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CATH Superfamily 2.170.270.10

SET domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SET domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Putative histone-lysine N-methyltransferase EZH2
812
3D
 4mi5A00 - 82.6
2
Histone-lysine N-methyltransferase
572
3D
 3ooiA00 - 78.0
3
Histone-lysine N-methyltransferase
537
3D
 4z4pA00 - 85.2
4
Histone-lysine N-methyltransferase
481 - - 73.4
5
Euchromatic histone-lysine N-methyltransferase 2
481
3D
 5vseB00 - 66.4
6
Histone-lysine N-methyltransferase
350
3D
 4au7B02 - 89.0
7
PR domain zinc finger protein 10
334
3D
 3ihxD01 - 82.8
8
Histone-lysine N-methyltransferase
284
3D
 2r3aA00 - 78.0
9
SET domain-containing protein 5
223 - - 65.5
10
Histone-lysine N-methyltransferase
197 - - 74.1
11
Histone-lysine N-methyltransferase
193
3D
 4ypuB00 - 72.8
16
Histone-lysine N-methyltransferase
157
3D
 5lszA00 - 77.6
12
PR domain zinc finger protein 8
156 - - 76.8
13
Histone-lysine N-methyltransferase SMYD1 isoform 1
156 - - 97.4
14
PR domain-containing protein 11
155
3D
 3rayA00 - 58.5
15
Zinc finger protein
154 - - 62.1
17
Histone-lysine N-methyltransferase
146 - - 78.6
24
Histone-lysine N-methyltransferase SETD7
142
3D
 5yltA02 - 58.8
21
Histone-lysine N-methyltransferase
140
3D
 6bozB00 - 64.8
19
PR domain zinc finger protein 1
130
3D
 3dalB00 - 83.3
18
PR domain zinc finger protein 12
129 - - 48.0
20
Histone-lysine N-methyltransferase
118 - - 58.6
22
PR domain zinc finger protein 4
107 - - 59.8
23
putative histone-lysine N-methyltransferase PRDM6
104 - - 74.5
25
MDS1 and EVI1 complex locus protein isoform X1
99 - - 68.6
26
PR domain zinc finger protein 2
92
3D
 2jv0A01 - 40.0
27
PR domain zinc finger protein 13
57 - - 62.1
28
Histone-lysine N-methyltransferase
56 - - 82.7
31
probable histone-lysine N-methyltransferase PRDM7
55
3D
 4c1qB00 - 89.9
29
Histone-lysine N-methyltransferase SETDB2
54 - - 89.6
39
Histone-lysine N-methyltransferase SMYD3
54
3D
 5v37A01 - 53.7
30
Histone-lysine N-methyltransferase ATX4
53 - - 20.3
38
Histone-lysine N-methyltransferase ATXR5
49
3D
 5vbcB00 - 73.5
32
PR domain containing 14
49 - - 70.2
33
Histone-lysine N-methyltransferase
48 - - 70.7
34
Histone-lysine N-methyltransferase
47 - - 71.0
35
Histone-lysine N-methyltransferase
45 - - 76.3
36
Blimp-1, isoform A
43 - - 86.4
37
Histone-lysine N-methyltransferase
41 - - 64.2
40
Histone-lysine N-methyltransferase
30 - - 51.0
41
Histone-lysine N-methyltransferase SETMAR
30
3D
 3bo5A00 - 63.2
43
Histone-lysine N-methyltransferase
25 - - 75.6
42
Variant-silencing SET protein
25 - - 12.5
44
Zinc finger protein 408
23 - - 89.2
50
Chromosome 1, whole genome shotgun sequence
18
3D
 3kmaB00 - 85.1
45
Putative zinc finger protein ZFPM2
18 - - 34.1
49
Histone-lysine N-methyltransferase, putative
16
3D
 4rz0B00 - 12.5
51
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6
