	78.2
457	PDZ domain-containing protein 2	234			-	-	58.1
7523	Scribbled, isoform L	229			-	-	14.9
23941	Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 1	227			-	-	87.4
23680	PDZ and LIM domain protein 7	227		3D	2q3gA00	-	68.0
881	Disks large homolog 5	226		3D	1uitA00	-	68.9
372	Multiple PDZ domain protein	223			-	-	51.1
23650	PDZD7 splice variant 7	218			-	-	69.9
23706	Harmonin isoform b4	216		3D	1x5nA00	-	72.6
15753	FERM and PDZ domain-containing protein 4	216			-	-	51.3
23455	Harmonin isoform b4	216		3D	3k1rA02	-	71.9
368	InaD-like Drosophila	214		3D	2ehrA00	-	66.7
3874	Disks large homolog 5	209			-	-	69.5
13093	Serine protease pepA	204			-	-	7.0
23625	Nitric oxide synthase, brain	200	EC	3D	1b8qA00	-	72.8
23418	Rho GTPase-activating protein 21	198		3D	2yuyA00	-	76.7
24154	PDZ domain-containing protease	193			-	-	0.0
979	Multiple PDZ domain protein	185		3D	2o2tA00	-	49.9
865	Harmonin isoform b4	181		3D	1v6bA00	-	73.5
10659	Multiple PDZ domain protein	179		3D	2fneA00	-	43.9
23595	Syntaxin-binding protein 4	173		3D	1wi4A01	-	74.4
12049	Glutamate receptor-interacting protein 1	172			-	-	52.5
24165	DegP protease family protein	171			-	-	92.7
16127	Still life, isoform N	171			-	-	38.3
21698	Trypsin-like serine protease with PDZ domain	170			-	-	0.0
13033	Regulator of G-protein signaling 3	167		3D	1whdA00	-	42.3
23565	ER lumen protein-retaining receptor	165			-	-	62.1
11385	Heat shock protein HtrA	163	EC		-	-	66.5
23865	Ligand of numb-protein X 2	157			-	-	73.8
295	Glutamate receptor-interacting protein 1	156		3D	1m5zA00	-	52.6
15586	DEP domain-containing mTOR-interacting protein	156			-	-	61.0
1364	Canoe, isoform H	152			-	-	35.5
5976	Erbb2 interacting protein	151		3D	1mfgA00	-	46.0
105	PDZ domain-containing protein 2	148			-	-	73.0
24070	FERM and PDZ domain-containing protein 1	143		3D	2edvA00	-	87.8
2377	Syntenin-1 isoform 1	142		3D	1n99A01	-	60.0
9446	Whirlin	142		3D	1uezA00	-	66.0
17526	Putative zinc metalloprotease SAR1238	141			-	-	23.4
524	E3 ubiquitin-protein ligase LNX	141	EC		-	-	72.8
23606	Similar to Piccolo protein Aczonin	141		3D	1ujdA00	-	60.5
11994	Probable CtpA-like serine protease	139	EC		-	-	7.1
23465	Tyrosine-protein phosphatase non-receptor type 13	136	EC	3D	5gljA00	-	61.4
23456	Tight junction protein ZO-1	134			-	-	31.4
2856	Serine protease HTRA3	132		3D	2p3wA01	-	66.0
251	Tyrosine-protein phosphatase non-receptor type 13	132	EC		-	-	51.1
23665	PDZ and LIM domain protein 3	129		3D	1v5lA00	-	68.3
871	Leucine-rich repeat-containing protein 7	129			-	-	34.2
23653	Tyrosine-protein phosphatase non-receptor type 13	128	EC		-	-	67.5
16474	Chromosome 6 SCAF14605, whole genome shotgun sequence	126			-	-	71.7
9058	Protein scribble homolog	126		3D	1whaA01	-	37.8
23821	PDZ domain-containing protein 6	125			-	-	86.7
23614	Glutamate receptor-interacting protein 2	123		3D	1v62A00	-	58.0
23663	PDZ and LIM domain protein 2	120		3D	3pdvA00	-	53.9
23496	Tyrosine-protein phosphatase non-receptor type 13	119	EC		-	-	50.0
4902	RIP metalloprotease RseP	118			-	-	14.0
4413	PDZ and LIM domain 5	118		3D	2uzcA00	-	22.8
23479	InaD-like Drosophila	115		3D	2db5A00	-	63.8
