CATH Release Notes

This page contains the release notes for each major version of CATH.

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CATH Version 3.5

Based on PDB release: Sept 20, 2011

Changes since v3.4:

  • 20,616 newly assigned domains
  • 77 new homologous superfamilies
  • 31 new folds (topologies)

The table below summarises the number of clusters within each of the four classes in CATH.

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 386 875 2917 3843 5069 10098 37038
2 20 229 520 2618 3796 6147 10744 43881
3 14 594 1113 6183 9107 11668 24452 90029
4 1 104 118 208 259 359 574 2588
Total 40 1313 2626 11926 17005 23243 45868 173536

CATH Version 3.4

Based on PDB release: Nov 13, 2010

Changes since v3.3:

  • 24,232 newly assigned domains
  • 163 new homologous superfamilies
  • 49 new folds (topologies)

The table below summarises the number of clusters within each of the four classes in CATH.

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 376 839 2763 3571 4679 9217 32396
2 20 228 514 2514 3573 5668 9824 39140
3 14 577 1082 5849 8381 10626 21900 79038
4 1 101 114 204 253 352 547 2346
Total 40 1282 2549 11330 15778 21325 41488 152920

CATH Version 3.3

Based on PDB release: July 7, 2009

Changes since v3.2:

  • 14,473 newly assigned domains
  • 199 new homologous superfamilies
  • 123 new folds (topologies)

The table below summarises the number of clusters within each of the four classes in CATH.

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 360 773 2400 3092 4040 7838 26880
2 14 558 1031 5151 7294 9192 18679 66456
3 20 217 473 2283 3225 5002 8589 33469
4 1 98 109 185 233 323 477 1883
Total 40 1233 2386 10019 13844 18557 35583 128688

CATH Version 3.2

Based on PDB release: July 14, 2008

The v3.2.0 release of CATH has a number of improvements in the backend data and the frontend web pages.

Changes since v3.1:

  • 20,330 newly assigned domains
  • 87 new homologous superfamilies
  • 26 new folds (topologies)

The table below summarises the number of clusters within each of the four classes in CATH.

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 310 682 2078 2689 3540 6685 23491
2 20 196 438 2062 2902 4468 7656 29992
3 14 512 956 4558 6473 8135 16346 58967
4 1 92 102 173 217 301 445 1765
Total 40 1110 2178 8871 12281 16444 31132 114215

CATH Version 3.1

Based on PDB release: 14 Jan, 2007

We spent a great deal of effort identifying and correcting errors such as incorrectly chopped chains and misassigned domains. This meant that a number of homologous superfamilies (and folds) were merged with other nodes or removed as CATH domains were rechopped or reassigned.

Changes since v3.0:

  • 7,734 newly assigned domains
  • 47 homologous superfamilies were merged or removed
  • 26 folds (topologies) were merged or removed

The table below summarises the number of clusters within each of the four classes in CATH.

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 305 652 1850 2329 3001 5587 19729
2 20 191 415 1860 2531 3846 6503 25537
3 14 496 922 3922 5303 6659 12998 47193
4 1 92 102 162 200 275 403 1426
Total 40 1084 2091 7794 10363 13781 25491 93885

CATH Version 3.0

Based on PDB release: 5 May, 2006

Class Architecture Topology Homologous Superfamily S35 Family S60 Family S95 Family S100 Family Domains
1 5 316 674 1877 2280 2862 5207 18271
2 20 195 428 1843 2436 3653 6152 23482
3 14 506 941 3956 5103 6239 12184 43025
4 1 93 104 165 197 267 387 1373
Total 40 1110 2147 7841 10016 13021 23930 86151