16
3D
 6a5nA03 - 80.7
46
SET-domain containing protein lysine methyltransferase family protein
16 - - 59.4
48
Histone-lysine N-methyltransferase, putative
15 - - 0.0
47
Histone-lysine N-methyltransferase
15 - - 13.0
52
SET and MYND domain-containing protein 4
13 - - 17.4
55
PR/SET domain 2
12 - - 12.0
56
Histone-lysine N-methyltransferase, H3 lysine-4 specific
12 - - 57.7
53
Histone-lysine N-methyltransferase
12 - - 74.8
54
Blast:Chromosome-associated kinesin KIF4A
12 - - 30.4
58
Histone-lysine N-methyltransferase
11 - - 66.8
57
Histone-lysine N-methyltransferase
11 - - 81.0
61
Down and out, isoform A
10 - - 4.6
60
SET domain containing protein
10 - - 20.1
62
Histone-lysine N-methyltransferase, H3 lysine-36 specific
10 - - 65.2
59
Potential protein lysine methyltransferase SET5
10 - - 0.0
63
SET domain protein, putative
9 - - 2.9
64
SET_domain_containing_protein_-_putative
9 - - 8.8
65
Histone-lysine N-methyltransferase ATXR3
9 - - 13.4
66
Histone-lysine N-methyltransferase
9 - - 79.3
67
Uncharacterized protein, isoform D
9 - - 12.1
68
SET domain-containing protein
8 - - 2.0
69
protein msta
8 - - 18.6
70
protein msta
8 - - 14.8
71
Down and out, isoform A
8 - - 6.6
74
PR domain 14
8 - - 74.9
72
SET
Trithorax/polycomb
8 - - 17.1
73
AGAP013139-PA
8 - - 51.4
76
Histone-lysine N-methyltransferase
7 - - 46.2
77
protein msta
7 - - 13.9
75
Histone-lysine N-methyltransferase 2D
7 - - 31.5
98
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4
7
3D
 4qepA03 - 9.3
78
SMYD family member 5
6 - - 54.3
80
SET
Trithorax/polycomb
6 - - 19.0
82
Histone-lysine N-methyltransferase
6 - - 45.3
81
GD10068
6 - - 13.3
79
GM24661
6 - - 10.9
83
PR/SET domain 2
6 - - 32.5
85
Histone-lysine N-methyltransferase family member SUVH9
6
3D
 4nj5A02 - 32.9
89
N-lysine methyltransferase SMYD2
5 - - 35.0
91
Uncharacterized protein
5 - - 8.8
92
Pleiomorphic adenoma gene-like 1
5 - - 10.9
90
SET-8
5 - - 9.6
84
UpSET, isoform A
5 - - 4.2
93
Histone-lysine N-methyltransferase
5 - - 10.0
96
Histone-lysine N-methyltransferase set-26
5 - - 69.3
94
GM20595
5 - - 9.9
95
Uncharacterized protein
5 - - 14.6
86
Histone-lysine N-methyltransferase
5 - - 56.3
87
Zinc finger protein
5 - - 18.8
88
Predicted protein
5 - - 80.9
105
Uncharacterized protein
4 - - 41.8
99
Histone-lysine N-methyltransferase Su
var
4 - - 20.2
102
AGAP013275-PA
4 - - 6.9
100
PR domain-containing 2, with ZNF domain b
4 - - 21.9
103
Hamlet, isoform B
4 - - 8.1
101
Putative positive regulatory Domain/B-lymphocyte induced maturation protein 1, version B
4 - - 41.5
106
Histone-lysine N-methyltransferase
4 - - 70.0
104
PR/SET domain 16
4 - - 0.0
97
Histone-lysine N-methyltransferase
4 - - 73.7
112
ATP-grasp domain containing protein, putative
3 - - 28.2
111
Probable histone-lysine N-methyltransferase lin-59
3 - - 30.5
113
Histone-lysine N-methyltransferase
3 - - 35.8
119
Histone-lysine N-methyltransferase
3 - - 28.2