11039	PDZ domain-containing protein 2	115			-	-	12.2
23690	Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 1	113		3D	3qikA01	-	67.8
23461	InaD-like Drosophila	113			-	-	55.4
9837	Serine protease pepD	113	EC		-	-	1.4
23888	Pro-apoptotic serine protease NMA111	108			-	-	91.1
9847	RIP metalloprotease RseP	106			-	-	21.3
15126	RIP metalloprotease RseP	105			-	-	25.8
23757	CG6416-PB, isoform B	104			-	-	78.5
6715	Periaxin	100			-	-	41.8
23476	Na + +	100		3D	4f8kA00	-	59.8
23441	PDZ domain-containing protein 2	98			-	-	30.2
23597	Na + +	97			-	-	79.1
2770	Serine protease HtrA	95	EC		-	-	5.5
23553	T-lymphoma invasion and metastasis-inducing protein 2	92			-	-	52.0
8599	General receptor for phosphoinositides 1-associated scaffold protein	91		3D	2pntA00	-	30.5
10894	T-lymphoma invasion and metastasis-inducing protein 1	85		3D	2d8iA01	-	73.7
6595	PDZ-containing carboxyl-terminal protease processing protease	83	EC		-	-	1.4
430	Pro-interleukin-16	82			-	-	58.5
10454	Putative zinc metalloprotease mll0638	80			-	-	52.0
5982	RIP metalloprotease RseP	80			-	-	2.5
23844	Putative rhophilin-2-like protein RHPN2P1	79		3D	2vsvA01	-	84.1
4488	Polychaetoid, isoform G	79	EC		-	-	34.3
5264	Whirlin	79		3D	1uf1A00	-	49.9
1736	Polychaetoid, isoform I	78	EC		-	-	4.3
606	Big bang, isoform C	74			-	-	60.7
23434	Disks large homolog 5	74			-	-	55.9
23514	Tight junction protein ZO-2	72			-	-	48.8
23621	Caspase recruitment domain-containing protein 11	71			-	-	73.2
4084	Serine protease HTRA2, mitochondrial	69	EC	3D	1lcyA03	-	40.7
4993	Periplasmic serine peptidase DegS	67	EC		-	-	0.0
23505	Synaptopodin 2	67			-	-	45.3
2465	Sorting nexin family member 27 Predicted	67		3D	3qdoA00	-	33.5
11704	YIL007Cp-like protein	65		3D	4o06A00	-	12.9
16406	Signal-induced proliferation-associated protein 1	65			-	-	59.0
23668	Tight junction protein ZO-3	65			-	-	41.2
8667	Na + +	63			-	-	39.8
23538	Synaptopodin 2-like protein	61			-	-	50.5
23487	Ras-associating and dilute domain-containing protein	60		3D	1um1A00	-	42.7
2218	PDZ domain containing 8	60			-	-	30.8
23460	Probable serine protease HTRA4	59			-	-	58.6
24172	Putative membrane-associated zinc metalloprotease	58			-	-	80.4
10511	Stardust, isoform M	54	EC		-	-	14.6
23904	Pro-apoptotic serine protease NMA111	52			-	-	76.0
509	Putative microtubule-associated serine/threonine kinase	52			-	-	18.2
5981	Serine protease Do-like HtrA	50	EC		-	-	1.3
5262	Outer membrane stress sensor protease DegS	50	EC		-	-	4.2
23463	Glutamate receptor-interacting protein 2	50			-	-	26.9
7755	PDZ domain-containing protein 5C	49			-	-	43.4
3262	Dyschronic, isoform G	49			-	-	41.4
20684	Protease DO	48	EC		-	-	3.6
9824	Putative uncharacterized protein	46			-	-	20.5
1366	E3 ubiquitin-protein ligase PDZRN3	46	EC	3D	1uhpA00	-	35.0
5549	Rap GTPase interactor	45			-	-	30.2
1715	Serine protease Do-like HtrB	44	EC		-	-	5.6
6452	Uncharacterised protein	44			-	-	2.5
9877	Myosin heavy chain-like, isoform A	39	EC		-	-	41.2
23438	Bazooka, isoform B	38			-	-	22.1
6159	Fife, isoform D	38			-	-	25.5
6779	RIP metalloprotease RseP	38			-	-	52.8
15026	Lon protease 1	36	EC		-	-	0.0
