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CATH Superfamily 4.10.280.10

Helix-loop-helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Putative transcription factor 12
1647
3D
 2ql2C00 - 82.4
2
Basic helix-loop-helix transcription factor
1394 - - 89.3
3
microphthalmia-associated transcription factor isoform X1
1290
3D
 6g1lA00 - 76.9
4
Basic helix-loop-helix transcription factor
891 - - 91.4
5
Myogenic factor
808
3D
 1mdyD00 - 90.0
6
Neurogenic differentiation factor
771
3D
 2ql2D00 - 73.4
7
single-minded homolog 1 isoform X1
730 - - 80.5
8
Nuclear receptor coactivator
724 - - 91.8
9
Transcription factor HES-1
686 - - 86.0
10
Scleraxis bHLH transcription factor
668 - - 86.4
11
Aryl hydrocarbon receptor nuclear translocator 2
608 - - 57.8
12
hairy/enhancer-of-split related with YRPW motif protein 1
583 - - 76.7
13
Circadian locomoter output cycles protein kaput
561
3D
 4f3lA01 - 85.7
14
Max dimerization protein 1
484
3D
 1nlwD00 - 74.7
15
T-cell acute lymphocytic leukemia 1
472
3D
 2ypbA00 - 82.0
16
Sterol regulatory element-binding transcription factor 1
471
3D
 1am9D00 - 77.5
17
Transcription factor bHLH66
446 - - 84.8
18
Aryl hydrocarbon receptor nuclear translocator-like protein 1
442
3D
 4f3lB01 - 71.4
19
Myc proto-oncogene protein
427
3D
 5i50B00 - 98.9
20
class E basic helix-loop-helix protein 40
344 - - 68.9
23
MAX isoform 13
316
3D
 5eyoC00 - 78.8
21
Transcription factor bHLH130 family
315 - - 82.4
22
Basic helix-loop-helix transcription factor
308 - - 86.8
24
Aryl hydrocarbon receptor 2
290 - - 71.1
25
protein atonal homolog 7
282 - - 70.7
26
Basic helix-loop-helix family, member e23
281 - - 66.0
27
Nescient helix-loop-helix 1
279 - - 63.3
28
MLX interacting protein like
275 - - 93.8
29
Achaete-scute family bHLH transcription factor 1
257 - - 83.5
30
Twist transcription factor
256 - - 64.5
31
Oligodendrocyte transcription factor 3
233 - - 61.7
32
Transcription factor bHLH123 family
223 - - 82.1
33
Transcription factor HES-5
220 - - 87.4
34
MAX network transcriptional repressor
217 - - 83.1
35
Pancreas-specific transcription factor 1a
214 - - 73.6
36
Transcription factor AP-4
212 - - 71.4
37
max-like protein X isoform X2
199 - - 77.2
38
achaete-scute homolog 3
192 - - 74.4
39
DNA-binding protein inhibitor ID-3
189
3D
 2lfhB00 - 82.1
40
MAX gene-associated protein isoform X1
175 - - 80.1
41
aryl hydrocarbon receptor repressor
169 - - 72.8
42
transcription factor bHLH48-like isoform X1
165 - - 50.9
43
Helix-loop-helix DNA binding protein
163 - - 31.0
44
Basic helix-loop-helix transcription factor
157 - - 58.5
45
upstream stimulatory factor 2 isoform X1
153 - - 39.4
46
Transcription factor bHLH83
143 - - 81.4
47
mesoderm posterior protein 1
141 - - 68.0
49
MAX isoform 16
131
3D
 1hloB00 - 24.7
48
DNA-binding protein inhibitor ID-4
129 - - 79.9
50
Basic helix-loop-helix transcription factor
128 - - 69.1
51
Basic helix-loop-helix domain-containing protein KIAA2018