110
Histone-lysine N-methyltransferase
3 - - 3.8
118
Histone-lysine N-methyltransferase
3 - - 4.8
116
Prdm2 protein
3 - - 6.9
108
Histone-lysine N-methyltransferase SETD5
3 - - 5.3
117
PR domain zinc finger protein 10
3 - - 2.2
109
Histone-lysine N-methyltransferase SUVR5
3 - - 4.6
107
N-lysine methyltransferase KMT5A-B
3 - - 15.3
115
Uncharacterized protein
3 - - 8.5
208
Histone-lysine N-methyltransferase, H3 lysine-9 specific
3
3D
 1mvxA00 - 0.0
114
PR domain zinc finger protein 10-like Protein
3 - - 70.2
142
SET domain containing protein, putative
2 - - 0.0
128
SMYD family member 5
2 - - 11.5
132
Histone-lysine N-methyltransferase
2 - - 7.8
149
Myeloid/lymphoid or mixed-lineage leukemia
2 - - 29.4
139
PR domain zinc finger protein 13
2 - - 0.0
129
Histone-lysine N-methyltransferase
2 - - 6.5
124
PR domain 4
2 - - 14.2
131
Histone-lysine N-methyltransferase
2 - - 0.0
148
Predicted protein
2 - - 42.2
141
Histone-lysine N-methyltransferase
2 - - 8.7
144
Uncharacterized protein
2 - - 10.9
125
Histone-lysine N-methyltransferase
2 - - 36.1
126
Euchromatic histone lysine N-methyltransferase 2a
2 - - 10.8
143
SET domain containing protein, putative
2 - - 0.0
133
Uncharacterized protein
2 - - 30.8
134
Uncharacterized protein
2 - - 38.7
127
Histone-lysine N-methyltransferase Clr4
AFU_orthologue AFUA_1G11090
2 - - 0.0
136
Uncharacterized protein
2 - - 20.0
137
Putative transcription factor blimp-1/prdi-bf1
2 - - 9.5
147
Uncharacterized protein
2 - - 36.4
135
Uncharacterized protein
2 - - 42.7
145
Histone-lysine N-methyltransferase
2 - - 0.0
120
Predicted protein
2 - - 34.1
121
Histone-lysine N-methyltransferase
2 - - 37.8
146
Histone-lysine N-methyltransferase
2 - - 37.4
138
Predicted protein
2 - - 0.9
130
Uncharacterized protein
2 - - 0.0
140
Histone-lysine N-methyltransferase
2 - - 9.5
122
SET
Trithorax/polycomb
2 - - 35.3
150
PR/SET domain 13
2 - - 25.2
123
PR domain-containing 1b, with ZNF domain
2 - - 9.1
191
Uncharacterized protein
1 - - 0.0
170
Uncharacterized protein
1 - - 0.0
232
Uncharacterized protein
1 - - 0.0
225
Histone-lysine N-methyltransferase
1 - - 0.0
207
Histone-lysine N-methyltransferase
1 - - 0.0
184
Histone-lysine N-methyltransferase
1 - - 0.0
181
Uncharacterized protein
1 - - 0.0
222
Uncharacterized protein
1 - - 0.0
217
Predicted protein
1 - - 0.0
158
PR domain containing 15
1 - - 0.0
165
Uncharacterized protein
1 - - 0.0
209
SET and MYND domain-containing protein DDB_G0288495
1 - - 0.0
168
Uncharacterized protein
1 - - 0.0
178
PR/SET domain 8
1 - - 0.0
224
Uncharacterized protein
1 - - 0.0
192
Histone-lysine N-methyltransferase
1 - - 0.0
233
PR/SET domain 12
1 - - 0.0
199
Uncharacterized protein
1 - - 0.0
183
Uncharacterized protein
1 - - 0.0
157
Protein CBG24432
1 - - 0.0
204
Uncharacterized protein
1 - - 0.0
179
PR domain 4
1 - - 0.0
236
Uncharacterized protein
1 - - 0.0
234
Uncharacterized protein
1 - - 0.0
193
