CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.42 | Pdz3 Domain |
|
2.30.42.10 | PDZ domain |
Domain Context
CATH Clusters
| Superfamily | 2.30.42.10 |
| Functional Family | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 |
Enzyme Information
| 2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt P09619
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| P09619 |
PGFRB_HUMAN
Homo sapiens
Platelet-derived growth factor receptor beta
|
PDB Structure
| PDB | 1GQ5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Determinants of the Na+/H+ Exchanger Regulatory Factor Interaction with the Beta 2 Adrenergic and Platelet-Derived Growth Factor Receptors
J.Biol.Chem.
|