115 - - 85.9
52
Protein atonal homolog 8
114 - - 88.6
53
BHLH transcription factor
113 - - 73.0
54
hairy and enhancer of split-related protein HELT
112 - - 80.3
55
DNA-binding protein inhibitor ID-2
109
3D
 4ayaB00 - 49.3
56
mesogenin-1
106 - - 57.6
59
transcription factor UNE10 isoform X1
100 - - 75.2
58
transcription factor BEE 3-like
100 - - 64.8
57
transcription factor-like 5 protein-like
100 - - 86.9
60
Scute protein
95 - - 69.4
61
Transcription factor SPEECHLESS
88 - - 69.0
62
Neuronal PAS domain-containing protein 3
88 - - 85.9
63
transcription factor HES-7 isoform X1
86 - - 88.8
64
Transcription factor MUTE
85 - - 66.7
65
class A basic helix-loop-helix protein 15
81 - - 50.7
66
BHLH transcription factor
80 - - 72.7
67
upstream stimulatory factor 1 isoform X1
76 - - 23.1
68
factor in the germline alpha
70 - - 78.0
69
Transcription factor PIF7
65 - - 78.4
70
transcription factor bHLH30
63 - - 79.1
71
spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
61 - - 73.2
72
enhancer of split mgamma protein-like
52 - - 44.7
74
Transcription factor ORG2
51 - - 91.4
73
MAX dimerization protein 3
51 - - 42.4
75
Transcription factor bHLH113 family
48 - - 79.3
76
hypoxia-inducible factor 3-alpha isoform X1
47 - - 69.0
77
transcription factor HES-3 isoform X2
45 - - 77.5
78
Transcription factor bHLH13
44 - - 66.0
79
CLUMA_CG001539, isoform A
43 - - 77.8
80
Taiman isoform A
41 - - 88.3
81
transcription cofactor HES-6 isoform X1
40 - - 85.3
83
Neuronal PAS domain protein 1
40 - - 72.2
82
Transcription factor ILI6
40 - - 66.2
84
class A basic helix-loop-helix protein 9
37 - - 43.3
85
Transcription factor bHLH126
37 - - 91.9
86
protein extra-macrochaetae
37 - - 73.7
87
Transcription factor hes-1
36 - - 63.1
88
HLH DNA binding protein
35 - - 23.1
89
Transcription factor LAX PANICLE
35 - - 70.4
90
Salivary gland-expressed bHLH
32 - - 82.8
99
Myc-family transcription factor
31
3D
 1a0aB00 - 76.3
93
BHLH domain class transcription factor
30 - - 56.0
92
transcription factor bHLH68 isoform X1
30 - - 36.7
94
Blast:Carbohydrate-responsive element-binding protein
30 - - 67.5
91
HLH DNA binding domain protein
30 - - 35.1
96
Basic helix-loop-helix
BHLH
29 - - 82.3
98
Sterol regulatory element-binding protein
29 - - 69.8
95
Basic helix-loop-helix family protein
29 - - 73.2
97
Neuronal PAS domain-containing protein 2
29 - - 57.2
100
Transcription factor BEE 3
27 - - 59.2
102
Nescient helix-loop-helix 1
27 - - 58.5
101
Transcription factor PRE4
27 - - 52.9
103
Transcription factor bHLH162
25 - - 87.3
104
Transcription factor bHLH34
25 - - 80.5
105
Rtg3p
24 - - 67.2
106
Transcription factor ILI5
22 - - 27.7
107
Basic helix-loop-helix transcription factor
22 - - 38.3
108
Basic helix-loop-helix transcription factor
21 - - 29.3
110
Aspartyl-phosphate phosphatase Spo0E
19 - - 0.0
109
Transcription factor bHLH91-like
19 - - 75.2
111
HLH transcription factor
Hpa3
18 - - 52.0
112
Hes family bHLH transcription factor 6
