CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.42 | Pdz3 Domain |
|
2.30.42.10 | PDZ domain |
Domain Context
CATH Clusters
| Superfamily | 2.30.42.10 |
| Functional Family | Serine protease HTRA2, mitochondrial |
Enzyme Information
| 3.4.21.108 |
HtrA2 peptidase.
based on mapping to UniProt O43464
Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.
-!- Up-regulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment. -!- Can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP). -!- Belongs to peptidase family S1B.
|
UniProtKB Entries (1)
| O43464 |
HTRA2_HUMAN
Homo sapiens
Serine protease HTRA2, mitochondrial
|
PDB Structure
| PDB | 1LCY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
Nat.Struct.Biol.
|