15712	Cell division topological determinant MinJ	36			-	-	0.0
4177	Na + +	35		3D	4p0cA00	-	38.3
23550	PDZ domain-containing protein 2	34			-	-	35.7
14351	Zinc metalloprotease	33			-	-	1.5
4189	CG6509, isoform D	32			-	-	45.3
10179	Putative zinc metalloprotease Atu1380	32			-	-	11.3
10507	Glutamate receptor-interacting protein 2	31			-	-	28.2
23629	Probable periplasmic serine endoprotease DegP-like	31	EC		-	-	34.6
11841	GA16054, isoform C	29			-	-	12.6
19	GI18770	28	EC		-	-	26.6
16958	Putative zinc metalloprotease CPE1693	27			-	-	4.1
13694	Connector enhancer of kinase suppressor of ras 1	27			-	-	48.2
15702	Carboxy-terminal processing protease CtpA	27	EC		-	-	2.8
21500	General secretion pathway protein C	26			-	-	20.1
9190	Putative zinc metalloprotease RSc1411	26			-	-	17.1
4013	Putative membrane serine protease Do	24	EC		-	-	2.4
9179	LIM domain only protein 7	24		3D	2eaqA00	-	5.4
65	Scribbled, isoform K	23			-	-	8.7
15021	Na + +	21			-	-	15.3
1716	Serine protease Do-like HtrA	21	EC		-	-	5.0
13123	Probable membrane-associated zinc protease	21			-	-	3.1
19400	Glutamate receptor binding protein, isoform B	21			-	-	45.5
16408	Probable membrane-associated zinc protease	21			-	-	1.5
110	GD25223	20	EC		-	-	31.2
16956	Serine endoprotease DegS	20	EC		-	-	8.6
11085	Inactivation no afterpotential D, isoform B	19		3D	2la8A00	-	24.8
7530	Putative zinc metalloprotease RSc1411	18			-	-	14.6
1874	PDZ domain-containing protein 5C	18			-	-	17.9
9188	Putative zinc metalloprotease	18			-	-	3.4
1142	Glutamate receptor binding protein, isoform B	18			-	-	16.7
23446	Serine protease HTRA2, mitochondrial	18	EC		-	-	17.6
420	CG6509, isoform D	17			-	-	12.7
9193	Inactivation no afterpotential D, isoform B	17			-	-	44.8
1251	Protein AHNAK2	17			-	-	23.3
297	MPZ-1, isoform i	16			-	-	14.1
1021	MPZ-1, isoform a	16			-	-	10.0
6013	Putative tricorn protease	16			-	-	31.8
23494	Syntenin-2	16			-	-	24.0
23581	ZOO-1, isoform e	16	EC		-	-	50.9
308	Big bang, isoform C	15			-	-	11.1
876	MPZ-1, isoform e	15			-	-	22.0
9573	Serine protease	15	EC		-	-	50.0
1472	Protease Do-like 9	15			-	-	12.3
1891	MPZ-1, isoform d	14			-	-	14.3
749	Dyschronic, isoform E	14			-	-	6.1
8112	Protostome-specific GEF, isoform G	14			-	-	2.5
24086	Probable periplasmic serine endoprotease DegP-like	13	EC		-	-	34.7
8635	MPZ-1, isoform e	13			-	-	14.2
3880	PDZ domain-containing RING finger protein 4	12			-	-	8.0
16528	MPZ-1, isoform c	12			-	-	7.3
1333	MPZ-1, isoform d	12			-	-	9.0
23961	Carboxyl-terminal-processing peptidase 2, chloroplastic	12	EC		-	-	58.5
2261	Inactivation no afterpotential D, isoform B	12			-	-	20.9
141	Glutamate receptor binding protein, isoform B	11			-	-	13.8
415	Inactivation no afterpotential D, isoform B	11			-	-	14.4
1478	Protease Do-like 2, chloroplastic	10			-	-	6.4
9580	MAGI-1, isoform a	10			-	-	20.0
4974	Tricorn protease homolog 1	10			-	-	14.5
940	NAB-1, isoform e	9			-	-	13.9
16435	Carboxyl-terminal protease	9			-	-	0.0
7986	MAGI-1, isoform b	9			-	-	16.3
6479	Bazooka, isoform D	9			-	-	3.9
11119	ZOO-1, isoform b	9			-	-	2.7
5047	ZOO-1, isoform a	9	EC		-	-	25.0
17024	Putative guanine nucleotide exchange factor RhoGEF2	9			-	-	0.0