Uncharacterized protein
1 - - 0.0
177
Myeloid/lymphoid or mixed-lineage leukemia
1 - - 0.0
205
Uncharacterized protein
1 - - 0.0
227
Histone-lysine N-methyltransferase
1 - - 0.0
163
SET domain containing 5
1 - - 0.0
214
Uncharacterized protein
1 - - 0.0
186
Histone-lysine N-methyltransferase
1 - - 0.0
156
Uncharacterized protein
1 - - 0.0
196
Uncharacterized protein
1 - - 0.0
194
Histone-binding protein
1 - - 0.0
226
SET domain-containing protein 5
1 - - 0.0
237
Uncharacterized protein
1 - - 0.0
235
PR domain containing 4
1 - - 0.0
171
Histone-lysine N-methyltransferase set-1
1 - - 0.0
176
Uncharacterized protein
1 - - 0.0
215
AGAP003597-PA
1 - - 0.0
166
Uncharacterized protein
1 - - 0.0
185
Uncharacterized protein
1 - - 0.0
153
PR domain-containing 11
1 - - 0.0
180
Si:dkeyp-41f9.4
1 - - 0.0
187
Histone-lysine N-methyltransferase
1 - - 0.0
212
Uncharacterized protein
1 - - 0.0
155
Uncharacterized protein
1 - - 0.0
175
Uncharacterized protein
1 - - 0.0
198
Histone-lysine N-methyltransferase
1 - - 0.0
202
Whsc1 protein
1 - - 0.0
154
Histone-lysine N-methyltransferase
1 - - 0.0
229
Uncharacterized protein
1 - - 0.0
210
Uncharacterized protein
1 - - 0.0
242
Histone-lysine N-methyltransferase
1 - - 0.0
152
Protein CBG24719
1 - - 0.0
213
Uncharacterized protein
1 - - 0.0
200
Uncharacterized protein
1 - - 0.0
161
Uncharacterized protein
1 - - 0.0
195
SET domain-containing protein 3
1 - - 0.0
174
PR domain containing 1c
1 - - 0.0
188
Uncharacterized protein
1 - - 0.0
243
Eukaryotic translation initiation factor 2 subunit 3-like Protein
1 - - 0.0
203
Uncharacterized protein
1 - - 0.0
228
Uncharacterized protein
1 - - 0.0
238
Nuclear receptor-binding SET domain protein 1
1 - - 0.0
164
Histone-lysine N-methyltransferase
1 - - 0.0
211
SET domain-containing protein
1 - - 0.0
218
Histone-lysine N-methyltransferase
1 - - 0.0
160
Uncharacterized protein
1 - - 0.0
189
Histone-lysine N-methyltransferase
1 - - 0.0
221
Uncharacterized protein
1 - - 0.0
151
SET
Trithorax/polycomb
1 - - 0.0
182
Uncharacterized protein
1 - - 0.0
167
Nuclear receptor binding SET domain protein 1b
1 - - 0.0
240
SET and MYND domain-containing protein DDB_G0288495
1 - - 0.0
230
SET and MYND domain containing, arthropod-specific, member 4, isoform C
1 - - 0.0
239
SET and MYND domain containing 1b
1 - - 0.0
173
PR domain containing 11
1 - - 0.0
219
Uncharacterized protein
1 - - 0.0
206
Histone-lysine N-methyltransferase
1 - - 0.0
220
Uncharacterized protein
1 - - 0.0
197
Histone-lysine N-methyltransferase
1 - - 0.0
241
SET and MYND domain containing 1a
1 - - 0.0
159
Histone methyltransferase
1 - - 0.0
162
Predicted protein
1 - - 0.0
201
Predicted protein
1 - - 0.0
169
Uncharacterized protein
1 - - 0.0
190
Predicted protein
1 - - 0.0
231
BAH domaincontaining protein
1 - - 0.0
172
Si:dkeyp-41f9.4
1 - - 0.0
223
Uncharacterized protein
1 - - 0.0
216
Uncharacterized protein
1 - - 0.0