18 - - 72.3
114
N-acetyl-gamma-glutamyl-phosphate partial
17 - - 75.5
113
Transcription factor ILI1
17 - - 22.6
115
Transcription factor bHLH113
14 - - 36.5
116
Putative HLH transcription factor
14 - - 73.8
118
Transcription factor bHLH10
13 - - 70.1
120
Spermatogenesis and oogenesis specific basic helix-loop-helix 1
13 - - 13.6
117
Os01g0108400 protein
13 - - 63.0
119
Helix Loop Helix
13 - - 11.9
121
Serine-rich protein TYE7
13 - - 4.1
122
Retrograde regulation protein 1
13 - - 25.9
123
Transcription factor bHLH113
12 - - 52.9
124
transcription factor AP-4 isoform X3
12 - - 5.4
130
Unplaced genomic scaffold supercont1.11, whole genome shotgun sequence
11 - - 16.2
126
Protein WBSCR14 homolog
11 - - 45.5
129
HLH DNA binding protein
Penr2
11 - - 11.1
131
Basic helix-loop-helix protein
11 - - 3.8
132
CRE-HLH-2 protein
11 - - 61.7
127
Helix-loop-helix protein 11
11 - - 60.6
128
Basic helix-loop-helix protein
11 - - 42.4
125
Transcription factor EGL1
11 - - 30.4
133
BHLH transcription factor
10 - - 51.1
134
Max-like protein X
10 - - 41.1
135
Transcription factor MYC1
10 - - 22.7
136
CBN-MXL-2 protein
9 - - 71.0
140
High-copy mep suppressor
9 - - 11.1
139
Clockwork orange, isoform B
9 - - 0.0
137
Transcription factor bHLH52
9 - - 69.5
138
Basic helix-loop-helix
BHLH
9 - - 55.7
144
Uncharacterized protein
8 - - 14.0
141
Basic helix-loop-helix
BHLH
8 - - 36.1
142
Spermatogenesis and oogenesis specific basic helix-loop-helix 1
8 - - 40.8
145
Helix-loop-helix DNA-binding domain containing protein, expressed
8 - - 67.2
143
Rtg1p
8 - - 13.1
147
Transcription factor AP-4
activating enhancer binding protein 4
7 - - 7.5
146
Transcription factor bHLH162
7 - - 70.1
149
Related to centromere binding factor 1
6 - - 10.8
151
Transcription factor HES-1-B
6 - - 41.6
152
Nuclear pore complex protein NUP155
6 - - 11.2
148
Basic helix-loop-helix
BHLH
6 - - 43.9
150
Mesoderm posterior protein 1
6 - - 14.1
154
Protein CBR-HLH-12
5 - - 30.3
155
Upstream stimulatory factor 2
5 - - 23.2
153
Transcription factor bHLH167
5 - - 29.6
156
Myogenic determination factor
5 - - 41.4
159
Basic helix-loop-helix
BHLH
4 - - 0.0
157
Uncharacterized protein
4 - - 27.6
163
Transcriptional regulator CBF1
4 - - 14.3
160
Putative transcription factor bHLH041
4 - - 13.6
158
Sterol regulatory element Binding Protein
4 - - 43.2
165
Transcription factor bHLH104
4 - - 41.0
164
Putative dna-binding protein inhibitor
4 - - 12.8
161
Predicted protein
4 - - 6.8
162
Transcription factor BHLH148
4 - - 0.0
179
Aryl hydrocarbon receptor nuclear translocator-like protein 2
3 - - 0.0
174
YALI0D24167p
3 - - 0.0
182
Basic helix-loop-helix
3 - - 31.1
181
Hairy enhancer of split
3 - - 41.3
166
Transcription factor bHLH52
3 - - 27.1
172
Basic helix-loop-helix
BHLH
3 - - 1.3
171
Basic helix-loop-helix family protein
3 - - 7.3
177
Transcription factor
3 - - 19.9
178
Uncharacterized protein
3 - - 0.0
175
Inhibitor of DNA binding 1
3 - - 0.0
168