3883	Serine protease HTRA4	8			-	-	11.1
663	Lap1, isoform B	8			-	-	3.1
3908	CG6509, isoform D	8			-	-	3.2
13036	Protein scribble homolog	8			-	-	0.0
13370	Connector enhancer of KSR protein CNK	7			-	-	8.5
23943	Probable membrane metalloprotease ARASP2, chloroplastic	7			-	-	53.0
564	Inactivation no afterpotential D, isoform B	7			-	-	6.3
23797	Putative serine protease HhoA	6			-	-	40.9
21780	FI03335p	6			-	-	17.2
22375	Binding protein	6			-	-	16.2
18923	PXF-1, isoform e	6			-	-	0.0
4913	SHN-1, isoform a	6			-	-	9.2
5132	Membrane metalloprotease ARASP, chloroplastic	6			-	-	8.3
12369	ALP-1, isoform d	6			-	-	5.1
23949	Carboxyl-terminal protease	5	EC		-	-	42.8
23816	Carboxyl-terminal-processing protease	5	EC		-	-	33.1
18891	Protease Do-like 7	5			-	-	11.6
909	LIM-8, isoform b	5			-	-	24.1
5032	Glutamate receptor binding protein, isoform B	5			-	-	5.5
22113	Putative zinc metalloprotease CPn_0344/CP_0416/CPj0344/CpB0350	5			-	-	0.0
23305	Metallo endopeptidase	5			-	-	5.5
23796	Putative protease Do-like 13	4			-	-	44.5
21121	Putative zinc metalloprotease BB_0118	4			-	-	4.7
17528	Probable CtpA-like serine protease	4			-	-	0.0
5053	DLG-1, isoform a	4			-	-	12.3
19861	Putative zinc metalloprotease TM_0890	4			-	-	0.0
4447	Partitioning defective protein 3	3			-	-	0.0
8185	Protease Do-like 4, mitochondrial	3			-	-	7.1
23388	Membrane-bound transcription factor site 2 protease	3			-	-	2.3
2772	Serine protease HTRA1	3			-	-	8.3
2017	Protein Rhpn1	3			-	-	6.5
7770	Carboxyl-terminal-processing peptidase 1, chloroplastic	3	EC		-	-	0.0
13697	Putative zinc metalloprotease FN1322	2			-	-	0.0
21208	Uncharacterized protein	2			-	-	0.0
78	Partitioning defective protein 3	2			-	-	0.0
1269	Slip1, isoform C	2			-	-	8.6
9293	P100 LMO7 variant protein	2			-	-	0.0
6449	Protein lap1	2			-	-	0.0
23624	Cytoplasmic signalling transducer	2			-	-	0.0
11731	Uncharacterized protein	2			-	-	0.0
23743	Protein inturned	2			-	-	18.5
15027	PDZ and LIM domain protein 7	2			-	-	6.5
23951	Putative serine protease HtrA	2			-	-	41.3
23814	Pro-apoptotic serine protease NMA111	2			-	-	33.6
18073	Na + +	2			-	-	1.4
655	Glutamate receptor-interacting protein 2	2			-	-	3.8
11328	Putative protease Do-like 12, mitochondrial	2			-	-	17.0
5482	Putative zinc metalloprotease all3971	2			-	-	1.3
13749	Sdcbp protein	2			-	-	0.0
5484	Putative protease Do-like 14	2			-	-	8.8
8617	Uncharacterized protein	2			-	-	0.0
23048	Pro-apoptotic serine protease NMA111	1			-	-	0.0
23609	Putative uncharacterized protein	1			-	-	0.0
13699	Membrane protein insertase YidC	1			-	-	0.0
10063	Uncharacterized protein	1			-	-	0.0
8229	Uncharacterized protein	1			-	-	0.0
24004	PDZ domain-containing protein C23G3.12c	1			-	-	0.0
20879	Uncharacterized protein MJ0971	1			-	-	0.0
987	Putative protease Do-like 11, mitochondrial	1			-	-	0.0
13251	Uncharacterized protein	1			-	-	0.0
15028	Probable CtpA-like serine protease	1			-	-	0.0
10449	Membrane endopeptidase MmpA	1			-	-	0.0
20648	Probable 26S proteasome regulatory subunit p27	1			-	-	0.0
12348	Protease Do-like 10, mitochondrial	1			-	-	0.0
18071	Putative zinc metalloprotease DR_1507	1			-	-	0.0