transcription factor protein
3 - - 4.8
170
Putative myc-like protein MYCLP1
3 - - 12.2
167
Helix-loop-helix protein 6
3 - - 8.6
173
helix-loop-helix protein delilah
3 - - 7.2
180
Transcription factor BPE
3 - - 36.7
183
Transcription factor protein
3 - - 30.4
169
FI24210p1
3 - - 5.6
176
Carbohydrate metabolism regulator TYE7
3 - - 11.6
189
Uncharacterized protein
2 - - 0.0
184
Uncharacterized protein
2 - - 17.1
193
Uncharacterized protein
2 - - 0.0
190
Protein INO4, putative
2 - - 5.9
202
Transcription factor hes-1, putative
2 - - 46.1
196
Uncharacterized protein
2 - - 0.0
201
Hms1p
2 - - 0.0
185
Uncharacterized protein
2 - - 10.5
187
YALI0F05126p
2 - - 0.0
204
Neuronal stem cell leukemia 2-like protein
2 - - 53.6
188
Transcription factor bHLH66
2 - - 0.0
192
Transcription factor bHLH109
2 - - 0.0
191
Transcription factor UDT1
2 - - 0.0
199
Uncharacterized protein
2 - - 0.0
194
Max-like protein X
2 - - 0.0
195
cDNA FLJ52911, highly similar to Max-like protein X
2 - - 9.3
186
Transcriptional regulator of yeast form adherence 6
2 - - 7.7
198
Polyadenylate-binding protein
2 - - 38.1
203
Uncharacterized protein
2 - - 48.0
200
Hms1p
2 - - 0.0
197
Predicted protein
2 - - 29.6
243
Uncharacterized protein
1 - - 0.0
205
REF-1
1 - - 0.0
231
Uncharacterized bHLH domain-containing protein C3F10.12c
1 - - 0.0
232
MAX dimerization protein MLX
1 - - 0.0
229
Uncharacterized protein
1 - - 0.0
224
Uncharacterized protein
1 - - 0.0
240
Uncharacterized protein
1 - - 0.0
208
Predicted protein
1 - - 0.0
221
Uncharacterized protein ASH2
1 - - 0.0
222
Transcription factor bHLH99
1 - - 0.0
239
Predicted protein
1 - - 0.0
234
Helix Loop Helix
1 - - 0.0
216
BHLH transcription factor
1 - - 0.0
207
Transcription factor bHLH117
1 - - 0.0
235
Transcription factor bHLH130
1 - - 0.0
228
Transcription factor bHLH95
1 - - 0.0
210
Protein CBG18500
1 - - 0.0
227
Transcription factor bHLH14
1 - - 0.0
213
MAX-like-1 homolog
1 - - 0.0
225
Uncharacterized protein
1 - - 0.0
246
Uncharacterized protein
1 - - 0.0
238
Uncharacterized protein
1 - - 0.0
209
Uncharacterized protein
1 - - 0.0
237
Id-1
1 - - 0.0
223
uncharacterized protein LOC100176581
1 - - 0.0
206
Uncharacterized protein
1 - - 0.0
217
Uncharacterized protein
1 - - 0.0
220
Achaete-scute family bHLH transcription factor 4
1 - - 0.0
218
DNA binding protein
1 - - 0.0
244
Transcription factor bHLH62
1 - - 0.0
241
Predicted protein
1 - - 0.0
242
Uncharacterized protein
1 - - 0.0
233
Uncharacterized protein
1 - - 0.0
230
Extra macrochaetae-like protein
1 - - 0.0
215
HER-2 protein
1 - - 0.0
214
MLX-interacting protein-like protein
1 - - 0.0
219
Hairy-related 9
1 - - 0.0
236
Os03g0279500 protein
1 - - 0.0
248
Predicted protein
1 - - 0.0
247
Uncharacterized protein
1 - - 0.0
245
Transcription factor, putative
1 - - 0.0
226
Uncharacterized protein
1 - - 0.0
211
Uncharacterized protein
1 - - 0.0
212
Transcription factor DYT1
1 - - 0.0
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